The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Efficacy of the Long-Acting Repeatable Formulation of the Somatostatin Analogue Octreotide in Postoperative Dumping
Abstract
Background & aims Several studies have established symptomatic and mechanistic benefits of the somatostatin analogue octreotide in patients with dumping syndrome, but clinical use is hampered by the requirement for subcutaneous administration 3 times daily. We compared the efficacy of subcutaneous octreotide with that of the long-acting repeatable (LAR) octreotide formulation, which is administered monthly, in patients with dumping syndrome. Methods The study included 30 consecutive patients with postoperative dumping, evidenced by oral glucose tolerance test (OGTT) results and insufficient response to dietary measures. OGTT, dumping severity score (summary of scores 0-3 for 8 early and 6 late dumping symptoms), and quality-of-life data were evaluated at baseline, after 3 days of subcutaneous administration of octreotide (0.5 mg), and then after 3 monthly intramuscular injections of octreotide LAR (20 mg). Results Both formulations of octreotide significantly reduced total dumping severity scores (21.7 +/- 1.6 at baseline, 11.2 +/- 1.2 for subcutaneous and 14.0 +/- 1.8 for LAR formulations; P Conclusions Monthly administration of LAR octreotide improves OGTT results, symptoms, and quality of life in patients with postoperative dumping.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In severe cases, dumping syndrome is associated with a substantial reduction in quality of life and significant weight loss as a result of avoidance of food intake (15).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“However, gastric emptying studies generally have low sensitivity and specificity, probably because the process of rapid gastric emptying occurs soon after ingestion, a phase that is not adequately assessed in most studies.”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Arts et al. developed a dumping-severity score in which symptoms of early and late dumping (eight and six symptoms, respectively) were scored on a 4-point Likert scale (15).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Furthermore, the duration of the entire study of up to 4 h is integrated into a single value (half emptying time), which may neutralize the rapid initial emptying effect (3,15,37).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Short-acting formulations may be more effective at improving some dumping symptoms such as hypoglycemia (15,(81)(82)(83)85); however, the need for repeated injections throughout the day is often a major limitation to the long-term administration of short-acting”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Both short-acting and long-acting formulations of somatostatin analogues have demonstrated efficacy by slowing gastric emptying, improving hypoglycemia and reducing early and late dumping symptoms (Table 4) (15,66,(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93)(94)(95).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Somatostatin analogues target various steps in the pathophysiology of dumping syndrome, including delaying gastric emptying, delaying transit through the small intestine, inhibiting the release of GI hormones, inhibiting insulin secretion and inhibiting postprandial vasodilation (15,(67)(68)(69)(70)(71)(72)(73)(74)(75)(76)(77)(78).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
In the citing paper
“Long-acting formulations are preferred by patients because of less frequent administration and the associated improvements in quality of life (15,89).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [15]
Citations
Cites
Esophageal Resection for Cancer of the Esophagus: Long-Term Function and Quality of Life
McLarty, A. J., Deschamps, C., Trastek, V. F., Allen, M. S., Pairolero, P. C., & Harmsen, W. S. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(97)00125-2 · Cited by 272
Moschetta, A., Stolk, M. F. J., Rehfeld, J. F., Portincasa, P., Slee, P. H. T. J., Koppeschaar, H. P. F., Van Erpecum, K. J., & Vanberge‐Henegouwen, G. P. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00924.x · Cited by 79
Efficacy of depot long‐acting release octreotide therapy in severe dumping syndrome
PENNING, C., VECHT, J., & MASCLEE, A. A. M. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02681.x · Cited by 48
Effect of octreotide on gastric and small bowel motility in patients with gastroparesis
Edmunds, Chen, Soykan, Lin, & McCallum (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00289.x · Cited by 41
EWINS, D., JAVAID, A., COSKERAN, P., SHAN, S., BUTLER, J., DEPREZ, P., MIELL, J., CALAM, J., BARRETT, J., DAWSON, J., et al. (1992) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068669 · Cited by 25
Research works printed but not linked: 36
- Vecht, 1997, The dumping syndrome, Scand J Gastroenterol, 223, 21
