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Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling
Open accessAbstract
The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels. However, the role of stretch-activated ion channels (SACs) in arterial smooth muscle cells in the adult remains unknown. Here, we show that Piezo1 is highly expressed in myocytes of small-diameter arteries and that smooth-muscle-specific Piezo1 deletion fully impairs SAC activity. While Piezo1 is dispensable for the arterial myogenic tone, it is involved in the structural remodeling of small arteries. Increased Piezo1 opening has a trophic effect on resistance arteries, influencing both diameter and wall thickness in hypertension. Piezo1 mediates a rise in cytosolic calcium and stimulates activity of transglutaminases, cross-linking enzymes required for the remodeling of small arteries. In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling.
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Citations
Cites
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
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Piezo1 and its inhibitors: Overview and perspectives
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Metadata
- Authors
- Retailleau, K., Duprat, F., Arhatte, M., Ranade, S. S., Peyronnet, R., Martins, J. R., Jodar, M., Moro, C., Offermanns, S., Feng, Y., Demolombe, S., Patel, A., & Honoré, E.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 13
- Issue
- 6
- Pages
- 1161-1171
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2171517688
- Cited by
- 355
- References
- 1
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- gold
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