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Cited by 383

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Modeling the Spatiotemporal Dynamics of Light and Heat Propagation for In Vivo Optogenetics

Open access
Stujenske, Joseph M., Spellman, Timothy, Gordon, Joshua A.·2015·Cell Reports
DOI 10.1016/j.celrep.2015.06.036
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Abstract

Despite the increasing use of optogenetics in vivo, the effects of direct light exposure to brain tissue are understudied. Of particular concern is the potential for heat induced by prolonged optical stimulation. We demonstrate that high-intensity light, delivered through an optical fiber, is capable of elevating firing rate locally, even in the absence of opsin expression. Predicting the severity and spatial extent of any temperature increase during optogenetic stimulation is therefore of considerable importance. Here, we describe a realistic model that simulates light and heat propagation during optogenetic experiments. We validated the model by comparing predicted and measured temperature changes in vivo. We further demonstrate the utility of this model by comparing predictions for various wavelengths of light and fiber sizes, as well as testing methods for reducing heat effects on neural targets in vivo.

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Metadata

Authors
Stujenske, J. M., Spellman, T., & Gordon, J. A.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2015-07
Volume
12
Issue
3
Pages
525-534
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2015.06.036
OpenAlex
W1912996233
Cited by
383
References
39
FWCI
11.82
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.