- Pimpalwar, 2002, Results of laparoscopic antireflux procedures in neurologically impaired children, Semin Laparosc Surg, 9, 190, 10.1053/slas.2002.126992 · DOI
- Lawaetz, 1983, Gut hormone profile and gastric emptying in the dumping syndrome, Scand J Gastoenterol, 18, 73, 10.3109/00365528309181562 · DOI
- Sagor, 1981, Release of vasoactive intestinal peptide in the dumping syndrome, Br Med J, 282, 507, 10.1136/bmj.282.6263.507 · DOI
- Kellum, 1990, Gastrointestinal hormone response to meals before and after gastric bypass and vertical banded gastroplasty, Ann Surg, 211, 763, 10.1097/00000658-199006000-00016 · DOI
- Kaushik, 1980, Use of a provocation test for objective assessment of dumping syndrome in patients undergoing surgery for duodenal ulcer, Am J Gastroenterol, 74, 251
- van der Kleij, 1996, Diagnostic value of dumping provocation in patients after gastric surgery, Scand J Gastroenterol, 31, 1162, 10.3109/00365529609036905 · DOI · Paper page
- Linehan, 1986, The 15-minute dumping provocation test, Br J Surg, 73, 810, 10.1002/bjs.1800731017 · DOI
- Hopman, 1988, Treatment of the dumping syndrome with the somatostatin analogue SMS201-995, Ann Surg, 207, 155, 10.1097/00000658-198802000-00007 · DOI · Paper page
- Andersen, 1989, Trial of pectin-enriched muffins in patients with severe dumping syndrome after gastric resection, Acta Chir Scand, 155, 39
- Harju, 1983, Efficacy of guar gum in preventing the dumping syndrome, J Parenter Enteral Nutr, 7, 470, 10.1177/0148607183007005470 · DOI
- Lyons, 1985, Effect of acarbose on biochemical responses and clinical symptoms in dumping syndrome, Digestion, 31, 89, 10.1159/000199185 · DOI
- Vogel, 1988, Clinical and radionuclide evaluation of Roux-Y diversion for postgastrectomy dumping, Ann J Surg, 155, 57, 10.1016/S0002-9610(88)80258-7 · DOI
- Ramus, 1982, The use of jejunal interposition for intractable symptoms complicating peptic ulcer surgery, Br J Surg, 69, 265, 10.1002/bjs.1800690512 · DOI
- Morz, 1982, Influence of somatostatin (SS-14) on early dumping reaction in patients after partial gastrectomy, Z Gastroentrol, 20, 299
- Long, 1985, Somatostatin and the dumping syndrome, Br Med J (Clin Res Ed), 290, 886, 10.1136/bmj.290.6472.886 · DOI
- Reasbeck, 1986, The effect of somatostatin on dumping after gastric surgery: a preliminary report, Surgery, 99, 462
- Tulassay, 1989, Long acting somatostatin analogue in dumping syndrome, Br J Surg, 76, 1294, 10.1002/bjs.1800761223 · DOI · Paper page
- Geer, 1990, Efficacy of octreotide acetate in treatment of severe postgastrectomy dumping syndrome, Ann Surg, 212, 678, 10.1097/00000658-199012000-00005 · DOI
- Li-Ling, 2001, Therapeutic value of octreotide for patients with severe dumping syndrome: a review of randomised controlled trials, Postgrad Med J, 77, 441, 10.1136/pmj.77.909.441 · DOI
- Vecht, 1999, Long-term results of octreotide-therapy in severe dumping syndrome, Clin Endocrinol (Oxf), 51, 619, 10.1046/j.1365-2265.1999.00819.x · DOI
- Fuessl, 1987, Effect of a long-acting somatostatin analogue (SMS 201-995) on postprandial gastric emptying of 99mTc-tin colloid and mouth-to-caecum transit time in man, Digestion, 36, 101, 10.1159/000199407 · DOI · Paper page
- van Berge Henegouwen, 1997, The effect of octreotide on gastric emptying at a dosage used to prevent complications after pancreatic surgery: a randomised, placebo controlled study in volunteers, Gut, 41, 758, 10.1136/gut.41.6.758 · DOI
- Foxx-Orenstein, 2003, Effect of a somatostatin analogue on gastric motor and sensory functions in healthy humans, Gut, 52, 1555, 10.1136/gut.52.11.1555 · DOI
- Hasler, 1996, Mechanisms by which octreotide ameliorates symptoms in the dumping syndrome, J Pharmacol Exp Ther, 277, 1359, 10.1016/S0022-3565(25)13083-8 · DOI
- Di Lorenzo, 1999, Effect of sequential erythromycin and octreotide on antroduodenal manometry, J Pediatr Gastroenterol Nutr, 29, 293
- Nelson-Piercy, 1994, Effect of a new oral somatostatin analog (SDZCO611) on gastric emptying, mouth to cecum transit time, and pancreatic and gut hormone release in normal male subjects, J Clin Endocrinol Metab, 78, 329
- von der Ohe, 1995, Differential regional effects of octreotide on human gastrointestinal motor function, Gut, 36, 743, 10.1136/gut.36.5.743 · DOI
- Kreanzlin, 1985, Effect of long-acting somatostatin analogue SMS 201-995 on gut hormone secretion in normal subjects, Experinthia, 41, 738, 10.1007/BF02012573 · DOI
- Williams, 1986, Postprandial effects of SMS 201-995 on gut hormones and glucose tolerance, Scand J Gastroenterol, 21, 73, 10.3109/00365528609087434 · DOI
- Parkinson, 2002, A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin, and pancreatic polypeptide responses to oral glucose and a standard mixed meal, J Clin Endocrinol Metab, 87, 1797, 10.1210/jcem.87.4.8432 · DOI
- Kemmer, 1992, Inhibition of human exocrine pancreatic secretion by the long-acting somatostatin analogue octreotide (SMS201-995), Aliment Pharmacol Ther, 6, 41, 10.1111/j.1365-2036.1992.tb00543.x · DOI
