Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Open accessAbstract
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy as a protective factor against neurodegeneration associated with intracytoplasmic aggregate-prone protein accumulation as well as other roles, including in neuronal stem cell differentiation. We then describe how autophagy may be affected in a range of neurodegenerative diseases. Finally, we describe how autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions and consider possible pathways and druggable targets that may be suitable for this objective.
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Endogenous defects in autophagy are associated with embryonic lethality, developmental defects, and multiple pathological disorders including neurodegeneration, cancer, and cardiovascular disorders.
“and permanent or transient endogenous defects in autophagy have been associated with embryonic lethality, developmental defects, and multiple pathological disorders, including (but not limited to) neurodegeneration, cancer, and cardiovascular disorders [812–817].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [813]
Molecular and histopathologic analyses of patient tissues demonstrate mislocalized or accumulated autophagy machinery, pathogenic mutations underlying familial neurodegenerative diseases disable known autophagy-related factors, and genetically ablating autophagy effectors produces neurodegeneration in cell and animal model systems, supporting a role for autophagy dysfunction in age-related neurode
“Molecular and histopathologic analyses of patient tissues demonstrate mislocalized or accumulated autophagy machinery, pathogenic mutations underlying familial neurodegenerative diseases disable known autophagy-related factors, and genetically ablating autophagy effectors produce neurodegeneration in cell and animal model systems [74–81], supporting a role for autophagy dysfunction in the devel”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [80]
The autophagic process is essential in preserving homeostatic requirements of post-mitotic neurons in both central and peripheral nervous systems.
“The autophagic process is essential in preserving the homeostatic requirements of post‐mitotic neurons, both at the central and at the peripheral nervous system levels (Menzies et al, 2017; Scrivo et al, 2018; Mallucci et al, 2020)”
From Autophagy in major human diseases (2021) · cites this paper as Menzies et al, 2017
A comparable phenotype to ATG5 suppression has been described in Atg16l1 hypomorphic mice.
“By analogy, a comparable phenotype has been described in Atg16l1 hypomorphic mice (Lv et al, 2014; Wu et al, 2016; Menzies et al, 2017).”
From Autophagy in major human diseases (2021) · cites this paper as Menzies et al, 2017
Aβ is targeted for autophagy-dependent degradation within the lysosome, explaining why activation of autophagy reduces the burden of Aβ plaques in rodents.
“Aβ is targeted for autophagy‐dependent degradation within the lysosome, explaining why activation of autophagy reduces the burden of Aβ plaques in rodents (Boland et al, 2008; Menzies et al, 2017; Meng et al, 2019).”
From Autophagy in major human diseases (2021) · cites this paper as Menzies et al, 2017
Autophagy is implicated in the non-canonical secretion of Aβ into the extracellular space.
“However, autophagy appears to be causally implicated in the PSEN1 (presenilin 1)‐mediated conversion of APP (amyloid beta precursor protein) into Aβ (Yu et al, 2005), as well as in the non‐canonical secretion of Aβ into the extracellular space (Nilsson et al, 2013; Menzies et al, 2017).”
From Autophagy in major human diseases (2021) · cites this paper as Menzies et al, 2017
Autophagy proteins have been shown to impact the clearance of protein aggregates in neurons, most likely by canonical aggrephagy.
“While autophagy proteins have been shown to impact the clearance of protein aggregates in neurons, most likely by the canonical autophagic process of aggrephagy (Frake et al., 2015; Menzies et al., 2017; Qaisiya et al., 2017; Sarkar et al., 2007; Sarkar et al., 2009; Webb et al., 2003; Yamamoto and Simonsen, 2011), effects in microglia of the CNS are more likely due to LANDO.”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Menzies et al., 2017
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Self-citationLipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease
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Self-citationThe Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
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Self-citationAlsin Is a Rab5 and Rac1 Guanine Nucleotide Exchange Factor
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InfluentialSelf-citationMutation in TECPR2 Reveals a Role for Autophagy in Hereditary Spastic Paraparesis
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InfluentialThe proteostasis network and its decline in ageing
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Self-citationLysosomes as a therapeutic target
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BackgroundA brief history of autophagy from cell biology to physiology and disease
Mizushima, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0092-5 · Cited by 696 · see citing works
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Self-citationSelective autophagy of intracellular organelles: Recent research advances
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“Dysregulation of autophagy has a close relationship with several diseases, such as aging and neurodegeneration of the central nervous system [23, 24], cancer [25-27], metabolic disease [26, 28], heart dysfunction [29, 30] and inflammatory diseases [31, 32].”
