Cited by 50Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function StudiesNeurogenesis and neuroplasticity mechanisms

Mechanisms of myeloid cell entry to the healthy and diseased central nervous system

Amann, Lukas, Masuda, Takahiro, Prinz, Marco·2023·Nature Immunology

Abstract

Myeloid cells in the central nervous system (CNS), such as microglia, CNS-associated macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune homeostasis as well as the resolution of tissue damage during brain development or disease-related pathology. The complementary usage of multimodal high-throughput and high-dimensional single-cell technologies along with recent advances in cell-fate mapping has revealed remarkable myeloid cell heterogeneity in the CNS. Despite the establishment of extensive expression profiles revealing myeloid cell multiplicity, the local anatomical conditions for the temporal- and spatial-dependent cellular engraftment are poorly understood. Here we highlight recent discoveries of the context-dependent mechanisms of myeloid cell migration and settlement into distinct subtissular structures in the CNS. These insights offer better understanding of the factors needed for compartment-specific myeloid cell recruitment, integration and residence during development and perturbation, which may lead to better treatment of CNS diseases.

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Crossref · 10.1038/s41590-022-01415-8

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  • Single-cell profiling suggested that CAMs share functions with microglia and astrocytes in maintaining CNS homeostasis and regulating barrier functions.

    “Single-cell profiling suggested functions shared with microglia and astrocytes in maintaining CNS homeostasis [372] and regulating barrier functions [367,378,379,380].”

    From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [378]

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Authors
Amann, L., Masuda, T., & Prinz, M.
Affiliations
  • University of Freiburg (DE)
  • Kyushu University (JP)
Corresponding author
  • Masuda, Takahiro
  • Prinz, Marco
Venue
Nature Immunology
Published
2023-02-09
Volume
24
Issue
3
Pages
393-407
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W4319812098
Cited by
50
References
146
Citations by year
2026: 7 · 2025: 14 · 2024: 22 · 2023: 7
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (23K21383)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
myeloid cells, central nervous system, microglia, dendritic cells, monocytes, myeloid cell migration, myeloid cell recruitment, myeloid cell heterogeneity, cell fate mapping, brain development, neuroinflammation
MeSH terms
Central Nervous System, Macrophages, Monocytes, Microglia, Myeloid Cells

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