Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377

Cancer treatment and survivorship statistics, 2016

Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., Stein, K. D., Alteri, R., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21349 · Cited by 6,066

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576

The gut microbiota, bacterial metabolites and colorectal cancer

Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925

Cancer treatment and survivorship statistics, 2014

Desantis, C. E., Lin, C. C., Mariotto, A. B., Siegel, R. L., Stein, K., Kramer, J. L., Alteri, R., Robbins, A. S., & Jemal, A. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21235 · Cited by 2,847

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · cited 5×

Intestinal inflammation targets cancer-inducing activity of the microbiota

Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182

Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms

Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000

Selective BCL-2 inhibitor triggers STING-dependent antitumor immunity via inducing mtDNA release

Zhang, W., Pan, X., Wang, L., Li, W., Dai, X., Zheng, M., Guo, H., Chen, X., Xu, Y., Wu, H., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010889 · Cited by 12

Selective Editing of Herpes Simplex Virus 1 Enables Interferon Induction and Viral Replication That Destroy Malignant Cells

Liu, X., & He, B. (2018) · Journal of Virology · doi:10.1128/jvi.01761-18 · Cited by 12

gRNA Sequence Heterology Tolerance Catalyzed by CRISPR/Cas in an In Vitro Homology-Directed Repair Reaction

Hewes, A. M., Sansbury, B. M., Barth, S., Tarcic, G., & Kmiec, E. B. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.03.012 · Cited by 12

Engineering the Immune Adaptor Protein STING as a Functional Carrier

Sun, X., Ni, Y., He, Y., Yang, M., Tani, T., Kitajima, S., Barbie, D. A., & Li, J. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100066 · Cited by 13

Intracellular DNA sensing pathway of cGAS-cGAMP is decreased in human newborns and young children

Wang, Z.-S., Liu, Y., Mi, N., & Duan, D.-Y. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.04.007 · Cited by 12

Overcoming Immune Therapy Resistance in Cancer Through Innate Immune Reprogramming

Mandracci, G., Soliman, N., & Khawanky, N. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199554 · Cited by 15

RGD targeted magnetic ferrite nanoparticles enhance antitumor immunotherapeutic efficacy by activating STING signaling pathway

Shi, G., Liu, X., Du, Y., & Tian, J. (2024) · iScience · doi:10.1016/j.isci.2024.109062 · Cited by 11

STING activation increases the efficiency of temozolomide in PTEN harbouring glioblastoma cells

Yildirim, Z., Doğan, E., Kara, H. G., Kosova, B., & Çetintaş, V. B. (2024) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.55730/1300-0144.5828 · Cited by 11

Assessing the cGAS-cGAMP-STING Activity of Cancer Cells

Pépin, G., & Gantier, M. P. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7568-6_20 · Cited by 11

Type I Interferon Induction in Cutaneous DNA Damage Syndromes

Klein, B., & Günther, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.715723 · Cited by 16

The tumor cell-intrinsic cGAS–STING pathway is associated with the high density of CD8+ T cells after chemotherapy in esophageal squamous cell carcinoma

Matsuishi, A., Nakajima, S., Kaneta, A., Saito, K., Fukai, S., Sakuma, M., Tsumuraya, H., Okayama, H., Saito, M., Mimura, K., et al. (2024) · Esophagus · doi:10.1007/s10388-024-01044-0 · Cited by 10

Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer

Shu, C., Li, J., Rui, J., Fan, D., Niu, Q., Bai, R., Cicka, D., Doyle, S. P., Wahafu, A., Zheng, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57297-5 · Cited by 11

Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T-cell–Mediated Tumor Control

Marinković, E., Chen, M., Schubert, N., Dar, E. D., Poth, T., Leung, J. Y., Lohre, J., Sahni, J. M., Tun, C., Rajeswaran, P., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2262 · Cited by 11

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Mao, C., Fan, W., Liu, J., Yang, F., Li, W., Li, L., Shi, Z., Li, Q., Yuan, Z., Jiang, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202507904 · Cited by 12

ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation

Meng, J., Cai, H., Sun, Y., Wen, S., Wu, H., & Ren, D. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00731-3 · Cited by 10

DNA sensing of dendritic cells in cancer immunotherapy

Qian, W. P., Ye, J., & Xia, S. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1391046 · Cited by 10