- Högenauer, 2002, Effect of octreotide on fluid absorption and secretion by the normal human jejunum and ileum in vivo, Aliment Pharmacol Ther, 16, 769, 10.1046/j.1365-2036.2002.01228.x · DOI
- Maton, 1989, Use of long-acting somatostatin analog SMS 201-995 in patients with pancreatic islet cell tumors, Dig Dis Sci, 34, 28S, 10.1007/BF01536043 · DOI
- Didden, 2006, Octreotide therapy in dumping syndrome: analysis of long-term results, Aliment Pharmacol Ther, 24, 1367, 10.1111/j.1365-2036.2006.03124.x · DOI
- Turner, 1999, Differing effects on gall-bladder motility of lanreotide SR and octreotide LAR for treatment of acromegaly, Eur J Endocrinol, 141, 590, 10.1530/eje.0.1410590 · DOI
Cited by
Sorted by citations
Pathophysiology, diagnosis and management of postoperative dumping syndrome
Tack, J., Arts, J., Caenepeel, P., De Wulf, D., & Bisschops, R. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.148 · Cited by 387
Self-citationvan Beek, A. P., Emous, M., Laville, M., & Tack, J. (2017) · Obesity Reviews · doi:10.1111/obr.12467 · Cited by 288
“(15) Single-arm, open-label study N = 30 Octreotide LAR 20 mg for 3 months vs subcutaneous”
BackgroundInfluentialSelf-citationScholtz, S., Miras, A. D., Chhina, N., Prechtl, C. G., Sleeth, M., Daud, N. M., Ismail, N. A., Durighel, G., Ahmed, A. R., Olbers, T., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-305008 · Cited by 293
International consensus on the diagnosis and management of dumping syndrome
Scarpellini, E., Arts, J., Karamanolis, G. P., Laurenius, A., Siquini, W., Suzuki, H., Ukleja, A., van Beek, A. P., Vanuytsel, T., Bor, S., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0357-5 · Cited by 316
“Arts et al.(17) 30 Octreotide longacting release 20 mg (intramuscular) Suppression of rise in pulse rate and haematocrit; inhibition of postprandial hypoglycaemia; inhibition of rise in plasma levels of insulin; improvement of symptoms of early and late dumping syndrome and quality of life; preferred by patients over…”
BackgroundSelf-citationComplications of bariatric surgery: Dumping syndrome, reflux and vitamin deficiencies
Tack, J., & Deloose, E. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.010 · Cited by 181
“In severe cases, dumping syndrome is associated with significant impairment of quality-of-life [3] and may contribute to significant weight loss by avoidance of food intake.”
BackgroundMethodInfluentialSelf-citationHofsø, D., Fatima, F., Borgeraas, H., Birkeland, K. I., Gulseth, H. L., Hertel, J. K., Johnson, L. K., Lindberg, M., Nordstrand, N., Småstuen, M. C., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30344-4 · Cited by 213
Diet approach before and after bariatric surgery
Bettini, S., Belligoli, A., Fabris, R., & Busetto, L. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09571-8 · Cited by 173
Current management strategies and emerging treatments for functional dyspepsia
Camilleri, M., & Stanghellini, V. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.11 · Cited by 180
Papamargaritis, D., Koukoulis, G., Sioka, E., Zachari, E., Bargiota, A., Zacharoulis, D., & Tzovaras, G. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0711-3 · Cited by 112
“The Sigstad scoring system [17] was used for diagnosis of dumping syndrome (score >7), whereas the Arts’ questionnaire [18] was used for differentiating between early and late dumping.”
MethodPostgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery.
Davis, J. L., & Ripley, R. T. (2017) · Surgical Clinics of North America · doi:10.1016/j.suc.2016.11.005 · Cited by 110
Tzovaras, G., Papamargaritis, D., Sioka, E., Zachari, E., Baloyiannis, I., Zacharoulis, D., & Koukoulis, G. (2012) · Obesity Surgery · doi:10.1007/s11695-011-0461-7 · Cited by 97
Emous, M., Wolffenbuttel, B., Totté, E., & van Beek, A. V. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2017.04.028 · Cited by 71
“Time between surgery and study (months) 31 [20-41] 27 [19-33] 0.”
BackgroundAhmad, A., Kornrich, D. B., Krasner, H., Eckardt, S., Ahmad, Z., Braslow, A., & Broggelwirth, B. (2019) · Obesity Surgery · doi:10.1007/s11695-018-03699-y · Cited by 68
Øhrstrøm, C. C., Worm, D., Højager, A., Andersen, D., Holst, J. J., Kielgast, U. L., & Hansen, D. L. (2019) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13796 · Cited by 72
“statin analogues in PBH, although hypoglycaemia was not always completely averted.(14,28) Pasireotide has a multi-receptor binding pro-”
BackgroundOral peptide delivery by tetraether lipid liposomes
Parmentier, J., Thewes, B., Gropp, F., & Fricker, G. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.05.066 · Cited by 73
Diagnostic tools for post‐gastric bypass hypoglycaemia
Emous, M., Ubels, F. L., & van Beek, A. P. (2015) · Obesity Reviews · doi:10.1111/obr.12307 · Cited by 58
“developed a dumping severity score in which the symptoms of early and late dumping (eight and six symptoms, respectively) were scored on a 4-point Likert scale (31).”
