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Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions

Robinson, M. B., Lee, M. L., & DaSilva, S. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02974-8 · Cited by 51 · see citing works

Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity

Li, N., Karaca, M., & Maechler, P. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.012 · Cited by 47 · see citing works

Interplay between bioenergetics and oxidative stress at normal brain aging. Aging as a result of increasing disbalance in the system oxidative stress–energy provision

Lushchak, V. I. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02531-4 · Cited by 47 · see citing works

Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology

Parpura, V., Fisher, E. S., Lechleiter, J. D., Schousboe, A., Waagepetersen, H. S., Brunet, S., Baltan, S., & Verkhratsky, A. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1848-6 · Cited by 46 · see citing works

Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila

Zhao, X. L., & Karpac, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.003 · Cited by 43 · see citing works

AMP‐activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics

Voss, C. M., Andersen, J. V., Jakobsen, E., Siamka, O., Karaca, M., Maechler, P., & Waagepetersen, H. S. (2020) · Glia · doi:10.1002/glia.23808 · Cited by 43 · see citing works

Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion

Kim, A. Y., Jeong, K., Lee, J. H., KANG, Y. Y., Lee, S., & Baik, E. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.007 · Cited by 41 · see citing works

Cisplatin Toxicity in Dorsal Root Ganglion Neurons Is Relieved by Meclizine via Diminution of Mitochondrial Compromise and Improved Clearance of DNA Damage

Gorgun, M. F., Zhuo, M., & Englander, E. W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0273-9 · Cited by 41 · see citing works

Glutamate Dehydrogenase as a Neuroprotective Target Against Neurodegeneration

Kim, A. Y., & Baik, E. J. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2467-1 · Cited by 39 · see citing works

Enzyme Complexes Important for the Glutamate–Glutamine Cycle

McKenna, M. C., & Ferreira, G. C. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-45096-4_4 · Cited by 35 · see citing works

Glutamate metabolism in cerebral mitochondria after ischemia and post‐ischemic recovery during aging: relationships with brain energy metabolism

Ferrari, F., Gorini, A., Hoyer, S., & Villa, R. F. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14464 · Cited by 34 · see citing works

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

Voss, C. M., Arildsen, L., Nissen, J. D., Waagepetersen, H. S., Schousboe, A., Maechler, P., Ott, P., Vilstrup, H., & Walls, A. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.646291 · Cited by 32 · see citing works

Diurnal regulation of the function of the rat brain glutamate dehydrogenase by acetylation and its dependence on thiamine administration

Aleshin, V. A., Mkrtchyan, G. V., Kaehne, T., Graf, A. V., Maslova, M. V., & Bunik, V. I. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14951 · Cited by 31 · see citing works

Age-Dependent Neurochemical Remodeling of Hypothalamic Astrocytes

Santos, C. L., Roppa, P. H. A., Chiarello, P. T., Fontella, F. U., Souza, D. O., Bobermin, L. D., & Quincozes‐Santos, A. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0786-x · Cited by 31 · see citing works

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Andersson, L. E., Shcherbina, L., Al‐Majdoub, M., Vishnu, N., Balderas, C., Carrara, J. A., Wollheim, C. B., Fex, M., Mulder, H., Wierup, N., et al. (2017) · Diabetes · doi:10.2337/db16-1441 · Cited by 27 · see citing works

Augmentation of glycolytic metabolism by meclizine is indispensable for protection of dorsal root ganglion neurons from hypoxia-induced mitochondrial compromise

Zhuo, M., Gorgun, M. F., & Englander, E. W. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.022 · Cited by 26 · see citing works

Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease

Pan, C., Mao, S., Xiong, Z., Chen, Z., & Xu, N. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175733 · Cited by 23 · see citing works

Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions

Spanaki, C., Kotzamani, D., & Plaitakis, A. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1986-x · Cited by 23 · see citing works

The nature of early astroglial protection—Fast activation and signaling

Kardos, J., Héja, L., Jemnitz, K., Kovács, R., & Palkovits, M. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.005 · Cited by 23 · see citing works

The glutamate receptor GluK2 contributes to the regulation of glucose homeostasis and its deterioration during aging

Abarkan, M., Gaitan, J., Lebreton, F., Perrier, R., Jaffredo, M., Mulle, C., Magnan, C., Raoux, M., & Lang, J. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.011 · Cited by 20 · see citing works

Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293

Aleshin, V. A., Artiukhov, A. V., Kaehne, T., Graf, A. V., & Bunik, V. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158006 · Cited by 22 · see citing works

Dietary supplementation with glutamate enhanced antioxidant capacity, ammonia detoxification and ion regulation ability in Nile tilapia (Oreochromis niloticus) exposed to acute alkalinity stress

Wang, M., Li, E., Huang, Y., Liu, W., Wang, S., Li, W., Chen, L., & Wang, X. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741360 · Cited by 20 · see citing works

A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and pharmacology identifies important, unresolved topics for future studies

Dienel, G. A., Schousboe, A., McKenna, M. C., & Rothman, D. L. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15812 · Cited by 14 · see citing works

Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells

Domith, I., Duarte-Silva, A. T., Garcia, C. G., Calaza, K. D. C., Paes‐de‐Carvalho, R., & Cossenza, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.023 · Cited by 12 · see citing works