BackgroundSelf-citationHeckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503 · see citing works
“While autophagy proteins have been shown to impact the clearance of protein aggregates in neurons, most likely by the canonical autophagic process of aggrephagy (Frake et al., 2015; Menzies et al., 2017; Qaisiya et al., 2017; Sarkar et al., 2007; Sarkar et al., 2009; Webb et al., 2003; Yamamoto and Simonsen, 2011), ef…”
The different autophagy degradation pathways and neurodegeneration
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Self-citationConverging pathways in neurodegeneration, from genetics to mechanisms
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The Role of PI3K/Akt and ERK in Neurodegenerative Disorders
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“[39], impaired neuronal mitochondrial metabolism decreases adenosine triphosphate (ATP) generation, elevates O2 free radicals, and increases the generation of extracellular Aβ and the phosphorylation of intracellular Tau proteins.”
BackgroundRusmini, P., Cortese, K., Crippa, V., Cristofani, R., Cicardi, M. E., Ferrari, V., Vezzoli, G., Tedesco, B., Meroni, M., Messi, E., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1535292 · Cited by 436 · see citing works
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“This mechanism activates ULK1 through phosphorylation of Ser317 and Ser77 under glucose deprivation or Ser555 under amino acid deprivation and mitophagy [248].”
BackgroundMechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Nixon, R. A., & Rubinsztein, D. C. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00757-5 · Cited by 435 · see citing works
“Much activity has focused on identifying drugs to induce auto-phagosome formation and improve lysosome function 4,267,268 .”
Self-citationRoles of Autophagy in Oxidative Stress
Yun, H. R., Jo, Y. H., Kim, J., Shin, Y., Kim, S. S., & Choi, T. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093289 · Cited by 403 · see citing works
“A loss of GBA induces the accumulation of its substrate glucosylceramide within lysosomes, leading to autophagy impairment by lysosomal dysfunction [226].”
BackgroundMicroglia and astrocyte dysfunction in parkinson's disease
Kam, T., Hinkle, J. T., Dawson, T. M., & Dawson, V. L. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105028 · Cited by 399 · see citing works
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“On the other hand, an updated Cochrane review found only a low to moderate certainty of evidence for interventions with the MedDiet in primary prevention of CVDs (Rees et al., 2019).”
BackgroundAutophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives
Zhang, Z., Yang, X., Song, Y., & Tu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101464 · Cited by 378 · see citing works
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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
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“Defective autophagy, one of the components of the proteostasis network, associates with neurodegenerative diseases, including Parkinson’s disease (PD) and Alzheimer’s disease (AD) (Menzies et al., 2017; Scrivo et al., 2018).”
BackgroundUbiquitin-mediated regulation of autophagy
Chen, R., Chen, Y.-H., & Huang, T.-Y. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0569-y · Cited by 320 · see citing works
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“Thus, regulating autophagy in the CNS could be a potential therapeutic approach against HIV-associated neurocognitive disorders [77].”
BackgroundThe effect of fasting or calorie restriction on autophagy induction: A review of the literature
Bagherniya, M., Butler, A. E., Barreto, G. E., & Sahebkar, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.08.004 · Cited by 317 · see citing works
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“It should be mentioned that autophagy begins to fail in neurodegenerative disorders because itself becomes the target of toxic protein oligomers [97, 102].”
BackgroundMitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure
Wang, Y., Xu, E., Musich, P. R., & Lin, F. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13116 · Cited by 298 · see citing works
Autophagy and the hallmarks of aging
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Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence?
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“The degradation of dysfunctional mitochondria through mitophagy and the manipulation of this process has been suggested to be an important therapeutic avenue for many degenerative diseases [141].”
BackgroundThe Ageing Brain: Molecular and Cellular Basis of Neurodegeneration
Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 257 · see citing works
Role of AMPK mediated pathways in autophagy and aging
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Autophagy, aging, and age-related neurodegeneration
Palmer, J. E., Wilson, N., Son, S. M., Obrocki, P., Wróbel, L., Rob, M., Takla, M., Korolchuk, V. I., & Rubinsztein, D. C. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.015 · Cited by 255 · see citing works
“105,204,205 An attractive space for such drugs might be to bolster lysosomal function.”
