The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice
Open accessAbstract
Different subsets and/or polarized phenotypes of monocytes and macrophages may play distinct roles during the development and resolution of inflammation. Here, we demonstrate in a murine model of rheumatoid arthritis that nonclassical Ly6C(-) monocytes are required for the initiation and progression of sterile joint inflammation. Moreover, nonclassical Ly6C(-) monocytes differentiate into inflammatory macrophages (M1), which drive disease pathogenesis and display plasticity during the resolution phase. During the development of arthritis, these cells polarize toward an alternatively activated phenotype (M2), promoting the resolution of joint inflammation. The influx of Ly6C(-) monocytes and their subsequent classical and then alternative activation occurs without changes in synovial tissue-resident macrophages, which express markers of M2 polarization throughout the course of the arthritis and attenuate joint inflammation during the initiation phase. These data suggest that circulating Ly6C(-) monocytes recruited to the joint upon injury orchestrate the development and resolution of autoimmune joint inflammation.
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Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · cited 2×
“Macrophages may be readily manipulated in vitro to generate distinct classically activated/M1 or alternatively activated/M2 cells (Mosser and Edwards, 2008); however, their phenotypes in vivo may not be as straightforward (Sica and Mantovani, 2012; Xue et al.”
Macrophage plasticity and polarization: in vivo veritas
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
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Nomenclature of monocytes and dendritic cells in blood
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“Here, we generated bone marrow chimeric mice with selective shielding of the joint during irradiation to demonstrate that the naive mouse joint contains a heterogeneous population of macrophages, namely tissue-resident and bone-marrow-derived macrophages (Ginhoux and Jung, 2014; Hashimoto et al., 2013; Yona et al., 20…”
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Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162152 · Cited by 1,133
Self-citationAlivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0939-8 · Cited by 740
Self-citationMonocyte heterogeneity and functions in cancer
Olingy, C. E., Dinh, H. Q., & Hedrick, C. C. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ri0818-311r · Cited by 579
Nonclassical Patrolling Monocyte Function in the Vasculature
Thomas, G., Tacke, R., Hedrick, C. C., & Hanna, R. N. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304650 · Cited by 367
The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review
Ma, W.-T., Gao, F., Gu, K., & Chen, D.-K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01140 · Cited by 361
Metadata
- Authors
- Misharin, A. V., Cuda, C. M., Saber, R., Turner, J. D., Gierut, A. K., Haines, G. K., Berdnikovs, S., Filer, A., Clark, A. R., Buckley, C. D., Mutlu, G. M., Budinger, G. R. S., & Perlman, H.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 9
- Issue
- 2
- Pages
- 591-604
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2065639597
- Cited by
- 326
- References
- 56
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Misharin, A. V., Cuda, C. M., Saber, R., Turner, J. D., Gierut, A. K., Haines, G. K., Berdnikovs, S., Filer, A., Clark, A. R., Buckley, C. D., Mutlu, G. M., Budinger, G. R. S., & Perlman, H. (2014). Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice. Cell Reports. https://doi.org/10.1016/j.celrep.2014.09.032
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
