Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis
Open accessAbstract
Stimulator of interferon genes (STING) has been shown to be critical for controlling antiviral responses as well as anti-tumor adaptive immunity, but little is known regarding its regulation in human tumors. Here, we report that STING signaling is recurrently suppressed in a wide variety of cancers, including colorectal carcinoma. Loss of STING signaling impeded DNA damage responses accountable for generating key cytokines that facilitate tissue repair and anti-tumor T cell priming, such as type I interferons (IFNs). Correspondingly, defective STING function was also highly predictive of effectual DNA-virus-mediated oncolytic activity. Thus, impaired STING responses may enable damaged cells to evade host immunosurveillance processes, although they provide a critical prognostic measurement that could help predict the outcome of effective oncoviral therapy.
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Cancer cells often inactivate the cGAS-STING pathway to evade immune detection.
“Accordingly, cancer cells often inactivate the cGAS-STING pathway to evade immune detection (Xia et al., 2016).”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Xia et al., 2016
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Cites
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377 · see citing works
Cancer treatment and survivorship statistics, 2016
Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., Stein, K. D., Alteri, R., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21349 · Cited by 6,066 · see citing works
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576 · see citing works
Self-citationThe gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,836 · see citing works
Cancer treatment and survivorship statistics, 2014
Desantis, C. E., Lin, C. C., Mariotto, A. B., Siegel, R. L., Stein, K., Kramer, J. L., Alteri, R., Robbins, A. S., & Jemal, A. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21235 · Cited by 2,781 · see citing works
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · see citing works
Self-citationIntestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works
Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182 · see citing works
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000 · see citing works
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.017 · Cited by 1,917 · see citing works
Self-citationThe DNA damage response and cancer therapy
Lord, C. J., & Ashworth, A. (2012) · Nature · doi:10.1038/nature10760 · Cited by 1,843 · see citing works
Molecular Genetics of Colorectal Cancer
Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805 · see citing works
STING is a direct innate immune sensor of cyclic di-GMP
Burdette, D. L., Monroe, K. M., Sotelo-Troha, K., Iwig, J. S., Eckert, B., Hyodo, M., Hayakawa, Y., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10429 · Cited by 1,570 · see citing works
Corrales, L., Glickman, L. H., McWhirter, S. M., Kanne, D. B., Sivick, K. E., Katibah, G. E., Woo, S.-R., Lemmens, E., Banda, T., Leong, J. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.031 · Cited by 1,560 · see citing works
Oxidative stress and cancer: An overview
Iglesias, V. S., Moliné, T., Somoza, R., Paciucci, R., Kondoh, H., & LLeonart, M. E. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.10.004 · Cited by 1,445 · see citing works
The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
Cai, X., Chiu, Y., & Chen, Z. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.040 · Cited by 995 · see citing works
Zitvogel, L., Galluzzi, L., Smyth, M. J., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.014 · Cited by 879 · see citing works
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Fu, J., Kanne, D. B., Leong, M., Glickman, L. H., McWhirter, S. M., Lemmens, E., Mechette, K., Leong, J. J., Lauer, P., Liu, W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4306 · Cited by 720 · see citing works
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Huber, S., Gagliani, N., Zenewicz, L. A., Huber, F. J., Bosurgi, L., Hu, B., Hedl, M., Zhang, W., O’Connor, W., Murphy, A. J., et al. (2012) · Nature · doi:10.1038/nature11535 · Cited by 719 · see citing works
Epigenetics and Colorectal Cancer
Lao, V., & Grady, W. (2011) · Nature Reviews Gastroenterology &Hepatology · doi:10.1038/nrgastro.2011.173 · Cited by 708 · see citing works
