Locus coeruleus and dopaminergic consolidation of everyday memory
Open accessAbstract
The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH+) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH+ neurons project more profusely than ventral tegmental area TH+ neurons to the hippocampus, optogenetic activation of locus coeruleus TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH+ photoactivation are sensitive to hippocampal D 1/D 5 receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.
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Stimulation of locus coeruleus neurons enhances hippocampus-dependent memory.
“Notably, stimulation of locus coeruleus neurons, presumably releasing noradrenaline or dopamine, enhances hippocampus-dependent memory [105–108].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [105]
Memory consolidation induced by contextual novelty was modulated by DA release from the locus coeruleus rather than the ventral tegmental area, dependent on hippocampal DA D1/5-R but not adrenergic-R.
“Memory consolidation induced by contextual novelty was modulated by the DA release from the locus coeruleus, rather than ventral tegmental area, which is dependent on the hippocampal DA D1/5-R, but not adrenergic-R”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Takeuchi et al., 2016
DAergic projections to the dorsal hippocampus originate primarily from the locus coeruleus rather than the ventral tegmental area.
“the DAergic projections to the dorsal hippocampus, which originate primarily from the locus coeruleus, rather than ventral tegmental area”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Takeuchi et al., 2016
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- Authors
- Takeuchi, T., Duszkiewicz, A. J., Sonneborn, A., Spooner, P. A., Yamasaki, M., Watanabe, M., Smith, C. C., Fernández, G., Deisseroth, K., Greene, R. W., & Morris, R. G. M.
- Affiliations
- University of Edinburgh (GB)
- The University of Texas Southwestern Medical Center (US)
- Hokkaido University (JP)
- Radboud University Nijmegen (NL)
- Stanford University (US)
- University of Tsukuba (JP)
- Instituto de Neurociencias (ES)
- Corresponding author
- Greene, Robert W.
- Morris, Richard G. M.
- ORCID
- Venue
- Nature
- Published
- 2016-09
- Volume
- 537
- Issue
- 7620
- Pages
- 357-362
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5161591
- OpenAlex
- W2508644210
- Cited by
- 827
- References
- 58
- Citations by year
- 2026: 82 · 2025: 91 · 2024: 121 · 2023: 98 · 2022: 73 · 2021: 81 · 2020: 79 · 2019: 63 · 2018: 87 · 2017: 47 · 2016: 4 · 2014: 1
- FWCI
- 42.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- European Commission (600725)
- University of Tsukuba
- National Institutes of Health
- Medical Research Council (MC_UU_12024/3)
- National Institute of Mental Health (R01MH080297)
- National Institute on Drug Abuse (T32DA007290)
- FP7 Ideas: European Research Council (268800)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- locus coeruleus, everyday memory, episodic-like memory, novelty effect, tyrosine hydroxylase neurons, ventral tegmental area, hippocampus, dopamine D1/D5 receptors, synaptic potentiation, CA1, optogenetic stimulation, flashbulb memory
- MeSH terms
- Memory Consolidation, Animals, Dopamine, Locus Coeruleus, Male, Mice, Inbred C57BL, Synaptic Transmission, Neurons, Receptors, Adrenergic, Receptors, Dopamine D1, Ventral Tegmental Area, Receptors, Dopamine D5, Mice, CA1 Region, Hippocampal, Optogenetics, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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