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Cited by 116IL-33, ST2, and ILC PathwaysParasites and Host InteractionsHelminth infection and control

IL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity

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Zaiss, Mario M., Maslowski, Kendle M., Mosconi, Ilaria, Guenat, Nadine, Marsland, Benjamin J., Harris, Nicola L.·2013·PLoS Pathogens
DOI 10.1371/journal.ppat.1003531PMC PMC3731249
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Abstract

Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution between helminths and their mammalian hosts; however, the molecular mechanisms by which these organisms avert immune rejection are not clear. We have found that the natural murine helminth, Heligmosomoides polygyrus bakeri (Hp) elicits the secretion of IL-1β in vivo and in vitro and that this cytokine is critical for shaping a mucosal environment suited to helminth chronicity. Indeed in mice deficient for IL-1β (IL-1β(-/-)), or treated with the soluble IL-1βR antagonist, Anakinra, helminth infection results in enhanced type 2 immunity and accelerated parasite expulsion. IL-1β acts to decrease production of IL-25 and IL-33 at early time points following infection and parasite rejection was determined to require IL-25. Taken together, these data indicate that Hp promotes the release of host-derived IL-1β that suppresses the release of innate cytokines, resulting in suboptimal type 2 immunity and allowing pathogen chronicity.

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  1. [1]de Silva NR, Brooker S, Hotez PJ, Montresor A, Engels D, et al (2003) Soil-transmitted helminth infections: updating the global picture. Trends Parasitol 19: 547– 551. 14642761
  2. [3]Anthony RM, Rutitzky LI, Urban JF Jr, Stadecker MJ, Gause WC (2007) Protective immune mechanisms in helminth infection. Nat Rev Immunol 7: 975– 987. 18007680 PMC2258092
  3. [4]Harris N, Gause WC (2010) To B or not to B: B cells and the Th2-type immune response to helminths. Trends Immunol 32: 80– 88. 21159556 PMC3076625
  4. [5]Monroy FG, Enriquez FJ (1992) Heligmosomoides polygyrus: a model for chronic gastrointestinal helminthiasis. Parasitol Today 8: 49– 54. 15463566
  5. [6]Wilson M, Taylor M, O'Gorman M, Balic A, Barr T, et al (2010) Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. European journal of immunology 40: 1682– 1778. 20306466 PMC3179601
  6. [7]McSorley H, O'Gorman M, Blair N, Sutherland T, Filbey K, et al (2012) Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus. European journal of immunology 42: 2667– 82. 22706967 PMC4916998
  7. [8]Blum A, Hang L, Setiawan T, Urban J, Stoyanoff K, et al (2012) Heligmosomoides polygyrus bakeri Induces Tolerogenic Dendritic Cells that Block Colitis and Prevent Antigen-Specific Gut T Cell Responses. Journal of immunology (Baltimore, Md: 1950) 189: 2512– 20. PMC3424321 22844110
  8. [9]Massacand JC, Stettler RC, Meier R, Humphreys NE, Grencis RK, et al (2009) Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc Natl Acad Sci U S A 106: 13968– 13973. 19666528 PMC2729004
  9. [10]Grainger JR, Smith KA, Hewitson JP, McSorley HJ, Harcus Y, et al (2010) Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway. J Exp Med 207: 2331– 2341. 20876311 PMC2964568
  10. [11]Anthony R, Urban J, Alem F, Hamed H, Rozo C, et al (2006) Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nature medicine 12: 955– 960. PMC1955764 16892038
  11. [12]McCoy KD, Stoel M, Stettler R, Merky P, Fink K, et al (2008) Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection. Cell Host Microbe 4: 362– 373. 18854240
  12. [13]Behnke JM, Parish HA (1979) Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum. Parasite Immunol 1: 13– 26. 551374
  13. [15]Perregaux D, Gabel C (1994) Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. The Journal of biological chemistry 269: 15195– 15398. 8195155
  14. [17]Bresnihan B, Alvaro-Gracia JM, Cobby M, Doherty M, Domljan Z, et al (1998) Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 41: 2196– 2204. 9870876
  15. [19]Dinarello CA, Donath MY, Mandrup-Poulsen T (2010) Role of IL-1beta in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 17: 314– 321. 20588114