Konno, H., Konno, K., & Barber, G. N. (2013) · Cell · doi:10.1016/j.cell.2013.09.049 · Cited by 676 · see citing works
Self-citationDNA Methyltransferases, DNA Damage Repair, and Cancer
Jin, B., & Robertson, K. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9967-2_1 · Cited by 521 · see citing works
STING manifests self DNA-dependent inflammatory disease
Ahn, J., Gutman, D. M., Saijo, S., & Barber, G. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215006109 · Cited by 512 · see citing works
Self-citationInflammation-driven carcinogenesis is mediated through STING
Ahn, J., Xia, T., Konno, H., Konno, K., Ruiz, P., & Barber, G. N. (2014) · Nature Communications · doi:10.1038/ncomms6166 · Cited by 449 · see citing works
Self-citationSalcedo, R., Worschech, A., Cardone, M., Jones, Y., Gyulai, Z., Dai, R.-M., Wang, E., Ma, W., Haines, D., O'hUigin, C., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100199 · Cited by 429 · see citing works
Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis
Kim, E. R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9872 · Cited by 420 · see citing works
Arthur, J. C., Gharaibeh, R. Z., Mühlbauer, M., Perez-Chanona, E., Uronis, J. M., McCafferty, J., Fodor, A. A., & Jobin, C. (2014) · Nature Communications · doi:10.1038/ncomms5724 · Cited by 392 · see citing works
Kondo, T., Kobayashi, J., Saitoh, T., Maruyama, K., Ishii, K. J., Barber, G. N., Komatsu, K., Akira, S., & Kawai, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222694110 · Cited by 346 · see citing works
Self-citationOAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
Hornung, V., Hartmann, R., Ablasser, A., & Hopfner, K. (2014) · Nature reviews. Immunology · doi:10.1038/nri3719 · Cited by 341 · see citing works
The Role of the Microbiota in Inflammation, Carcinogenesis, and Cancer Therapy
Dzutsev, A., Goldszmid, R. S., Viaud, S., Zitvogel, L., & Trinchieri, G. (2015) · European Journal of Immunology · doi:10.1002/eji.201444972 · Cited by 300 · see citing works
Yi, G., Brendel, V., Shu, C., Li, P., Palanathan, S., & Kao, C. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077846 · Cited by 274 · see citing works
The STING pathway and the T cell-inflamed tumor microenvironment
Woo, S., Corrales, L. P., & Gajewski, T. F. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.003 · Cited by 271 · see citing works
Interplay between DNA repair and inflammation, and the link to cancer
Kidane, D., Chae, W. J., Czochor, J. R., Eckert, K. A., Glazer, P. M., Bothwell, A. L. M., & Sweasy, J. B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.875514 · Cited by 186 · see citing works
Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING
Ahn, J., Ruiz, P., & Barber, G. N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401337 · Cited by 185 · see citing works
Self-citationThe signal pathways in azoxymethane-induced colon cancer and preventive implications
Chen, J., & Huang, X. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.14.8983 · Cited by 177 · see citing works
A panel of genes methylated with high frequency in colorectal cancer
Mitchell, S. M., Ross, J. P., Drew, H. R., Ho, T., Brown, G. S., Saunders, N. F. W., Duesing, K., Buckley, M. J., Dunne, R. A., Beetson, I., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-54 · Cited by 162 · see citing works
Zhu, Q., Man, S. M., Gurung, P., Liu, Z., Vogel, P., Lamkanfi, M., & Kanneganti, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1402051 · Cited by 154 · see citing works
Diverse roles of STING-dependent signaling on the development of cancer
Ahn, J., Konno, H., & Barber, G. N. (2015) · Oncogene · doi:10.1038/onc.2014.457 · Cited by 142 · see citing works
Self-citationDNA damage and innate immunity: links and trade-offs
Chatzinikolaou, G., Karakasilioti, I., & Garinis, G. A. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.06.003 · Cited by 139 · see citing works
Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease
Ahn, J., & Barber, G. N. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.10.009 · Cited by 138 · see citing works
Self-citationIdentification and characterization of a loss-of-function human MPYS variant
Jin, L., Xu, L., Yang, I. V., Davidson, E. J., Schwartz, D. A., Wurfel, M. M., & Cambier, J. C. (2011) · Genes and Immunity · doi:10.1038/gene.2010.75 · Cited by 130 · see citing works
Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines
Barker, B. R., Taxman, D. J., & Ting, J. P. ‐. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.005 · Cited by 124 · see citing works
