Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

Xia, Tianli, Konno, Hiroyasu, Ahn, Jeonghyun, Barber, Glen N.·2016·Cell Reports

DOI 10.1016/j.celrep.2015.12.029

Cited by (590)

Items 301–400 of 590

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BCG invokes superior STING ‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer
Kara A. Lombardo, Aleksandar Obradović, Alok Kumar Singh, James L. Liu, Gregory A. Joice, Max R. Kates, William R. Bishai, David James McConkey, Alcides Chaux, Marie‐Lisa Eich et al. · 2021 · The Journal of Pathology
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Juan Miguel Cejalvo, Claudette Falato, Lorea Villanueva, Pablo Tolosa, Xavier González, Mariona Pascal, Jordi Canes, Joaquín Gavilá, Luís Manso, Tomás Pascual et al. · 2022 · Cancer Treatment Reviews
On taking the STING out of immune activation
Andra Banete, Kyle Seaver, Devyani Bakshi, Katrina Gee, Sameh Basta · 2018 · Journal of Leukocyte Biology
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Yikai Lu, Mengmeng Zhao, Li Chen, Yan Wang, Tianhao Liu, Haipeng Liu · 2024 · Frontiers in Immunology
Chromosome instability and aneuploidy as context-dependent activators or inhibitors of antitumor immunity
Xiaohong Kuang, Jian Li · 2022 · Frontiers in Immunology
STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway
Huihui Yao, Suo Wang, Xin Zhou, Jinbing Sun, Guoqiang Zhou, Diyuan Zhou, Guoliang Chen, Xinyu Shi, Junjie Chen, Bo Shi et al. · 2022 · Journal of Gastrointestinal Oncology
Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity
Kim, Jennie C., Liu, Xian, Fitzgerald, Karen, Eng, Jason S., Orf, Jessica, O’Brien, Sarah A., Belmontes, Brian, Casbon, Amy-Jo, Novitskiy, Sergey V., Tarbell, Kristin V. et al. · 2023 · Cancer Immunology, Immunotherapy
Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA
Yi Ye, Guihui Qin, Hongmei Yang, Jia Hao, Qibing Zeng, Dejin Zheng, Sen Ye, Zhiming Zhang, Tzu‐Ming Liu, Kathy Qian Luo et al. · 2024 · Advanced Science
Targeting STING signaling for the optimal cancer immunotherapy
Yan Xu, Ying Xiong · 2024 · Frontiers in Immunology
STING-Dependent Interferon-λ1 Induction in HT29 Cells, a Human Colorectal Cancer Cell Line, After Gamma-Radiation
Jianzhou Chen, Boštjan Markelc, Jakob Kaeppler, Vivian M.L. Ogundipe, Yunhong Cao, William Gillies McKenna, Ruth J. Muschel · 2018 · International Journal of Radiation Oncology*Biology*Physics
Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade
Blake R. Heath, Nicole Lynn Michmerhuizen, Christopher R. Donnelly, Kanokwan Sansanaphongpricha, Duxin Sun, John Chad Brenner, Yu L. Lei · 2019 · Journal of Dental Research
The activation of cGAS-STING pathway offers novel therapeutic opportunities in cancers
Yumin Wang, Yonglin Zhu, Yuwei Cao, Yulin Li, Zhe Zhang, Joshua S. Fleishman, Sihang Cheng, Jichao Chen, Mingchao Ding · 2025 · Frontiers in Immunology
Midostaurin Modulates Tumor Microenvironment and Enhances Efficacy of Anti-PD-1 against Colon Cancer
Cheng-Ta Lai, Chih‐Wen Chi, Shu-Hua Wu, Hui-Ru Shieh, Jiin‐Cherng Yen, Yu-Jen Chen · 2022 · Cancers
A recombinant oncolytic influenza virus expressing a PD-L1 antibody induces CD8+ T-cell activation via the cGas-STING pathway in mice with hepatocellular carcinoma
Fang Sun, Yan Xu, Zhuoya Deng, Penghui Yang · 2023 · International Immunopharmacology
STING Activation and its Application in Immuno-Oncology