  16. [20]So A, De Smedt T, Revaz S, Tschopp J (2007) A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther 9: R28. 17352828 PMC1906806
  17. [21]Fleischmann RM, Tesser J, Schiff MH, Schechtman J, Burmester GR, et al (2006) Safety of extended treatment with anakinra in patients with rheumatoid arthritis. Ann Rheum Dis 65: 1006– 1012. 16396977 PMC1798263
  18. [22]Larsen CM, Faulenbach M, Vaag A, Volund A, Ehses JA, et al (2007) Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356: 1517– 1526. 17429083
  19. [23]Cappello M, Keshav S, Prince C, Jewell DP, Gordon S (1992) Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation. Gut 33: 1214– 1219. 1427374 PMC1379489
  20. [24]Youngman KR, Simon PL, West GA, Cominelli F, Rachmilewitz D, et al (1993) Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology 104: 749– 758. 8440434
  21. [25]Brynskov J, Tvede N, Andersen CB, Vilien M (1992) Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease. Gut 33: 55– 58. 1740278 PMC1373865
  22. [26]Ligumsky M, Simon PL, Karmeli F, Rachmilewitz D (1990) Role of interleukin 1 in inflammatory bowel disease–enhanced production during active disease. Gut 31: 686– 689. 2379873 PMC1378497
  23. [27]Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, et al (2010) Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med 207: 1745– 1755. 20603313 PMC2916133
  24. [28]Miao EA, Mao DP, Yudkovsky N, Bonneau R, Lorang CG, et al (2010) Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A 107: 3076– 3080. 20133635 PMC2840275
  25. [29]Pereira MS, Morgantetti GF, Massis LM, Horta CV, Hori JI, et al (2011) Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo. J Immunol 187: 6447– 6455. 22079982
  26. [31]Mohrs K, Harris D, Lund F, Mohrs M (2005) Systemic dissemination and persistence of Th2 and type 2 cells in response to infection with a strictly enteric nematode parasite. Journal of immunology (Baltimore, Md: 1950) 175: 5306– 5313. 16210636
  27. [32]Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87: 2095– 2147. 8630372
  28. [33]Greenwald RJ, Urban JF, Ekkens MJ, Chen S, Nguyen D, et al (1999) B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite. J Immunol 162: 4133– 4139. 10201938
  29. [34]Urban J, Katona I, Finkelman F (1991) Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice. Experimental parasitology 73: 500– 511. 1683629
  30. [35]Urban J, Katona I, Paul W, Finkelman F (1991) Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proceedings of the National Academy of Sciences of the United States of America 88: 5513– 5517. 2062833 PMC51907
  31. [36]Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, et al (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23: 479– 490. 16286016
  32. [37]Fort MM, Cheung J, Yen D, Li J, Zurawski SM, et al (2001) IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15: 985– 995. 11754819
  33. [38]Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, et al (2006) Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 203: 843– 849. 16606667 PMC1800834
  34. [39]Humphreys NE, Xu D, Hepworth MR, Liew FY, Grencis RK (2008) IL-33, a potent inducer of adaptive immunity to intestinal nematodes. J Immunol 180: 2443– 2449. 18250453
  35. [40]Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, et al (2010) Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A 107: 11489– 11494. 20534524 PMC2895098
  36. [41]Hepworth MR, Danilowicz-Luebert E, Rausch S, Metz M, Klotz C, et al (2012) Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines. Proc Natl Acad Sci U S A 109: 6644– 6649. 22493240 PMC3340035
  37. [42]Whitehead RH, VanEeden PE, Noble MD, Ataliotis P, Jat PS (1993) Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. Proc Natl Acad Sci U S A 90: 587– 591. 7678459 PMC45708
  38. [43]Sonobe Y, Takeuchi H, Kataoka K, Li H, Jin S, et al (2009) Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner. The Journal of biological chemistry 284: 31834– 31876. 19776017 PMC2797254
  39. [44]Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, et al (2013) Innate lymphoid cells - a proposal for uniform nomenclature. Nat Rev Immunol 13: 145– 149. 23348417
  40. [45]Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, et al (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464: 1367– 1370. 20200518 PMC2862165