MyD88 and its divergent toll in carcinogenesis
Salcedo, R., Cataisson, C., Hasan, U. A., Yuspa, S. H., & Trinchieri, G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.008 · Cited by 95 · see citing works
Epigenetic regulation of colon cancer and intestinal stem cells
Hammoud, S. S., Cairns, B. R., & Jones, D. A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.01.007 · Cited by 91 · see citing works
Primate-specific miR-576-3p sets host defense signalling threshold
Yarbrough, M. L., Zhang, K., Sakthivel, R., Forst, C. V., Posner, B. A., Barber, G. N., White, M. A., & Fontoura, B. M. A. (2014) · Nature Communications · doi:10.1038/ncomms5963 · Cited by 59 · see citing works
Self-citationWu, J. S. (2007) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-2007-984859 · Cited by 34 · see citing works
Rowe, J. H., & Cen, P. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.973323 · Cited by 25 · see citing works
Kolodkin‐Gal, D., Edden, Y., Hartshtark, Z., Ilan, L., Khalaileh, A., Pikarsky, A. J., Pikarsky, E., Rabkin, S. D., Panet, A., & Zamir, G. A. (2009) · Gene Therapy · doi:10.1038/gt.2009.44 · Cited by 25 · see citing works
Evaluation of Innate Immune Signaling Pathways in Transformed Cells
Heiber, J. F., & Barber, G. N. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-340-0_15 · Cited by 14 · see citing works
Self-citation
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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333 · see citing works
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
Vanpouille-Box, C., Alard, A., Aryankalayil, M. J., Sarfraz, Y., Diamond, J. M., Schneider, R. J., Inghirami, G., Coleman, C. N., Formenti, S. C., & Demaria, S. (2017) · Nature Communications · doi:10.1038/ncomms15618 · Cited by 1,834 · see citing works
cGAS surveillance of micronuclei links genome instability to innate immunity
Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752 · see citing works
The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
Kwon, J., & Bakhoum, S. F. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0761 · Cited by 1,293 · see citing works
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
Li, T., & Chen, Z. J. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180139 · Cited by 1,293 · see citing works
cGAS in action: Expanding roles in immunity and inflammation
Ablasser, A., & Chen, Z. J. (2019) · Science · doi:10.1126/science.aat8657 · Cited by 1,077 · see citing works
cGAS is essential for cellular senescence
Yang, H., Wang, H., Ren, J., Chen, Q., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705499114 · Cited by 1,009 · see citing works
The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment
Bakhoum, S. F. W., & Cantley, L. C. (2018) · Cell · doi:10.1016/j.cell.2018.08.027 · Cited by 717 · see citing works
Cold and hot tumors: from molecular mechanisms to targeted therapy
Wu, B., Zhang, B., Li, B., Wu, H., & Jiang, M. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01979-x · Cited by 751 · see citing works
Integrating oncolytic viruses in combination cancer immunotherapy
Bommareddy, P. K., Shettigar, M., & Kaufman, H. L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0014-6 · Cited by 704 · see citing works
The cGAS–STING pathway and cancer
Samson, N., & Ablasser, A. (2022) · Nature Cancer · doi:10.1038/s43018-022-00468-w · Cited by 705 · see citing works
cGAS-STING, an important pathway in cancer immunotherapy
Jiang, M., Chen, P., Wang, L., Li, W., Chen, B., Liu, Y., Wang, H., Zhao, S., Ye, L., He, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00916-z · Cited by 647 · see citing works
Marcus, A., Mao, A. J., Lensink-Vasan, M., Wang, L., Vance, R. E., & Raulet, D. H. (2018) · Immunity · doi:10.1016/j.immuni.2018.09.016 · Cited by 609 · see citing works
PARP inhibition elicits STING-dependent antitumor immunity in brca1-deficient ovarian cancer
Ding, L., Kim, H.-J., Wang, Q., Kearns, M., Jiang, T., Ohlson, C. E., Li, B. B., Xie, S., Liu, J. F., Stover, E. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.054 · Cited by 572 · see citing works
Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
Wolf, N. K., Kissiov, D. U., & Raulet, D. H. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00732-1 · Cited by 591 · see citing works
Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies
Patel, S. A., & Minn, A. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.007 · Cited by 574 · see citing works
