Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity
Open accessAbstract
Recent studies have demonstrated that many parasites release extracellular vesicles (EVs), yet little is known about the specific interactions of EVs with immune cells or their functions during infection. We show that EVs secreted by the gastrointestinal nematode Heligmosomoides polygyrus are internalized by macrophages and modulate their activation. EV internalization causes downregulation of type 1 and type 2 immune-response-associated molecules (IL-6 and TNF, and Ym1 and RELMα) and inhibits expression of the IL-33 receptor subunit ST2. Co-incubation with EV antibodies abrogated suppression of alternative activation and was associated with increased co-localization of the EVs with lysosomes. Furthermore, mice vaccinated with EV-alum generated protective immunity against larval challenge, highlighting an important role in vivo. In contrast, ST2-deficient mice are highly susceptible to infection, and they are unable to clear parasites following EV vaccination. Hence, macrophage activation and the IL-33 pathway are targeted by H. polygyrus EVs, while neutralization of EV function facilitates parasite expulsion.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Helminths release extracellular vesicles, often termed exosomes, which are able to fuse and enter host cells, carrying with them a cargo of miRNAs.
“A paradigm-shifting discovery has been that helminths release extracellular vesicles (EVs), often termed exosomes, which are able to fuse and enter host cells, carrying with them a cargo of miRNAs (Buck et al., 2014, Coakley et al., 2017).”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Coakley et al., 2017
The Introduction (page unavailable) says helminths release exosome-like EVs containing small non-coding RNAs. The Results section on EV uptake (page unavailable) shows that H. polygyrus EVs enter macrophages and intestinal epithelial cells. Our copy does not identify the RNA cargo specifically as miRNAs or show that entry occurs by fusion. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn H. polygyrus infections, EVs target epithelial cells and macrophages, resulting in their loss of expression of the IL-33 receptor and downregulation of other immune genes.
“In H. polygyrus infections, these EVs target epithelial cells and macrophages, resulting in their loss of expression of the IL-33 receptor (IL-33R, also termed ST2) and downregulation of other immune genes.”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Coakley et al., 2017
The Results sections on EV uptake and ST2/IL-33R show that H. polygyrus EVs enter cultured epithelial cells and macrophages and suppress ST2 expression in macrophages. The paper also reports earlier findings of ST2-gene suppression in an epithelial cell line, while its macrophage-activation Results show reduced expression of other immune genes. These experiments do not establish that the same changes occur in epithelial cells and macrophages during H. polygyrus infection. (LLM, conf=0.86)
Experimental — accuracy not yet measuredEVs are an adaptable part of the armory of helminth immunomodulators, allowing extracellular pathogens to manipulate events within host cells in a receptor-independent manner.
“Hence EVs are an adaptable part of the armory of helminth immunomodulators, allowing extracellular pathogens to manipulate events within host cells in a receptor-independent manner (Coakley et al., 2017).”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Coakley et al., 2017
The Introduction and Discussion report that EVs from an extracellular helminth enter host cells and suppress macrophage activation, supporting their role as immunomodulators. The Discussion does not establish that this occurs independently of receptors; it raises CD206 binding as a possible route for EV uptake. Page numbers are unavailable in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredH. polygyrus releases small RNA-containing extracellular vesicles that suppress transcription of the IL-33 receptor.
“through the release of small RNA-containing extracellular vesicles that suppress transcription of the IL-33 receptor”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Coakley et al., 2017
These EV effects result in suppression of both alternative and inflammatory macrophage activation.
“These effects result in suppression of both alternative and inflammatory macrophage activation (Coakley et al., 2017).”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Coakley et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079 · see citing works
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075 · see citing works
Buck, A. H., Coakley, G., Simbari, F., McSorley, H. J., Quintana, J. F., Le Bihan, T., Kumar, S., Abreu-Goodger, C., Lear, M., Harcus, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms6488 · Cited by 770 · see citing works
Self-citationDeatherage, B. L., & Cookson, B. T. (2012) · Infection and Immunity · doi:10.1128/iai.06014-11 · Cited by 765 · see citing works
Kurowska‐Stolarska, M., Stolarski, B., Kewin, P., Murphy, G., Corrigan, C. J., Ying, S., Pitman, N. I., Mirchandani, A. S., Rana, B. M. J., van Rooijen, N., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901575 · Cited by 716 · see citing works
