Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

Xia, Tianli, Konno, Hiroyasu, Ahn, Jeonghyun, Barber, Glen N.·2016·Cell Reports

DOI 10.1016/j.celrep.2015.12.029

Cited by (590)

Items 201–300 of 590

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DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma
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STING activation in macrophages by vanillic acid exhibits antineoplastic potential
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MAD 2L2 inhibits colorectal cancer growth by promoting NCOA 3 ubiquitination and degradation
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Vaccinia Virus Activation and Antagonism of Cytosolic DNA Sensing
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Cloaked Viruses and Viral Factors in Cutting Edge Exosome-Based Therapies
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STING regulates BCR signaling in normal and malignant B cells
Chih-Hang Anthony Tang, Avery C. Lee, Shiun Chang, Qin Song Xu, Andong Shao, Yun Lo, Walker T. Spalek, Javier A. Pinilla-Ibarz, Juan R. Del Valle, Chih‐Chi Andrew Hu · 2020 · Cellular and Molecular Immunology
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The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies
Weitao Zheng, Dechao Feng, Xingyu Xiong, Xinyang Liao, Sheng Wang, Hang Xu, Weizhen Le, Qiang Wei, Lu Yang · 2023 · Aging and Disease
Engineered sTRAIL-armed MSCs overcome STING deficiency to enhance the therapeutic efficacy of radiotherapy for immune checkpoint blockade
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Epigenetically suppressed tumor cell intrinsic STING promotes tumor immune escape
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Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer
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Liangmei He, Ya‐Yun Chen, Yuanbing Wu, Ying Jun Xu, Zixiang Zhang, Zhiping Liu · 2017 · Cellular and Molecular Life Sciences
cGAS and cancer therapy: a double-edged sword
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Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization
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Junli Zhao, Yul Huh, Andrey V. Bortsov, Luda B. Diatchenko, Ru‐Rong Ji · 2023 · Pharmacology & Therapeutics
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Hung-Ching Hsia, Jessica E. Hutti, Albert S. Baldwin · 2017 · Journal of Biological Chemistry
G10 is a direct activator of human STING
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Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
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Nikolai N. Khodarev · 2018 · International review of cytology
PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells
Davide Massa, Marcin Baran, José Antonio Bengoechea, Andrew Bowie · 2020 · Journal of Biological Chemistry
Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′- O -methyl gapmer oligonucleotides
Roxane Valentin, Christophe Wong, Arwaf S. Alharbi, Solène Pradeloux, Makala P Morros, Kim A. Lennox, Julia I. Ellyard, Aurélie Garcin, Tomalika Rahmat Ullah, Gina D. Kusuma et al. · 2021 · Nucleic Acids Research
The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
Ghazal Mohseni, Juan Li, Abakundana Nsenga Ariston Gabriel, Lutao Du, Yunshan Wang, Chuanxin Wang · 2021 · Frontiers in Immunology
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair
Hui Xu, Jing Jin, Ying Chen, Guoqing Wu, Hua Zhu, Qing Wang, Ji Wang, Shenggang Li, Florina Grigore, Jun Ma et al. · 2022 · Oncogene
Association of homozygous variants of STING1 with outcome in human cervical cancer
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Mathieu J. F. Crupi, John Cameron Bell, Ragunath Singaravelu · 2019 · Stem Cells
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Activation of STING in the pancreatic tumor microenvironment: A novel therapeutic opportunity
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Targeting tumor-associated macrophages with STING agonism improves the antitumor efficacy of osimertinib in a mouse model of EGFR-mutant lung cancer
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Balancing STING in antimicrobial defense and autoinflammation
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Nucleic Acid Sensing Machinery: Targeting Innate Immune System for Cancer Therapy
Sandra Iurescia, Daniela Piergili Fioretti, Monica Rinaldi · 2017 · Recent Patents on Anti-Cancer Drug Discovery
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