Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377

Cancer treatment and survivorship statistics, 2016

Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., Stein, K. D., Alteri, R., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21349 · Cited by 6,066

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576

The gut microbiota, bacterial metabolites and colorectal cancer

Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925

Cancer treatment and survivorship statistics, 2014

Desantis, C. E., Lin, C. C., Mariotto, A. B., Siegel, R. L., Stein, K., Kramer, J. L., Alteri, R., Robbins, A. S., & Jemal, A. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21235 · Cited by 2,847

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · cited 5×

Intestinal inflammation targets cancer-inducing activity of the microbiota

Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182

Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms

Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000

Histopathologic classification and immunohistochemical features of papillary renal neoplasm with potential therapeutic targets

Park, J. H., Shin, S., Kim, H. J., Oh, S., & Cho, Y. M. (2024) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2024.07.31 · Cited by 2

Nucleic Acid Sensing at the Interface Between Innate and Adaptive Immunity

Vanpouille‐Box, C., & Galluzzi, L. (2019) · International review of cytology · doi:10.1016/s1937-6448(19)30041-3 · Cited by 2

Naringenin Regulates FKBP4/NR3C1/TMEM173 Signaling Pathway in Autophagy and Proliferation of Breast Cancer and Tumor-Infiltrating Dendritic Cell MaturationPreprint

Xiong, H., Chen, Z., Lin, B., Chen, C., Li, Z., Jia, Y., Wang, L., & Zhou, J. (2021) · Research Square · doi:10.21203/rs.3.rs-659646/v1 · Cited by 2

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axisPreprint

Shu, C., Jin, R., Niu, Q., Cicka, D., Doyle, S. P., Wahafu, A., Fan, D., Zheng, X., Du, Y., Ivanov, A. A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.17.460294 · Cited by 2

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancerPreprint

Challoner, B. R., Woolston, A., Lau, D. K., Buzzetti, M., Fong, C., Barber, L. J., Anandappa, G., Crux, R., Assiotis, I., Fenwick, K., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.16.479224 · Cited by 2

STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK mTOR pathwayPreprint

Yao, H., Wang, S., Zhou, X., Zhou, G., Zhou, D., Chen, G., Shi, X., Chen, J., Wu, G., Sun, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1469741/v2 · Cited by 2

Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice

Sampaio, L. R., Dias, R. D. B., Goes, J. V. C., de Melo, R. P. M., Borges, D. D. P., Melo, M. M. D. L., de Oliveira, R. T. G., Ribeiro, H. L., Magalhães, S. M. M., & Pinheiro, R. F. (2024) · Medical Oncology · doi:10.1007/s12032-024-02376-8 · Cited by 1

High expression of ARHGEF5 predicts unfavorable prognosis in acute myeloid leukemia

Xu, H., Chen, D., Lu, J., & Zhong, L. (2024) · Discover Oncology · doi:10.1007/s12672-024-01364-8 · Cited by 1

STING rs7380824 Polymorphism Contributes to the Susceptibility of Colorectal Cancer in Chinese Population

Zhang, X., Wu, W., Li, H., Jian, Y., Li, A., Zhang, X., & Zhang, X. (2025) · DNA and Cell Biology · doi:10.1089/dna.2025.0020 · Cited by 1

Carriers Multimerize STING Protein Fragments to Activate Type I Interferon Signaling in STING-Deficient Cancer Cells

Kaskow, J. A., & Hammond, P. T. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00226 · Cited by 2

Combination of LowDose Epigenetic Modifiers and TIC10 for the Activation of Antitumor Immunity and Inhibition of Tumor Growth in Gastrointestinal Cancer

Zou, J., Yang, W., Li, S., Liu, F., Chang, J., Li, W., Huang, M., Zhu, X., Zou, J., Guo, W., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.71061 · Cited by 2

Cancer therapies targeting the STING pathway

Karimova, A. O., Sadovskaya, Y. O., & Солопова, О. Н. (2025) · Russian Journal of Oncology · doi:10.17816/onco689194 · Cited by 1

A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels

Thöne, F. M. B., Polovitskaya, M. M., Höpken, U. E., Rehm, A., & Jentsch, T. J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.111060 · Cited by 1

Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

Wu, S., Wang, B., Li, H., Wang, H., Du, S., Huang, X., Fan, Y., Gao, Y., Gu, L., Huang, Q., et al. (2026) · Oncogene · doi:10.1038/s41388-025-03671-y · Cited by 2

C5aR1 and cGAS/STING and their possible involvement in radiosensitivity of colorectal cancer

Pham, Q. T. T., Lee, P.-J., & Le, N. Q. K. (2026) · iScience · doi:10.1016/j.isci.2026.115009 · Cited by 1

A biomimetic nanodisc system selectively activates type I interferons by nonclassical STING pathway for cancer immunotherapy

Mu, Q., Deng, H., Li, S., An, X., Liu, X., Xi, Y., Liang, H., Sun, D. T., Wang, X., Liu, X., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71363-6 · Cited by 1

STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma

Nelson, T. S., Pacini, C., Nguyen, A., Zeigler, T. M., Ziff, A., Paulsen, K., Simpson, A., Bhaduri‐McIntosh, S., & Ma, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1823240 · Cited by 1

A sequential cascaded cGAS–STING amplifier based on hybrid multienzymes for efficient catalytic immunotherapy of hepatocellular carcinoma

Sun, W., Wang, Y., Song, J., Guo, X., Tang, S., Jiang, B., & Shen, X. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.177768 · Cited by 1

Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING

Qin, P., Qin, Q., Hao, Y., Liu, M., Li, Y., Liu, Y., Jiang, Z., Ma, T., Wang, W., Hou, Y., et al. (2026) · Nature Biotechnology · doi:10.1038/s41587-026-03224-y · Cited by 1

The Expression Patterns of cGAS and STING as Potential Diagnostic Markers in Gastric Cancer

Hosseinzadeh, S., Safarzadeh, E., Yazdanbod, A., Pourfarzi, F., & Kenari, S. A. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.s03.025 · Cited by 1

The promise, progress, and challenges of in situ immunization agents in cancer immunotherapy

Giacalone, M. J. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.02.004 · Cited by 1

Current Challenges and Applications of Oncolytic Viruses in Overcoming the Development of Resistance to Therapies in Cancer

Swanner, J. L., Meisen, W. H., McCormack, R., Lewis, C. T., Hong, B., & Kaur, B. (2019) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-030-21477-7_3 · Cited by 1

DMBA Induction Increases H-Ras Gene Expression and Decreases CD8 Count in Sprague Dawley Rats

Hidayati, T., Indrayanti, I., & Sagiran, S. (2019) · International Conference on Biomedical and Bioinformatics Engineering (ICBBE) · doi:10.1145/3375923.3375942 · Cited by 1

Shedding Light on Immunological Research in Lyon, France. IRCI2022 Brings the Scientific World to Lyon and Bridges the Latest Immunological Findings in Cancer and Infection

Fallone, L., Lalle, G., Pereira-Abrantes, M., Sible, E., Michallet, M., Vuong, B. Q., & Hasan, U. A. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200744 · Cited by 1

Engineering the Immune Adaptor Protein STING as a BiologicPreprint

Sun, X., Ni, Y., He, Y., Yang, M., Tani, T., Kitajima, S., Barbie, D. A., & Li, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.18.431824 · Cited by 1

Analysis of HSD11B2 as a prognostic marker in Melanoma via TCGA data miningPreprint

Fu, H., Tang, Y., & Ding, Y. (2020) · doi:10.21203/rs.3.rs-42538/v1 · Cited by 1

Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cellsPreprint

Nguyen, V. N., Brunon, S., Pavlova, M. N., Lazarchuk, P., Sharifian, R., & Sidorova, J. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.16.440118 · Cited by 1

The crosstalk between DNA-PK and cGAS drives tumor immunogenicityPreprint

Taffoni, C., Marines, J., Chamma, H., Saccas, M., Bouzid, A., Guha, S., Valadão, A. L. C., Polak, K., Rio, M. D., Gongora, C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.08.495278 · Cited by 1

cGAS/STING and NLRP3 cooperatively activate CD8+ T cell-mediated anti-tumor immunity in colorectal cancerPreprint

