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TMEM97 ablation aggravates oxidant-induced retinal degeneration

Shen, Hongtao, Li, Jing, Heisler-Taylor, Tyler, Makin, Ryan, Yang, Huan, Mavlyutov, Timur A., Gelfand, Bradley, Cebulla, Colleen M., Guo, Lian-Wang·2021·Cellular Signalling
DOI 10.1016/j.cellsig.2021.110078PMC PMC8869839
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  • TMEM97 knockout cell lines exhibit aberrant autophagic flux and lysosome dysfunction.

    “TMEM97 knockout cell lines exhibit aberrant autophagic flux and lysosome dysfunction [119].”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [119]

  • S2R expression is elevated in retinal pigment epithelium-specific Clic4 knockout mice, which exhibit functional and pathological hallmarks of dry AMD; TMEM97 knockout mice have exhibited conflicting results in dry AMD models; and S2R-selective modulation with CM398 reduced photoreceptor loss and retinal autofluorescent granules in an illumination-induced AMD model.

    “S2R expression is elevated in retinal pigment epithelium-specific Clic4 knockout mice, which exhibit both functional and pathological hallmarks of dry AMD. Conversely, TMEM97 knockout mice have exhibited conflicting results in dry AMD models, which are likely dependent upon the type of stressor used to induce pathology. Intravenous administration of sodium iodate to TMEM97 knockout animals induced”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [119]

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Research works printed but not linked: 46

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Metadata

Authors
Shen, H., Li, J., Heisler-Taylor, T., Makin, R., Yang, H., Mavlyutov, T. A., Gelfand, B., Cebulla, C. M., & Guo, L.-W.
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2021-10
Volume
86
Pages
110078
ISSN
0898-6568
DOI
10.1016/j.cellsig.2021.110078
PMC
PMC8869839
Cited by
19
References
5
Language
en
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