Cited by 65Axon Guidance and Neuronal SignalingDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

Dorsally derived spinal interneurons in locomotor circuits

Vallstedt, Anna, Kullander, Klas·2013·Annals of the New York Academy of Sciences

Abstract

During neuronal circuit formation, axons are guided to their targets by the help of axon guidance molecules, which are required for establishing functional circuits. A promising system to dissect the development and functionalities of neuronal circuitry is the spinal cord central pattern generator (CPG) for locomotion, which converts a tonic supraspinal drive to rhythmic and coordinated movements. Here we describe concepts arising from genetic studies of the locomotor network with a focus on the position and roles of commissural interneurons. In particular, this involves studies of several families of axon guidance molecules relevant for midline crossing, the Eph/ephrins and Netrin/DCC. Effects on developing commissural interneurons in mice with aberrant midline axon guidance capabilities suggest that, in addition to ventral populations, dorsal commissural interneurons also play a role in coordinating locomotor circuitry. Recent findings implicate the novel dI6 interneuron marker Dmrt3 in this role. Strikingly, mutations in Dmrt3 result in divergent gait patterns in both mice and horses.

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Crossref · 10.1111/j.1749-6632.2012.06801.x

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  • A subset of cells from the dorsal dI4.6/dI6 lineages contributed to most ventral inhibitory populations.

    “A subset of cells from the dorsal dI4.6/dI6 lineages contributed to most ventral inhibitory populations, which was unexpected though there have been reports of scattered dI4 Ptf1a-derived cells in the embryonic and perinatal ventral horn103,104, and the very small dI6 population is known to be ventrally located105–107.”

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Authors
Vallstedt, A., & Kullander, K.
Affiliations
Uppsala University (SE)
Corresponding author
Kullander, Klas
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2013-03
Volume
1279
Issue
1
Pages
32-42
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1574524525
Cited by
64
References
76
Citations by year
2026: 2 · 2025: 1 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 13 · 2014: 7 · 2013: 3
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Royal Swedish Academy of Sciences
  • Knut och Alice Wallenbergs Stiftelse
  • Vetenskapsrådet
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
locomotor circuits, axon guidance, midline crossing, DMRT3, gait disturbance, neural circuit development
MeSH terms
Animals, Humans, Interneurons, Functional Laterality, Locomotion, Models, Biological, Motor Neurons, Nerve Net, Spinal Cord, Mice

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