Linking cellular stress responses to systemic homeostasis
Galluzzi, L., Yamazaki, T., & Kroemer, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0068-0 · Cited by 529 · see citing works
Optimizing oncolytic virotherapy in cancer treatment
Harrington, K. J., Freeman, D. J., Kelly, E. J., Harper, J. A., & Soria, J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0029-0 · Cited by 523 · see citing works
The host STING pathway at the interface of cancer and immunity
Corrales, L., McWhirter, S. M., Dubensky, T. W., & Gajewski, T. F. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86892 · Cited by 487 · see citing works
Glover, H. L., Schreiner, A., Dewson, G., & Tait, S. W. G. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01429-4 · Cited by 489 · see citing works
Interferons α and β in cancer: therapeutic opportunities from new insights
Borden, E. C. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0011-2 · Cited by 423 · see citing works
Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy
Li, A., Yi, M., Qin, S., Song, Y., Chu, Q., & Wu, K. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0721-x · Cited by 413 · see citing works
Zhou, Y., Fei, M., Zhang, G., Liang, W., Lin, W., Wu, Y., Piskol, R., Ridgway, J. B., McNamara, E., Huang, H., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.014 · Cited by 399 · see citing works
Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis
Xia, T., Konno, H., & Barber, G. N. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1404 · Cited by 384 · see citing works
Self-citationWang, Y., Deng, W., Li, N., Neri, S., Sharma, A., Jiang, W., & Lin, S. H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00185 · Cited by 376 · see citing works
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy
Garland, K. M., Sheehy, T. L., & Wilson, J. T. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00750 · Cited by 368 · see citing works
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Cao, J., & Yan, Q. (2020) · Trends in Cancer · doi:10.1016/j.trecan.2020.02.003 · Cited by 298 · see citing works
Mutant p53 Suppresses Innate Immune Signaling to Promote Tumorigenesis
Ghosh, M., Saha, S., Bettke, J. A., Nagar, R., Parrales, A., Iwakuma, T., van der Velden, A. W. M., & Martinez, L. A. (2020) · Cancer Cell · doi:10.1016/j.ccell.2021.01.003 · Cited by 344 · see citing works
STING pathway agonism as a cancer therapeutic
Flood, B. A., Higgs, E. F., Li, S., Luke, J. J., & Gajewski, T. F. (2019) · Immunological Reviews · doi:10.1111/imr.12765 · Cited by 338 · see citing works
Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
Zheng, J., Mo, J., Zhu, T., Zhuo, W., Yi, Y., Hu, S., Yin, J., Zhang, W., Zhou, H., & Liu, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01250-1 · Cited by 332 · see citing works
The emerging field of oncolytic virus-based cancer immunotherapy
Ma, R., Li, Z., Chiocca, E. A., Caligiuri, M. A., & Yu, J. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.10.003 · Cited by 326 · see citing works
DNA Damage and Cancer Immunotherapy: A STING in the Tale
Reisländer, T., Groelly, F. J., & Tarsounas, M. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.07.026 · Cited by 318 · see citing works
Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
Schadt, L., Sparano, C., Schweiger, N. A., Siliņa, K., Cecconi, V., Lucchiari, G., Yagita∥, H., Guggisberg, E., Saba, S., Naščáková, Z., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.065 · Cited by 290 · see citing works
Cytoplasmic DNA: sources, sensing, and role in aging and disease
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Molecular mechanisms of viral oncogenesis in humans
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Konno, H., Yamauchi, S., Berglund, A., Putney, R. M., Mulé, J. J., & Barber, G. N. (2018) · Oncogene · doi:10.1038/s41388-017-0120-0 · Cited by 274 · see citing works
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Li, S., Hong, Z., Wang, Z., Li, F., Mei, J., Huang, L., Lou, X., Zhao, S., Song, L., Chen, W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.097 · Cited by 275 · see citing works
Immune control by amino acid catabolism during tumorigenesis and therapy
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Wang, Q., Bergholz, J. S., Ding, L., Lin, Z., Kabraji, S. K., Hughes, M. E., He, X., Xie, S., Jiang, T., Wang, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30568-1 · Cited by 268 · see citing works
