γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43

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Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

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γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment

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The mechanism of γ‐Secretase dysfunction in familial Alzheimer disease

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Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase

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Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

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Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

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Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch

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Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

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Potent amyloidogenicity and pathogenicity of Aβ43

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Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

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Presenilins mediate a dual intramembranous γ‐secretase cleavage of Notch‐1

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Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3

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Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase

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Secretase inhibitors and modulators for Alzheimer’s disease treatment

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γ‐Secretase inhibitors and modulators for Alzheimer’s disease

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Secretion of the Notch-1 Aβ-like Peptide during Notch Signaling

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The 28‐amino acid form of an APLP1‐derived Aβ‐like peptide is a surrogate marker for Aβ42 production in the central nervous system

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Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase

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A Novel Presenilin-1 Mutation (Leu85Pro) in Early-Onset Alzheimer Disease With Spastic Paraparesis

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Phosphoinositides Suppress γ-Secretase in Both the Detergent-soluble and -insoluble States

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Novel PSEN1 Mutation in a Bulgarian Patient With Very Early-Onset Alzheimer’s Disease, Spastic Paraparesis, and Extrapyramidal Signs

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The amyloid hypothesis of Alzheimer's disease at 25 years

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

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Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

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Making the final cut: Pathogenic amyloid-β peptide generation by γ-secretase

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Modulation of γ- and β-secretases as early prevention against Alzheimer's disease

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Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease

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Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

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Chemical Cleavage of Proteins at Asparaginyl-Glycyl Peptide Bonds

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Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin

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Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

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Loss‐of‐function presenilin mutations in Alzheimer disease

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Are Presenilins Intramembrane-Cleaving Proteases? Implications for the Molecular Mechanism of Alzheimer's Disease

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