Yiqian Lian, Kevin J. Duffy, Jingsong Yang · 2019 · Current Topics in Medicinal Chemistry
Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer
Ryo Kanoda, Shotaro Nakajima, Hirokazu Okayama, Akinao Kaneta, Shun Chida, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Yuya Maruyama, Hiroya Suzuki et al. · 2025 · Scientific Reports
2′,3′‐Cyclic GMP‐AMP Dinucleotides for STING‐Mediated Immune Modulation: Principles, Immunotherapeutic Potential, and Synthesis
Mengdi Shang, Kuan Lu, Wenli Guan, Shujie Cao, Mengtian Ren, Chuanzheng Zhou · 2021 · ChemMedChem
Agents of cancer immunosurveillance: HSPs and dsDNA
Devanshi A. Nayak, Robert Julian Binder · 2022 · Trends in Immunology
Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer
Nenad Kunac, Marina Degoricija, Jelena Viculin, Jasminka Omerović, Janoš Terzić, Katarina Vilović, Jelena Korać-Prlić · 2022 · Cancers
Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
Haipeng Liu, Hang Su, Fei Wang, Yifang Dang, Yijiu Ren, Shenyi Yin, Huinan Lu, Hang Zhang, Jun Wu, Zhu Xu et al. · 2023 · Cell Reports
Combination of IFN-gamma with STING agonist and PD-1 immune checkpoint blockade: a potential immunotherapy for gastric cancer
Shahnaz Hosseinzadeh, Mahsa Imani, Farhad Pourfarzi, Narjes Jafari, Saeid Abediankenari, Elham Safarzadeh · 2024 · Medical Oncology
STING mediates LPS-induced acute lung injury by regulating ferroptosis
Yanli Gu, Liting Lv, Jiajia Jin, Xin Hua, Qiuli Xu, Ranpu Wu, Suhua Zhu, Xin Liu, Tangfeng Lv, Yong Song et al. · 2024 · Experimental Cell Research
Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma
Sadaaki Nishimura, Juan F. Linares, Antoine L’Hermitte, Ángeles Durán, Tania Cid-Diaz, Anxo Martínez-Ordóñez, Marc Ruíz-Martínez, Yotaro Kudo, Antonio Marzio, Mathias F Heikenwälder et al. · 2024 · Molecular Cell
A STING-related prognostic score predicts high-risk patients of colorectal cancer and provides insights into immunotherapy
Si-Yuan Chen, Siyu Chen, Wanjing Feng, Ziteng Li, Yixiao Luo, Xiaodong Zhu · 2021 · Annals of Translational Medicine
Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R. Acharya, Timothy N. Trotter, Pankaj Agarwal, Jun-Ping Wei, Tao Wang, Xiaoyi Yang, Gangjun Lei, Takuya Osada et al. · 2022 · Journal for ImmunoTherapy of Cancer
Nanoscale Hafnium Metal–Organic Frameworks Enhance Radiotherapeutic Effects by Upregulation of Type I Interferon and TLR7 Expression
Eun-Seo Choi, Madeleine R. Landry, Nathan D. Pennock, Megan J. Neufeld, Katherine Weinfurter, A.M. Goforth, Joshua M. Walker, Conroy Sun · 2023 · Advanced Healthcare Materials
Analysis of mRNA-miRNA-lncRNA differential expression in prediabetes/type 2 diabetes mellitus patients as potential players in insulin resistance
Hebatalla Said Ali, Marwa Mostafa Kamel, Sara H. A. Agwa, Mohamed S. Abdel-Hakeem, Mahmoud El‐Meteini, Marwa Matboli · 2023 · Frontiers in Endocrinology
Exogenous DNA enhances DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway
Stephen L. Wang, Yongzhong Wu, Mariam M. Konaté, Jiamo Lu, David J. Mallick, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Iris M. Dahan, Agnes N. Juhasz et al. · 2023 · Free Radical Biology and Medicine
Synergistic combination of oncolytic virotherapy with CAR T-cell therapy
Adam Ajina, John F. Maher · 2019 · Progress in molecular biology and translational science
Mitochondria as the decision makers for cancer cell fate: from signaling pathways to therapeutic strategies