BackgroundSelf-citationRoot, J. T., Merino, P., Nuckols, A., Johnson, M. A., & Kukar, T. L. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105360 · Cited by 230 · see citing works
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases
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BackgroundSelf-citationTargeting autophagy in disease: established and new strategies
Koçak, M., Erdi, S. E., Jorba, G., Maestro, I., Farrés, J., Kirkin, V., Martı́nez, A., & Pleß, O. (2021) · Autophagy · doi:10.1080/15548627.2021.1936359 · Cited by 229 · see citing works
“Upregulation of autophagy proteins, such as AMPK or Atg8a in Drosophila, or ATG5, ATG7, BECN1 or TFEB (transcription factor EB; a transcriptional regulator of autophagy and lysosome genes) in mice, not only induces autophagy, but also reduces age-associated phenotype/pathologies and extended the lifespan [18,58,59].”
BackgroundGao, F., Almeida, S., & Lopez‐Gonzalez, R. (2017) · The EMBO Journal · doi:10.15252/embj.201797568 · Cited by 218 · see citing works
“Autophagy has been implicated in many human diseases, including different forms of neurodegeneration (Nixon, 2013; Menzies et al , 2017).”
Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3
Houtman, J., Freitag, K., Gimber, N., Schmoranzer, J., Heppner, F. L., & Jendrach, M. (2019) · The EMBO Journal · doi:10.15252/embj.201899430 · Cited by 212 · see citing works
“Impaired autophagy has been linked to AD in various ways as detailed in recent reviews (Menzies et al , 2015, 2017), but research until now has concentrated almost exclusively on neurons.”
Beyond autophagy: LC3-associated phagocytosis and endocytosis
Peña-Martinez, C., Rickman, A. D., & Heckmann, B. L. (2022) · Science Advances · doi:10.1126/sciadv.abn1702 · Cited by 212 · see citing works
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Fregno, I., Fasana, E., Bergmann, T. J., Raimondi, A., Loi, M., Soldà, T., Galli, C., D'Antuono, R., Morone, D., Danieli, A., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899259 · Cited by 207 · see citing works
“In fact, these strategies of enhancing autophagy are so promising that they are currently progressing into clinical validation (Menzies et al, 2017).”
BackgroundInfluentialAutophagy in Neurodegenerative Diseases: A Hunter for Aggregates
Park, H., Kang, J., & Lee, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093369 · Cited by 205 · see citing works
Zhang, W., Xu, C., Sun, J., Shen, H., Wang, J., & Yang, C. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.008 · Cited by 214 · see citing works
Li, Y., Zhang, J., Wan, J., Liu, A., & Sun, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110887 · Cited by 212 · see citing works
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Boya, P., Codogno, P., & Rodriguez-Muela, N. (2018) · Development · doi:10.1242/dev.146506 · Cited by 197 · see citing works
“Indeed, autophagy is implicated in a plethora of pathologies, including neurodegenerative, metabolic and immune diseases (Boya et al., 2016; Deretic et al., 2015; Galluzzi et al., 2015; Menzies et al., 2017; Stienstra et al., 2014).”
Autophagy in aging and longevity
Wong, S. Q., Kumar, A. V., Mills, J., & Lapierre, L. R. (2019) · Human Genetics · doi:10.1007/s00439-019-02031-7 · Cited by 204 · see citing works
Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
The Effects of Intermittent Fasting on Brain and Cognitive Function
Gudden, J., Vásquez, A. A., & Bloemendaal, M. (2021) · Nutrients · doi:10.3390/nu13093166 · Cited by 204 · see citing works
“BDNF levels, that are associated with both chronic stress [122] and chronic depression [123], were increased by a 9 h fast in a recent mice study also inducing antidepressant effects [84].”
BackgroundInfluentialThe role of lysosomes in metabolic and autoimmune diseases
Gros, F., & Muller, S. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00692-2 · Cited by 199 · see citing works
Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Guerrini, R., Conti, V., Mantegazza, M., Balestrini, S., Galanopoulou, A. S., & Benfenati, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00063.2021 · Cited by 196 · see citing works
Chakraborty, R., Nonaka, T., Hasegawa, M., & Zurzolo, C. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05835-8 · Cited by 190 · see citing works
Emerging roles of ATG7 in human health and disease
Collier, J. J., Suomi, F., Oláhová, M., McWilliams, T. G., & Taylor, R. W. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114824 · Cited by 191 · see citing works
Sarkar, C., Jones, J. W., Hegdekar, N., Thayer, J. A., Kumar, A., Faden, A. I., Kane, M. A., & Lipinski, M. M. (2019) · Autophagy · doi:10.1080/15548627.2019.1628538 · Cited by 188 · see citing works
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
Malik, B. R., Maddison, D. C., Smith, G. A., & Peters, O. M. (2019) · Molecular Brain · doi:10.1186/s13041-019-0504-x · Cited by 180 · see citing works
“Through their implication in a broad range of neurodegenerative disorders, endo-lysosomal and autophagy mechanisms have become appealing targets for therapeutic intervention [163].”