DNA-PK–Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance

Wang, H., Zhang, Y., Tian, Y., Yang, W., Wang, Y., Hou, H., Pan, H., Pei, S., Zhu, H., Gu, Z., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-0744 · Cited by 9

Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I

Choy, L., Norris, S., Wu, X., Kolumam, G. A., Firestone, A. J., Settleman, J. E., & Stokoe, D. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0432 · Cited by 12

Revitalizing antitumor immunity: Leveraging nucleic acid sensors as therapeutic targets

Liu, D., He, W., & Yang, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216729 · Cited by 9

A Novel Chimeric Oncolytic Virus Mediates a Multifaceted Cellular Immune Response in a Syngeneic B16 Melanoma Model

Glauß, S., Neumeyer, V., Hanesch, L., Marek, J., Hartmann, N., Wiedemann, G. M., & Altomonte, J. (2024) · Cancers · doi:10.3390/cancers16193405 · Cited by 9

SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

Liang, B., Zhang, E. H., Ye, Z., Storts, H., Wei, J., Zheng, X., Hylton, H., Zaleski, O., Xing, X., Miles, W. O., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0265 · Cited by 9

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer

Jilderda, L. J., Zhou, L., & Foijer, F. (2021) · Cells · doi:10.3390/cells10020342 · Cited by 9

Tackling HLA Deficiencies Head on with Oncolytic Viruses

Fisher, K. D., Hazini, A., & Seymour, L. W. (2021) · Cancers · doi:10.3390/cancers13040719 · Cited by 10

Consequences of mitotic failure – The penalties and the rewards

Štorchová, Z. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.03.007 · Cited by 9

Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer

Viculin, J., Degoricija, M., Vilović, K., Gabela, I., Franković, L., Vrdoljak, E., & Korać-Prlić, J. (2023) · Cancers · doi:10.3390/cancers15133510 · Cited by 10

Type I interferons: One stone to concurrently kill two birds, viral infections and cancers

Kumar, A., Khani, A. T., & Swaminathan, S. (2021) · Current Research in Virological Science · doi:10.1016/j.crviro.2021.100014 · Cited by 9

Intratumoral STING activation causes durable immunogenic tumor eradication in the KP soft tissue sarcoma model

Marritt, K., Hildebrand, K. M., Hildebrand, K., Singla, A. K., Zemp, F. J., Mahoney, D. J., Jirik, F. R., & Monument, M. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1087991 · Cited by 12

STING in tumors: a focus on non-innate immune pathways

Yang, J., Yang, M., Wang, Y., Sun, J., Liu, Y., Zhang, L., & Guo, B. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1278461 · Cited by 11

Advances in Oncolytic Viral Therapy in Melanoma: A Comprehensive Review

Garg, A., Rao, R., Tejawinata, F., Shamita, G., Herpel, M. S., Yoshida, A., Goolamier, G., Sidiropoulos, J., Sheng, I. Y. F., Abboud, S.-T., et al. (2025) · Vaccines · doi:10.3390/vaccines13070727 · Cited by 10

VAPB is a negative regulator of STING-mediated innate immune signaling

Ji, W., Yin, Z., Zhang, L., Liu, Q., Niu, S., Feng, Y., Chen, F., Liu, X., & Li, X. (2025) · Science Advances · doi:10.1126/sciadv.aea3996 · Cited by 8

Immune Regulation by Cytosolic DNA Sensors in the Tumor Microenvironment

Fukuda, K. (2023) · Cancers · doi:10.3390/cancers15072114 · Cited by 8

STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling

Zhou, X., Meng, F., Xu, B., Ma, R., Cheng, Y., Wu, J., & Qian, J. (2023) · Oncology Reports · doi:10.3892/or.2023.8682 · Cited by 8

Uncovering the Anticancer Potential of Murine Cytomegalovirus against Human Colon Cancer Cells

Massara, L., Khairallah, C. F., Yared, N., Pitard, V., Rousseau, B., Izotte, J., Giese, A., Dubus, P. R., Gauthereau, X., Déchanet‐Merville, J., et al. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.01.007 · Cited by 8

C-REV Retains High Infectivity Regardless of the Expression Levels of cGAS and STING in Cultured Pancreatic Cancer Cells

