The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer
Open accessAbstract
Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial reprogramming and mitochondria-regulated cancer pathways in triple-negative breast cancer (TNBC). Analysis of cybrids and established breast cancer (BC) cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419. Manipulation of FAO including the knocking down of carnitine palmitoyltransferase-1A (CPT1) and 2 (CPT2), the rate-limiting proteins of FAO, and analysis of patient-derived xenograft models confirmed the role of mitochondrial FAO in Src activation and metastasis. Analysis of TCGA and other independent BC clinical data further reaffirmed the role of mitochondrial FAO and CPT genes in Src regulation and their significance in BC metastasis.
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“As FAO activates oncogenic Src and its target genes, as discussed previously, ETX also reverses the Src-regulated gene pattern and abolishes the metastasis potential of TNBC 76 .”
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Metadata
- Authors
- Park, J. H., Vithayathil, S., Kumar, S., Sung, P.-L., Dobrolecki, L. E., Putluri, V., Bhat, V. B., Bhowmik, S. K., Gupta, V., Arora, K., Wu, D., Tsouko, E., Zhang, Y., Maity, S., Donti, T. R., Graham, B. H., Frigo, D. E., Coarfa, C., Yotnda, P., Putluri, N., Sreekumar, A., Lewis, M. T., Creighton, C. J., Wong, L.-J. C., & Kaipparettu, B. A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 14
- Issue
- 9
- Pages
- 2154-2165
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2281758534
- Cited by
- 313
- References
- 65
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- gold
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