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Cited by 196Gastrointestinal motility and disordersGut microbiota and healthInfant Health and Development

Systematic Review and Meta-analysis of the Prevalence of Irritable Bowel Syndrome in Individuals With Dyspepsia

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Ford, Alexander C., Marwaha, Avantika, Lim, Allen, Moayyedi, Paul·2010·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2009.07.020
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Abstract

Background & aims Dyspepsia and irritable bowel syndrome (IBS) are common conditions that can coexist in patients. We performed a systematic review and meta-analysis to estimate prevalence of IBS in dyspepsia.Methods Relevant articles published through August 2008 were identified from MEDLINE and EMBASE literature searches (23,457 citations). Eligible studies included adults recruited from the community, the workplace, blood donation or screening clinics, and family physician offices or internal medicine clinics. Selected studies reported prevalence of dyspepsia and IBS within the same population. The prevalence of IBS in subjects with and without dyspepsia was pooled for all studies and compared. Odds ratios (OR) and confidence intervals (CI) were calculated. The degree of overlap between dyspepsia and IBS was determined.Results Of 239 papers evaluated, 150 reported prevalence of dyspepsia and 19 (involving 18,173 subjects) reported the proportion of subjects with IBS within the same population. The prevalence of dyspepsia was 27% (95% CI, 23%-31%). The prevalence of IBS in subjects with dyspepsia was 37% (95% CI, 30%-45%) compared with 7% (95% CI, 5%-10%) in those without. The pooled OR for IBS in subjects with dyspepsia was 8 (95% CI, 5.74-11.16). The degree of overlap between the 2 conditions varied from 15% to 42%, depending on diagnostic criteria used for each.Conclusions Individuals with dyspepsia have an 8-fold increase in prevalence of IBS compared with the population. The strength of the association suggests common pathogenic mechanisms. Dyspeptic patients should be assessed routinely for IBS.

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Crossref · 10.1016/j.cgh.2009.07.020

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60 of 60 references verified0 citation errors · 0 not checkable

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  • Probably the most common association is the one between IBS and functional dyspepsia.

    “Probably the most common association is the one between IBS and functional dyspepsia (FD).”

    From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]

    The Discussion (page unavailable) reports substantial overlap between IBS and dyspepsia, and the Abstract (page unavailable) explains that many people with dyspepsia have functional dyspepsia. The paper does not compare this association with others or establish it as the most common, and its pooled estimate concerns dyspepsia rather than functional dyspepsia specifically. (LLM, conf=0.86)

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  • A high prevalence of overlap between IBS and functional dyspepsia has been consistently reported in numerous studies.

    “A high prevalence of overlap between these 2 conditions has been consistently reported in numerous studies.”

    From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]

  • People with dyspepsia had an 8-fold increase in the prevalence of IBS.

    “Moreover people with dyspepsia had an 8-fold increase in the prevalence of IBS.”

    From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]

  • In a recent meta-analysis, Ford et al. reported the degree of overlap between IBS and functional dyspepsia to be between 15-42%.

    “In a recent meta-analysis, Ford et al.11 reported the degree of overlap to be between 15-42%.”

    From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]

  • IBS patients have been reported to have lower, rather than higher, thresholds for somatic stimulation.

    “Although IBS patients have been reported to have lower, rather than higher thresholds for somatic stimulation,11,12”

    From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]

    The Discussion mentions visceral hypersensitivity as a possible mechanism shared by IBS and dyspepsia, but does not report thresholds for somatic stimulation. Searches for lower somatic thresholds and somatic pain sensitivity found no passage addressing the claim. Page numbers were not available in our copy. (LLM, conf=0.74)

    Experimental — accuracy not yet measured

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Cites

2 retracted

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2 of the 62 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Drossman DA, Thompson WG, Talley NJ. Identification of sub- groups of functional gastrointestinal disorders. Gastroenterology Intl 1990;3:159 -172.

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Related

Authors
Ford, A. C., Marwaha, A., Lim, A., & Moayyedi, P.
Affiliations
McMaster University (CA)
Corresponding author
Ford, Alexander C.
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2010-05
Volume
8
Issue
5
Pages
401-409
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2009.07.020
OpenAlex
W1968773048
Cited by
195
References
62
Citations by year
2026: 7 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 18 · 2021: 12 · 2020: 18 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 9 · 2015: 14 · 2014: 15 · 2013: 9 · 2012: 16
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords
irritable bowel syndrome, dyspepsia, prevalence, comorbidities, diagnostic criteria, pathophysiological mechanisms, screening
MeSH terms
Dyspepsia, Humans, Comorbidity, Prevalence, Irritable Bowel Syndrome

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