BackgroundLong-term pharmacotherapy considerations in the bariatric surgery patient
Bland, C. M., Miller, A. D., Love, B. L., Yeager, C. A., McMichael, B., & Bookstaver, P. B. (2016) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp151062 · Cited by 53
“Initially, octreotide 50–100 mg can be administered subcutaneously three times daily to assess tolerability and effectiveness; patients with a good response can be transitioned to a slow-release depot injection.(37) Patients who do not respond to medical therapies for dumping syndrome may require surgical revision or…”
BackgroundGonzález-González, A., Delgado‐Rodríguez, M., & Fraga-Fuentes, M. D. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2011.05.010 · Cited by 50
“The syndrome usually occurs 1.5–8 years after RYGB.”
BackgroundInfluentialVargas, E. J., Dayyeh, B. K. A., Storm, A. C., Bazerbachi, F., Matar, R., Vella, A. V., Kellogg, T. A., & Stier, C. K. (2020) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2020.02.029 · Cited by 60
Impact of gastric cancer treatment on quality of life of patients
Schütte, K., Schulz, C., & Middelberg-Bisping, K. (2021) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2021.101727 · Cited by 49
Svanevik, M., Lorentzen, J., Borgeraas, H., Sandbu, R., Seip, B., Medhus, A. W., Hertel, J. K., Kolotkin, R. L., Småstuen, M. C., Hofsø, D., et al. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00127-4 · Cited by 59
D'hoedt, A., & Vanuytsel, T. (2023) · Acta gastro-enterologica Belgica · doi:10.51821/86.3.11476 · Cited by 39
“(6).”
Rogers, C. L. (2011) · Nutrition in Clinical Practice · doi:10.1177/0884533611400070 · Cited by 40
Deloose, E., Bisschops, R., Holvoet, L., Arts, J., De Wulf, D., Caenepeel, P., Lannoo, M., Vanuytsel, T., Andrews, C., & Tack, J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12333 · Cited by 35
Self-citationPostbariatric surgery hypoglycemia: Nutritional, pharmacological and surgical perspectives
Rossini, G., Risi, R., Monte, L., Sancetta, B. M., Quadrini, M., Ugoccioni, M., Masi, D., Rossetti, R., D’Alessio, R., Mazzilli, R., et al. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3750 · Cited by 35
“105,106 However, not all studies agree, as only partial response was reported with Octreotide 50–100 mcg given sc every 12 h. 87 However, in most subjects, Octreotide was used as a third ‐ line treatment, highlighting a population with more severe PBH, likely to be resistant to pharmacologic…”
MethodSomatostatin analogues for the treatment of hyperinsulinaemic hypoglycaemia
Haris, B., Saraswathi, S., & Hussain, K. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820965068 · Cited by 45
Gastroparesis and Dumping Syndrome: Current Concepts and Management
Vavricka, S. R., & Greuter, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081127 · Cited by 39
Hauge, J. W., Borgeraas, H., Birkeland, K. I., Johnson, L. K., Hertel, J. K., Hagen, M. C., Gulseth, H. L., Lindberg, M., Lorentzen, J., Seip, B., et al. (2025) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00396-6 · Cited by 45
Hazlehurst, J., Khoo, B. C. E., Lobato, C. B., Ilesanmi, I., Abbott, S., Chan, T. L., Pillai, S., Maslin, K., Purkayastha, S., McGowan, B. M., et al. (2024) · Endocrine Connections · doi:10.1530/ec-23-0285 · Cited by 43
“They have been found to be effective for both for early and late dumping syndromes, with late dumping syndrome being the analogous condition to PBH in individuals undergoing upper GI surgery such as oesophagectomy or gastrectomy (115, 116, 117 , 118).”
Safety and efficacy of pasireotide in dumping syndrome—results from a phase 2, multicentre study
Tack, J. F., Aberle, J., Arts, J., Laville, M., Oppert, J., Bender, G., Bhoyrul, S., McLaughlin, T., Yoshikawa, T., Vella, A., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14664 · Cited by 36
“Octreotide, a first-generation somatostatin analogue approved for use in acromegaly and gastroenteropancreatic neuroendocrine tumours, administered either as subcutaneous (SC) or as intramuscular (IM) long-acting injection, has been used off-label for the treatment of patients with dumping syndrome in whom firstline m…”
BackgroundInfluentialSelf-citationPontecorvi, V., Matteo, M. V., Bove, V., Siena, M. D., Giannetti, G., Carlino, G., Polidori, G., Vinti, L., Angelini, G., Iaconelli, A., et al. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06466-w · Cited by 39
“To further evaluate the severity of both early and late DS, we used the Arts Dumping Score (ADS) questionnaire (Table 2) [20].”
