Mechanisms of myeloid cell entry to the healthy and diseased central nervous system
Abstract
Myeloid cells in the central nervous system (CNS), such as microglia, CNS-associated macrophages (CAMs), dendritic cells and monocytes, are vital for steady-state immune homeostasis as well as the resolution of tissue damage during brain development or disease-related pathology. The complementary usage of multimodal high-throughput and high-dimensional single-cell technologies along with recent advances in cell-fate mapping has revealed remarkable myeloid cell heterogeneity in the CNS. Despite the establishment of extensive expression profiles revealing myeloid cell multiplicity, the local anatomical conditions for the temporal- and spatial-dependent cellular engraftment are poorly understood. Here we highlight recent discoveries of the context-dependent mechanisms of myeloid cell migration and settlement into distinct subtissular structures in the CNS. These insights offer better understanding of the factors needed for compartment-specific myeloid cell recruitment, integration and residence during development and perturbation, which may lead to better treatment of CNS diseases.
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Single-cell profiling suggested that CAMs share functions with microglia and astrocytes in maintaining CNS homeostasis and regulating barrier functions.
“Single-cell profiling suggested functions shared with microglia and astrocytes in maintaining CNS homeostasis [372] and regulating barrier functions [367,378,379,380].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [378]
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“The intracerebroventricular injection of clodronate liposomes affords the selective deletion of PvMΦ and MnMΦ [2].”
BackgroundInfluentialModulation of host immunity by sensory neurons.
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BackgroundSpatiotemporal expression patterns of ZBP1 in the brain of mouse experimental stroke model
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“The nervous system signi fi cantly in fl uences leukocyte migration and function via systemic modulation, affecting immune function in both healthy and stress-induced conditions (20, 57, 58).”
Niche-specific therapeutic targeting of myeloid cells in the central nervous system
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Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
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- Authors
- Amann, L., Masuda, T., & Prinz, M.
- Affiliations
- University of Freiburg (DE)
- Kyushu University (JP)
- Corresponding author
- Masuda, Takahiro
- Prinz, Marco
- Venue
- Nature Immunology
- Published
- 2023-02-09
- Volume
- 24
- Issue
- 3
- Pages
- 393-407
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W4319812098
- Cited by
- 50
- References
- 146
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 22 · 2023: 7
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23K21383)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- myeloid cells, central nervous system, microglia, dendritic cells, monocytes, myeloid cell migration, myeloid cell recruitment, myeloid cell heterogeneity, cell fate mapping, brain development, neuroinflammation
- MeSH terms
- Central Nervous System, Macrophages, Monocytes, Microglia, Myeloid Cells
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