The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Efficacy of the Long-Acting Repeatable Formulation of the Somatostatin Analogue Octreotide in Postoperative Dumping
Abstract
Background & aims Several studies have established symptomatic and mechanistic benefits of the somatostatin analogue octreotide in patients with dumping syndrome, but clinical use is hampered by the requirement for subcutaneous administration 3 times daily. We compared the efficacy of subcutaneous octreotide with that of the long-acting repeatable (LAR) octreotide formulation, which is administered monthly, in patients with dumping syndrome. Methods The study included 30 consecutive patients with postoperative dumping, evidenced by oral glucose tolerance test (OGTT) results and insufficient response to dietary measures. OGTT, dumping severity score (summary of scores 0-3 for 8 early and 6 late dumping symptoms), and quality-of-life data were evaluated at baseline, after 3 days of subcutaneous administration of octreotide (0.5 mg), and then after 3 monthly intramuscular injections of octreotide LAR (20 mg). Results Both formulations of octreotide significantly reduced total dumping severity scores (21.7 +/- 1.6 at baseline, 11.2 +/- 1.2 for subcutaneous and 14.0 +/- 1.8 for LAR formulations; P Conclusions Monthly administration of LAR octreotide improves OGTT results, symptoms, and quality of life in patients with postoperative dumping.
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“In severe cases, dumping syndrome is associated with a substantial reduction in quality of life and significant weight loss as a result of avoidance of food intake (15).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“However, gastric emptying studies generally have low sensitivity and specificity, probably because the process of rapid gastric emptying occurs soon after ingestion, a phase that is not adequately assessed in most studies.”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Arts et al. developed a dumping-severity score in which symptoms of early and late dumping (eight and six symptoms, respectively) were scored on a 4-point Likert scale (15).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Furthermore, the duration of the entire study of up to 4 h is integrated into a single value (half emptying time), which may neutralize the rapid initial emptying effect (3,15,37).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Short-acting formulations may be more effective at improving some dumping symptoms such as hypoglycemia (15,(81)(82)(83)85); however, the need for repeated injections throughout the day is often a major limitation to the long-term administration of short-acting”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Both short-acting and long-acting formulations of somatostatin analogues have demonstrated efficacy by slowing gastric emptying, improving hypoglycemia and reducing early and late dumping symptoms (Table 4) (15,66,(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93)(94)(95).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Somatostatin analogues target various steps in the pathophysiology of dumping syndrome, including delaying gastric emptying, delaying transit through the small intestine, inhibiting the release of GI hormones, inhibiting insulin secretion and inhibiting postprandial vasodilation (15,(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Long-acting formulations are preferred by patients because of less frequent administration and the associated improvements in quality of life (15,89).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
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Items 101–123 of 123
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Yang, Z., & Graham, A. (2019) · Gastrointestinal Emergencies · doi:10.1007/978-3-319-98343-1_125 · Cited by 1
Managing Early and Late Postoperative Complications Following Gastric Surgery
Badgwell, B., Day, R., & Aloia, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-15826-6_17 · Cited by 1
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Rivero, H. G., Abdemur, A., & Rosenthal, R. J. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1710-2_16
Schipper, R. M., Heusschen, L., Schepers, L., Verstraete, F. F., Hazebroek, E. J., Kampman, E., & Berendsen, A. A. M. (2026) · BMJ Open · doi:10.1136/bmjopen-2026-119119
LONG-ACTING INJECTABLE (LAI) SYSTEMS- CURRENT PROGRESS IN CHRONIC DISEASETHERAPY
Lakshmanan, L., Jayakumar, D., Pawar, S. D., Supria, K. A. S., S., K., Arvinthkumar, R., K., M., & S, N. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.51s.153
“Several formulation strategies, such as complexing proteins with stabilizing agents, coating microspheres, or employing hybrid polymers, have been employed to mitigate this risk 65 .”
Tase, A., Askari, A., Abed, M., Mussendeki, D., Al-Taan, O., Munasinghe, A., Rashid, F., Adil, T., Jambulingam, P., & Whitelaw, D. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08657-7
“Diagnostic tools include the Sigstad score [18], Dump-ing Symptom Rating Scale [14, 19], and Dumping Severity Score [20, 21], with Sigstad being most widely used.”