Mowat, C., Schiller, D., & Baker, K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.22.554371 · Cited by 1

Selective inflammation of the tumor microenvironment and invigorated T cell-mediated tumor control upon induced systemic inactivation of TREX1Preprint

Marinković, E., Chen, M., Schubert, N., Dar, E. D., Leung, J. Y., Lohre, J., Sahni, J. M., Tun, C., Rajeswaran, P., Mehlo-Jensen, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.09.598086 · Cited by 1

Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection

Zu, Q. (2018) · doi:10.21007/etd.cghs.2018.0462

The contribution of Sting and Nlrp3 activation to anti-tumour immunity in microsatellite instable colorectal cancer

Mowat, C. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-jywj-nr54

Differential effects of high versus low linear energy transfer (LET) radiation on type-I interferon (IFNβ) and TREX1 responsesPreprint

Miles, D., Cao, N., Sandison, G. A., Stewart, R. D., Moffitt, G., Pulliam, T., Parvathaneni, U., Goff, P. H., Nghiem, P., & Stantz, K. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.07.451516

STING pathway and modulation for cancer immunotherapy

Su, T., Ahmed, N. T., Zhou, S., Liu, X., & Zhu, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823397-9.00011-9

Faculty Opinions recommendation of Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells.

Waters, C. M. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733123158.793545591

STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathwayPreprint

Yao, H., Wang, S., Zhou, X., Zhou, G., Zhou, D., Chen, G., Shi, X., Chen, J., Wu, G., Sun, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1469741/v1

Faculty Opinions recommendation of Old dogs, new trick: classic cancer therapies activate cGAS.

Murray, B. W. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738147190.793586197

Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathwayPreprint

Wang, S. L., Wu, Y., Konaté, M. M., Lu, J., Antony, S., Meitzler, J. L., Jiang, G., Dahan, I. M., Juhasz, A. N., Diebold, B. A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.14.491678

STING promotes proliferation and induces drug resistance via regulating the AMPK-mTOR signaling pathway in colorectal cancer cellsPreprint

Yao, H., Wang, S., Zhou, X., Zhou, G., Zhou, D., Chen, G., Shi, X., Chen, J., Wu, G., Sun, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1459358/v1

WITHDRAWN: AZD5153 enhances the oncolytic adenovirus effect by affecting the STING in cervical cancerPreprint

Dou, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-2043096/v1

WITHDRAWN: AZD5153 enhances the oncolytic adenovirus effect by affecting the STING in cervical cancerPreprint

(2022) · Research Square · doi:10.21203/rs.3.rs-2043096/v2

Data from Heterogeneity of IFN-Mediated Responses and Tumor Immunogenicity in Patients with Cervical Cancer Receiving Concurrent Chemoradiotherapy

Chen, J., Chen, C., Zhan, Y., Zhou, L., Chen, J., Cai, Q., Wu, Y., Sui, Z., Zeng, C., Wei, X., et al. (2023) · doi:10.1158/1078-0432.c.6530765

Data from Heterogeneity of IFN-Mediated Responses and Tumor Immunogenicity in Patients with Cervical Cancer Receiving Concurrent Chemoradiotherapy

Chen, J., Chen, C., Zhan, Y., Zhou, L., Chen, J., Cai, Q., Wu, Y., Sui, Z., Zeng, C., Wei, X., et al. (2023) · doi:10.1158/1078-0432.c.6530765.v1

SIX4 Controls STING Expression Enhancing anti-PD-1 EfficacyPreprint

Liang, B., Zhang, E. H., Ye, Z., Storts, H., Zheng, X., Zaleski, O., Jin, W., Xing, X., & Wang, J. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.26.542458

Glioblastome : vers une nouvelle stratégie thérapeutique ciblant la voie de signalisation cGAS-STING

Taffoni, C., & Laguette, N. (2023) · médecine/sciences · doi:10.1051/medsci/2023149

The role of USP22 in nucleic acid sensing pathways and interferon-induced necroptotic cell death

