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Cited by 278

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Park, Yeonwoo, Reyna-Neyra, Andrea, Philippe, Lucas, Thoreen, Carson C.·2017·Cell Reports
DOI 10.1016/j.celrep.2017.04.042PMC PMC5811220
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Crossref · 10.1016/j.celrep.2017.04.042

Cites

6 of 6 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In mammals, mTORC1 inhibition decreases translation of ATF4, the mammalian homologue of Gcn4.

    “It is not clear if this system is conserved in mammals because in mammals mTORC1 inhibition decreases translation of the mammalian homologue of Gcn4, ATF4 58,59.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [58]

    The Results and Discussion section reports that mTOR inhibition reduces ATF4 translation through a uORF-dependent mechanism, supporting the main claim. Our copy does not identify ATF4 as the mammalian homologue of Gcn4, so that part of the cited sentence is not verified by this source. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 22

  1. Adams, 2007, Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids, J. Biol. Chem., 282, 16744, 10.1074/jbc.M610510200 · DOI
  2. Crawford, 2015, Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element, J. Biol. Chem., 290, 15878, 10.1074/jbc.M114.635144 · DOI
  3. Dowling, 2010, mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs, Science, 328, 1172, 10.1126/science.1187532 · DOI
  4. Duffy, 2015, Tracking Distinct RNA Populations Using Efficient and Reversible Covalent Chemistry, Mol. Cell, 59, 858, 10.1016/j.molcel.2015.07.023 · DOI
  5. Düvel, 2010, Activation of a metabolic gene regulatory network downstream of mTOR complex 1, Mol. Cell, 39, 171, 10.1016/j.molcel.2010.06.022 · DOI · Paper page
  6. Feldman, 2009, Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2, PLoS Biol., 7, e38, 10.1371/journal.pbio.1000038 · DOI
  7. Harding, 2000, Regulated translation initiation controls stress-induced gene expression in mammalian cells, Mol. Cell, 6, 1099, 10.1016/S1097-2765(00)00108-8 · DOI
  8. Harding, 2003, An integrated stress response regulates amino acid metabolism and resistance to oxidative stress, Mol. Cell, 11, 619, 10.1016/S1097-2765(03)00105-9 · DOI
  9. Ingolia, 2012, The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments, Nat. Protoc., 7, 1534, 10.1038/nprot.2012.086 · DOI
  10. Iwamoto, 2010, A general chemical method to regulate protein stability in the mammalian central nervous system, Chem. Biol., 17, 981, 10.1016/j.chembiol.2010.07.009 · DOI
  11. Kang, 2013, mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin, Science, 341, 1236566, 10.1126/science.1236566 · DOI
  12. Laplante, 2012, mTOR signaling in growth control and disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017 · DOI · Paper page
  13. Lu, 2004, Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response, J. Cell Biol., 167, 27, 10.1083/jcb.200408003 · DOI · Paper page
  14. Mendell, 2004, Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise, Nat. Genet., 36, 1073, 10.1038/ng1429 · DOI
  15. Peng, 2002, The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation, Mol. Cell. Biol., 22, 5575, 10.1128/MCB.22.15.5575-5584.2002 · DOI
  16. Sato, 2004, Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation, Biochem. Biophys. Res. Commun., 325, 109, 10.1016/j.bbrc.2004.10.009 · DOI
  17. Smith, 1998, Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes, Mol. Cell. Biol., 18, 6897, 10.1128/MCB.18.12.6897 · DOI
  18. Sonenberg, 2009, Regulation of translation initiation in eukaryotes: mechanisms and biological targets, Cell, 136, 731, 10.1016/j.cell.2009.01.042 · DOI · Paper page
  19. Vattem, 2004, Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells, Proc. Natl. Acad. Sci. USA, 101, 11269, 10.1073/pnas.0400541101 · DOI · Paper page
  20. Walter, 2011, The unfolded protein response: from stress pathway to homeostatic regulation, Science, 334, 1081, 10.1126/science.1209038 · DOI
  21. Yamaguchi, 2008, ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress, Cell Metab., 7, 269, 10.1016/j.cmet.2008.01.008 · DOI
  22. Ye, 2015, GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2, Genes Dev., 29, 2331, 10.1101/gad.269324.115 · DOI

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Metadata

Authors
Park, Y., Reyna-Neyra, A., Philippe, L., & Thoreen, C. C.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2017-05
Volume
19
Issue
6
Pages
1083-1090
ISSN
2211-1247
DOI
10.1016/j.celrep.2017.04.042
PMC
PMC5811220
Cited by
278
References
6
Language
en
Licence
Funders
American Cancer Society

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