  41. [46]Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, et al (2009) Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463: 540– 544. 20023630
  42. [47]Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, et al (2006) Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med 203: 1105– 1116. 16606668 PMC2118283
  43. [48]Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, et al (2012) Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc Natl Acad Sci U S A 109: 3451– 3456. 22331917 PMC3295287
  44. [49]Hepworth M, Maurer M, Hartmann S (2012) Regulation of type 2 immunity to helminths by mast cells. Gut microbes 3: 476– 481. 22892692 PMC3467025
  45. [50]Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban JF Jr, et al (2010) IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 464: 1362– 1366. 20200520 PMC2861732
  46. [51]Smith K, Harcus Y, Garbi N, Hämmerling Gn, MacDonald A, et al (2012) Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion. Infection and immunity 80: 3481Р3489. 22851746 PMC3457557
  47. [52]Greenbaum LA, Horowitz JB, Woods A, Pasqualini T, Reich EP, et al (1988) Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells. J Immunol 140: 1555– 1560. 2964479
  48. [53]Lichtman AH, Chin J, Schmidt JA, Abbas AK (1988) Role of interleukin 1 in the activation of T lymphocytes. Proc Natl Acad Sci U S A 85: 9699– 9703. 3264404 PMC282842
  49. [54]Weaver CT, Hawrylowicz CM, Unanue ER (1988) T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc Natl Acad Sci U S A 85: 8181– 8185. 2973060 PMC282391
  50. [55]Schmitz J, Assenmacher M, Radbruch A (1993) Regulation of T helper cell cytokine expression: functional dichotomy of antigen-presenting cells. Eur J Immunol 23: 191– 199. 8419171
  51. [56]Sandborg CI, Imfeld KL, Zaldivar F Jr, Wang Z, Buckingham BA, et al (1995) IL-4 expression in human T cells is selectively inhibited by IL-1 alpha and IL-1 beta. J Immunol 155: 5206– 5212. 7594531
  52. [57]Satoskar AR, Okano M, Connaughton S, Raisanen-Sokolwski A, David JR, et al (1998) Enhanced Th2-like responses in IL-1 type 1 receptor-deficient mice. Eur J Immunol 28: 2066– 2074. 9692874
  53. [58]Von Stebut E, Ehrchen JM, Belkaid Y, Kostka SL, Molle K, et al (2003) Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice. J Exp Med 198: 191– 199. 12860932 PMC2194079
  54. [59]Helmby H, Grencis RK (2004) Interleukin 1 plays a major role in the development of Th2-mediated immunity. Eur J Immunol 34: 3674– 3681. 15549727
  55. [60]Humphreys NE, Grencis RK (2009) IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes. Eur J Immunol 39: 1036– 1045. 19247983
  56. [61]Willart M, Deswarte K, Pouliot P, Braun H, Beyaert R, et al (2012) Interleukin-1a controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. The Journal of experimental medicine 209: 1505– 1522. 22802353 PMC3409497
  57. [62]Kool M, Willart M, van Nimwegen M, Bergen I, Pouliot P, et al (2011) An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 34: 527– 567. 21474346
  58. [63]Kang Z, Swaidani S, Yin W, Wang C, Barlow JL, et al (2012) Epithelial Cell-Specific Act1 Adaptor Mediates Interleukin-25-Dependent Helminth Expulsion through Expansion of Lin(-)c-Kit(+) Innate Cell Population. Immunity 36: 821– 833. 22608496 PMC3376903
  59. [64]Varilek GW, Neil GA, Bishop WP (1994) Caco-2 cells express type I interleukin-1 receptors: ligand binding enhances proliferation. Am J Physiol 267: G1101– 1107. 7810657
  60. [65]Sutherland DB, Varilek GW, Neil GA (1994) Identification and characterization of the rat intestinal epithelial cell (IEC-18) interleukin-1 receptor. Am J Physiol 266: C1198– 1203. 8203483
  61. [66]Homaidan FR, Zhao L, Chakroun I, Martin CA, Burakoff R (1999) The mechanisms of action of interleukin-1 on rabbit intestinal epithelial cells. Mediators Inflamm 8: 189– 197. 10704072 PMC1781803
  62. [67]Barlow JL, Bellosi A, Hardman CS, Drynan LF, Wong SH, et al (2011) Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol 129: 191– 194, 191-198, e191-194. 22079492
  63. [68]Rank M, Kobayashi T, Kozaki H, Bartemes K, Squillace D, et al (2009) IL-33-activated dendritic cells induce an atypical TH2-type response. The Journal of allergy and clinical immunology 123: 1047– 1101. 19361843 PMC2711963
