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Efficient Strategies for Microglia Replacement in the Central Nervous System
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“We here and others recently developed a rapid and near-complete replacement of microglia in mice with circulation-derived myeloid cells (CDMCs) eliminating the large variability observed following conventional bone marrow transplantation (BMT) (16, 17).”
From Treatment of a genetic brain disease by CNS-wide microglia replacement (2022) · cites this paper as [17]
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“In consistent with a previous report (17), these data demonstrate that elimination of endogenous microglia is critically required for bone marrow cells to engraft in the brain and differentiate into microglia-like cells.”
From Treatment of a genetic brain disease by CNS-wide microglia replacement (2022) · cites this paper as [17]
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Cited by
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Sankowski, R., Süß, P., Benkendorff, A., Böttcher, C., Fernandez-Zapata, C., Chhatbar, C., Cahueau, J., Monaco, G., Gasull, A. D., Khavaran, A., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02673-1 · Cited by 156
Treatment of a genetic brain disease by CNS-wide microglia replacement
Shibuya, Y., Kumar, K. K., Mader, M. M.-D., Yoo, Y., Ayala, L. A., Zhou, M., Mohr, M. A., Neumayer, G., Kumar, I., Yamamoto, R., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl9945 · Cited by 126
The niche matters: Origin, function and fate of CNS-associated macrophages during health and disease
Dalmau Gasull, A., Glavan, M., Samawar, S. K. R., Kapupara, K., Kelk, J., Rubio, M., Fumagalli, S., Sorokin, L., Vivien, D., & Prinz, M. (2024) · Acta Neuropathologica · doi:10.1007/s00401-023-02676-9 · Cited by 60
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system
Amann, L., Masuda, T., & Prinz, M. (2023) · Nature Immunology · doi:10.1038/s41590-022-01415-8 · Cited by 50
Cancer Hacks Neurodegeneration: Cystatin-C as a Bridge for Microglial Amyloid Clearance via TREM2
Zhang, Y., Li, C., & Li, C. (2026) · Research · doi:10.34133/research.1456
Metadata
- Authors
- Xu, Z., Rao, Y., Huang, Y., Zhou, T., Feng, R., Xiong, S., Yuan, T.-F., Qin, S., Lu, Y., Zhou, X., Li, X., Qin, B., Mao, Y., & Peng, B.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 32
- Issue
- 6
- Pages
- 108041
- ISSN
- 2211-1247
- Cited by
- 172
- References
- 36
- Language
- en
- Update notices
- erratum (2020-11-24)
- Licence
- Funders
- National Natural Science Foundation of China
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