The Role of the Microbiota in Inflammation, Carcinogenesis, and Cancer Therapy
Open accessAbstract
Commensal microorganisms colonize barrier surfaces of all multicellular organisms, including those of humans. For more than 500 million years, commensal microorganisms and their hosts have coevolved and adapted to each other. As a result, the commensal microbiota affects many immune and nonimmune functions of their hosts, and de facto the two together comprise one metaorganism. The commensal microbiota communicates with the host via biologically active molecules. Recently, it has been reported that microbial imbalance may play a critical role in the development of multiple diseases, such as cancer, autoimmune conditions, and increased susceptibility to infection. In this review, we focus on the role of the commensal microbiota in the development, progression, and immune evasion of cancer, as well as some modulatory effects on the treatment of cancer. In particular, we discuss the mechanisms of microbiota‐mediated regulation of innate and adaptive immune responses to tumors, and the consequences on cancer progression and whether tumors subsequently become resistant or susceptible to different anticancer therapeutic regiments.
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The gut microbiome is a major tumor-extrinsic regulator of anti-PD-1 responses.
“the gut microbiome is a major tumor-extrinsic regulator of responses to anti–PD-1 (6–9).”
From Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients (2021) · cites this paper as [6]
The gut microbiome functions as a tumor-extrinsic biomarker that predicts response to immune checkpoint blockade.
“The intestinal microbiome has emerged as a tumor-extrinsic predictive biomarker to immune checkpoint blockade (ICB)1–6.”
From Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1 (2022) · cites this paper as [3]
The commensal microbiota modulates inflammatory/immune responses in the organism and is likely to play a major role in regulating inflammation and immunity to cancer at different levels.
“The commensal microbiota modulates inflammatory/immune responses in the organism and is, therefore, likely to play a major role in regulating inflammation and immunity to cancer at different levels [17].”
From A Clinical Outcome of the Anti-PD-1 Therapy of Melanoma in Polish Patients Is Mediated by Population-Specific Gut Microbiome Composition (2022) · cites this paper as [17]
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Self-citationXia, T., Konno, H., Ahn, J., & Barber, G. N. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.029 · Cited by 589 · see citing works
A history of exploring cancer in context
Maman, S., & Witz, I. P. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0006-7 · Cited by 502 · see citing works
McCulloch, J. A., Davar, D., Rodrigues, R. R., Badger, J. H., Fang, J. R., Cole, A. M., Balaji, A. K., Vetizou, M., Prescott, S. M., Fernandes, M. R., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01698-2 · Cited by 472 · see citing works
Self-citationGut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer
Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355 · see citing works
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Dzutsev, A., Badger, J. H., Perez-Chanona, E., Roy, S., Salcedo, R., Smith, C. K., & Trinchieri, G. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052133 · Cited by 302 · see citing works
Self-citationFrom the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation
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“The commensal microbiota modulates inflammatory/immune responses i the organism and is, therefore, likely to play a major role in regulating inflammation and immunity to cancer at different levels [17].”
BackgroundBugs as drugs: The role of microbiome in cancer focusing on immunotherapeutics
Araujo, D. V., Watson, G. A., Oliva, M., Heirali, A., Coburn, B., Spreafico, A., & Siu, L. L. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102125 · Cited by 29 · see citing works
- Authors
- Dzutsev, A., Goldszmid, R. S., Viaud, S., Zitvogel, L., & Trinchieri, G.
- Affiliations
- National Institutes of Health (US)
- Université Paris-Sud (FR)
- Corresponding author
- Trinchieri, Giorgio
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2014-11-13
- Volume
- 45
- Issue
- 1
- Pages
- 17-31
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2063262427
- Cited by
- 300
- References
- 185
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 36 · 2023: 34 · 2022: 39 · 2021: 45 · 2020: 28 · 2019: 28 · 2018: 17 · 2017: 17 · 2016: 9 · 2015: 9
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Center for Cancer Research, National Cancer Institute, NIH
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Keywords
- gut microbiota, commensal microorganisms, inflammation, carcinogenesis, cancer therapy, immune evasion, antitumor immunity, innate immunity, adaptive immunity, dysbiosis, tumor progression, antimicrobial resistance, host-microbe coevolution, metaorganism
- MeSH terms
- Animals, Antineoplastic Agents, Autoimmune Diseases, Biological Evolution, Humans, Immunity, Innate, Inflammation, Neoplasms, Symbiosis, Tumor Escape, Mice, Metagenome, Adaptive Immunity, Immunomodulation, Carcinogenesis, Microbiota
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