Ilaria Genovese, Bianca Vezzani, Alberto Danese, Lorenzo Modesti, Veronica Angela Maria Vitto, Virginia Corazzi, Stefano Pelucchi, Paolo Pinton, Carlotta Giorgi · 2020 · Cell Calcium
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells
Seongji Park, Jeonghyun Ahn, Glen N. Barber · 2024 · Science Immunology
The role of type I interferon signaling in myeloid anti-tumor immunity
Sofie Patrizia Meyer, Rebekka Bauer, Bernhard Brüne, Tobias Schmid · 2025 · Frontiers in Immunology
Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery
Eric de Sousa, Joana R. Lérias, Antonio Lopez-beltran B, Georgia Paraschoudi, Carolina Condeço, Jéssica Kamiki, Patrícia António, Nuno Figueiredo, Carlos Torres Carvalho, Mireia Castillo-Martín et al. · 2021 · Frontiers in Immunology
Histone Deacetylase 3 Governs β-Estradiol-ERα-Involved Endometrial Tumorigenesis via Inhibition of STING Transcription
Guofang Chen, Qiang Yan, Lin Liu, Xinyue Wen, Hongliang Zeng, Shasha Yin · 2022 · Cancers
STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage
Chenyao Wang, Nan Jing, Elise G. Holvey-Bates, Xing Chen, Samantha M. Wightman, Muhammad-Bilal Latif, Junjie Zhao, Xiaoxia Li, Ganes C. Sen, George Robert Stark et al. · 2023 · Proceedings of the National Academy of Sciences
Activation of STING in Response to Partial-Tumor Radiation Exposure
Mickael Mathieu, Sadna Budhu, Prerna Ramesh Nepali, James Russell, Simon N. Powell, John Laurence Humm, Joseph O. Deasy, Adriana Haimovitz‐Friedman · 2023 · International Journal of Radiation Oncology*Biology*Physics
The Role of the Toll-like Receptor 2 and the cGAS-STING Pathways in Breast Cancer: Friends or Foes?
Chiara Cossu, Antonino Di Lorenzo, Irene Fiorilla, Alberto Maria Todesco, Valentina Audrito, Laura Conti · 2023 · International Journal of Molecular Sciences
Stimulating STING for cancer therapy: Taking the extracellular route
Lingyin Li · 2024 · Cell chemical biology
Colorectal cancer-specific IFNβ delivery overcomes dysfunctional dsRNA-mediated type I interferon signaling to increase the abscopal effect of radiotherapy
Kevin Chih‐Yang Huang, Shu‐Fen Chiang, Hsin‐Yu Chang, Wei-Ze Hong, Jhen-Yu Chen, Pei‐Chih Lee, Ji‐An Liang, Tao‐Wei Ke, Shin‐Lei Peng, An‐Cheng Shiau et al. · 2024 · Journal for ImmunoTherapy of Cancer
Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
Beiyuan Liang, Xuanxuan Xing, Hayden Storts, Zhen Ye, Hazel Claybon, Ryan Austin, Rachel Ding, Bei Liu, Haitao Wen, Wayne O. Miles et al. · 2024 · Frontiers in Oncology
Overcoming malignant cell-based mechanisms of resistance to immune checkpoint blockade antibodies
Reham Ajina, David J. Zahavi, Yongwei Zhang, Louis M. Weiner · 2019 · Seminars in Cancer Biology
The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer
Gavin Fullstone, Tabea L. Bauer, Cristiano Guttà, Manuela Salvucci, Jochen H.M. Prehn, Markus Rehm · 2020 · Cell Death and Differentiation
STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets
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DNA methylation protects cancer cells against senescence
Chen, Xiaoying, Yamaguchi, Kosuke, Rodgers, Brianna, Goehrig, Delphine, Vindrieux, David, Lahaye, Xavier, Nolot, Matthieu, Ferry, Laure, Lanciano, Sophie, Martin, Nadine et al. · 2025 · Nature Communications
In Situ Vaccination by Tumor Ablation: Principles and Prospects for Systemic Antitumor Immunity
Tinatin Chikovani, Eli Magen · 2025 · Vaccines