MethodDiazoxide for the treatment of hypoglycaemic dumping syndrome
Thondam, S. K., Nair, S., Wile, D. B., & Gill, G. V. (2011) · QJM · doi:10.1093/qjmed/hcr234 · Cited by 35
Prevalence of hypoglycaemia in a random population after Roux-en-Y gastric bypass after a meal test
Emous, M., van den Broek, M., Wijma, R. B., de Heide, L. J. M., van Dijk, G., Laskewitz, A. J., Totté, E., Wolffenbuttel, B. H. R., & van Beek, A. P. (2019) · Endocrine Connections · doi:10.1530/ec-19-0268 · Cited by 30
Masclee, G. M. C., & Masclee, A. (2023) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s392265 · Cited by 33
“Both Arts et al 37 and Didden et al 55 reported that, in patients with the most severe dumping symptoms, better symptom control was obtained with short-acting octreotide three times a day than with long-acting octreotide administered monthly.”
BackgroundMethodFurth, A. V., van den Broek, M., Emous, M., de Heide, L. D., Kuipers, F., & van Beek, A. V. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.08.009 · Cited by 24
Octreotide improves early dumping syndrome potentially through incretins: a case report
Sato, D., Morino, K., Ohashi, N., Ueda, E., Ikeda, K., Yamamoto, H., Ugi, S., Yamamoto, H., Araki, S., & Maegawa, H. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej12-0288 · Cited by 21
Gastrointestinal hormones and regulation of gastric emptying
Mori, H., Verbeure, W., Schol, J., Carbone, F., & Tack, J. (2022) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000707 · Cited by 21
Self-citationFatima, F., Hjelmesaeth, J. S., Birkeland, K. I., Gulseth, H. L., Hertel, J. K., Svanevik, M., Sandbu, R., Småstuen, M. C., Hartmann, B., Holst, J. J., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab643 · Cited by 37
“OGTT) were assessed and graded using Arts’ dumping score (19).”
MethodA Low Dose of Pasireotide Prevents Hypoglycemia in Roux-en-Y Gastric Bypass-Operated Individuals
Øhrstrøm, C., Hansen, D., Kielgast, U., Hartmann, B., Holst, J., & Worm, D. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04248-x · Cited by 21
The Impact and Clinical Implications of Gastric Surgery on the Gastric Conduction System
Carson, D., Robertson, S., Wang, T., Varghese, C., Gharibans, A., Windsor, J., & O'Grady, G. (2022) · Foregut: The Journal of the American Foregut Society · doi:10.1177/26345161221130117 · Cited by 20
Dumping Syndrome and Postbariatric Hypoglycemia: Supporting Evidence for a Common Etiology
van Furth, A. M., de Heide, L. J. M., Emous, M., Veeger, N. J. G. M., & van Beek, A. P. (2021) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2021.05.020 · Cited by 26
Emous, M., Wolffenbuttel, B., van Dijk, G., Totté, E., & van Beek, A. V. (2018) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2018.04.011 · Cited by 18
“The dumping severity score developed by Arts et al. [17] was used for assessment of the severity of early and late dumping syndrome, using a 4-point Likert scale (Supplemental Tables 1 and 2).”
BackgroundMethodInfluentialWölnerhanssen, B., Meyer-Gerspach, A. C., Peters, T., Beglinger, C., & Peterli, R. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2015.11.022 · Cited by 17
“A cumulative dumping severity score was obtained by adding early and late scores [5].”
MethodPostoperative problems 2011: fundoplication and obesity surgery.
Rohof, W., Bisschops, R., Tack, J., & Boeckxstaens, G. E. E. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2011.09.002 · Cited by 17
Self-citationde Heide, L. J. M., Wouda, S. H. T., Peters, V. J. T., Oosterwerff‐Suiker, M., Gerdes, V. A., Emous, M., & van Beek, A. P. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14920 · Cited by 15
“4] Total weight loss (%) 34 [26-41] T2D, n (%) 22 (18.”
Carpentieri, G. B., Gonçalves, S. E. A. B., Mourad, W. M., Pinto, L. G. C., & Zanella, M. T. (2023) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000598 · Cited by 19
“However, somatostatin analogues exert their therapeutic effect by inhibiting insulin and GLP-1 secretion to prevent postprandial hypoglycemia (26).”
BackgroundInfluentialWijma, R. B., Emous, M., van den Broek, M., Laskewitz, A. J., Kobold, A. C. M., & van Beek, A. P. (2018) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2018.10.004 · Cited by 14
Dumping syndrome : Update on pathophysiology, diagnosis, and management
Tack, J. F., Raymenants, K., de Bruaene, C. V., & Scarpellini, E. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14962 · Cited by 12
Self-citationAnandavadivelan, P., Wikman, A., Malberg, K., Martin, L., Rosenlund, H., Rueb, C., Johar, A., & Lagergren, P. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.005 · Cited by 14
“The OSCAR dumping questionnaire is based on Sigstad's score [12] and the Arts dumping questionnaire [13] which are the most commonly used dumping symptom-based questionnaires.”