Interaction and uptake of exosomes by ovarian cancer cells
Escrevente, C., Keller, S., Altevogt, P., & Costa, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-108 · Cited by 666 · see citing works
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638 · see citing works
Anthony, R. M., Urban, J. F., Alem, F., Hamed, H. A., Rozo, C. T., Boucher, J.-L., Van Rooijen, N., & Gause, W. C. (2006) · Nature Medicine · doi:10.1038/nm1451 · Cited by 522 · see citing works
Townsend, M. J., Fallon, P. G., Matthews, D. J., Jolin, H. E., & McKenzie, A. N. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.6.1069 · Cited by 482 · see citing works
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths
Gause, W. C., Wynn, T. A., & Allen, J. E. (2013) · Nature reviews. Immunology · doi:10.1038/nri3476 · Cited by 461 · see citing works
Visualizing of the cellular uptake and intracellular trafficking of exosomes by live‐cell microscopy
Tian, T., Wang, Y., Wang, H., Zhu, Z., & Xiao, Z. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22733 · Cited by 457 · see citing works
Heusermann, W., Hean, J., Trojer, D., Steib, E., von Bueren, S., Graff-Meyer, A., Genoud, C., Martin, K., Pizzato, N., Voshol, J., et al. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201506084 · Cited by 447 · see citing works
Alternatively activated macrophages in helminth infections
Kreider, T., Anthony, R. M., Urban, J. F., & Gause, W. C. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.07.002 · Cited by 362 · see citing works
Marcilla, A., Trelis, M., Cortés, A., Sotillo, J., Cantalapiedra, F., Minguez, M. T., Valero, M. L., del Pino, M. M. S., Muñoz-Antolí, C., Toledo, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045974 · Cited by 350 · see citing works
Silverman, J. M., Clos, J., Horáková, E., Wang, A. Y., Wiesgigl, M., Kelly, I., Lynn, M. A., McMaster, W. R., Foster, L. J., Levings, M. K., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000541 · Cited by 331 · see citing works
Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections
Coakley, G., Maizels, R. M., & Buck, A. H. (2015) · Trends in Parasitology · doi:10.1016/j.pt.2015.06.009 · Cited by 310 · see citing works
Self-citationSzempruch, A. J., Sykes, S. E., Kieft, R., Dennison, L., Becker, A. C., Gartrell, A., Martin, W. J., Nakayasu, E. S., de Almeida, I. C., Hajduk, S. L., et al. (2016) · Cell · doi:10.1016/j.cell.2015.11.051 · Cited by 276 · see citing works
Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host∶Parasite Interactions
Twu, O., de Miguel, N., Lustig, G., Stevens, G. C., Vashisht, A. A., Wohlschlegel, J. A., & Johnson, P. J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003482 · Cited by 273 · see citing works
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
Reynolds, L. A., Filbey, K. J., & Maizels, R. M. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0347-3 · Cited by 233 · see citing works
Self-citationCwiklinski, K., de la Torre-Escudero, E., Trelis, M., Bernal, D., Dufresne, P. J., Brennan, G. P., O’Neill, S. M., Tort, J. F., Paterson, S., Marcilla, A., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.053934 · Cited by 229 · see citing works
Human vascular endothelial cells transport foreign exosomes from cow's milk by endocytosis
Kusuma, R. J., Manca, S., Friemel, T., Sukreet, S., Nguyen, C., & Zempleni, J. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00169.2015 · Cited by 212 · see citing works
Vannella, K. M., Ramalingam, T. R., Borthwick, L. A., Barron, L., Hart, K. M., Thompson, R. W., Kindrachuk, K. N., Cheever, A. W., White, S., Budelsky, A. L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1938 · Cited by 188 · see citing works
Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi
Zamanian, M., Fraser, L. M., Agbedanu, P. N., Harischandra, H., Moorhead, A. R., Day, T. A., Bartholomay, L. C., & Kimber, M. J. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004069 · Cited by 165 · see citing works
McSorley, H. J., Blair, N. F., Smith, K. A., McKenzie, A. N. J., & Maizels, R. M. (2014) · Mucosal Immunology · doi:10.1038/mi.2013.123 · Cited by 163 · see citing works
Self-citationNowacki, F. C., Swain, M., Klychnikov, O. I., Niazi, U. H. K., Ivens, A. C., Quintana, J. F., Hensbergen, P. J., Hokke, C. H., Buck, A. H., & Hoffmann, K. F. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.28665 · Cited by 158 · see citing works
Self-citationPhadwal, K., Alegre-Abarrategui, J., Watson, A. S., Pike, L., Anbalagan, S., Hammond, E. M., Wade-Martins, R., McMichael, A., Klenerman, P., & Simon, A. K. (2012) · Autophagy · doi:10.4161/auto.18935 · Cited by 155 · see citing works
Trypanosoma cruzi: Shedding of surface antigens as membrane vesicles
Goncalves, M. F., Umezawa, E. S., Katzin, A. M., de Souza, W., Alves, M. J. M., Zingales, B. S., & Colli, W. (1991) · Experimental Parasitology · doi:10.1016/0014-4894(91)90119-h · Cited by 155 · see citing works
Immortalization of mouse intestinal epithelial cells by the SV40-large T gene
Vidal, K., Grosjean, I., Revillard, J., Gespach, C. P., & Kaiserlian, D. (1993) · Journal of Immunological Methods · doi:10.1016/0022-1759(93)90329-6 · Cited by 146 · see citing works