Morimoto, D., Matsumura, S., Bustos‐Villalobos, I., Sibal, P. A., Ichinose, T., Naoe, Y., Eissa, I. R., Abdelmoneim, M., Mukoyama, N., Miyajima, N., et al. (2021) · Cells · doi:10.3390/cells10061502 · Cited by 8

Lipid nanoparticles delivering constitutively active STING mRNA as a novel anti-cancer therapeutic approachPreprint

Liu, W., Alameh, M., Yang, J. F., Xu, J. R., Lin, P. J. C., Tam, Y. K., Weissman, D., & You, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.08.475499 · Cited by 8

The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance

Carloni, V., Morganti, E., Galli, A., & Mazzocca, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010245 · Cited by 7

Epigenetic regulation of cGAS and STING expression in cancer

Zhao, C., Guo, S., & Ge, S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112556 · Cited by 8

Advances in diagnostic and therapeutic applications of mismatch repair loss in cancer

DeWitt, J., Jimenez-Tovar, D., Mazumder, A., & Haricharan, S. (2025) · DNA Repair · doi:10.1016/j.dnarep.2025.103822 · Cited by 7

cGAS–STING: From immunology and oncology view

Liu, X., Ding, C., Lü, J., & Zhang, N. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003889 · Cited by 8

Unlocking the therapeutic potential of immuno-radiotherapy: insights from preclinical and clinical research

Cogels, M., Caluwé, A. D., Buisseret, L., & Penninckx, S. (2026) · OncoImmunology · doi:10.1080/2162402x.2025.2608436 · Cited by 9

Differential gene expression of immunity and inflammation genes in colorectal cancer using targeted RNA sequencing

Holubeková, V., Loderer, D., Grendár, M., Mikolajčík, P., Kolková, Z., Turyova, E., Kúdelová, E., Kalman, M., Marcinek, J., Miklušica, J., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1206482 · Cited by 7

Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells

Nguyen, V. N., Brunon, S., Pavlova, M. N., Lazarchuk, P., Sharifian, R., & Sidorova, J. M. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1048726 · Cited by 7

Adding STING to the Tale of Oncolytic Virotherapy

Thorne, S. H. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.01.002 · Cited by 7

Decoding STING’s roles in cancer: immunity, pain, dormancy, and autophagy

Lin, H., Tang, Y., & Liang, X. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05281-4 · Cited by 6

Dual blockade of PD-1 and CTLA-4 generates long-lasting immunity against irradiated glioblastoma

Martino, M. D., Daviaud, C., Lira, M. C., Hernandez-Zirofsky, K., & Vanpouille‐Box, C. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217856 · Cited by 8

Novel anti-HER2 nanobody-drug conjugates with enhanced penetration of solid tumor and BBB, reduced systemic exposure and superior antitumor efficacy

Wang, Y., Liu, L., Yang, Q., & Yu, K. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01634-3 · Cited by 6

“Emerging precision drug delivery systems for controlled activation of the cGAS–STING pathway in Cancer, infection, and autoimmune disorders”

Pavani, G., Matada, G. S. P., Ghara, A., Paik, A., David, A. R., & Kavyasree, C. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116052 · Cited by 6

Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

Delaunay, T., Son, S., Park, S., Kaur, B., Ahn, J., & Barber, G. N. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101528 · Cited by 6

Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer

Du, Y., Salehi‐Rad, R., Zhang, T.-H., Crosson, W. P., Abascal, J. W., Chen, D., Shi, Y., Jiang, H. F., Tseng, Y.-W., Ma, X., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-1075 · Cited by 9

Harnessing Genomic Stress for Antitumor Immunity

Pu, C., Tao, S., Xu, J., & Huang, M. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8221 · Cited by 6

Au naturale: use of biologically derived cyclic di-nucleotides for cancer immunotherapy

Waters, C. M. (2021) · Open Biology · doi:10.1098/rsob.210277 · Cited by 6

SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia.

Chen, X., Zhao, L., Tian, Y., Zeng, J., & Chen, M. (2022) · PubMed Central · Cited by 6

STING and transplantation: can targeting this pathway improve outcomes?