MethodThe Role of Somatostatin in the Gastrointestinal Tract
Papantoniou, K., Aggeletopoulou, I., Pastras, P., & Triantos, C. K. (2025) · Biology · doi:10.3390/biology14050558 · Cited by 13
“They observed reduced symptoms and improved severity scores with both forms, while long-acting octreotide significantly improved the quality of life in these patients [132].”
Long‐term nutrition alterations after surgery for gastrointestinal cancers
Jacobson, R. A., Gurd, E. N., & Pimiento, J. M. (2023) · Nutrition in Clinical Practice · doi:10.1002/ncp.11035 · Cited by 14
Ruban, A., Glaysher, M. A., Miras, A. D., Goldstone, A. P., Prechtl, C. G., Johnson, N. A., Li, J. V., Aldhwayan, M., Aldubaikhi, G., Glover, B. M., et al. (2020) · Efficacy and Mechanism Evaluation · doi:10.3310/eme07060 · Cited by 11
[Somatostatin and the digestive system. Clinical experiences].
Herszényi, L., Mihály, E., & Tulassay, Z. (2013) · Orvosi Hetilap · doi:10.1556/oh.2013.29721 · Cited by 13
Ri, M., Nunobe, S., Ida, S., Ishizuka, N., Atsumi, S., Makuuchi, R., Kumagai, K., Ohashi, M., & Sano, T. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i23.3386 · Cited by 12
Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome
Wauters, L. I., & Vanuytsel, T. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.09.005 · Cited by 12
Wauters, L. I., Arts, J., Caenepeel, P., Holvoet, L., Tack, J. F., Bisschops, R., & Vanuytsel, T. (2019) · United European Gastroenterology Journal · doi:10.1177/2050640619862166 · Cited by 16
Self-citationManaging gastrointestinal manifestations in systemic sclerosis, a mechanistic approach
Kaniecki, T., Hughes, M., & McMahan, Z. H. (2024) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2024.2320205 · Cited by 17
“The use of moderate-to-high doses of somatostatin analogs in the treatment of excessive motility syndromes, such as postoperative dumping syndrome and idiopathic refractory diarrhea, is well characterized in general population studies [119–123].”
BackgroundKraljević, M., Schneider, R., Wölnerhanssen, B. K., Bueter, M., Delko, T., & Peterli, R. (2021) · Trials · doi:10.1186/s13063-021-05313-6 · Cited by 12
“In addition, questionnaires will be also assessed to study the quality of life (Bariatric Analysis and Reporting Outcome System [BAROS] [18] and the Gastrointestinal Quality of Life Index [GIQLI] [19]), the Arts questionnaire [20] to determine postoperative determine dumping syndrome and questionnaire for quantificati…”
Occurrence of Dumping Syndrome After Esophageal Cancer Surgery: Systematic Review and Meta-analysis
Lin, Y., Wang, H., Qu, Y., Liu, Z., Lagergren, P., & Xie, S.-H. (2024) · Annals of Surgical Oncology · doi:10.1245/s10434-024-15881-x · Cited by 10
Matteo, M. V., Gallo, C., Pontecorvi, V., Bove, V., Siena, M. D., Carlino, G., Costamagna, G., & Boškoski, I. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101664 · Cited by 12
“This clinical condition can be physically and mentally d bilitant, with a ignifica t mpact n everyday life [10,16].”
BackgroundIs Sigstad’s score really capable of detecting post-surgical late dumping syndrome?
Rieck, J.-H., Heidinger, H., Schlöricke, E., Schmidt, N., & Krause, S. (2024) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-024-03283-2 · Cited by 10
“Underestimation of late dumping syndrome [25, 50] should be addressed in modified Sigstad score, like Arts et al. has shown [51].”
Herbal Medicine for Dumping Syndrome: A Systematic Review and Meta-Analysis
Hong, S., Park, B., Noh, H.-S., & Choi, D.-J. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419873404 · Cited by 8
“Dietary supplements (pectin, guar gum, acarbose(25-30)), somatostatin analogs (pasireotide,(5,31-33) octreotide(31)), miglitol,(34-36) iraglutide,(37) exendin-(9-39),(38) and diazoxide(39) are prescribed for postprandial hypoglycemia or hyperglycemia caused by dumping syndrome.”
BackgroundGys, B., Plaeke, P., Lamme, B., Lafullarde, T., Komen, N., Beunis, A., & Hubens, G. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03818-3 · Cited by 8
[Dumping syndrome following gastric surgery].
