The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria
Open accessAbstract
In the absence of low-level ER-to-mitochondrial Ca(2+) transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we demonstrate that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond similarly but that autophagy is insufficient for survival, and cancer cells die while their normal counterparts are spared. Cancer cell death is due to compromised bioenergetics that can be rescued with metabolic substrates or nucleotides and caused by necrosis associated with mitotic catastrophe during their proliferation. Our findings reveal an unexpected dependency on constitutive Ca(2+) transfer to mitochondria for viability of tumorigenic cells and suggest that mitochondrial Ca(2+) addiction is a feature of cancer cells.
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Cites
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Madreiter-Sokolowski, C. T., Thomas, C., & Ristow, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101678 · Cited by 365
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ER-mitochondria interactions: Both strength and weakness within cancer cells
Doghman-Bouguerra, M., & Lalli, E. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.01.009 · Cited by 94
Urra, F. A., Muñoz, F., Córdova-Delgado, M., Ramírez, M. P., Peña-Ahumada, B., Rios, M., Cruz, P., Ahumada-Castro, U., Bustos, G., Silva-Pavez, E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31367-9 · Cited by 69
Self-citation
Metadata
- Authors
- Cárdenas, C., Müller, M., McNeal, A., Lovy, A., Jaňa, F., Bustos, G., Urra, F., Smith, N., Molgó, J., Diehl, J. A., Ridky, T. W., & Foskett, J. K.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 14
- Issue
- 10
- Pages
- 2313-2324
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2291641483
- Cited by
- 247
- References
- 18
- FWCI
- 28.89
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cárdenas, C., Müller, M., McNeal, A., Lovy, A., Jaňa, F., Bustos, G., Urra, F., Smith, N., Molgó, J., Diehl, J. A., Ridky, T. W., & Foskett, J. K. (2016). Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria. Cell Reports. https://doi.org/10.1016/j.celrep.2016.02.030
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