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Cited by 313

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

Open access
Park, Jun Hyoung, Vithayathil, Sajna, Kumar, Santosh, Sung, Pi-Lin, Dobrolecki, Lacey Elizabeth, Putluri, Vasanta, Bhat, Vadiraja B., Bhowmik, Salil Kumar, Gupta, Vineet, Arora, Kavisha, Wu, Danli, Tsouko, Efrosini, Zhang, Yiqun, Maity, Suman, Donti, Taraka R., Graham, Brett H., Frigo, Daniel E., Coarfa, Cristian, Yotnda, Patricia, Putluri, Nagireddy, Sreekumar, Arun, Lewis, Michael T., Creighton, Chad J., Wong, Lee-Jun C., Kaipparettu, Benny Abraham·2016·Cell Reports
DOI 10.1016/j.celrep.2016.02.004
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Abstract

Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial reprogramming and mitochondria-regulated cancer pathways in triple-negative breast cancer (TNBC). Analysis of cybrids and established breast cancer (BC) cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419. Manipulation of FAO including the knocking down of carnitine palmitoyltransferase-1A (CPT1) and 2 (CPT2), the rate-limiting proteins of FAO, and analysis of patient-derived xenograft models confirmed the role of mitochondrial FAO in Src activation and metastasis. Analysis of TCGA and other independent BC clinical data further reaffirmed the role of mitochondrial FAO and CPT genes in Src regulation and their significance in BC metastasis.

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Metadata

Authors
Park, J. H., Vithayathil, S., Kumar, S., Sung, P.-L., Dobrolecki, L. E., Putluri, V., Bhat, V. B., Bhowmik, S. K., Gupta, V., Arora, K., Wu, D., Tsouko, E., Zhang, Y., Maity, S., Donti, T. R., Graham, B. H., Frigo, D. E., Coarfa, C., Yotnda, P., Putluri, N., Sreekumar, A., Lewis, M. T., Creighton, C. J., Wong, L.-J. C., & Kaipparettu, B. A.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2016-03
Volume
14
Issue
9
Pages
2154-2165
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2016.02.004
OpenAlex
W2281758534
Cited by
313
References
65
FWCI
9.34
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.