Prognostic Perspectives of STING and PD-L1 Expression and Correlation with the Prognosis of Epstein-Barr Virus-Associated Gastric Cancers
Qi Sun, Yao Shi Fu, Xiaobing Chen, Lin Li, Hongyan Wu, Yixuan Liu, Haojun Xu, Guoren Zhou, Xiangshan Fan, Hongping Xia · 2022 · Gut and Liver
The role of dendritic cells in radiation-induced immune responses
Aanchal Preet Kaur, Alejandro F. Alice, Marka R. Crittenden, Michael J. Gough · 2023 · International review of cytology
Nucleic Acid Sensing and Innate Immunity: Signaling Pathways Controlling Viral Pathogenesis and Autoimmunity
Laura R. H. Ahlers, Alan G. Goodman · 2016 · Current Clinical Microbiology Reports
A STING inhibitor suppresses EBV‐induced B cell transformation and lymphomagenesis
Shouhei Miyagi, Takahiro Watanabe, Yuya Hara, Masataka Arata, Md. Kamal Uddin, Keisuke Mantoku, Ken Sago, Yusuke Yanagi, Takeshi Suzuki, H. M. Abdullah Al Masud et al. · 2021 · Cancer Science
The cGAS-STING signaling pathway is modulated by urolithin A
Helena Borland Madsen, Jae Hyeon Park, X. Chu, Yujun Hou, Zaiwang Li, Lene Juel Rasmussen, Deborah L. Croteau, Vilhelm A. Bohr, Mansour Akbari · 2023 · Mechanisms of Ageing and Development
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Olga Sokołowska, Anna Rodziewicz-Lurzyńska, Zofia Pilch, Hanna Kędzierska, Justyna Chlebowska, Anna Sosnowska, Anna Szumera‐Ciećkiewicz, Kamil Sokół, Joanna Barankiewicz, Aleksander Salomon‐Perzyński et al. · 2022 · Clinical and Experimental Medicine
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Shashwat Tripathi, Hinda Najem, Akanksha Mahajan, Peng Zhang, Justin Low, Alexander H. Stegh, Michael A. Curran, David M. Ashley, Charles David James, Amy B. Heimberger · 2022 · F1000Research
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Sita S. Withers, Cambri E. Moeller, Cally N. Quick, Chin‐Chi Liu, Shelby M. Baham, Jayme Looper, Ramesh Subramanian, Konstantin Gus Kousoulas · 2023 · PLoS ONE
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ATP-elicited Cation Fluxes Promote Volume-regulated Anion Channel LRRC8/VRAC Transport cGAMP for Antitumor Immunity
Li Wang, Limin Cao, Zhihong Li, Zhugui Shao, Xia Chen, Zhicheng Huang, Xiaoxiao He, Junke Zheng, L.-Z. Liu, Xin‐Ming Jia et al. · 2024 · The Journal of Immunology
Loss of the DNA repair protein, polynucleotide kinase/phosphatase, activates the type 1 interferon response independent of ionizing radiation
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Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells
Yanyan Xu, Rui Jin, Guo‐Ping Zhou, Hua‐Guo Xu · 2017 · Scientific Reports
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Shengyuan Zhao, Samy L. Habib, Alireza Ghodsi Senejani, Manu M. Sebastian, Dawit Kidane · 2022 · Biomedicines
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Molly A Guscott, Akash Saha, Jovanna Maharaj, Sarah Elizabeth McClelland · 2022 · The International Journal of Biochemistry & Cell Biology
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Suli Chong, Yang Liu, Ziming Bian, Dongxue Hu, Shiqun Guo, Chenfei Dong, Jiayue Zeng, Sairong Fan, Xiaoming Chen · 2025 · Cellular Signalling
Cell-type specific activation of the cGAS-STING pathway in tumor immunotherapy: mechanisms and therapeutic implications
Lusheng Wang, Sudi Zhu, Zhixian Ding, Jie Hong, Lijie Zheng, Jiting Sun, Yu Tang, Xiaohui Chen, Xiang Yong, Mengxue Hu et al. · 2026 · Journal of Translational Medicine
