The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus
Open accessAbstract
Experience-dependent plasticity shapes postnatal development of neural circuits, but the mechanisms that refine dendritic arbors, remodel spines, and impair synaptic activity are poorly understood. Mature brain-derived neurotrophic factor (BDNF) modulates neuronal morphology and synaptic plasticity, including long-term potentiation (LTP) via TrkB activation. BDNF is initially translated as proBDNF, which binds p75(NTR). In vitro, recombinant proBDNF modulates neuronal structure and alters hippocampal long-term plasticity, but the actions of endogenously expressed proBDNF are unclear. Therefore, we generated a cleavage-resistant probdnf knockin mouse. Our results demonstrate that proBDNF negatively regulates hippocampal dendritic complexity and spine density through p75(NTR). Hippocampal slices from probdnf mice exhibit depressed synaptic transmission, impaired LTP, and enhanced long-term depression (LTD) in area CA1. These results suggest that proBDNF acts in vivo as a biologically active factor that regulates hippocampal structure, synaptic transmission, and plasticity, effects that are distinct from those of mature BDNF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Domingos da Silveira da Luz, A. C., Pereira Dias, G., do Nascimento Bevilaqua, M. C., Cocks, G., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 3,995
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340
Self-citationMorphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136
Self-citationConner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02295.1997 · Cited by 1,097
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013
Self-citationLyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 865
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815
Self-citationBDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?
Lu, Y., Christian, K., & Lu, B. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.018 · Cited by 768
New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function
Greenberg, M. E., Xu, B., Lu, B., & Hempstead, B. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3566-09.2009 · Cited by 597
Self-citationNeurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481
Pozzo-Miller, L. D., Gottschalk, W., Zhang, L., McDermott, K., Du, J., Gopalakrishnan, R., Oho, C., Sheng, Z.-H., & Lu, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04972.1999 · Cited by 472
Yang, J., Siao, C.-J., Nagappan, G., Marinic, T., Jing, D., McGrath, K., Chen, Z.-Y., Mark, W., Tessarollo, L., Lee, F. S., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2244 · Cited by 449
Self-citationProtocadherins mediate dendritic self-avoidance in the mammalian nervous system
Lefebvre, J. L., Kostadinov, D., Chen, W. V., Maniatis, T., & Sanes, J. R. (2012) · Nature · doi:10.1038/nature11305 · Cited by 443
Donovan, M. J., Lin, M. I., Wiegn, P., Ringstedt, T., Kraemer, R., Hahn, R., Wang, S., Ibañez, C. F., Rafii, S., & Hempstead, B. L. (2000) · Development · doi:10.1242/dev.127.21.4531 · Cited by 435
Self-citationBrain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity.
Cowansage, K., LeDoux, J., & Monfils, M.-H. (2010) · Current Molecular Pharmacology · doi:10.2174/1874467211003010012 · Cited by 372 · cited 1×
“Numerous studies suggest that binding of proBDNF to the p75 receptor (p75NTR) and mature BDNF to the TrkB receptor have opposing effects on neuronal structure and synaptic plasticity (Woo et al., 2005; Cowansage et al., 2010; Teng et al., 2010).”
BackgroundBiosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Korte, M., & Barde, Y.-A. (2008) · Nature Neuroscience · doi:10.1038/nn2038 · Cited by 360
Mowla, S. J., Pareek, S., Farhadi, H. F., Petrecca, K., Fawcett, J. P., Seidah, N. G., Morris, S. J., Sossin, W. S., & Murphy, R. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02069.1999 · Cited by 350
Dendrite Self-Avoidance Is Controlled by Dscam
Matthews, B. J., Kim, M. E., Flanagan, J. J., Hattori, D., Clemens, J. C., Zipursky, S. L., & Grueber, W. B. (2007) · Cell · doi:10.1016/j.cell.2007.04.013 · Cited by 350
BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons
Dieni, S., Matsumoto, T., Dekkers, M., Rauskolb, S., Ionescu, M. S., Deogracias, R., Gundelfinger, E. D., Kojima, M., Nestel, S., Frotscher, M., et al. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201201038 · Cited by 346
Pang, P. T., & Lu, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.07.002 · Cited by 340
Local protein synthesis, actin dynamics, and LTP consolidation
Bramham, C. R. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.09.013 · Cited by 301
Rauskolb, S., Zagrebelsky, M., Dreznjak, A., Deogracias, R., Matsumoto, T., Wiese, S., Erne, B., Sendtner, M., Schaeren-Wiemers, N., Korte, M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5100-09.2010 · Cited by 291
Zagrebelsky, M., Holz, A., Dechant, G., Barde, Y.-A., Bonhoeffer, T., & Korte, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2492-05.2005 · Cited by 286
Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth
Yacoubian, T. A., & Lo, D. C. (2000) · Nature Neuroscience · doi:10.1038/73911 · Cited by 278
Scharfman, H. E., Mercurio, T. C., Goodman, J. H., Wilson, M. A., & MacLusky, N. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11641.2003 · Cited by 271
Self-citationControl of extracellular cleavage of ProBDNF by high frequency neuronal activity
Nagappan, G., Zaitsev, E., Senatorov, V. V., Yang, J., Hempstead, B. L., & Lu, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807322106 · Cited by 270