The skin is an important bulwark of acquired immunity against intestinal helminths
Obata‐Ninomiya, K., Ishiwata, K., Tsutsui, H., Nei, Y., Yoshikawa, S., Kawano, Y., Minegishi, Y., Ohta, N., Watanabe, N., Kanuka, H., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130761 · Cited by 142 · see citing works
M2 polarization enhances silica nanoparticle uptake by macrophages
Hoppstädter, J., Seif, M., Dembek, A., Cavelius, C., Huwer, H., Kraegeloh, A., & Kiemer, A. K. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00055 · Cited by 132 · see citing works
Filbey, K. J., Grainger, J. R., Smith, K. A., Boon, L., van Rooijen, N., Harcus, Y., Jenkins, S., Hewitson, J. P., & Maizels, R. M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2013.109 · Cited by 130 · see citing works
Self-citationIL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity
Zaiss, M. M., Maslowski, K. M., Mosconi, I., Guenat, N., Marsland, B. J., & Harris, N. L. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003531 · Cited by 116 · see citing works
Weng, M., Huntley, D., Huang, I.-F., Foye-Jackson, O., Wang, L., Sarkissian, A., Zhou, Q., Walker, W. A., Cherayil, B. J., & Shi, H. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4721 · Cited by 116 · see citing works
On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites
Perrigoue, J., Marshall, F. A., & Artis, D. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01174.x · Cited by 109 · see citing works
Simbari, F., McCaskill, J. L., Coakley, G., Millar, M., Maizels, R. M., Fabriàs, G., Casas, J., & Buck, A. H. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.30741 · Cited by 109 · see citing works
Self-citationHost parasite communications—Messages from helminths for the immune system
Coakley, G., Buck, A. H., & Maizels, R. M. (2016) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2016.06.003 · Cited by 105 · see citing works
Self-citationType 2 innate lymphoid cells constitutively express arginase-I in the naïve and inflamed lung
Bando, J. K., Nussbaum, J. C., Liang, H.-E., & Locksley, R. M. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0213084 · Cited by 102 · see citing works
Hewitson, J. P., Filbey, K. J., Bieren, J. E., Camberis, M., Schwartz, C., Murray, J., Reynolds, L. A., Blair, N. F., Robertson, E., Harcus, Y. M., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004676 · Cited by 99 · see citing works
Self-citationFinlay, C. M., Stefanska, A. M., Walsh, K. P., Kelly, P. J., Boon, L., Lavelle, E. C., Walsh, P. T., & Mills, K. H. G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501820 · Cited by 94 · see citing works
Johnston, C. J. C., Robertson, E., Harcus, Y. M., Grainger, J. R., Coakley, G., Smyth, D. J., McSorley, H. J., & Maizels, R. M. (2015) · Journal of Visualized Experiments · doi:10.3791/52412 · Cited by 93 · see citing works
Self-citationFeng, X., Deng, T., Zhang, Y., Su, S., Wei, C., & Han, D. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03364.x · Cited by 92 · see citing works
Crucial and Diverse Role of the Interleukin-33/ST2 Axis in Infectious Diseases
Rostan, O., Arshad, M. I., Piquet‐Pellorce, C., Robert-Gangneux, F., Gangneux, J., & Samson, M. (2015) · Infection and Immunity · doi:10.1128/iai.02908-14 · Cited by 90 · see citing works
Macrophage proliferation, provenance, and plasticity in macroparasite infection
Rückerl, D., & Allen, J. E. (2014) · Immunological Reviews · doi:10.1111/imr.12221 · Cited by 84 · see citing works
Paveley, R. A., Aynsley, S. A., Turner, J. D., Bourke, C. D., Jenkins, S. J., Cook, P. C., Martínez‐Pomares, L., & Mountford, A. P. (2011) · International Journal for Parasitology · doi:10.1016/j.ijpara.2011.08.005 · Cited by 73 · see citing works
IL-33 Signaling Regulates Innate and Adaptive Immunity to Cryptococcus neoformans
Flaczyk, A., Duerr, C. U., Shourian, M., Lafferty, E. I., Fritz, J. H., & Qureshi, S. T. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300426 · Cited by 70 · see citing works
Behnke, J. M., Menge, D. M., & Noyes, H. A. (2009) · Parasitology · doi:10.1017/s0031182009006003 · Cited by 67 · see citing works
Secretion of RNA-Containing Extracellular Vesicles by the Porcine Whipworm,Trichuris suis
Hansen, E. P., Kringel, H., Williams, A. R., & Nejsum, P. L. (2015) · Journal of Parasitology · doi:10.1645/14-714.1 · Cited by 58 · see citing works
Tzelos, T., Matthews, J. B., Buck, A. H., Simbari, F., Frew, D., Inglis, N. F., McLean, K., Nisbet, A. J., Whitelaw, B., Knox, D. P., et al. (2016) · Veterinary Parasitology · doi:10.1016/j.vetpar.2016.03.008 · Cited by 56 · see citing works
Self-citationHewitson, J. P., Filbey, K. J., Grainger, J. R., Dowle, A., Pearson, M. S., Murray, J., Harcus, Y. M., & Maizels, R. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004140 · Cited by 55 · see citing works
Self-citationTrelis, M., Galiano, A., Bolado, A., Toledo, R., Marcilla, A., & Bernal, D. (2016) · International Journal for Parasitology · doi:10.1016/j.ijpara.2016.07.003 · Cited by 55 · see citing works
Chaiyadet, S., Smout, M. J., Johnson, M. S., Whitchurch, C. B., Turnbull, L., Kaewkes, S., Sotillo, J., Loukas, A. C., & Sripa, B. (2015) · International Journal for Parasitology · doi:10.1016/j.ijpara.2015.06.001 · Cited by 51 · see citing works
Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines
Pearson, M. S., Tribolet, L., Cantacessi, C., Periago, M. V., Valerio, M. A., Jariwala, A. R., Hotez, P. J., Diemert, D. J., Loukas, A. C., & Bethony, J. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.029 · Cited by 47 · see citing works
Participation of MyD88 and Interleukin-33 as Innate Drivers of Th2 Immunity to Trichinella spiralis
Scalfone, L. K., Nel, H. J., Gagliardo, L. F., Cameron, J. L., Al-Shokri, S. D., Leifer, C. A., Fallon, P. G., & Appleton, J. A. (2013) · Infection and Immunity · doi:10.1128/iai.01307-12 · Cited by 41 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
Maizels, R. M., Smits, H. H., & McSorley, H. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.016 · Cited by 435 · see citing works
Self-citationDevelopment of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities
Claridge, B., Lozano, J., Poh, Q. H., & Greening, D. W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734720 · Cited by 235 · see citing works
Eichenberger, R. M., Ryan, S., Jones, L., Buitrago, G., Polster, R., Montes de Oca, M., Zuvelek, J., Giacomin, P. R., Dent, L. A., Engwerda, C. R., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00850 · Cited by 197 · see citing works
HpARI protein secreted by a helminth parasite suppresses interleukin-33
Osbourn, M., Soares, D. C., Vacca, F., Cohen, E. S., Scott, I. C., Gregory, W. F., Smyth, D. J., Toivakka, M., Kemter, A. M., le Bihan, T., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.015 · Cited by 178 · see citing works
Self-citationHelminth parasites and immune regulation
Gazzinelli-Guimarães, P. H., & Nutman, T. B. (2018) · F1000Research · doi:10.12688/f1000research.15596.1 · Cited by 171 · see citing works
Liu, J., Zhu, L., Wang, J., Qiu, L., Chen, Y., Davis, R. E., & Cheng, G. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007817 · Cited by 159 · see citing works
Immunomodulation by Helminths: Intracellular Pathways and Extracellular Vesicles
Zakeri, A., Hansen, E. P., Andersen, S. D., Williams, A. R., & Nejsum, P. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02349 · Cited by 131 · see citing works
Hansen, E. P., Fromm, B., Andersen, S. D., Marcilla, A., Andersen, K. L., Borup, A., Williams, A. R., Jex, A. R., Gasser, R. B., Young, N. D., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1578116 · Cited by 127 · see citing works
Cryptococcus extracellular vesicles properties and their use as vaccine platforms
Rizzo, J., Wong, S. S. W., Gazi, A. D., Moyrand, F., Chaze, T., Commère, P., Novault, S., Matondo, M., Pehau‐Arnaudet, G., Reis, F. C. G., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12129 · Cited by 120 · see citing works
Regulatory T‐cells in helminth infection: induction, function and therapeutic potential
White, M. P. J., McManus, C. M., & Maizels, R. M. (2020) · Immunology · doi:10.1111/imm.13190 · Cited by 115 · see citing works
Self-citationde la Torre-Escudero, E., Gerlach, J. Q., Bennett, A. P. S., Cwiklinski, K., Jewhurst, H., Huson, K. M., Joshi, L., Kilcoyne, M., O’Neill, S. M., Dalton, J. P., et al. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007087 · Cited by 111 · see citing works
Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides
Chow, F. W., Koutsovoulos, G., Ovando‐Vázquez, C., Neophytou, K., Bermúdez‐Barrientos, J. R., Laetsch, D. R., Robertson, E., Kumar, S., Claycomb, J. M., Blaxter, M., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz142 · Cited by 105 · see citing works
Self-citationHelminth extracellular vesicles: Interactions with the host immune system
Drurey, C., & Maizels, R. M. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.06.017 · Cited by 106 · see citing works
Self-citationThe yin and yang of human soil-transmitted helminth infections
Loukas, A. C., Maizels, R. M., & Hotez, P. J. (2021) · International Journal for Parasitology · doi:10.1016/j.ijpara.2021.11.001 · Cited by 103 · see citing works
Self-citationAdvances in Exosomes‐Based Drug Delivery Systems
Millán, C. G., Díaz, C. C., Lanao, J. M., & Colino, C. I. (2020) · Macromolecular Bioscience · doi:10.1002/mabi.202000269 · Cited by 100 · see citing works
Extracellular vesicles induce protective immunity against Trichuris muris
Shears, R. K., Bancroft, A. J., Hughes, G. W., Grencis, R. K., & Thornton, D. J. (2018) · Parasite Immunology · doi:10.1111/pim.12536 · Cited by 81 · see citing works
Gavinho, B., Sabatke, B., Santiago, V. F., Rossi, I. V., da Silva, J. M., Osses, I. S. E., Palmisano, G., Lange, S., & Ramirez, M. I. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00417 · Cited by 83 · see citing works
Rai, A. K., & Johnson, P. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912356116 · Cited by 81 · see citing works
Immunobiology of parasitic worm extracellular vesicles
Eichenberger, R. M., Sotillo, J., & Loukas, A. C. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12171 · Cited by 79 · see citing works
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING
Brown, H. E., Kwaku, G. N., Reardon, C. M., Khan, N. S., Zamith‐Miranda, D., Żarnowski, R., Tam, J. M., Bohaen, C. K., Richey, L. J., Mosallanejad, K., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01546-0 · Cited by 80 · see citing works