Bader, C. S., Jin, L., & Levy, R. B. (2021) · Blood · doi:10.1182/blood.2020008911 · Cited by 6

Resolving systematic errors in widely-used enhancer activity assays in human cells enables genome-wide functional enhancer characterizationPreprint

Muerdter, F., Boryń, Ł. M., Woodfin, A. R., Neumayr, C., Rath, M., Zabidi, M. M. A., Pagani, M., Haberle, V., Kazmar, T., Catarino, R. R., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/164590 · Cited by 6

IFNλ1 is a STING-dependent mediator of DNA damage and induces immune activation in lung cancer

Godsk, S. H., Jensen, C. M. S., Larsen, T. V., Ahrenfeldt, J., Gammelgaard, K. R., & Jakobsen, M. R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1525083 · Cited by 6

Overcoming conditional immune resistance in MSS and pMMR colorectal cancer: A sequential gating framework for immunotherapy

Farah, H. S., Polatova, D., Rizaev, J., Mhdy, F. A., Muhammad, F. A., Maharana, L., Bainsal, N., & Singh, R. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105353 · Cited by 5

Pharmacological potential of cyclic nucleotide signaling in immunity

Ednacot, E. M. Q., Nabhani, A., Dinh, D. M., & Morehouse, B. R. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108653 · Cited by 5

The interferon response at the intersection of genome integrity and innate immunity

Duzanic, F. D., & Penengo, L. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103786 · Cited by 5

Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform

Zhang, Y., Li, Z., Ritter, J., Brea, E. J., Mahadevan, N. R., Dillon, D. A. R., Park, S.-R., Liu, E. M., Tolstorukov, M. Y., McGourty, W. E., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102198 · Cited by 6

Effects on Metabolism in Astrocytes Caused by cGAMP, Which Imitates the Initial Stage of Brain Metastasis

Okawa, T., Hara, K., Goto, M., Kikuchi, M., Kogane, M., Hatakeyama, H., Tanaka, H., Shirane, D., Akita, H., Hisaka, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169028 · Cited by 5

Role of N6-methyladenosine methylation in head and neck cancer and its regulation of innate immune pathways

Cao, L., Huang, G., Fan, J., Liu, X., & Ma, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1458884 · Cited by 5

Exploring nucleotide and non-nucleotide cGAS-STING agonists: Therapeutic applications and future directions in cancer immunotherapy

Ghara, A., Matada, G. S. P., Pramanick, P., Sharma, U. R., & Dhiwar, P. S. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104412 · Cited by 5

Cancer Immunotherapy—An Emerging Field That Bridges Oncology and Immunology Research

Adams, J. L., Duffy, K. J., Moore, M. L., & Yang, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12400-x · Cited by 7

Insight into the dichotomous regulation of STING activation in immunotherapy

Hu, Z., Yang, Y. K., Fang, L., Zhou, J., & Zhang, H. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1890118 · Cited by 5

Autophagy takes the STING out of DNA sensing

de Motes, C. M. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00797-3 · Cited by 5

Role of stimulator of interferon genes ( STING ) in the enteric nervous system in health and disease

Balasubramaniam, A., & Srinivasan, S. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14603 · Cited by 5

Nucleic Acid Sensing at the Interface Between Innate and Adaptive Immunity

Vanpouille‐Box, C., & Galluzzi, L. (2019) · International review of cytology · doi:10.1016/s1937-6448(19)30030-9 · Cited by 5

Cancer cell-extrinsic STING shapes immune-active microenvironment and predicts clinical outcome in gastric cancer

Ye, W., Ren, Q., Hu, P., Zou, Y., Yao, W., & Qiu, H. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03726-8 · Cited by 4

The human STING agonist E7766 induces immunogenic tumor clearance, independent of tumor-intrinsic STING expression in the KRAS G12D/+ Trp53 −/− murine model of sarcoma

Hildebrand, K. M., Hildebrand, K., Arcila, C. S., Marritt, K., Rajwani, J., Assadzadeh, G. E., Dufour, A., Jirik, F. R., & Monument, M. J. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2534912 · Cited by 5

cGAS-STING signaling: a therapeutic target in inflammatory bowel disease and related colorectal cancer

Chen, X., Tang, X., Chen, S., Ye, Y., & Mao, F. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1709908 · Cited by 4

UNC93B1 promotes pancreatic cancer progression through modulation of cGAS–STING signaling

Yang, H., Li, Y., Su, J., Zhang, H., Zhu, W., Shen, K., & Xu, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1718849 · Cited by 4

