The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions
Open accessAbstract
Endoplasmic reticulum (ER)-plasma membrane (PM) junctions are highly conserved subcellular structures. Despite their importance in Ca(2+) signaling and lipid trafficking, the molecular mechanisms underlying the regulation and functions of ER-PM junctions remain unclear. By developing a genetically encoded marker that selectively monitors ER-PM junctions, we found that the connection between ER and PM was dynamically regulated by Ca(2+) signaling. Elevation of cytosolic Ca(2+) triggered translocation of E-Syt1 to ER-PM junctions to enhance ER-to-PM connection. This subsequently facilitated the recruitment of Nir2, a phosphatidylinositol transfer protein (PITP), to ER-PM junctions following receptor stimulation. Nir2 promoted the replenishment of PM phosphatidylinositol 4,5-bisphosphate (PIP2) after receptor-induced hydrolysis via its PITP activity. Disruption of the enhanced ER-to-PM connection resulted in reduced PM PIP2 replenishment and defective Ca(2+) signaling. Altogether, our results suggest a feedback mechanism that replenishes PM PIP2 during receptor-induced Ca(2+) signaling via the Ca(2+) effector E-Syt1 and the PITP Nir2 at ER-PM junctions.
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Cites
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Metadata
- Authors
- Chang, C.-L., Hsieh, T.-S., Yang, T. T., Rothberg, K. G., Azizoglu, D. B., Volk, E., Liao, J.-C., & Liou, J.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 5
- Issue
- 3
- Pages
- 813-825
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2111332270
- Cited by
- 366
- References
- 40
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chang, C.-L., Hsieh, T.-S., Yang, T. T., Rothberg, K. G., Azizoglu, D. B., Volk, E., Liao, J.-C., & Liou, J. (2013). Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions. Cell Reports. https://doi.org/10.1016/j.celrep.2013.09.038
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