Jenkins, T. P., Formenti, F., Castro, C., Piubelli, C., Perandin, F., Buonfrate, D., Otranto, D., Griffin, J. L., Krause, L., Bisoffi, Z., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33937-3 · Cited by 78 · see citing works
Kuipers, M. E., Hoen, E. N. M. N., van der Ham, A. J., Ozir‐Fazalalikhan, A., Nguyen, D. L., de Korne, C. M., Koning, R. I., Tomes, J. J., Hoffmann, K. F., Smits, H. H., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1753420 · Cited by 78 · see citing works
The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola
Cwiklinski, K., Donnelly, S., Drysdale, O., Jewhurst, H., Smith, D. W., Veríssimo, C. D. M., Pritsch, I. C., O’Neill, S. M., Dalton, J. P., & Robinson, M. W. (2019) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2019.01.001 · Cited by 75 · see citing works
Pathogens and Their Effect on Exosome Biogenesis and Composition
Jones, L. B., Bell, C. R., Bibb, K. E., Gu, L., Coats, M. T., & Matthews, Q. L. (2018) · Biomedicines · doi:10.3390/biomedicines6030079 · Cited by 74 · see citing works
Extracellular vesicles in parasite survival
Ofir‐Birin, Y., & Regev‐Rudzki, N. (2019) · Science · doi:10.1126/science.aau4666 · Cited by 74 · see citing works
Davis, C. N., Phillips, H. C., Tomes, J. J., Swain, M., Wilkinson, T., Brophy, P. M., & Morphew, R. M. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007191 · Cited by 70 · see citing works
Exosomes on the border of species and kingdom intercommunication
Schuh, C. M. A. P., Cuenca, J., Alcayaga‐Miranda, F., & Khoury, M. (2019) · Translational research · doi:10.1016/j.trsl.2019.03.008 · Cited by 68 · see citing works
Roig, J., Sáiz, M. L., Galiano, A., Trelis, M., Cantalapiedra, F., Monteagudo, C. C., Giner, E., Giner, R. M., Recio, M. C., Bernal, D., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01036 · Cited by 67 · see citing works
Extracellular vesicles isolated from Toxoplasma gondii induce host immune response
Silva, V. O., Maia, M. M., Torrecilhas, A. C., Taniwaki, N. N., Namiyama, G. M., Oliveira, K. C., Ribeiro, K. S., Toledo, M. D. S., Xander, P. B., & Pereira‐Chioccola, V. L. (2018) · Parasite Immunology · doi:10.1111/pim.12571 · Cited by 69 · see citing works
A helminth-derived suppressor of ST2 blocks allergic responses
Vacca, F., Chauché, C., Jamwal, A., Hinchy, E. C., Heieis, G. A., Webster, H. C., Ogunkanbi, A., Sekne, Z., Gregory, W. F., Wear, M. A., et al. (2020) · eLife · doi:10.7554/elife.54017 · Cited by 68 · see citing works
Self-citationExtracellular vesicles: new targets for vaccines against helminth parasites
Drurey, C., Coakley, G., & Maizels, R. (2020) · International Journal of Parasitology · doi:10.1016/j.ijpara.2020.04.011 · Cited by 48 · see citing works
Self-citationOrganoids – New Models for Host–Helminth Interactions
Correa, M. A. D., Maizels, R. M., Grencis, R. K., & Berriman, M. (2019) · Trends in Parasitology · doi:10.1016/j.pt.2019.10.013 · Cited by 65 · see citing works
Self-citationYan, C., Zhou, Q.-Y., Wu, J., Xu, N., Du, Y., Li, J., Liu, J., Koda, S., Zhang, B., Yu, Q., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102206118 · Cited by 65 · see citing works
Barbosa, F. M. C., Dupin, T. V., Toledo, M. D. S., Reis, N. F. D. C., Ribeiro, K. S., Andrade, A. C., Rugani, J. M. N., Lorenzo, B. H. P. D., Brito, R. R. N. E., Soares, R. P., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03056 · Cited by 64 · see citing works
Zhou, X., Wang, W., Cui, F., Shi, C., Ma, Y., Yu, Y., Zhao, W., & Zhao, J. (2019) · International Journal for Parasitology · doi:10.1016/j.ijpara.2019.08.003 · Cited by 63 · see citing works
Murphy, A., Cwiklinski, K., Lalor, R., O’Connell, B., Robinson, M. W., Gerlach, J. Q., Joshi, L., Kilcoyne, M., Dalton, J. P., & O’Neill, S. M. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008626 · Cited by 62 · see citing works
Dubie, T., & Mohammed, Y. (2020) · Journal of Immunology Research · doi:10.1155/2020/2496713 · Cited by 64 · see citing works
White, R. F., Sotillo, J., Ancarola, M. E., Borup, A., Boysen, A. T., Brindley, P. J., Buzás, E. I., Cavallero, S., Chaiyadet, S., Chalmers, I. W., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12298 · Cited by 60 · see citing works
Self-citationZhang, H., Lang, W., Wang, S., Li, B., Li, G., & Shi, Q. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106974 · Cited by 59 · see citing works
Extracellular vesicles: important collaborators in cancer progression
Sato, S., & Weaver, A. M. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170080 · Cited by 56 · see citing works
Helminth extracellular vesicles in host–parasite interactions
Tritten, L., & Geary, T. G. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2018.08.002 · Cited by 56 · see citing works
Chaiyadet, S., Sotillo, J., Krueajampa, W., Thongsen, S., Brindley, P. J., Sripa, B., Loukas, A. C., & Laha, T. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007450 · Cited by 56 · see citing works
Host Immunity and Inflammation to Pulmonary Helminth Infections
Weatherhead, J. E., Gazzinelli-Guimarães, P. H., Knight, J. M., Fujiwara, R. T., Hotez, P. J., Bottazzi, M. E., & Corry, D. B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594520 · Cited by 55 · see citing works
Soil-Transmitted Helminth Vaccines: Are We Getting Closer?