ISGylation prevents autophagic degradation of STING and promotes antitumor immunity in lung cancer

Cao, D., Bin, H., Fu, X., Liu, M., Niu, X., Zhai, H., & Huang, H. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08527-1 · Cited by 4

The cGAS–STING pathway in cancer immunotherapy: prognostic value and therapeutic potential

Alabi, F. A., Imodoye, S. O., Adedokun, K. A., Eltokhy, M. A., Curcic, M., Okoyeocha, E., Thapa, I., Tiwari, S., Ogundele, A. V., Ayo, T. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1760947 · Cited by 5

Therapeutic targeting of the cGAS-STING pathway in human disease

Mahajan, A. S., Forsyth, C. M., Phung, C. D., Shen, X., Jarvis, R., & Stegh, A. H. (2026) · Journal of Clinical Investigation · doi:10.1172/jci204547 · Cited by 4

Mutations in genes encoding innate immune molecules identified in bladder cancer samples as potential biomarkers for immunotherapy with BCG and agonists

de Queiroz, N. M. G. P., Mambelli, F., Silva, B. M., & Oliveira, S. C. (2023) · Frontiers in Urology · doi:10.3389/fruro.2023.984967 · Cited by 4

Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer

Shboul, S. A., Karsaneh, O. A. A., Alrjoub, M., Alqudah, M. A. Y., El‐Sadoni, M., Alhesa, A., Ramadan, M., Barukba, M., Al-Quran, E. F., Masaadeh, A. H., et al. (2025) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320251324821 · Cited by 4

STING and metabolism-related diseases: Roles, mechanisms, and applications

Zhang, Z., Wang, X., Zhao, C., Zhu, H., Liao, X., & Tsai, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111833 · Cited by 4

Administration of a glypican‐3 peptide increases the infiltration and cytotoxicity of CD8 + T cells against testicular yolk sac tumor, associated with enhancing the intratumoral cGAS / STING signaling

Zhao, J., Qin, L., He, G., Xie, T., Hu, G., Wang, F., Zhong, H., Zhu, J., & Xu, Y. (2023) · Cancer Medicine · doi:10.1002/cam4.6605 · Cited by 3

Identification of Nonfunctional Alternatively Spliced Isoforms of STING in Human Acute Myeloid Leukemia

Boda, A. R., Liu, A. J., Castro-Pando, S., Whitfield, B. T., Molldrem, J. J., Alatrash, G., Francesco, M. E. D., JONES, P. G., Ager, C. R., & Curran, M. A. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0095 · Cited by 4

Innate immune sensing of macromolecule homeostasis

Yang, K., Jeltema, D., & Yan, N. (2024) · Advances in immunology · doi:10.1016/bs.ai.2024.03.004 · Cited by 4

Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer

Cho, M.-G., & Gupta, G. P. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103868 · Cited by 5

Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies

Taffoni, C., Schüssler, M., Vila, I. K., & Laguette, N. (2023) · BioEssays · doi:10.1002/bies.202300045 · Cited by 4

Immunomodulatory Gene-Splicing Dysregulation in Tumorigenesis: Unmasking the Complexity

Maebele, L. T., Mulaudzi, T. V., Madhavan, Y., Dlamini, Z., & Damane, B. P. (2023) · Molecules · doi:10.3390/molecules28165984 · Cited by 4

Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma

Nie, A.-Y., Xiao, Z.-H., Deng, J., Li, N., Hao, L., Li, S.-H., & Hu, X.-Y. (2025) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v17.i2.98556 · Cited by 3

Extrachromosomal circular DNA drives ferroptosis and immunity in trophoblasts via the STING pathway in preeclampsia

Wang, X., Bian, W., Huang, M., Li, T., Xiong, H., Xiang, S., Li, H., Yang, H., & Yang, H. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152522 · Cited by 3

Context-dependent actions of STING pathway in colitis and associated colon cancer

Qu, J., Cai, Y., Li, F., Li, Y., & Liu, R. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101855 · Cited by 4

Application and SARs of Pyrazolo[1,5-a]pyrimidine as Antitumor Agents Scaffold

Zhang, Y., Wen, D., Shen, J., Tian, L., Zhu, Y., Zhang, J., Zhao, L., Ding, S., Liu, J., & Chen, Y. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230228111629 · Cited by 3