BackgroundPersistent remodeling and neurodegeneration in late-stage retinal degeneration
Pfeiffer, R. L., Marc, R. E., & Jones, B. W. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.07.004 · Cited by 178 · see citing works
“pathways leading to autophagy and its role in neurodegeneration diseases (including RD), is the subject of numerous reviews (Boya et al., 2016; Menzies et al., 2017; Moreno et al., 2018).”
BackgroundNovel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease
Bulck, M. V., Sierra‐Magro, A., Alarcón-Gil, J., Pérez‐Castillo, A., & Morales-Garcia, J. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030719 · Cited by 179 · see citing works
The effects of metformin on autophagy
Lu, G., Wu, Z., Shang, J., Xie, Z., Chen, C., & zhang, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111286 · Cited by 179 · see citing works
Wei, R., Mao, L., Xu, P., Zheng, X., Hackman, R. M., Mackenzie, G. G., & Wang, Y. (2018) · Food & Function · doi:10.1039/c8fo01397g · Cited by 173 · see citing works
Cao, Y., Li, Q.-L., Liu, L.-L., Wu, H., Huang, F., Wang, C.-H., Lan, Y., Zheng, F., Xing, F., Zhou, Q., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14626 · Cited by 151 · see citing works
“Autophagy is an intracellular degradation event in which a portion of cytoplasm is sequestered into autophagosomes, which degrade proteins and cellular structures upon fusing with lysosomes (Klionsky, 2005; Mizushima, 2007).”
BackgroundLiquid–liquid phase separation in autophagy
Noda, N. N., Wang, Z., & Zhang, H. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202004062 · Cited by 168 · see citing works
“Aberrant accumulation of protein aggregates as a result of impaired autophagic degradation has been linked with aging and pathogenesis of various diseases (Levine et al., 2011; Menzies et al., 2017; Zhao and Zhang, 2019a).”
BackgroundColacurcio, D. J., Pensalfini, A., Jiang, Y., & Nixon, R. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.001 · Cited by 167 · see citing works
Autophagy and intermittent fasting: the connection for cancer therapy?
Antunes, F., Erustes, A. G., Costa, A. J., Nascimento, A. C., Bincoletto, C., Ureshino, R. P., Pereira, G. J. S., & Smaili, S. S. (2018) · Clinics · doi:10.6061/clinics/2018/e814s · Cited by 165 · see citing works
“Throughout the past decade, autophagy has attracted considerable attention as a potential target of pharmacological agents or dietary interventions that inhibit or activate this process for several human disorders, including infections and inflammatory diseases (22), neurodegeneration (23), metabolic and cardiovascula…”
BackgroundMolecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression
Andronie-Cioară, F. L., Ardelean, A. I., Nistor-Cseppento, C. D., Jurcău, A., Jurcău, M. C., Pașcalău, N., & Marcu, F. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031869 · Cited by 164 · see citing works
Consensus Paper. Cerebellar Reserve: From Cerebellar Physiology to Cerebellar Disorders
Mitoma, H., Buffo, A., Gelfo, F., Guell, X., Fucà, E., Kakei, S., Lee, J., Manto, M. U., Petrosini, L., Shaikh, A. G., et al. (2019) · The Cerebellum · doi:10.1007/s12311-019-01091-9 · Cited by 166 · see citing works
“Significant dysfunctions in the autophagy pathway have been identified in several neurodegenerative diseases [158, 159].”
BackgroundThe aging lysosome: An essential catalyst for late-onset neurodegenerative diseases
Nixon, R. A. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140443 · Cited by 149 · see citing works
“The dysfunction of autophagy in aging-related neurodegenerative disorders has been extensively reviewed (Boland et al., 2018; Menzies et al., 2017; Nixon, 2016; Nixon, 2013; Scrivo et al., 2018).”