Karlowitz, R. (2024) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.81916

The cGAS-STING Pathway

García‐Lepe, U. O., & Harding, S. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00132-0

Ginsenoside CK inhibits melanoma growth by promoting apoptosis and targeting cGAS-STING pathway to regulate the immune microenvironment

Tang, H., Xu, Y., Fu, R., Duan, Z., Zhu, C., & Fan, D. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250480

Common Signaling Pathways in Cancer and Alzheimer's Disease May Point to New Treatments

Wu, C., Jiang, L., Zhong, Y., & Liu, Z. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266340314250303003647

cGAS-STING signaling in melanoma: regulation and therapeutic targeting

Jiang, T., & Fei, L. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04141-8 · Cited by 1

Interfaces Between the DNA Damage Response and Anti-cancer Immunity

Hak, C. C. W., & Dillon, M. T. (2025) · The Cancer Journal · doi:10.1097/ppo.0000000000000773

Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression

Gao, L., Jiang, J., Zhu, L., Xie, Z., Chen, Y., Lv, Z., Chen, Y., Zhou, W., Chen, J., Zhong, Y., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04561-6

Additional file 2 of Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma

Zhu, C., Li, J., Yao, M., & Fang, C. (2021) · Figshare · doi:10.6084/m9.figshare.16778327

Additional file 3 of Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma

Zhu, C., Li, J., Yao, M., & Fang, C. (2021) · Figshare · doi:10.6084/m9.figshare.16778330

Additional file 6 of Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma

Zhu, C., Li, J., Yao, M., & Fang, C. (2021) · Figshare · doi:10.6084/m9.figshare.16778339

Additional file 7 of Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma

Zhu, C., Li, J., Yao, M., & Fang, C. (2021) · Figshare · doi:10.6084/m9.figshare.16778342

Additional file 5 of Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma

Zhu, C., Li, J., Yao, M., & Fang, C. (2021) · Figshare · doi:10.6084/m9.figshare.16778336

Additional file 1 of Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma

Zhu, C., Li, J., Yao, M., & Fang, C. (2021) · Figshare · doi:10.6084/m9.figshare.16778324

Additional file 4 of Potential for treatment benefit of STING agonists plus immune checkpoint inhibitors in oral squamous cell carcinoma

Zhu, C., Li, J., Yao, M., & Fang, C. (2021) · Figshare · doi:10.6084/m9.figshare.16778333

Interferon-independent STING enforces epithelial genome-integrity checkpoint to restrain tumor evolutionPreprint

Hang, X., Macino, M., Woitaske-Proske, C., Bodenstein, N., Bernardes, J. P., Tran, F., Schmid, N. A., Martini, G. R., Wottawa, F., Bornhaeuser, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.17.706442

Roles and clinical translational prospects of TMEM proteins in the tumor immune microenvironment

Fan, S., Zu, T., Hu, X., Zhong, J., & Zhu, H. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116532

Propagation d'un signal pro-apoptotique paracrine via la voie cGAS/STING lors des chimitothérapies antimitotiques

Lohard, S. (2019) · doi:10.70675/10e179e8zfcc6z4481zbb4bzafeef9c41257

Implication des cellules souches du follicule pileux dans la physiopathologie de l'hidradénite suppurée

Orvain, C. (2019) · theses.fr (ABES) · doi:10.70675/6c48db5bzeb06z4af8zb7e4z24b9f4446179

Exploiting DNA Repair Vulnerabilities to Modulate Anti-Cancer Immunity : a Study of the Immunological Potential of PARP inhibitors

Chabanon, R. M. (2019) · theses.fr (ABES) · doi:10.70675/00b851efzb998z4aaczb6baz4ab892005882

Implication du récepteur NLRP6, de la voie STING et de la cytokine BAFF dans la réponse inflammatoire pulmonaire provoquée par l’exposition aigüe à la fumée de cigarette

Nascimento, M. (2019) · theses.fr (ABES) · doi:10.70675/cdb12968z83bdz4e78za8bczd26a3f65daef

Etude du rôle de STING dans la biologie des lymphocytes T CD4 : application en immunothérapie anticancéreuse

