The multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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On Respiratory Impairment in Cancer Cells

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Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

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Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

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Glucose feeds the TCA cycle via circulating lactate

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Lactate Metabolism in Human Lung Tumors

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Regulation of hepatic glucose metabolism in health and disease

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Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

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Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

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Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

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Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

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A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, <i>Drosophila</i> , and Humans

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Brain metabolism in health, aging, and neurodegeneration

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Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

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Regional aerobic glycolysis in the human brain

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Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

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Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation

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The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

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Insulin regulation of gluconeogenesis

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A Mitochondrial Switch Promotes Tumor Metastasis

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Metabolic Signaling in Fuel-Induced Insulin Secretion

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Exenatide and the treatment of patients with Parkinson's disease

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A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

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Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis

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Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

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Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease

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Metabolic cycling in control of glucose-stimulated insulin secretion.

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Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

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Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

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Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

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Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase IIb study

Harrison, S. A., Alkhouri, N., Davison, B. A., Sanyal, A., Edwards, C., Colca, J. R., Lee, B. H., Loomba, R., Cusi, K., Kolterman, O., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.023 · Cited by 211 · see citing works

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

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Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

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Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection

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Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

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The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis

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Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease

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Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy

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Structure and function of SemiSWEET and SWEET sugar transporters

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Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

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Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer

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The transport of pyruvate in rat liver mitochondria

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Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

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Glucose metabolism in nerve terminals

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Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

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Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes

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Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study

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Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

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Glitazone use associated with reduced risk of Parkinson's disease

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Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

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Loss of MPC1 reprograms retinal metabolism to impair visual function

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Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

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Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression

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Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect

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Impaired mitochondrial pyruvate importation in a patient and a fetus at risk

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Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro

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Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

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PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

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What Effects Might Exenatide have on Non-Motor Symptoms in Parkinson’s Disease: A Post Hoc Analysis

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The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

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The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state

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Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells

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Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity

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Bioenergetics failure in neurodegenerative diseases: back to the future

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Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

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Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

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Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart

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Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice

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The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?

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MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer

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An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer’s Disease

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Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity

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A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism

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Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

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Differential Regulation of Mitochondrial Pyruvate Carrier Genes Modulates Respiratory Capacity and Stress Tolerance in Yeast

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Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series

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Mitochondrial pyruvate carrier 1 expression controls cancer epithelial‐mesenchymal transition and radioresistance

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MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells

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Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer

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Alzheimer's and Parkinson's Disease Novel Therapeutic Target

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Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells

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Effects of Metabolism on Macrophage Polarization Under Different Disease Backgrounds

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Cancer cell metabolism: Rewiring the mitochondrial hub

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Omics and Male Infertility: Highlighting the Application of Transcriptomic Data

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The Staphylococcus aureus CidA and LrgA Proteins Are Functional Holins Involved in the Transport of By-Products of Carbohydrate Metabolism

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Transcriptome Analysis on Key Metabolic Pathways in Rhodotorula mucilaginosa Under Pb(II) Stress

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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

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Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease

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Ethyl pyruvate, a versatile protector in inflammation and autoimmunity

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Structure of mitochondrial pyruvate carrier and its inhibition mechanism

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Inorganic Phosphate as “Bioenergetic Messenger” Triggers M2‐Type Macrophage Polarization

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Targeting mitochondrial transporters and metabolic reprogramming for disease treatment

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Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer

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Influence of perfluoroalkyl substances, with focus on perfluorobutanoic acid on the responding characteristics and molecular mechanisms of Thalassiosira pseudonana

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Post-harvest precooling technology and fresh-keeping mechanism of fruits and vegetables: A review

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Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide

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The Metabolic Syndrome: An Overview and Proposed Mechanisms

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Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies

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Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson’s Disease

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PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation

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Novel targets for ameliorating energy metabolism disorders in depression through stable isotope-resolved metabolomics

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MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy

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Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease

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Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes

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Role of Mitochondrial Transporters on Metabolic Rewiring of Pancreatic Adenocarcinoma: A Comprehensive Review

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Sepsis: Evidence-based pathogenesis and treatment

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Integrated Metabolomic and Transcriptomic Analysis Reveals the Underlying Antibacterial Mechanisms of the Phytonutrient Quercetin-Induced Fatty Acids Alteration in Staphylococcus aureus ATCC 27217

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Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi

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Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase

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Metabolic Mechanisms Connecting Alzheimer’s and Parkinson’s Diseases: Potential Avenues for Novel Therapeutic Approaches

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Berberine regulates glucose metabolism in largemouth bass by modulating intestinal microbiota

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Efficacy of Astragalus membranaceus–Carthamus tinctorius in cerebral ischemia/reperfusion injury: Insights from metabolomics and mass spectrometry imaging

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Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain

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Comprehensive metabolomics profiling of seminal plasma in asthenozoospermia caused by different etiologies

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A Commonly Used Tire Rubber Antioxidant and its Quinone Derivative Facilitate the Conjugative Transfer of Plasmid-Mediated Antibiotic Resistance Genes in Escherichia coli

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Effects of Bacillus licheniformis on the Growth Performance, Antioxidant Capacity, Ileal Morphology, Intestinal Short Chain Fatty Acids, and Colonic Microflora in Piglets Challenged with Lipopolysaccharide

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Adaptative response to changes in pyruvate metabolism on the epigenetic landscapes and transcriptomics of bovine embryos

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Key genomes, transcriptomes, proteins, and metabolic factors involved in the detoxification/tolerance of TNT and its intermediates by bacteria in anaerobic/aerobic environments

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Insulin sensitizers in 2023: lessons learned and new avenues for investigation

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The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma

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A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition

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Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination

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Metabolomic signature of sperm in men with obesity-associated asthenozoospermia

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Revisiting the concepts of de novo lipogenesis to understand the conversion of carbohydrates into fats: Stop overvaluing and extrapolating the renowned phrase “fat burns in the flame of carbohydrate”

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Metabolic reprogramming tailors T cell immunity in sepsis

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Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics

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Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide

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Mitochondrial metabolism of the facultative parasite Chilodonella uncinata (Alveolata, Ciliophora)

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Poly( ADP ‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation

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Analysis of Pathways in Triple-Negative Breast Cancer Cells Treated with the Combination of Electrochemotherapy and Cisplatin

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Enhancing vitamin B 5 biosynthesis by multimodule optimization and protein engineering

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Impact of low aging temperature on the microbial and metabolic dynamics of rice wine during long-term storage

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Comparative metabolomic evaluation of Schisandraceae leaves as novel food ingredients: nutritional quality and biofunctional components across genera

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