BackgroundFarfel-Becker, T., Roney, J. C., Cheng, X.-T., Li, S., Cuddy, S. R., & Sheng, Z.-H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.013 · Cited by 152 · see citing works
“…to the pathogenesis of major neurodegenerative diseases, including Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis (Nixon, 2013; Xie et al., 2015; Wong and Krainc, 2016; 2017; Menzies et al., 2017; Wang et al., 2018; Pitcairn et al., 2019; Klein and Mazzulli, 2018).”
Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
Agujetas, V. R., de Dios, C., Pinilla, L. L., Marı́, M., Morales, A., & Colell, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3809308 · Cited by 149 · see citing works
“The brain of individuals with these neurodegenerative proteinopathies also displays an accumulation of autophagosome-like structures, suggesting an impaired autophagic flux as the cause of the abnormal diseasespecific protein buildups [139].”
BackgroundSelvaraj, N. R., Nandan, D., Nair, B. J. B., Nair, V. A., Venugopal, P., & Aradhya, R. (2025) · Cells · doi:10.3390/cells14070511 · Cited by 147 · see citing works
“…increases oxidative stress [190] Autophagy Can promote both stemness maintenance and loss [189] Impairment contributes to protein aggregation [191] Genetic influence Oncogenes promote cell survival and growth (e.g., PARK7/DJ-1 antagonizing PTEN) [192] Tumor suppressor-like genes involved in…”
Wang, H., Chen, S., Zhang, Y., Xu, H., & Sun, H. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.07.004 · Cited by 145 · see citing works
Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine
Ding, M.-R., Qu, Y.-J., Hu, B., & An, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113208 · Cited by 144 · see citing works
Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases
Corti, O., Blomgren, K., Poletti, A., & Beart, P. M. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15002 · Cited by 141 · see citing works
“…continue to attract attention focusing on for example mTOR-dependent and-independent pathways, and broadly on signalling linked to Beclin1, Atg5, AMP-dependent protein kinase, PICALM and histone deacetylases (Shoji-Kawata et al. 2013, Hu et al. 2017, Menzies et al. 2017, Rahman & Rhim 2017).”
BackgroundAutophagy impairment in Parkinson’s disease
Karabiyik, C., Lee, M. J., & Rubinsztein, D. C. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170023 · Cited by 137 · see citing works
“Mutations underlying various neurodegenerative diseases that manifest with intracytoplasmic protein aggregates have been shown to affect the clearance of these substrates by compromising autophagy (4).”
BackgroundSelf-citationNeurodegenerative Disease Tauopathies
Creekmore, B. C., Watanabe, R., & Lee, E. B. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-120750 · Cited by 144 · see citing works
Zhang, Y., Wu, Q., Zhang, L., Wang, Q., Yang, Z.-X., Liu, J., & Feng, L. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104538 · Cited by 139 · see citing works
Adaptor protein complexes and disease at a glance
Sanger, A., Hirst, J., Davies, A. K., & Robinson, M. S. (2019) · Journal of Cell Science · doi:10.1242/jcs.222992 · Cited by 137 · see citing works
“Defective autophagy is implicated in the aetiology of many neurodegenerative diseases (Menzies et al., 2017) and neuronal-specific loss of Atg9a in mice causes severe neurological phenotypes (Yamaguchi et al., 2018).”
BackgroundNiewiadomska, G., Niewiadomski, W., Steczkowska, M., & Gąsiorowska, A. (2021) · Life · doi:10.3390/life11010028 · Cited by 132 · see citing works
Behl, T., Makkar, R., Sehgal, A., Singh, S., Sharma, N., Zengin, G., BUNGAU, S. G., Andronie-Cioară, F. L., Munteanu, M. A., Brisc, M. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147432 · Cited by 134 · see citing works
“neuronal cell death in diseases, such as protein homeostasis, [20] mitochondrial dysfunc-”
BackgroundInfluentialThe protective role of exercise against age-related neurodegeneration
Sujkowski, A. L., Hong, L., Wessells, R. J., & Todi, S. V. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101543 · Cited by 134 · see citing works
Autophagy Dysfunction in Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities
Di Meco, A., Curtis, M. E., Lauretti, E., & Praticò, D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.008 · Cited by 133 · see citing works
Parkinson's disease: convergence on synaptic homeostasis
Soukup, S., Vanhauwaert, R., & Verstreken, P. (2018) · The EMBO Journal · doi:10.15252/embj.201898960 · Cited by 129 · see citing works
“Following elongation and maturation, the autophagosome fuses with the lysosome, a process mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor activating protein receptors; Menzies et al, 2017).”
MethodMicroglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
Festa, B. P., Siddiqi, F. H., Jimenez-Sanchez, M., Won, H., Rob, M., Djajadikerta, A., Stamatakou, E., & Rubinsztein, D. C. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.006 · Cited by 129 · see citing works
“Furthermore, genetic or pharmacological induction of autophagy enhances the clearance of aggregate-prone proteins and attenuates deleterious phenotypes observed in animal models mimicking these disorders.(3,4)”
BackgroundSelf-citationFelodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
Siddiqi, F. H., Menzies, F. M., López, A., Stamatakou, E., Karabiyik, C., Ureshino, R. P., Ricketts, T., Jiménez-Sánchez, M., Esteban, M. A., Lai, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09494-2 · Cited by 129 · see citing works
Self-citationFedeli, C., Filadi, R., Rossi, A., Mammucari, C., & Pizzo, P. (2019) · Autophagy · doi:10.1080/15548627.2019.1596489 · Cited by 132 · see citing works
“formation of both protein aggregates [1,3].”
BackgroundGlycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward
Ruiz, S. M. A., & Eldar-Finkelman, H. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.792364 · Cited by 126 · see citing works
“From a mechanistic point of view, inhibition GSK-3 may reduce mHtt toxicity via the ability to increase the amount of heat shock proteins [activation of heat shock factor-1 (HSF1)], by activating autophagy, and by reducing tau pathology (Carmichael et al., 2002; L’Episcopo et al., 2016; Menzies et al., 2017; Rippin et…”
BackgroundRusso, R., Varano, G. P., Adornetto, A., Nazio, F., Tettamanti, G., Girardello, R., Cianfanelli, V., Cavaliere, F., Morrone, L. A., Corasaniti, M. T., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1044-5 · Cited by 127 · see citing works
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
Pedro, J. M. B., Sica, V., Martins, I., Pol, J. G., Loos, F., Maiuri, M. C., Durand, S., Bossut, N., Aprahamian, F., Anagnostopoulos, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.010 · Cited by 127 · see citing works
Neurodegeneration and Neuro-Regeneration—Alzheimer’s Disease and Stem Cell Therapy
Vasić, V., Barth, K., & Schmidt, M. H. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174272 · Cited by 128 · see citing works
“a link between the expression of several autophagy genes and AD [102,103].”
BackgroundAutophagy in health and disease: From molecular mechanisms to therapeutic target
Lu, G. X., Wang, Y., Shi, Y. P., Zhang, Z., Huang, C., He, W., Wang, C., & Shen, H. (2022) · MedComm · doi:10.1002/mco2.150 · Cited by 127 · see citing works
- Authors
- Menzies, F. M., Fleming, A., Caricasole, A., Bento, C. F., Andrews, S. P., Ashkenazi, A., Füllgrabe, J., Jackson, A., Jimenez Sanchez, M., Karabiyik, C., Licitra, F., Lopez Ramirez, A., Pavel, M., Puri, C., Renna, M., Ricketts, T., Schlotawa, L., Vicinanza, M., Won, H., Zhu, Y., Skidmore, J., & Rubinsztein, D. C.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Rubinsztein, David C.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 93
- Issue
- 5
- Pages
- 1015-1034
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2592067246
- Cited by
- 1,134
- References
- 288
- Citations by year
- 2026: 68 · 2025: 96 · 2024: 107 · 2023: 119 · 2022: 153 · 2021: 138 · 2020: 145 · 2019: 159 · 2018: 108 · 2017: 39 · 2016: 1
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
- Apollo
- Funders
- Tau Consortium
- Alzheimer’s Research UK
- Wellcome Trust (095317/Z/11/Z)
- Cambridge Institute for Medical Research (100140/Z/12/Z)
- NIHR Biomedical Research Unit in Dementia at Addenbrooke’s Hospital
- The Rosetrees Trust
- FEBS
- Addenbrooke’s Charitable Trust
- Sims Scholarship
- James Baird Fund
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- autophagy, neurodegeneration, lysosomal degradation, protein aggregation, neurodegenerative diseases, therapeutic target, druggable targets, mouse knockout models
- MeSH terms
- Animals, Autophagy, Humans, Lysosomes, Motor Neurons, Proteins, Signal Transduction, Neurodegenerative Diseases
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