Zawawi, A., & Else, K. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576748 · Cited by 55 · see citing works
Wang, L., Liu, T.-L., Liang, P.-H., Zhang, S., Li, T.-S., Li, Y., Liu, G., Mao, L., & Luo, X. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04186-z · Cited by 52 · see citing works
Sánchez‐López, C. M., Trelis, M., Bernal, D., & Marcilla, A. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.03.020 · Cited by 49 · see citing works
Immune Regulation of Metabolic Homeostasis by Helminths and Their Molecules
van der Zande, H. J. P., Zawistowska‐Deniziak, A., & Guigas, B. (2019) · Trends in Parasitology · doi:10.1016/j.pt.2019.07.014 · Cited by 47 · see citing works
Khosravi, M., Mirsamadi, E. S., Mirjalali, H., & Zali, M. R. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s250993 · Cited by 48 · see citing works
Guidelines for the purification and characterization of extracellular vesicles of parasites
Fernández-Becerra, C., Xander, P. B., Alfandari, D., Dong, G., Aparici‐Herraiz, I., Rosenhek‐Goldian, I., Shokouhy, M., Gualdrón‐López, M., Lozano, N., Cortes-Serra, N., et al. (2023) · Journal of Extracellular Biology · doi:10.1002/jex2.117 · Cited by 46 · see citing works
Extracellular vesicles from parasitic helminths and their potential utility as vaccines
Mekonnen, G. G., Pearson, M. S., Loukas, A. C., & Sotillo, J. (2018) · Expert Review of Vaccines · doi:10.1080/14760584.2018.1431125 · Cited by 46 · see citing works
Bobardt, S. D., Dillman, A. R., & Nair, M. G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.577846 · Cited by 45 · see citing works
Meiners, J., Reitz, M., Rüdiger, N., Turner, J., Heepmann, L., Rudolf, L., Hartmann, W., McSorley, H. J., & Breloer, M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1009121 · Cited by 46 · see citing works
Self-citationThe potential for vaccines against scour worms of small ruminants
Britton, C., Emery, D. L., McNeilly, T. N., Nisbet, A. J., & Stear, M. J. (2020) · International Journal for Parasitology · doi:10.1016/j.ijpara.2020.04.003 · Cited by 45 · see citing works
Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross‐kingdom communication
Soares, R. P., Xander, P. B., Costa, A. O., Marcilla, A., Menezes‐Neto, A., Portillo, H. A. D., Witwer, K. W., Wauben, M. H. M., Hoen, E. N. M. N., Olivier, M., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1407213 · Cited by 45 · see citing works
Kifle, D. W., Chaiyadet, S., Waardenberg, A. J., Wise, I. A., Cooper, M. M., Becker, L., Doolan, D. L., Laha, T., Sotillo, J., Pearson, M. S., et al. (2020) · International Journal for Parasitology · doi:10.1016/j.ijpara.2020.05.005 · Cited by 44 · see citing works
Macrophage regulation & function in helminth infection
Lechner, A., Bohnacker, S., & Bieren, J. E. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101526 · Cited by 41 · see citing works
Wan, B., Goguet, E., Ravallec, M., Pierre, O., Lemauf, S., Volkoff, A., Gatti, J., & Poirié, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01688 · Cited by 41 · see citing works
Mekonnen, G. G., Tedla, B., Pickering, D., Becker, L., Wang, L., Zhan, B., Bottazzi, M. E., Loukas, A. C., Sotillo, J., & Pearson, M. S. (2020) · Vaccines · doi:10.3390/vaccines8030416 · Cited by 41 · see citing works
Regulatory T cells in parasite infections: susceptibility, specificity and specialisation
McManus, C. M., & Maizels, R. M. (2023) · Trends in Parasitology · doi:10.1016/j.pt.2023.04.002 · Cited by 39 · see citing works
Self-citationIL-33: A central cytokine in helminth infections
McSorley, H. J., & Smyth, D. J. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101532 · Cited by 42 · see citing works
Self-citationWhat Can Parasites Tell Us About the Pathogenesis and Treatment of Asthma and Allergic Diseases
Bohnacker, S., Troisi, F., Jiménez, M. D. L. R., & Bieren, J. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02106 · Cited by 41 · see citing works
Correa, M. A. D., Schreiber, F., Rodgers, F. H., Goulding, D., Forrest, S., White, R. F., Buck, A. H., Grencis, R. K., & Berriman, M. (2020) · International Journal for Parasitology · doi:10.1016/j.ijpara.2020.06.001 · Cited by 37 · see citing works
Self-citationGao, X., Yang, Y., Liu, X., Wang, Y., Yang, Y., Boireau, P., Liu, M., & Bai, X. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105761 · Cited by 37 · see citing works
Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes
Loghry, H. J., Wang, Y., Zamanian, M., Wheeler, N. J., Day, T. A., & Kimber, M. J. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12036 · Cited by 37 · see citing works
Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach
Montaño, K. J., Cuéllar, C., & Sotillo, J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.639573 · Cited by 33 · see citing works
A new level of complexity in parasite-host interaction: The role of extracellular vesicles
