Functional diversity of glycinergic commissural inhibitory neurons in larval zebrafish

Commissural inhibitory CoBL neurons (including dI6 and V0d populations) are active during swimming.

“Commissural inhibitory CoBL neurons (including neurons from the dI6 and V0d populations) are active during swimming (Liao and Fetcho, 2008; Satou et al., 2020).”

CoBL neurons project to MNs, dI6s, and unidentified ipsilateral descending spinal neurons that could be V2as.

“CoBL neurons have been shown to project to MNs, dI6s, and unidentified ipsilateral descending spinal neurons that could be V2as (Satou et al., 2020).”

V0d neurons are involved with faster swimming, whereas dI6s are more likely to be active during slower swimming.

“V0d neurons were involved with faster swimming, whereas dI6s were more likely to be active during slower swimming (Satou et al., 2020).”

Genetic ablation of a subset of commissural inhibitory neurons in the dI6 population reduces left-right alternation.

“Genetic ablation of a subset of commissural inhibitory neurons in the dI6 population reduces left-right alternation (Satou et al., 2020).”

The reduction of left-right coordination seen in simulations was comparable to levels seen after genetic ablation of a commissural inhibitory subpopulation of dI6 INs but is not sufficient to prevent left-right alternation.

“The reduction of left-right coordination seen here was comparable to levels seen after genetic ablation of a commissural inhibitory subpopulation of dI6 INs (Satou et al., 2020) but is not sufficient to prevent left-right alternation.”

Swim frequency modules likely include commissural excitatory V0v INs and commissural inhibitory INs belonging to either the dI6 or V0d populations.

“Swim frequency modules likely include commissural excitatory V0v INs (Björnfors and El Manira, 2016; McLean et al., 2008) and commissural inhibitory INs belonging to either the dI6 or V0d populations (Satou et al., 2020).”