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Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis
Open accessAbstract
Stimulator of interferon genes (STING) has been shown to be critical for controlling antiviral responses as well as anti-tumor adaptive immunity, but little is known regarding its regulation in human tumors. Here, we report that STING signaling is recurrently suppressed in a wide variety of cancers, including colorectal carcinoma. Loss of STING signaling impeded DNA damage responses accountable for generating key cytokines that facilitate tissue repair and anti-tumor T cell priming, such as type I interferons (IFNs). Correspondingly, defective STING function was also highly predictive of effectual DNA-virus-mediated oncolytic activity. Thus, impaired STING responses may enable damaged cells to evade host immunosurveillance processes, although they provide a critical prognostic measurement that could help predict the outcome of effective oncoviral therapy.
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“Accordingly, cancer cells often inactivate the cGAS-STING pathway to evade immune detection (Xia et al., 2016).”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Xia et al., 2016
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Metadata
- Authors
- Xia, T., Konno, H., Ahn, J., & Barber, G. N.
- Affiliations
- University of Miami (US)
- Corresponding author
- Barber, Glen N.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 14
- Issue
- 2
- Pages
- 282-297
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC4845097
- OpenAlex
- W2220279767
- Cited by
- 589
- References
- 50
- Citations by year
- 2026: 46 · 2025: 61 · 2024: 70 · 2023: 66 · 2022: 77 · 2021: 76 · 2020: 51 · 2019: 57 · 2018: 44 · 2017: 28 · 2016: 13
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- National Cancer Institute (R01CA194404)
- National Institute of Allergy and Infectious Diseases (R01AI079336)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- STING signaling, colorectal cancer, DNA damage response, type I interferon, tumor surveillance, DNA viruses, carcinogenesis, prognostic factors, tissue repair
- MeSH terms
- Animals, DNA Damage, Humans, Transfection, Colorectal Neoplasms, Signal Transduction, Mice, Carcinogenesis
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