Mardahl, M., Borup, A., & Nejsum, P. L. (2019) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2019.02.003 · Cited by 35 · see citing works
Induction of stable human FOXP3+ Tregs by a parasite‐derived TGF‐β mimic
Cook, L. E., Reid, K. T., Häkkinen, E., de Bie, B., Tanaka, S., Smyth, D. J., White, M. P. J., Wong, M. Q., Huang, Q., Gillies, J. K., et al. (2021) · Immunology and Cell Biology · doi:10.1111/imcb.12475 · Cited by 32 · see citing works
Self-citationExploiting Helminth–Host Interactomes through Big Data
Sotillo, J., Toledo, R., Mulvenna, J. P., & Loukas, A. C. (2017) · Trends in Parasitology · doi:10.1016/j.pt.2017.06.011 · Cited by 34 · see citing works
Small RNAs in parasitic nematodes – forms and functions
Britton, C., Laing, R., & Devaney, E. (2019) · Parasitology · doi:10.1017/s0031182019001689 · Cited by 34 · see citing works
The mRNA Vaccine Technology Era and the Future Control of Parasitic Infections
You, H., Jones, M. K., Gordon, C. A., Arganda, A. E., Cai, P., Al-Wassiti, H., Pouton, C. W., & McManus, D. P. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00241-21 · Cited by 34 · see citing works
Exosomes: Biological Pharmaceutical Nanovectors for Theranostics
Thomas, S. C., Kim, J.-W., Pauletti, G. M., Hassett, D. J., & Kotagiri, N. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.808614 · Cited by 33 · see citing works
Quiarim, T. M., Maia, M. M., da Cruz, A. B., Taniwaki, N. N., Namiyama, G. M., & Pereira‐Chioccola, V. L. (2021) · Acta Tropica · doi:10.1016/j.actatropica.2021.105915 · Cited by 32 · see citing works
Trilateral Relationship: Ascaris, Microbiota, and Host Cells
Midha, A., Ebner, F., Schlosser-Brandenburg, J., Rausch, S., & Hartmann, S. (2020) · Trends in Parasitology · doi:10.1016/j.pt.2020.09.002 · Cited by 32 · see citing works
Fluorescent Labeling of Helminth Extracellular Vesicles Using an In Vivo Whole Organism Approach
Boysen, A. T., Whitehead, B. J., Stensballe, A., Carnerup, A. M., Nylander, T., & Nejsum, P. L. (2020) · Biomedicines · doi:10.3390/biomedicines8070213 · Cited by 31 · see citing works
Mossallam, S. F., Abou-El-Naga, I. F., Abdel-Bary, A., Elmorsy, E. A., & Diab, R. G. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009866 · Cited by 31 · see citing works
Message in a vesicle – trans-kingdom intercommunication at the vector–host interface
Chávez, A. S. O., O’Neal, A. J., Santambrogio, L., Kotsyfakis, M., & Pedra, J. H. F. (2019) · Journal of Cell Science · doi:10.1242/jcs.224212 · Cited by 30 · see citing works
Mining Helminths for Novel Therapeutics
Lothstein, K. E., & Gause, W. C. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.12.010 · Cited by 30 · see citing works
The Immune Response to Nematode Infection
Stear, M. J., Preston, S., Piedrafita, D. M., & Donskow‐Łysoniewska, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032283 · Cited by 32 · see citing works
White, R. F., Kumar, S., Chow, F. W., Robertson, E., Hayes, K. S., Grencis, R. K., Correa, M. A. D., & Buck, A. H. (2020) · International Journal for Parasitology · doi:10.1016/j.ijpara.2020.06.002 · Cited by 29 · see citing works
Self-citationHelminth infections and immunosenescence: The friend of my enemy
Abdoli, A., & Ardakani, H. M. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110852 · Cited by 28 · see citing works
Quintana, J. F., Kumar, S., Ivens, A. C., Chow, F. W., Hoy, A. M., Fulton, A., Dickinson, P., Martin, C., Taylor, M. D., Babayan, S. A., et al. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007811 · Cited by 26 · see citing works
Self-citationvan Dinther, M., Cunningham, K. T., Singh, S. P., White, M. P. J., Campion, T., Ciancia, C., van Veelen, P. A., de Ru, A. H., González‐Prieto, R., Mukundan, A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302370120 · Cited by 27 · see citing works
Self-citationBuffoni, L., Garza‐Cuartero, L., Pérez‐Caballero, R., Zafra, R., Martínez-Moreno, F. J., Molina-Hernández, V., Pérez, J., Martínez‐Moreno, Á., & Mulcahy, G. M. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04260-6 · Cited by 26 · see citing works
Sánchez‐López, C. M., González, A., Soler, C., Ramírez‐Toledo, V., Trelis, M., Bernal, D., & Marcilla, A. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12317 · Cited by 24 · see citing works
The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications
Ryan, N. M., Anderson, K., Volpedo, G., Varikuti, S., Satoskar, M. A., Satoskar, S., & Oghumu, S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00153 · Cited by 25 · see citing works
Emerging roles for extracellular vesicles in Schistosoma infection
Abou-El-Naga, I. F. (2022) · Acta Tropica · doi:10.1016/j.actatropica.2022.106467 · Cited by 25 · see citing works
The knowns and unknowns of helminth–host miRNA cross-kingdom communication
Chowdhury, S., Sais, D., Donnelly, S., & Tran, N. (2023) · Trends in Parasitology · doi:10.1016/j.pt.2023.12.003 · Cited by 23 · see citing works
Innate Lymphoid Cells in Helminth Infections—Obligatory or Accessory?