Prediction of dumping after oesophageal cancer surgery
Lagergren, P., Kampa, L., Mälberg, K., Jebril, W., Åkerström, J., Johar, A., & Schandl, A. (2026) · Acta oncologica · doi:10.2340/1651-226x.2026.45044
“The OSCAR dumping questionnaire is based on the Arts dumping questionnaire [6], the most commonly used questionnaire for dumping.”
Harker, M. J. R., Okkema, S., Schuurman, M., Heusschen, L., Vugts, G., & Hazebroek, E. J. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08528-1
“This results in a maximum score of 24 for early dumping and 18 for late dumping [16].”
Diagnosis and treatment of chronic abdominal pain after bariatric surgery: a systematic review
Zevallos, A. S., & Pouwels, S. (2026) · Surgical Endoscopy · doi:10.1007/s00464-025-12554-y · Cited by 1
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Mettananda, C., & Shah, P. (2025) · Journal of the Ceylon College of Physicians · doi:10.4038/jccp.v56i2.8109
“8,20 Somatostatin can be administered alone or in combination with acarbose.”
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Aldawsari, K. A., Mattos, C., Khan, D. M., Beckett, O., & Pagán, P. (2024) · Endocrinology, Diabetes & Metabolism Case Reports · doi:10.1530/edm-23-0137
“Its use requires subcutaneous injection prior to each meal, which may impact patient compliance, it may result in steatorrhea due to the inhibition of other pancreatic exocrine hormones, and it carries a dose related risk of necrotizing enterocolitis (NEC) (5, 6).”
BackgroundTrattamento delle complicanze delle gastrectomie
Frisoni, R., Germain, A., & Bresler, L. (2020) · EMC - Tecniche Chirurgiche Addominale · doi:10.1016/s1283-0798(20)43335-2
Tratamiento de las complicaciones de las gastrectomías
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The metabolic sequelae of oesophago-gastric resection
Roberts, G. (2019) · doi:10.17863/cam.37362
El-attar, A., Esmail, T., & Salam, W. A. (2017) · doi:10.11648/j.js.s.2017050301.24
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Mishra, S., & Raj, P. (2021) · Springer eBooks · doi:10.1007/978-981-33-4702-1_23
Early and Late Dumping Syndromes
Mattar, S., & Rogers, A. (2019) · The ASMBS Textbook of Bariatric Surgery · doi:10.1007/978-3-030-27021-6_23
Treatment of Obesity with Bariatric Surgery
Izaguirre, M., Frühbeck, G., & Catalán, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65164-4 · Cited by 2
Dumon, K., & Dempsey, D. T. (2019) · Shackelford's Surgery of the Alimentary Tract, 2 Volume Set · doi:10.1016/b978-0-323-40232-3.00062-5
Mathus-Vliegen, E. M. H., & Dargent, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-90074-2_6
Pak, K. H., & Noh, S. H. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2223-9_13
Störungen der Magenentleerung (Gastroparese, Dumping-Syndrom)
Keller, J. (2015) · Springer eBooks · doi:10.1007/978-3-642-54676-1_335-1
Metadata
- Authors
- Arts, J., Caenepeel, P., Bisschops, R., Dewulf, D., Holvoet, L., Piessevaux, H., Bourgeois, S., Sifrim, D., Janssens, J., & Tack, J.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Ziekenhuisnetwerk Antwerpen Stuivenberg (BE)
- Corresponding author
- Tack, Jan
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 7
- Issue
- 4
- Pages
- 432-437
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2095380880
- Cited by
- 142
- References
- 43
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 13 · 2021: 9 · 2020: 11 · 2019: 14 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Keywords
- octreotide, somatostatin analogues, subcutaneous administration, intramuscular injection, oral glucose tolerance test, quality of life, gallstones, postgastrectomy complications
- MeSH terms
- Adult, Belgium, Delayed-Action Preparations, Dumping Syndrome, Female, Gastrointestinal Agents, Glucose Tolerance Test, Humans, Male, Quality of Life, Severity of Illness Index, Octreotide, Treatment Outcome
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