Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives

Surai, Peter

doi:10.3390/antiox4010204

Cited by 738Silymarin and Mushroom PoisoningGenomics, phytochemicals, and oxidative stressSelenium in Biological Systems

Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives

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Surai, Peter·2015·Antioxidants

DOI 10.3390/antiox4010204PMC PMC4665566

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Abstract

Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various flavonolignans (with silybin being the major one), has received a tremendous amount of attention over the last decade as a herbal remedy for liver treatment. In many cases, the antioxidant properties of SM are considered to be responsible for its protective actions. Possible antioxidant mechanisms of SM are evaluated in this review. (1) Direct scavenging free radicals and chelating free Fe and Cu are mainly effective in the gut. (2) Preventing free radical formation by inhibiting specific ROS-producing enzymes, or improving an integrity of mitochondria in stress conditions, are of great importance. (3) Maintaining an optimal redox balance in the cell by activating a range of antioxidant enzymes and non-enzymatic antioxidants, mainly via Nrf2 activation is probably the main driving force of antioxidant (AO) action of SM. (4) Decreasing inflammatory responses by inhibiting NF-κB pathways is an emerging mechanism of SM protective effects in liver toxicity and various liver diseases. (5) Activating vitagenes, responsible for synthesis of protective molecules, including heat shock proteins (HSPs), thioredoxin and sirtuins and providing additional protection in stress conditions deserves more attention. (6) Affecting the microenvironment of the gut, including SM-bacteria interactions, awaits future investigations. (7) In animal nutrition and disease prevention strategy, SM alone, or in combination with other hepatho-active compounds (carnitine, betaine, vitamin B12, etc.), might have similar hepatoprotective effects as described in human nutrition.

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Pre-clinical and clinical studies have shown anti-oxidant properties of silibinin.
“Pre–clinical and clinical studies have shown anti-oxidant properties of silibinin [45].”
From Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells (2021) · cites this paper as [45]
Section 4.1 reports antioxidant effects of silibinin in cell experiments, and section 4.4 reports protective effects in animal experiments. These support the pre-clinical part of the claim, but the cited passages do not establish that clinical studies showed antioxidant effects of silibinin; the study of monocytes from pre-eclamptic women was conducted in vitro. No page numbers are available in our copy. (LLM, conf=0.82)
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Silymarin: not just another antioxidant
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silymarin 的 Hepatoprotective 效果
Nancy, Vargas-Mendoza, Eduardo, E., Madrigal-Santillán, ngel, Morales-González, Jaime, Esquivel-Soto, César, Esquivel-Chirino, et al. (2014)

Authors: Surai, P.
Affiliations: Magyar Agrár- és Élettudományi Egyetem (HU)
Corresponding author: Surai, Peter
ORCID: Surai, Peter
Venue: Antioxidants
Publisher: MDPI AG
Published: 2015-03-20
Volume: 4
Issue: 1
Pages: 204-247
ISSN: 2076-3921 (ISSN-L)
DOI: 10.3390/antiox4010204
PMC: PMC4665566
OpenAlex: W2142110193
Cited by: 738
References: 293
Citations by year: 2026: 61 · 2025: 92 · 2024: 91 · 2023: 89 · 2022: 61 · 2021: 69 · 2020: 89 · 2019: 53 · 2018: 42 · 2017: 57 · 2016: 26 · 2015: 7
FWCI: 7.86
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Antioxidants (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Silymarin and Mushroom Poisoning
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Keywords: silymarin, Silybum marianum, flavonolignans, silibinin, antioxidant defense, free radical scavenging, metal chelation, reactive oxygen species, mitochondria, Nrf2, NF-κB, inflammation, heat shock proteins, thioredoxin, sirtuins, gut microbiota, hepatoprotection, liver disease, hepatotoxicity, herbal medicine

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Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives

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