Cited by 130Liver Disease and TransplantationAlcohol Consumption and Health EffectsAbdominal vascular conditions and treatments

Rifaximin Improves Systemic Hemodynamics and Renal Function in Patients With Alcohol-Related Cirrhosis and Ascites

Kalambokis, Georgios N., Mouzaki, Athanasia, Rodi, Maria, Pappas, Konstantinos, Fotopoulos, Andreas, Xourgia, Xanthi, Tsianos, Epameinondas V.·2012·Clinical Gastroenterology and Hepatology

Abstract

Circulating levels of endotoxin, interleukin (IL)-6, and tumor necrosis factor (TNF)-α increase with intestinal bacterial overgrowth and translocation, and are believed to be involved in the pathogenesis of hyperdynamic circulatory syndrome and functional renal failure in patients with advanced cirrhosis. We investigated the effects of the antibiotic rifaximin on systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascites. We measured mean arterial pressure, cardiac output (CO) by Doppler ultrasound, systemic vascular resistance (as the ratio of mean arterial pressure:CO), plasma renin activity, levels of plasma aldosterone, the glomerular filtration rate by plasma clearance of technetium-99m-DTPA, natriuresis, levels of plasma endotoxin, and serum levels of IL-6 and TNF-α in 13 patients at baseline and after 4 weeks of treatment with rifaximin. Rifaximin treatment significantly reduced CO and significantly increased systemic vascular resistance, in association with a significant decrease in plasma rennin activity. The therapy also significantly increased the glomerular filtration rate and natriuresis while reducing levels of endotoxin, IL-6, and TNF-α. Intestinal decontamination with rifaximin improved systemic hemodynamics and renal function in patients with advanced cirrhosis.

Integrity signals

Registry

Crossref · 10.1016/j.cgh.2012.02.025

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Rifaximin appears to reduce spontaneous bacterial peritonitis and may improve portal hypertension, suggesting it effectively targets the gut-liver axis in advanced liver disease.

    “Moreover, rifaximin appears to reduce the development of spontaneous bacterial peritonitis and may improve portal hypertension, suggesting that it effectively targets the gut–liver axis in advanced liver disease93,114,115.”

Cites

Flagged first, then by citations

1 of the 21 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Kalambokis, G. N., Mouzaki, A., Rodi, M., Pappas, K., Fotopoulos, A., Xourgia, X., & Tsianos, E. V.
Affiliations
  • University of Ioannina (GR)
  • University of Patras (GR)
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2012-07
Volume
10
Issue
7
Pages
815-818
ISSN
1542-3565 (ISSN-L)
OpenAlex
W1999133483
Cited by
130
References
21
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 9 · 2021: 14 · 2020: 6 · 2019: 16 · 2018: 11 · 2017: 8 · 2016: 8 · 2015: 15 · 2014: 9 · 2013: 6 · 2012: 2
FWCI
6.47
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
Keywords
rifaximin, alcoholic cirrhosis, ascites, systemic hemodynamics, renal function, glomerular filtration rate, sodium excretion, plasma renin activity, plasma aldosterone, endotoxin, interleukin-6, TNF-α, intestinal bacterial overgrowth, intestinal decontamination, systemic vascular resistance, cardiac output
MeSH terms
Rifaximin, Anti-Bacterial Agents, Ascites, Blood Pressure, Cardiac Output, Endotoxins, Hemodynamics, Humans, Kidney, Kidney Function Tests, Liver Cirrhosis, Alcoholic, Male, Middle Aged, Pilot Projects, Prospective Studies, Renin, Rifamycins, Tumor Necrosis Factor-alpha, Interleukin-6, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review