  64. [70]Gratchev A, Kzhyshkowska J, Duperrier K, Utikal J, Velten F, et al (2004) The receptor for interleukin-17E is induced by Th2 cytokines in antigen-presenting cells. Scandinavian journal of immunology 60: 233– 240. 15320879
  65. [71]Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, et al (2008) A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. The Journal of experimental medicine 205: 2727– 2760. 19015310 PMC2585837
  66. [72]Ikeda K, Nakajima H, Suzuki K, Kagami S-i, Hirose K, et al (2003) Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation. Blood 101: 3594– 3596. 12511410
  67. [73]Wang Y-H, Angkasekwinai P, Lu N, Voo K, Arima K, et al (2007) IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. The Journal of experimental medicine 204: 1837– 1884. 17635955 PMC2118667
  68. [74]Caruso R, Stolfi C, De Nitto D, Pallone F, Monteleone G (2010) The dual role of interleukin-25 in the control of immune-mediated pathologies. Curr Mol Med 11: 26– 30. 21189120
  69. [76]Mariathasan S, Newton K, Monack D, Vucic D, French D, et al (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430: 213– 221. 15190255
  70. [77]Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, et al (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (New York, NY) 301: 640– 643. 12855817
  71. [78]Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, et al (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143– 193. 9697844
  72. [79]Horai R, Asano M, Sudo K, Kanuka H, Suzuki M, et al (1998) Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 187: 1463– 1475. 9565638 PMC2212263
  73. [80]Labow M, Shuster D, Zetterstrom M, Nunes P, Terry R, et al (1997) Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. Journal of immunology (Baltimore, Md: 1950) 159: 2452– 2461. 9278338
  74. [81]Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, et al (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68: 869– 877. 1547488
  75. [82]Townsend M, Fallon P, Matthews D, Jolin H, McKenzie A (2000) T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. The Journal of experimental medicine 191: 1069– 1076. 10727469 PMC2193113
  76. [83]Geuking M, Cahenzli J, Lawson M, Ng D, Slack E, et al (2011) Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 34: 794– 806. 21596591
  77. [84]Didierlaurent A, Brissoni B, Velin D, Aebi N, Tardivel A, et al (2006) Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol 26: 735– 742. 16428431 PMC1347014
  78. [85]Gross O (2012) Measuring the inflammasome. Methods Mol Biol 844: 199– 222. 22262445

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Authors
Zaiss, M. M., Maslowski, K. M., Mosconi, I., Guenat, N., Marsland, B. J., & Harris, N. L.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • University of Lausanne (CH)
  • Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author
Harris, Nicola L.
ORCID
Venue
PLoS Pathogens
Publisher
Public Library of Science (PLoS)
Published
2013-08-01
Volume
9
Issue
8
Pages
e1003531
ISSN
  • 1553-7366 (ISSN-L)
  • 1553-7374
DOI
10.1371/journal.ppat.1003531
PMC
PMC3731249
OpenAlex
W1984288384
Cited by
116
References
6
Citations by year
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FWCI
6.64
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Pathogens (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
  • SERVAL (Université de Lausanne) (submittedVersion, other-oa)
Funders
  • National Science Foundation
  • École Polytechnique Fédérale de Lausanne
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (241642)
  • Institute of Rheumatology Research
  • Swiss Vaccine Research Institute
  • National Health and Medical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
Keywords
IL-1β, IL-25, IL-33, Heligmosomoides polygyrus bakeri, intestinal helminth infection, Th2 immune response, parasite expulsion, mucosal immunity, anakinra, host-parasite coevolution
MeSH terms
Interleukin-33, Animals, Chronic Disease, Immunity, Innate, Interleukins, Mice, Inbred BALB C, Nematospiroides dubius, Strongylida Infections, Mice, Knockout, Th2 Cells, Antirheumatic Agents, Immunity, Mucosal, Mice, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein

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