STING activation in cancer immunotherapy
Su, T., Zhang, Y. L., Valerie, K. C., Wang, X., Lin, S., & Zhu, G. (2019) · Theranostics · doi:10.7150/thno.37574 · Cited by 259 · see citing works
Harnessing innate immune pathways for therapeutic advancement in cancer
Hu, A.-K., Sun, L., Lin, H., Liao, Y., Yang, H., & Mao, Y. Q. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01765-9 · Cited by 265 · see citing works
Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy
Aval, L. M., Pease, J. E., Sharma, R., & Pinato, D. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103323 · Cited by 250 · see citing works
cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity
Wang, Z., Chen, J., Hu, J., Zhang, H., Xu, F., He, W., Wang, X., Li, M., Lu, W., Zeng, G., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127471 · Cited by 253 · see citing works
Trial watch: TLR3 agonists in cancer therapy
Le Naour, J., Galluzzi, L., Zitvogel, L., Kroemer, G., & Vacchelli, E. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1771143 · Cited by 239 · see citing works
Qiao, J. T., Cui, C., Qing, L., Wang, L., He, T., Yan, F., Liu, F. Q., Shen, Y. H., Hou, X., & Chen, L. (2017) · Metabolism · doi:10.1016/j.metabol.2017.09.010 · Cited by 239 · see citing works
Exploiting DNA Replication Stress for Cancer Treatment
Ubhi, T., & Brown, G. W. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3631 · Cited by 227 · see citing works
Yang, K., Han, W., Jiang, X., Piffkó, A., Bugno, J., Han, C., Li, S., Liang, H. L., Xu, Z., Zheng, W., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01225-x · Cited by 223 · see citing works
cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development
Ng, K. W., Marshall, E. A., Bell, J. C., & Lam, W. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.07.013 · Cited by 215 · see citing works
Decreased expression of STING predicts poor prognosis in patients with gastric cancer
Song, S., Peng, P., Tang, Z., Zhao, J., Wu, W., Li, H., Shao, M., Li, L., Yang, C., Duan, F., et al. (2017) · Scientific Reports · doi:10.1038/srep39858 · Cited by 216 · see citing works
An, X., Zhu, Y., Zheng, T., Wang, G., Zhang, M., Li, J., Ji, H., Li, S., Yang, S., Xu, D., et al. (2019) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2018.11.003 · Cited by 188 · see citing works
Zhang, Z., Zhou, H., Ouyang, X., Dong, Y., Sarapultsev, A., Luo, S., & Hu, D. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01252-z · Cited by 216 · see citing works
Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy
Emran, A. A., Chatterjee, A., Rodger, E. J., Tiffen, J. C., Gallagher, S. J., Eccles, M. R., & Hersey, P. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.02.004 · Cited by 205 · see citing works
Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches
Khoo, L. T., & Chen, L. (2018) · The EMBO Reports · doi:10.15252/embr.201846935 · Cited by 204 · see citing works
Opposing Roles of Type I Interferons in Cancer Immunity
Boukhaled, G. M., Harding, S. M., & Brooks, D. G. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-031920-093932 · Cited by 195 · see citing works
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells
Ahn, J., Xia, T., Rabasa, A., Betancourt, D. M., & Barber, G. N. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.027 · Cited by 188 · see citing works
Self-citationDNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer
Paludan, S. R., Reinert, L. S., & Hornung, V. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-018-0117-0 · Cited by 183 · see citing works
Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs
Rañoa, D. R. E., Parekh, A. D., Pitroda, S. P., Huang, X., Darga, T. E., Wong, A., Huang, L., Andrade, J., Staley, J. P., Satoh, T., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8420 · Cited by 184 · see citing works
Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy
Medrano, R. F. V., Hunger, A., Mendonça, S. A., Barbuto, J. A. M., & Strauss, B. E. (2017) · Oncotarget · doi:10.18632/oncotarget.19531 · Cited by 185 · see citing works
Old dogs, new trick: classic cancer therapies activate cGAS
Yum, S., Li, M., & Chen, Z. J. (2020) · Cell Research · doi:10.1038/s41422-020-0346-1 · Cited by 181 · see citing works
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers
Elion, D. L., Jacobson, M. E., Hicks, D. J., Rahman, B., Sanchez, V. M., Ericsson, P. I. G., Fedorova, O., Pyle, A. M., Wilson, J. T., & Cook, R. S. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0730 · Cited by 178 · see citing works