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Activation of STING by the novel liposomal TLC388 enhances the therapeutic response to anti-PD-1 antibodies in combination with radiotherapy
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Stimulator of Interferon Genes Protein (STING) Expression in Cancer Cells: A Tissue Microarray Study Evaluating More than 18,000 Tumors from 139 Different Tumor Entities
Anne Menz, Julia Zerneke, Florian Viehweger, Şeyma Büyücek, David Dum, Ria Schlichter, Andrea Hinsch, Ahmed Abdulwahab Bawahab, Christoph Fraune, Christian Bernreuther et al. · 2024 · Cancers
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Zhumin Cao, Kai Deng, Jinxiu Jiang, Ke Tian, Bin Wang · 2024 · Biomedicine & Pharmacotherapy
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Mehrnoush Safarzadeh, Nastaran Saadat, Sara Abbasi-Molaei, Mohsen Rastegari‐Pouyani · 2025 · Cell Communication and Signaling
STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation
Joel M. Lee, Mohammed G. Ghonime, Kevin A. Cassady · 2019 · Molecular Therapy — Oncolytics
CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX
Jack T. Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A. Tamming, Giuseppe Pugliese, Nikolas Tim Martin, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin et al. · 2023 · Frontiers in Immunology
DNA damage in protective and adverse inflammatory responses: Friend of foe?
Tetiana Poliezhaieva, Maria Ermolaeva · 2016 · Mechanisms of Ageing and Development
Immunotherapy Sensitivity of Mismatch Repair-Deficient Cancer: Mutation Load Is Not Enough
Marco Gerlinger · 2021 · Cancer Cell
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Jiaqi Shi, Yingying Zhang, Na Zhao, Ekihiro Seki, Li Ma, Gordana M. Kocic, Xiaobo Li, Janoš Terzić, Tongsen Zheng · 2025 · The Innovation
Advances in nanomaterials for enhancing cGAS-STING pathway mediated anti-tumor treatment
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Ferroptosis and the cGAS–STING pathway into precision nano-immuno-theranostics: A mechanistic paradigm for reversing drug resistance in hepatocellular carcinoma
Alaa Elmetwalli · 2025 · Drug Resistance Updates
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Chase Kangas, Eric Krawczyk, Bin He · 2021 · Viruses
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PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors
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The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumors
Peng-Hui Zeng, Wen-Jun Yin · 2022 · Cell Cycle
T-Cell Mediated Immunity in Merkel Cell Carcinoma
Kelsey Ouyang, David X. Zheng, George W. Agak · 2022 · Cancers
The Impact of Tumor Cell-Intrinsic Expression of Cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) on the Infiltration of CD8+ T Cells and Clinical Outcomes in Mismatch Repair Proficient/Microsatellite Stable Colorectal Cancer
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Sulfonated Perylene as Three‐in‐One STING Agonist for Cancer Chemo‐Immunotherapy
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Riluzole Enhancing Anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer
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Therapeutic targeting of cGAS–STING pathway in lung cancer
Jinli Wang, Lumin Xing · 2024 · Cell Biology International
Research progress and development potential of oncolytic vaccinia virus
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