Acutely increased β-hydroxybutyrate plays a role in the prefrontal cortex to escape stressful conditions during the acute stress response

Son, H., Baek, J. H., Kang, J. S., Jung, S., Chung, H. J., & Kim, H. J. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.062 · Cited by 12 · see citing works

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis studyPreprint

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Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis studyPreprint

Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova‐Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/149526 · Cited by 12 · see citing works

Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution

Plaitakis, A., Kotzamani, D., Petraki, Z., Delidaki, M., Rinotas, V. E., Zaganas, I. V., Douni, E. K., Sidiropoulou, K., & Spanaki, C. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2546-3 · Cited by 10 · see citing works

Uncoupling Protein 2 (UCP2) Function in the Brain as Revealed by the Cerebral Metabolism of (1–13C)-Glucose

Contreras, L., Rial, E., Cerdán, S., & Satrústegui, J. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1999-5 · Cited by 7 · see citing works

In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

Joo, Y., Kim, Y.-K., Choi, I.-G., Kim, H. J., Son, Y., Kim, H.-K., Cumming, P. D., & Kim, J. (2020) · EJNMMI Research · doi:10.1186/s13550-020-00716-z · Cited by 6 · see citing works

Glutamate–aspartate transporter 1 attenuates oxygen–glucose deprivation‐induced injury by promoting glutamate metabolism in primary cortical neurons

Zhao, Y., Wei, J., Song, K., Zhou, C. Y., & Chai, Z. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30768 · Cited by 5 · see citing works

BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects

Scotti-Muzzi, E., Chile, T., Vallada, H., Otaduy, M. C. G., & Soeiro‐de‐Souza, M. G. (2023) · Brain Imaging and Behavior · doi:10.1007/s11682-023-00757-7 · Cited by 4 · see citing works

SLC38A3 deficiency reveals a critical role of blood-derived glutamine in brain development

Radzishevsky, I. S., Harb, L., Odeh, M., Maoz, I., Saeed, A., Lahkar, A., Agranovich, B., Abramovich, I., Chaudhry, F. A., Avital, A., et al. (2025) · Brain · doi:10.1093/brain/awaf473 · Cited by 3 · see citing works

Astroglial Adrenergic Receptor Signaling in Brain Cortex

Hertz, L., & Chen, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805088-0.00002-5 · Cited by 3 · see citing works

Amino Acids | Glutamate Dehydrogenase: An Anaplerotic Enzyme in Neurons and an Energy Producing Enzyme in Astrocytes

Schousboe, A., & Aldana, B. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.21361-7 · Cited by 1 · see citing works

Head Mild Hypothermia Inhibits the Increase of Extracellular Glutamate Concentration by Upregulating Glial Glutamate Transporter 1 During Ischemia-reperfusion InjuryPreprint

Ma, D., An, Q., Zhang, Z., Bian, Q., Li, Y., Li, Y., & Zhang, S. (2019) · doi:10.21203/rs.2.17383/v1

Influência de polimorfismos de genes funcionais (GAD1 rs1978340, CACNA1C rs100737 e BDNF rs6265) nos neurometabólitos cerebrais em pacientes com Transtorno Afetivo Bipolar e controles

Leitão, E. S. M. M. (2023) · doi:10.11606/t.5.2023.tde-22082023-162443

Revisiting the Neuroprotective Role of 17B-Estradiol (E2): A Multi-Omics Based Analysis of the Rat Brain and Serum

Zaman, K. (2018) · doi:10.12794/metadc1248456

In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion

Zhou, Y., Baez, N., Fu, T., Brun, T., & Maechler, P. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110661

Investigating the molecular pathways driving the sumoylation/desumoylation balance in rat hippocampal synapses

Schorova, L. (2018) · theses.fr (ABES) · doi:10.70675/a30a505az5e81z4089za24azcf43d27e33ce

Transistors Electrochimiques Organiques (OECTs) : nouveaux capteurs pour l’analyse de l’activité électrique des micro-organes pancréatiques

Abarkan, M. (2021) · theses.fr (ABES) · doi:10.70675/0f990149z612az4d86z9394z193eeae3b644

Communications intercellulaires dynamiques au sein des îlots pancréatiques analysées par multi-electrode arrays : rôles physiologiques et applications biotechnologiques en diabétologie

Jaffredo, M. (2021) · theses.fr (ABES) · doi:10.70675/00b154bazd615z4662zb0a0z275906108dbc

Glucose replaces glutamate as energy substrate to fuel glutamate uptake in glutamate dehydrogenase‐deficient astrocytes

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Glutamate Dehydrogenase (GDH) is essential to sustain energy metabolism in astrocyte cultures

Jensen, D. (2010) · Research at the University of Copenhagen (University of Copenhagen)

Is glutamate dehydrogenase in astrocytes one of the keys to control brain glutamate homeostasis?

Waagepetersen, H. S. (2016) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2016.0233

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation

Hohnholt, M. C., Andersen, V. H., Andersen, J. V., Christensen, S. K., Karaca, M., Maechler, P., & Waagepetersen, H. S. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17714680 · Cited by 61 · see citing works

The lifelong role of glutamate dehydrogenase in the brain

Bałkota, M. (2025) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:190102