The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications
Shen, M., Jiang, X., Qiu, P., Oyang, L., Ren, Z., Wang, J., Peng, M., Zhou, Y., Deng, X., & Liao, Q. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01691-5 · Cited by 197 · see citing works
Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers
Vanpouille‐Box, C., Formenti, S. C., & Demaria, S. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0037 · Cited by 173 · see citing works
KDM5 histone demethylases repress immune response via suppression of STING
Wu, L., Cao, J. P., Cai, W. L., Lang, S. M., Horton, J. R., Jansen, D. J., Liu, Z. Z., Chen, J. F.-Y., Zhang, M., Mott, B. T., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006134 · Cited by 175 · see citing works
STING signaling and host defense against microbial infection
Ahn, J., & Barber, G. N. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0333-0 · Cited by 173 · see citing works
Self-citationNuclear Membrane Rupture and Its Consequences
Maciejowski, J., & Hatch, E. M. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-120627 · Cited by 165 · see citing works
p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression
Ghosh, M., Saha, S., Li, J., Montrose, D. C., & Martinez, L. A. (2023) · Molecular Cell · doi:10.1016/j.molcel.2022.12.023 · Cited by 166 · see citing works
Genomic instability, inflammatory signaling and response to cancer immunotherapy
Chen, M., Linstra, R., & van Vugt, M. A. T. M. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188661 · Cited by 166 · see citing works
The balance of STING signaling orchestrates immunity in cancer
Lanng, K. R. B., Lauridsen, E. L., & Jakobsen, M. R. (2024) · Nature Immunology · doi:10.1038/s41590-024-01872-3 · Cited by 169 · see citing works
Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway
Chen, Y., Shen, Y., Hsia, H.-Y., Tiang, Y. P., Sung, T.-L., & Chen, L. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3498 · Cited by 158 · see citing works
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
Zhang, L., Jiang, C., Zhong, Y., Sun, K., Jing, H., Song, J., Xie, J., Zhou, Y., Tian, M., Zhang, C., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01185-x · Cited by 166 · see citing works
Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases
Hu, M., & Shu, H. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-070119-115052 · Cited by 156 · see citing works
Cordova, A. F., Ritchie, C., Böhnert, V., & Li, L. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c00440 · Cited by 151 · see citing works
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
Mender, I., Zhang, A., Ren, Z., Han, C., Deng, Y., Siteni, S., Li, H., Zhu, J., Vemula, A., Shay, J. W., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.020 · Cited by 149 · see citing works
Iracheta‐Vellve, A., Petrasek, J., Gyöngyösi, B., Satishchandran, A., Lowe, P., Kodys, K., Catalano, D. E., Calenda, C. D., Kurt‐Jones, E. A., Fitzgerald, K. A., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.736991 · Cited by 149 · see citing works
Marx, S., Maso, T. D., Chen, J.-W., Bury, M., Wouters, J., Michiels, C., & Calvé, B. L. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.018 · Cited by 149 · see citing works
Feng, X., Tubbs, A., Zhang, C., Tang, M., Sridharan, S., Wang, C., Jiang, D., Su, D., Zhang, H., Chen, Z., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019104036 · Cited by 145 · see citing works
The Crosstalk Between Hippo-YAP Pathway and Innate Immunity
Wang, S., Zhou, L.-L., Ling, L., Meng, X.-L., Chu, F., Zhang, S.-P., & Zhou, F.-F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00323 · Cited by 138 · see citing works
TMEM173 variants and potential importance to human biology and disease
Patel, S., & Jin, L. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0029-9 · Cited by 142 · see citing works
de Queiroz, N. M. G. P., Xia, T., Konno, H., & Barber, G. N. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0504 · Cited by 140 · see citing works
Self-citationMitochondria at the interface between neurodegeneration and neuroinflammation
Bader, V., & Winklhofer, K. F. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.028 · Cited by 134 · see citing works
cGAS‐cGAMP‐STING: The three musketeers of cytosolic DNA sensing and signaling
Tao, J., Zhou, X., & Jiang, Z. (2016) · IUBMB Life · doi:10.1002/iub.1566 · Cited by 132 · see citing works