Benoit-Lizon, I. (2021) · theses.fr (ABES) · doi:10.70675/2b159c6dz31eez488ez8948z2fc5261a35dc

T immune responses to SARS-CoV-2 : identification of the immunogenic region associated with protection against infection

Fahrner, J. (2021) · theses.fr (ABES) · doi:10.70675/6b8b8b92zda75z46a0z98e6zc9f888cb9715

Harnessing Living Therapies: The Role of CAR-T Cells, Oncolytic Viruses, and Bacteria in Cancer Treatment

Smail, S. W., Flaih, A. H., Ismail, B. A., Ahmed, A. A., Bapir, A. A., Qadir, F. A., & Janson, C. (2026) · Immuno · doi:10.3390/immuno6020034

Polyelectrolyte nanoparticles enable intracellular delivery of STING protein fragments for ovarian cancer immunotherapy

Kaskow, J. A., Bacchus, A., Gomerdinger, V. F., Berger, A. G., Li, Z., Gerton, T. J., Smith, M. A., Li, A., Treese, J., Kindopp, A., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103251

The Emerging Role of Nanocarrier-Based Delivery Systems for cGAS-STING Activation in Cancer Immunotherapy

Zhu, G., Li, D., Zhang, H., Wang, J., Li, X., Zeng, L., Zhang, L., & Yu, L. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s598118

STING Beyond Immunity: Tumour-Intrinsic Roles in Breast Cancer Progression and MetastasisPreprint

Joshi, V., Beecher, K., Duijf, P. H. G., Stacey, A., Druskovich, S., Reed, S., Simpson, P. T., Lakhani, S. R., & Reed, A. E. M. (2026) · Research Square · doi:10.21203/rs.3.rs-9535798/v1

A toxic STING-SAMHD1 axis drives replication stress in progeria and cancer cells

Teodoro-Castro, B., de Faria, R. C., Shashkova, E. V., Malique, A., Adolph, M. B., Silva, L. N. D. E., & Gonzalo, S. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag614 · Cited by 1

Dexamethasone activates anti-tumor immunity in multiple myeloma by dismantling the GR-PPP1CB complex to restore STING/IRF3 signaling

Wang, C. F., Liu, L., Zhang, J. Y., Sun, S., Lv, X., Liu, Z., Zhou, L., Zhu, Z., Ni, H., Gu, C., et al. (2026) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2026-015256

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Lyu, L., Yi, M., Chen, J., Zhao, Z., Liao, R., Wang, Y., Hu, S., Ding, J., Zhao, R., Jia, W. W.-G., et al. (2026) · Advanced Science · doi:10.1002/advs.202523356

m6A RNA modification: a central epitranscriptomic switch orchestrating oncogenic signaling and glycolytic reprogramming in cancer

Guo, Y., Kou, R., Huang, Z., Chen, Z., & Yun, H. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1864321

Low baseline cGAS expression is associated with longer progression-free survival in patients with pleural mesothelioma

Torchiat, A., Siliņa, K., Nair, A., Heeb, L., Opitz, I., Gupta, A. K., & Fontecedro, A. C. (2026) · Lung Cancer · doi:10.1016/j.lungcan.2026.109553

Advances in paclitaxel-mediated remodeling of the gastric cancer immune microenvironment and sensitization to immune checkpoint inhibitors via cGAS-STING pathway activation triggered by mtDNA release: challenges and translational perspectives

Wu, C., Sun, Z.-L., & Ye, K. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12570-8

The cGAS-STING/MITA pathway in innate antiviral immunity and beyond

Li, F.-X., & Zhong, B. (2026) · Cell Insight · doi:10.1016/j.cellin.2026.100357 · Cited by 1

STING Expression Progressively Increases During Esophageal Squamous Carcinogenesis but Predicts Favorable Outcome After Endoscopic Resection: A Paradox Resolved by Context-Dependent ImmunityPreprint

Wang, B., Yao, L., Zhao, Y., Su, Z., Chen, J., You, T., Wu, L., Wang, L., Wang, W., Liu, G., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10456885/v1

Context-Dependent cGAS-STING Activation Shapes Metastatic Progression and Dormancy