Mala, T., Hewitt, S., Høgestøl, I., Kjellevold, K., Kristinsson, J., & Risstad, H. (2015) · Tidsskrift for Den Norske Laegeforening · doi:10.4045/tidsskr.14.0550 · Cited by 8
Okkema, S., Boerboom, A. B., den Hengst, W. D., Aarts, E., Berends, F., & Hazebroek, E. (2025) · Surgical Endoscopy · doi:10.1007/s00464-025-11545-3 · Cited by 7
Lüscher, A., Vionnet, N., Pasquier, J., Chartoumpekis, D. V., Mantziari, S., Wojtsusizyn, A., & Favre, L. (2024) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2024.06.006 · Cited by 9
Bjerkan, K., Sandvik, J., Nymo, S., Johnsen, G., Hyldmo, Å., Kulseng, B., Salater, S., Høydal, K., & Hoff, D. A. L. (2024) · Obesity Research and Clinical Practice · doi:10.1016/j.orcp.2024.02.004 · Cited by 7
Late dumping syndrome or postprandial reactive hypoglycaemic syndrome after bariatric surgery
de Velde, F. V., & Lapauw, B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00473-6 · Cited by 7
Diazoxide for the Treatment of Hypoglycemia Resulting From Dumping Syndrome in a Child
Mejia‐Otero, J. D., Grishman, E. K., & Patni, N. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00120 · Cited by 7
“Octreotide and diazoxide have been used as second-line treatment of dumping syndrome in adults [1, 8, 9].”
Dunn, B., Foxe, M., Sprott, K., Hook, J. E., & Jump, C. S. (2025) · Nutrition in clinical practice · doi:10.1002/ncp.11348 · Cited by 6
Jans, A., Rask, E., Ottosson, J., Szabó, É., & Stenberg, E. (2024) · Clinical Obesity · doi:10.1111/cob.12709 · Cited by 6
“17 The Dumping Severity Scale (DSS), a questionnaire that was initially constructed to measure the treatment response to octreotide in patients with dumping syndrome, was developed by Arts et al. 18 The DSS has also been used to assess symptoms of dumping and hypoglycaemia after bariatric surgery.”
Recommendations for the diagnosis and treatment of hypoglycaemia after bariatric surgery
Vilarrasa, N., Lesmes, I. B., Ballesteros-Pomar, M. D., Lecube, A., Goday, A., Pellitero, S., Sánchez‐Santos, R., Zugasti, A., Ciudin, A., de Hollanda, A., et al. (2022) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2021.09.005 · Cited by 7
Mandatory and optional function tests in gastroduodenal disorders.
Tack, J. (2009) · Best practice & research. Clinical gastroenterology · doi:10.1016/j.bpg.2009.04.004 · Cited by 6
“In the rare case of dumping syndrome, dietary measures and somatostatin analogues can be used, but this is not guided by the result of gastric motility studies [6].”
BackgroundSelf-citationDumping Syndrome After One Anastomosis Gastric Bypass—A Systematic Review
Kermansaravi, M., Shahsavan, M., Amr, B., Stier, C. K., Parmar, C. D., & Chiappetta, S. (2025) · Obesity Surgery · doi:10.1007/s11695-025-07860-2 · Cited by 5
“The Art scoring system [38] is a severity-scoring assessment rather than a diagnostic tool.”
Seyfried, F., Wierlemann, A., Bala, M., Faßnacht, M., & Jurowich, C. F. (2015) · Der Chirurg · doi:10.1007/s00104-015-0047-3 · Cited by 9
Prevalence of post-bariatric hypoglycemia in the United States
Craig, C. M., Ramanujan, S., & McLaughlin, T. (2026) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2026.03.013 · Cited by 4
Kim, D.-W., Park, J.-S., Kil, B.-H., Jo, H.-M., Jung, D., Won, J.-Y., Cho, J.-H., & Lee, J.-E. (2020) · The Journal of Internal Korean Medicine · doi:10.22246/jikm.2020.41.5.868 · Cited by 4
Beattie, M., & Stanton, M. (2018) · Pediatrics in review · doi:10.1542/pir.2017-0089 · Cited by 4
Kim, C. Y. (2022) · Foregut Surgery · doi:10.51666/fs.2022.2.e4 · Cited by 8
Prevention of bariatric complications: best practices
Poon, D., & Rosenbluth, A. (2022) · Mini-invasive Surgery · doi:10.20517/2574-1225.2021.129 · Cited by 7
Post-bariatric Hypoglycemia Management: A Gulf Cooperation Council Consensus Statement
Abdelgadir, E., Rashid, F., Awadi, F. A. A., Busaidi, N. A., Alfaris, N., Hadad, M. A., Alkaabi, J., Kharusi, A. A., Al-Ozairi, E., Alromaihi, D., et al. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf225 · Cited by 3
“Also, in patients with an intact gallbladder, the increased risk of gallstones associated with octreotide LAR offsets the convenience of its once-monthly dosing [122].”
Scarpellini, E., Arts, J., Vanuytsel, T., & Tack, J. F. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00474-5 · Cited by 3
Self-citationNutritional Implications in Preparing Patients for Total Gastrectomy
Malik, S., & Semrad, C. E. (2020) · Current Surgery Reports · doi:10.1007/s40137-020-00273-3 · Cited by 5
“The use of long-acting octreotide (octreotide LAR 10–20 mg (mg) intramuscular injection every 4 weeks) improved symptoms, weight gain, and quality of life in two small studies [31, 32].”