Löser, S., Smith, K. A., & Maizels, R. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00620 · Cited by 23 · see citing works
Self-citationCoakley, G., Wright, M. D., & Borger, J. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01010 · Cited by 23 · see citing works
Self-citationWhitehead, B., Boysen, A., Mardahl, M., & Nejsum, P. (2020) · International Journal of Parasitology · doi:10.1016/j.ijpara.2020.03.012 · Cited by 19 · see citing works
Colomb, F., Ogunkanbi, A., Jamwal, A., Dong, B., Maizels, R. M., Finney, C. A. M., Wasmuth, J. D., Higgins, M. K., & McSorley, H. J. (2024) · Infection and Immunity · doi:10.1128/iai.00395-23 · Cited by 24 · see citing works
Self-citationA new landscape of host–protozoa interactions involving the extracellular vesicles world
Gavinho, B., Rossi, I. V., Osses, I. S. E., Inal, J. M., & Ramirez, M. I. (2018) · Parasitology · doi:10.1017/s0031182018001105 · Cited by 21 · see citing works
Exosomes: from biology to immunotherapy in infectious diseases
Rangel-Ramírez, V. V., González-Sánchez, H. M., & Lucio-García, C. (2022) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2022.2149852 · Cited by 20 · see citing works
Secreted filarial nematode galectins modulate host immune cells
Loghry, H. J., Sondjaja, N. A., Minkler, S. J., & Kimber, M. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.952104 · Cited by 21 · see citing works
Extracellular vesicles from Trichinella spiralis: Proteomic analysis and protective immunity
Gao, X., Yang, Y., Liu, X., Xu, F., Wang, Y., Liu, L., Yang, Y., Liu, M., & Bai, X. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010528 · Cited by 20 · see citing works
Shi, C., Zhou, X., Yang, W., Wu, J., Bai, M., Zhang, Y., Zhao, W., Yang, H., Nagai, A., Yin, M., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.805010 · Cited by 19 · see citing works
Chen, H., Liu, J., Peng, S., Yang, G., Cheng, X., Chen, L., Zhang, H., Zhao, Y., Yao, P., & Tang, Y. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109332 · Cited by 19 · see citing works
Loghry, H. J., Kwon, H., Smith, R. C., Sondjaja, N. A., Minkler, S. J., Young, S., Wheeler, N. J., Zamanian, M., Bartholomay, L. C., & Kimber, M. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-35940-9 · Cited by 19 · see citing works
Systemic Immune Modulation by Gastrointestinal Nematodes
Kasal, D. N., Warner, L. M., Bryant, A. S., Wojno, E. D. T., & von Moltke, J. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090222-101331 · Cited by 22 · see citing works
Pinheiro, A. A. S., Torrecilhas, A. C., Souza, B. S. D. F., Cruz, F. F., Guedes, H. L. D. M., Ramos, T. D., Lopes‐Pacheco, M., Caruso‐Neves, C., & Rocco, P. R. M. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12496 · Cited by 19 · see citing works
- Authors
- Coakley, G., McCaskill, J. L., Borger, J. G., Simbari, F., Robertson, E., Millar, M., Harcus, Y., McSorley, H. J., Maizels, R. M., & Buck, A. H.
- Affiliations
- Centre for Immunity, Infection and Evolution (GB)
- Centre for Inflammation Research (GB)
- Wellcome Centre for Molecular Parasitology (GB)
- Corresponding author
- Maizels, Rick M.
- Buck, Amy H.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 19
- Issue
- 8
- Pages
- 1545-1557
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5457486
- OpenAlex
- W2618954565
- Cited by
- 219
- References
- 53
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 32 · 2023: 23 · 2022: 21 · 2021: 22 · 2020: 38 · 2019: 23 · 2018: 21 · 2017: 4
- FWCI
- 20.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion, cc-by)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/J01446X/1)
- Wellcome Trust (AHB-097394, RMM-106122, 095831, 104111)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- extracellular vesicles, Heligmosomoides polygyrus, macrophage activation, alternative macrophage activation, vaccines, nematode infection, interleukin-6, TNF-α, Ym1, RELMα, protective immunity
- MeSH terms
- Extracellular Vesicles, Interleukin-1 Receptor-Like 1 Protein, Animals, Antibodies, Helminth, Antibody Formation, Bone Marrow Cells, Immunity, Macrophage Activation, Macrophages, Nematospiroides dubius, Parasites, Vaccination, Vaccines, Cytochalasin D, Receptors, Interleukin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