Self-citationA role for BDNF in the late-phase of hippocampal long-term potentiation
Korte, M., Kang, H., Bonhoeffer, T., & Schuman, E. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00035-5 · Cited by 268
Homophilic Dscam Interactions Control Complex Dendrite Morphogenesis
Hughes, M. E., Bortnick, R., Tsubouchi, A., Bäumer, P., Kondo, M., Uemura, T., & Schmucker, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.013 · Cited by 264
Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation
Chen, G., Kolbeck, R., Barde, Y.-A., Bonhoeffer, T., & Kossel, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07983.1999 · Cited by 243
Mizoguchi, H., Nakade, J., Tachibana, M., Ibi, D., Someya, E., Koike, H., Kamei, H., Nabeshima, T., Itohara, S., Takuma, K., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3118-11.2011 · Cited by 199
Je, H. S., Yang, F., Ji, Y., Nagappan, G., Hempstead, B. L., & Lu, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207767109 · Cited by 188
Self-citationRösch, H., Schweigreiter, R., Bonhoeffer, T., Barde, Y.-A., & Korte, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502460102 · Cited by 184
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
Dietz, D. M., Sun, H., Lobo, M. K., Cahill, M. E., Chadwick, B., Gao, V., Koo, J. W., Mazei-Robison, M. S., Dias, C., Maze, I., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3094 · Cited by 184
Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac
Deinhardt, K., Kim, T., Spellman, D. S., Mains, R. E., Eipper, B. A., Neubert, T. A., Chao, M. V., & Hempstead, B. L. (2011) · Science Signaling · doi:10.1126/scisignal.2002060 · Cited by 183
Self-citationDanzer, S. C., Crooks, K. R. C., Lo, D. C., & McNamara, J. O. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09754.2002 · Cited by 183
Understanding proneurotrophin actions: Recent advances and challenges
Teng, K. K., Felice, S., Kim, T., & Hempstead, B. L. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20768 · Cited by 179
Self-citationProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA
Sun, Y., Lim, Y. P., Li, F., Liu, S., Lu, J., Haberberger, R. V., Zhong, J., & Zhou, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035883 · Cited by 150
Skucas, V. A., Mathews, I. B., Yang, J., Cheng, Q., Treister, A. K., Duffy, Á., Verkman, A. S., Hempstead, B. L., Wood, M. A., Binder, D. K., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6249-10.2011 · Cited by 147
Self-citationPro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses
Yang, F., Je, H.-S., Ji, Y., Nagappan, G., Hempstead, B., & Lu, B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200811147 · Cited by 130
Self-citationKwon, M., Fernandez, J. R., Zegarek, G. F., Lo, S. B., & Firestein, B. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6785-10.2011 · Cited by 115
Estrogen promotes learning-related plasticity by modifying the synaptic cytoskeleton
Kramár, E. A., Babayan, A. H., Gall, C. M., & LYNCH, G. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.038 · Cited by 99
Orefice, L. L., Waterhouse, E. G., Partridge, J. G., Lalchandani, R. R., Vicini, S., & Xu, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0012-13.2013 · Cited by 87
Gao, X., Smith, G. M., & Chen, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.10.009 · Cited by 77
Plachta, N., Annaheim, C., Bissière, S., Lin, S., Rüegg, M. A., Hoving, S., Müller, D., Poirier, F., Bibel, M., & Barde, Y. (2007) · Nature Neuroscience · doi:10.1038/nn1897 · Cited by 70
Iyer, S. C., Wang, D. Y. Q., Iyer, E. P. R., Trunnell, S. A., Meduri, R., Shinwari, R., Sulkowski, M. J., & Cox, D. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033634 · Cited by 64
Lochner, J. E., Spangler, E., Chavarha, M., Jacobs, C. L., McAllister, K. A. L., Schuttner, L. C., & Scalettar, B. A. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20650 · Cited by 43
Tamalin Is a Critical Mediator of Electroconvulsive Shock-Induced Adult Neuroplasticity
Yanpallewar, S. U., Barrick, C. A., Palko, M. E., Fulgenzi, G., & Tessarollo, L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5493-11.2012 · Cited by 25
Leßmann, V., Stroh-Kaffei, S., Steinbrecher, V., Edelmann, E., Brigadski, T., Kilb, W., & Luhmann, H. J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.061 · Cited by 15
Quantitative intact specimen magnetic resonance microscopy at 3.0 T
Bath, K. G., Voss, H. U., Jing, D., Anderson, S., Hempstead, B. L., Lee, F. S., Dyke, J. P., & Ballon, D. (2009) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2008.11.008 · Cited by 8
Self-citation
Cited by
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425
Regulation of hippocampal synaptic plasticity by BDNF
Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410
A map of human circular RNAs in clinically relevant tissues
Maass, P. G., Glažar, P., Memczak, S., Dittmar, G., Hollfinger, I., Schreyer, L., Sauer, A. V., Toka, O., Aiuti, A., Luft, F. C., et al. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1582-9 · Cited by 384
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324
Metadata
- Authors
- Yang, J., Harte-Hargrove, L. C., Siao, C.-J., Marinic, T., Clarke, R., Ma, Q., Jing, D., LaFrancois, J. J., Bath, K. G., Mark, W., Ballon, D., Lee, F. S., Scharfman, H. E., & Hempstead, B. L.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 7
- Issue
- 3
- Pages
- 796-806
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2067302534
- Cited by
- 334
- References
- 55
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