BackgroundMigdanis, A., Koukoulis, G., Chougias, D., Migdanis, I., Armeni, E., Kanellakis, S., Manouras, A., Kapsoritakis, A. N., & Potamianos, S. (2023) · Cureus · doi:10.7759/cureus.48871 · Cited by 1
Reliability of the DSS-Swe Questionnaire
Jans, A., Rask, E., Ottosson, J., Magnuson, A., Szabó, É., & Stenberg, E. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06841-7 · Cited by 2
“…Severity Scale (DSS), a questionnaire that was initially constructed to measure the treatment response of octreotide on dumping syndrome, was developed by Arts and colleagues [16] and has recently also been used to assess symptoms of dumping and hypoglycemia after bariatric surgery [17, 18].”
BackgroundMethodKato, K., Kageyama, S., Nakashima, K., Ito, H., Ito, Y., & Miyake, T. (2023) · Internal medicine · doi:10.2169/internalmedicine.1704-23 · Cited by 2
A Case Study of a Dumping Syndrome Patient Treated with Gamchobunmil-tang
Choi, E., Hur, N., Kim, Y.-J., Jeong, H., Hong, S., & Insoo, J. (2022) · The Journal of Internal Korean Medicine · doi:10.22246/jikm.2022.43.5.1029 · Cited by 1
Strano, G. (2019) · doi:10.1007/978-3-540-35280-8_37 · Cited by 2
Rosen, J. M., & Saps, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_23 · Cited by 3
The Pathology of Chronic Inflammatory Bowel Disease
Russo, P. (2013) · doi:10.1007/978-1-4614-5061-0_21 · Cited by 2
Desmedt, S., Marlier, J., de Velde, F. V., Nieuwenhove, Y. V., Batens, A.-H., Matthys, I., & Lapauw, B. (2025) · Obesity Surgery · doi:10.1007/s11695-025-07929-y · Cited by 1
“Moreover, tolerance of OGTT after bariatric surgery is an issue because of possible provocation of early dumping [13].”
Abdelgadir, E., Rashid, F., & McGowan, B. (2025) · Journal of Diabetes and Endocrine Practice · doi:10.1055/s-0045-1809367 · Cited by 1
Henao, D. C., Gómez, A. M., Robledo, S., & Rosero, R. (2025) · Mini-invasive Surgery · doi:10.20517/2574-1225.2024.106 · Cited by 1
Jiang, B., Malone, A., & Schmiedel, O. (2025) · BMJ Case Reports · doi:10.1136/bcr-2024-262428 · Cited by 1
“28 29 Studies on the use of octreotide as a continuous subcutaneous infusion have been limited, with, to our knowledge, none for the treatment of post-bariatric hypoglycaemia.”
Useful of proximal gastrectomy with double-tract reconstruction in preventing glucose spikes
Fujimoto, D., Taniguchi, K., Takashima, J., & Kobayashi, H. (2024) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2024.06.012 · Cited by 1
Tumminia, A., Lombardo, A. M., Arpi, M., Baratta, R., Leonardi, D., Marturano, I., Frasca, F., & Gullo, D. (2024) · Journal of Clinical and Translational Endocrinology: Case Reports · doi:10.1016/j.jecr.2024.100163 · Cited by 1
Recomendaciones para el diagnóstico y tratamiento de las hipoglucemias tras cirugía bariátrica
Vilarrasa, N., Lesmes, I. B., Ballesteros-Pomar, M. D., Lecube, A., Goday, A., Pellitero, S., Sánchez‐Santos, R., Zugasti, A., Ciudin, A., de Hollanda, A., et al. (2021) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2021.09.003 · Cited by 1
Traitement des complications des gastrectomies
Frisoni, R., Germain, A., & Bresler, L. (2019) · EMC - Techniques chirurgicales - Appareil digestif · doi:10.1016/s0246-0424(18)57357-x · Cited by 1
Postprandial Hyperinsulinemic Hypoglycemia in Bariatric Surgery
de Heide, L. J. M., Emous, M., & van Beek, A. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804011-9.00054-6 · Cited by 2
Tack, J. (2012) · doi:10.1002/9781118321386.ch37 · Cited by 1
Self-citation
Metadata
- Authors
- Arts, J., Caenepeel, P., Bisschops, R., Dewulf, D., Holvoet, L., Piessevaux, H., Bourgeois, S., Sifrim, D., Janssens, J., & Tack, J.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Ziekenhuisnetwerk Antwerpen Stuivenberg (BE)
- Corresponding author
- Tack, Jan
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 7
- Issue
- 4
- Pages
- 432-437
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2095380880
- Cited by
- 142
- References
- 43
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 13 · 2021: 9 · 2020: 11 · 2019: 14 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Keywords
- octreotide, somatostatin analogues, subcutaneous administration, intramuscular injection, oral glucose tolerance test, quality of life, gallstones, postgastrectomy complications
- MeSH terms
- Adult, Belgium, Delayed-Action Preparations, Dumping Syndrome, Female, Gastrointestinal Agents, Glucose Tolerance Test, Humans, Male, Quality of Life, Severity of Illness Index, Octreotide, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review