Akter-Yasuoka, E., 이탁, Murayama, T., & Nakayama, J. (2026) · Cells · doi:10.3390/cells15171619

Interplay between pathogen-mediated immune evasion and innate immune negative regulation in gastrointestinal tumors

Shi, M., Zeng, Y., Chen, C., & Zuo, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1951036

Beyond the barrier: Engineering the tumor-immune-soil nexus–a mechanistic blueprint for integrating Traditional Chinese Medicine with immunotherapy in metastatic colorectal cancer

Sun, Y., Li, Y., Jiang, H., Liu, X., Yu, S., & Liu, Y. (2026) · Medical Oncology · doi:10.1007/s12032-026-03397-1

Lipid metabolism: a potential checkpoint for cGAS-STING regulation in colorectal cancer

Qiu, Q., Cheng, Z., Gu, J., Zhang, T., Cai, M., & Wang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1928380

cGAS‑STING pathway in digestive tract cancer: From molecular mechanisms to therapeutic applications (Review)

Chen, T., Zhang, J., Sun, J., Zhang, H., Huang, D., & Ye, H. (2026) · International Journal of Oncology · doi:10.3892/ijo.2026.5944

Context-dependent cGAS-STING signaling in solid tumors: biological determinants, clinical implications, and biomarker-guided therapeutic strategies

Wang, Z., Yu, Y., & Zhu, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1954279

Nanoengineered STING agonists for cancer therapy: toward immunodynamic control

Liu, N., Wang, X., Zhang, W., Kan, Y., Petrovna, B. M., Wang, Z., Kong, X., & Wang, J. (2026) · Journal of Hematology & Oncology · doi:10.1186/s13045-026-01860-0

Molecular Checkpoints of Nucleic Acid Sensing in Tumor Cells: Linking Innate Immune Evasion to Precision Cancer Immunotherapy

Wang, Y., Cao, B., Lu, H., Wang, Z., & Qin, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219417

Mutation-Associated cGAS-STING Signaling and the Co-evolution of the Tumor Immune Microenvironment in DNA Damage Repair-Deficient Tumors: From Spatial Architecture to Bedside Translation

Jiang, W., Zhang, Z., Li, X., Shi, R., Pan, B., & Yan, H. (2026) · Seminars in Oncology · doi:10.1016/j.seminoncol.2026.152569

BindingDB Entry 50015272: Discovery of Non-Nucleotide Small-Molecule STING Agonists

BindingDB (2023) · UC San Diego · doi:10.7270/q29s1vzm

Mechanism-driven nano-therapeutic platform integrating plant-derived compounds and membrane-active peptides reprograms inflammatory, cell cycle arrest, cGAS–STING, and apoptotic gene expression to quench colorectal cancer

Ibrahim, D., Khater, S. I., Abdelfattah‐Hassan, A., Babteen, N. A., Alqahtani, L. S., Qahl, S. H., Mostafa, M., El-Shaer, N. O., Abdel-Raheem, S. M., Alkhayyal, N., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1963760

STING signaling is a potential immunotherapeutic target in colorectal cancer

Chon, H. J., Kim, H., Noh, J. H., Yang, H., Lee, W. S., Kong, S. J., Lee, S., Lee, Y. S., Kim, W. R., Kim, J. H., et al. (2019) · Journal of Cancer · doi:10.7150/jca.32806 · Cited by 83

Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

Zhu, Q., Man, S. M., Gurung, P., Liu, Z., Vogel, P., Lamkanfi, M., & Kanneganti, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1402051 · Cited by 157

Diverse roles of STING-dependent signaling on the development of cancer

Ahn, J., Konno, H., & Barber, G. N. (2015) · Oncogene · doi:10.1038/onc.2014.457 · Cited by 140

STING protects against colitis-associated colorectal tumorigenesis by modulating intestinal inflammation (TUM7P.1018)

Zhu, Q., & Kanneganti, T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.194.supp.142.7

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

Konno, H., Yamauchi, S., Berglund, A., Putney, R. M., Mulé, J. J., & Barber, G. N. (2018) · Oncogene · doi:10.1038/s41388-017-0120-0 · Cited by 281