The impact of innate immune response on the efficacy of oncolytic viruses

Николаевич, Т. К., Pestov, N. B., Biryukova, Y. K., & Kolyasnikova, N. M. (2024) · Problems of Virology · doi:10.36233/0507-4088-275 · Cited by 3

PIKfyve Inhibition Induces Antitumor Immunogenicity by Attenuating STING Trafficking and Lysosomal Degradation

He, J., Huang, R., Zong, C., Li, Q., Wang, Y., Zheng, G., Wang, Y., Yang, X., Fang, Y., Fang, F., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0405 · Cited by 3

Utilizing Microbes to Treat Naturally Occurring Cancer in Veterinary Species

Withers, S. S., Sparger, E. E., Boudreaux, B. B., & Mason, N. J. (2019) · Current Clinical Microbiology Reports · doi:10.1007/s40588-019-00130-7 · Cited by 3

VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity

Nelson, K. L., Reil, K. A., Tsuji, S., Parikh, A. M., Robinson, M., House, C. D., McGuire, K. L., & Giacalone, M. J. (2025) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-24-0509 · Cited by 3

Combination of oncolytic viruses and immune checkpoint inhibitors in glioblastoma

Desai, K. B., Hubben, A. K., & Ahluwalia, M. S. (2019) · Glioma · doi:10.4103/glioma.glioma_5_19 · Cited by 3

Loss of MicroRNA-29b promotes DNMT3b-mediated STING downregulation to attenuate radiotherapy-induced antitumor immunity in KRAS-mutated colorectal cancer

Chang, H.-Y., Chen, J.-Y., Ke, T.-W., Jiang, Y.-W., Hong, W.-Z., Tsai, Y.-Y., Chiang, S., Lin, Y., Huang, C.-H., Chen, T.-H., et al. (2026) · npj Precision Oncology · doi:10.1038/s41698-026-01290-8 · Cited by 2

The Signaling Networks of TIM-3, TGF-β, and STING in Glioblastoma

Ahmady, F., Carnie, B. M. H., Anderson, G. E. C., Achari, E., Sharma, A., Achuthan, A. A., Kannourakis, G., & Luwor, R. B. (2026) · Cells · doi:10.3390/cells15110991 · Cited by 2

PARP1 trapping activates ATM-mediated NF-κB signaling independent of replication in response to TOP1 blockade

Bournique, E., Sanchez, A., Ha, K., Yan, K. M., Manjunath, L., Santiago, G., Ortega, P., & Buisson, R. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag561 · Cited by 2

Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors

Zhang, X., Ding, T., Yang, F., Xu, H., Zhang, J., Bai, Y., Shi, Y., Yang, J., Chen, C., & Zhang, H. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02018-y · Cited by 2

Genomic investigation of innate sensing pathways in the tumor microenvironment

Quinn, G. M., Maggiore, G., & Li, B. (2024) · BMC Cancer · doi:10.1186/s12885-024-12944-w · Cited by 3

Development of STimulator of Interferon Genes Agonists in Silico

Chen, M. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1893/1/012015 · Cited by 2

STING signaling is a potential immunotherapeutic target in colorectal cancer

Chon, H. J., Kim, H., Noh, J. H., Yang, H., Lee, W. S., Kong, S. J., Lee, S., Lee, Y. S., Kim, W. R., Kim, J. H., et al. (2019) · Journal of Cancer · doi:10.7150/jca.32806 · Cited by 83

Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

Zhu, Q., Man, S. M., Gurung, P., Liu, Z., Vogel, P., Lamkanfi, M., & Kanneganti, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1402051 · Cited by 157

Diverse roles of STING-dependent signaling on the development of cancer

Ahn, J., Konno, H., & Barber, G. N. (2015) · Oncogene · doi:10.1038/onc.2014.457 · Cited by 140

STING protects against colitis-associated colorectal tumorigenesis by modulating intestinal inflammation (TUM7P.1018)

Zhu, Q., & Kanneganti, T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.194.supp.142.7

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

Konno, H., Yamauchi, S., Berglund, A., Putney, R. M., Mulé, J. J., & Barber, G. N. (2018) · Oncogene · doi:10.1038/s41388-017-0120-0 · Cited by 281