Zhang, C.-X., Ye, S., Ni, J., Cai, T., Liu, Y.-N., Huang, D.-J., Mai, H., Chen, Q.-Y., He, J., Zhang, X.-S., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0302-0 · Cited by 130 · see citing works
Tijhuis, A. E., Johnson, S. C., & McClelland, S. E. (2019) · Molecular Cytogenetics · doi:10.1186/s13039-019-0429-1 · Cited by 127 · see citing works
Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies
Iurescia, S., Fioretti, D. P., & Rinaldi, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00711 · Cited by 125 · see citing works
Guo, X., Ni, J., Liang, Z., Xue, J., Fenech, M. F., & Wang, X. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.11.001 · Cited by 125 · see citing works
Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response
Ragu, S., Matos-Rodrigues, G. E., & López, B. S. (2020) · Genes · doi:10.3390/genes11040409 · Cited by 123 · see citing works
Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS–cGAMP–STING Pathway
Ritchie, C., Carozza, J. A., & Li, L. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-040320-101629 · Cited by 121 · see citing works
The role of cGAS-STING signalling in liver diseases
Chen, R., Du, J., Zhu, H., & Ling, Q. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100324 · Cited by 124 · see citing works
Exosome DNA: Critical regulator of tumor immunity and a diagnostic biomarker
Sharma, A., & Johnson, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29153 · Cited by 120 · see citing works
Prospects for combined use of oncolytic viruses and CAR T-cells
Ajina, A., & Maher, J. F. (2017) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-017-0294-6 · Cited by 117 · see citing works
Sevenich, L. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00163 · Cited by 117 · see citing works
Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy
Berger, G., Marloye, M., & Lawler, S. E. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.007 · Cited by 116 · see citing works
Lohard, S., Bourgeois, N., Maillet, L., Gautier, F., Fétiveau, A., Lasla, H., Nguyen, F., Vuillier, C., Dumont, A., Moreau‐Aubry, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13689-y · Cited by 114 · see citing works
Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells
Flynn, P. J., Koch, P. D., & Mitchison, T. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2103585118 · Cited by 111 · see citing works
The complementarity of DDR, nucleic acids and anti-tumour immunity
Kornepati, A. V. R., Rogers, C. M., Sung, P., & Curiel, T. J. (2023) · Nature · doi:10.1038/s41586-023-06069-6 · Cited by 115 · see citing works
Lv, H., Zong, Q., Chen, C., Lv, G., Xiang, W., Xing, F., Jiang, G., Yan, B., Sun, X., Ma, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-43743-9 · Cited by 114 · see citing works
STING, the Endoplasmic Reticulum, and Mitochondria: Is Three a Crowd or a Conversation?
Smith, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.611347 · Cited by 114 · see citing works
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING
Tian, J., Zhang, D., Kurbatov, V., Wang, Q., Wang, Y., Fang, D., Wu, L., Bosenberg, M., Muzumdar, M. D., Khan, S. A., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020106065 · Cited by 110 · see citing works
Immune Diseases Associated with TREX1 and STING Dysfunction
Yan, N. (2017) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2016.0086 · Cited by 108 · see citing works
- Authors
- Xia, T., Konno, H., Ahn, J., & Barber, G. N.
- Affiliations
- University of Miami (US)
- Corresponding author
- Barber, Glen N.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 14
- Issue
- 2
- Pages
- 282-297
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC4845097
- OpenAlex
- W2220279767
- Cited by
- 589
- References
- 50
- Citations by year
- 2026: 46 · 2025: 61 · 2024: 70 · 2023: 66 · 2022: 77 · 2021: 76 · 2020: 51 · 2019: 57 · 2018: 44 · 2017: 28 · 2016: 13
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- National Cancer Institute (R01CA194404)
- National Institute of Allergy and Infectious Diseases (R01AI079336)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- STING signaling, colorectal cancer, DNA damage response, type I interferon, tumor surveillance, DNA viruses, carcinogenesis, prognostic factors, tissue repair
- MeSH terms
- Animals, DNA Damage, Humans, Transfection, Colorectal Neoplasms, Signal Transduction, Mice, Carcinogenesis
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