FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway
Open accessAbstract
Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking advantage of the metabolic flexibility of TNBC MDA-MB-231 cells to generate subpopulations with glycolytic or oxidative phenotypes, we screened phenolic compounds containing an ortho-carbonyl group with mitochondrial activity and identified a bromoalkyl-ester of hydroquinone named FR58P1a, as a mitochondrial metabolism-affecting compound that uncouples OXPHOS through a protonophoric mechanism. In contrast to well-known protonophore uncoupler FCCP, FR58P1a does not depolarize the plasma membrane and its effect on the mitochondrial membrane potential and bioenergetics is moderate suggesting a mild uncoupling of OXPHOS. FR58P1a activates AMPK in a Sirt1-dependent fashion. Although the activation of Sirt1/AMPK axis by FR58P1a has a cyto-protective role, selectively inhibits fibronectin-dependent adhesion and migration in TNBC cells but not in non-tumoral MCF10A cells by decreasing β1-integrin at the cell surface. Prolonged exposure to FR58P1a triggers a metabolic reprograming in TNBC cells characterized by down-regulation of OXPHOS-related genes that promote cell survival but comprise their ability to migrate. Taken together, our results show that TNBC cell migration is susceptible to mitochondrial alterations induced by small molecules as FR58P1a, which may have therapeutic implications.
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FR58P1 mildly uncouples mitochondria, leading to mitochondrial clearance by mitophagy, activation of the cytoprotective AMPK/Sirt1 axis, and a glycolytic shift.
“In summary, FR58P1 mildly uncouples mitochondria, leading to a mitochondrial clearance by mitophagy, activation of the cytoprotective AMPK/Sirt1 axis, and a glycolytic shift.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [54]
The effect of mitochondrial uncouplers on ATP/AMP levels and AMPK activation has been found in multiple models and species, including white adipocytes, skeletal muscle cells, cancer cells, and neurons.
“This effect has been found in multiple models and species, including white adipocytes [91,251], skeletal muscle cells [252,253], cancer cells [54,254,255,256], and neurons [257].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [54]
The best-known effect of mitochondrial uncouplers is a drop in ATP/AMP levels, which induces activation of the AMPK signaling pathway.
“In terms of cell signaling, the best-known effect of mitochondrial uncouplers is probably a drop in ATP/AMP levels, which induces the activation of the AMPK signaling pathway (Figure 1).”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [54]
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Design and Evaluation of Novel Peptides Targeting Protein Disulfide Isomerase as Antiplatelet Agents
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- Authors
- Urra, F. A., Muñoz, F., Córdova-Delgado, M., Ramírez, M. P., Peña-Ahumada, B., Rios, M., Cruz, P., Ahumada-Castro, U., Bustos, G., Silva-Pavez, E., Pulgar, R., Morales, D., Varela, D., Millas-Vargas, J. P., Retamal, E., Ramírez-Rodríguez, O., Pessoa-Mahana, H., Pavani, M., Ferreira, J., Cárdenas, C., & Araya-Maturana, R.
- Affiliations
- University of Chile (CL)
- Millennium Nucleus of Ion Channel Associated Diseases (CL)
- Buck Institute for Research on Aging (US)
- Corresponding author
- Urra, Félix A.
- Cárdenas, César
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-09-04
- Volume
- 8
- Issue
- 1
- Pages
- 13190-13190
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6123471
- OpenAlex
- W2889062514
- Cited by
- 69
- References
- 95
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 4 · 2018: 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- Universidad de Talca (RU2107, PIA-CG, RU2107)
- Comisión Nacional de Investigación Científica y Tecnológica (15150012)
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (15150012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- triple-negative breast cancer, mitochondrial uncoupling, oxidative phosphorylation, cell migration, SIRT1, AMPK, beta1 integrin, metabolic reprogramming, phenolic compounds, MDA-MB-231 cells, glycolysis
- MeSH terms
- Animals, Antineoplastic Agents, Cell Movement, Energy Metabolism, Female, Humans, Hydroquinones, Oxidative Phosphorylation, Signal Transduction, Integrin beta1, Cell Line, Tumor, AMP-Activated Protein Kinases, Sirtuin 1, Triple Negative Breast Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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