Endoscopic Duodenal–Jejunal Bypass Liner Rapidly Improves Plasma Parameters of Nonalcoholic Fatty Liver Disease
Open accessAbstract
Bariatric surgery reduces nonalcoholic fatty liver disease (NAFLD). We investigated the effects of duodenal-jejunal bypass liner (DJBL), nonsurgical bariatric device, on plasma parameters of NAFLD. Seventeen obese subjects with type 2 diabetes received the DJBL for 24 weeks. Before, during, and after DJBL implantation, we determined plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltransferase (γ-GT), albumin, caspase-cleaved cytokeratin-18 (CK-18), and liver fatty acid-binding protein (L-FABP). At baseline, subjects had increased levels of AST (35 ± 4 IU/L), ALT (54 ± 5 IU/L), and γ-GT (66 ± 14 IU/L), compared with healthy individuals; subjects' mean concentrations of caspase-cleaved CK-18 and L-FABP were 214.4 ± 35.6 U/L and 29.3 ± 2.6 ng/mL, respectively. Three months after implantation of DJBL, all NAFLD-related parameters had decreased from baseline (AST, 28 ± 3 IU/L; ALT, 32 ± 2 IU/L; γ-GT, 44 ±7 IU/L; caspase-cleaved CK-18, 140.6 ± 16.3U/L; and L-FABP, 18.2 ± 1.5 ng/mL; all P < .05). After 6 months, levels of ALT and γ-GT had further decreased (ALT, 28 ± 2 IU/L and γ-GT, 35 ± 5 IU/L), whereas levels of AST, caspase-cleaved CK-18, and L-FABP had stabilized (P = not significant). Six months after DJBLs were removed, levels of ALT (37 ± 3 IU/L), γ-GT (42 ± 5 IU/L), and caspase-cleaved CK-18 (124.5 ± 12.5U/L) were still reduced (P < .05), whereas AST and L-FABP had returned to near baseline levels (P = not significant). Therefore, in obese subjects, DJBL reduces plasma parameters of NAFLD. ClinicalTrials.gov, Number: NCT00985114.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
EndoBarrier therapy reduces ALT by 48% (54 IU/L to 28 IU/L).
“EndoBarrier therapy followed with a 48% reduction (54 IU/L to 28 IU/L) [96]”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [96]
Cites
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works
The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective
Lazo, M., & Clark, J. M. (2008) · Seminars in Liver Disease · doi:10.1055/s-0028-1091978 · Cited by 737 · see citing works
Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis
Feldstein, A. E., Wieckowska, A., López, R., Liu, Y., Zein, N. N., & McCullough, A. J. (2009) · Hepatology · doi:10.1002/hep.23050 · Cited by 711 · see citing works
Wieckowska, A., Zein, N. N., Yerian, L. M., López, R., McCullough, A. J., & Feldstein, A. E. (2006) · Hepatology · doi:10.1002/hep.21223 · Cited by 668 · see citing works
Mathurin, P., Hollebecque, A., Arnalsteen, L., Buob, D., Leteurtre, E., Caiazzo, R. J., Pigeyre, M., Verkindt, H., Dharancy, S., Louvet, A., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.052 · Cited by 483 · see citing works
Clinical, Laboratory and Histological Associations in Adults with Nonalcoholic Fatty Liver Disease†
Neuschwander‐Tetri, B. A., Clark, J. M., Bass, N. M., Natta, M. L. V., Ünalp–Arida, A., Tonascia, J. A., Zein, C. O., Brunt, E. M., Kleiner, D. E., McCullough, A. J., et al. (2010) · Hepatology · doi:10.1002/hep.23784 · Cited by 463 · see citing works
Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis
Wieckowska, A., McCullough, A. J., & Feldstein, A. E. (2007) · Hepatology · doi:10.1002/hep.21768 · Cited by 422 · see citing works
Krill for human consumption: Nutritional value and potential health benefits
Tou, J. C., Jaczynski, J., & Chen, Y.-C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00283.x · Cited by 349 · see citing works
Mattar, S. G., Velcu, L. M., Rabinovitz, M., Demetris, A. J., Krasinskas, A. M., Barinas‐Mitchell, E., Eid, G. M., Ramanathan, R. C., Taylor, D. S., & Schauer, P. R. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000179652.07502.3f · Cited by 341 · see citing works
Non-alcoholic fatty liver disease
Smith, B. W., & Adams, L. A. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.596521 · Cited by 288 · see citing works
Schouten, R., Rijs, C. S., Bouvy, N. D., Hameeteman, W. M., Koek, G. H., Janssen, I. M. C., & Greve, J.-W. M. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181bdfbff · Cited by 279 · see citing works
Self-citationNon-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers
Shen, J., Chan, H. L., Wong, G. L., Choi, P. C., Chan, A. W. H., Chan, H., Chim, A. M., Yeung, D. K., Chan, F. K. L., Woo, J., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.025 · Cited by 247 · see citing works
Obesity and Nonalcoholic Fatty Liver Disease
Angulo, P. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00329.x · Cited by 223 · see citing works
Dixon, J., Bhathal, P., & O'Brien, P. (2006) · Obesity Surgery · doi:10.1381/096089206778663805 · Cited by 212 · see citing works
Obesity and Nonalcoholic Fatty Liver Disease
Angulo, P. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.jun.s57-s63 · Cited by 198 · see citing works
Diab, D. L., Yerian, L. M., Schauer, P. R., Kashyap, S. R., López, R., Hazen, S. L., & Feldstein, A. E. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.07.016 · Cited by 168 · see citing works
Endoscopic Duodenal–Jejunal Bypass Liner Rapidly Improves Type 2 Diabetes
de Jonge, C., Rensen, S. S., Verdam, F. J., Vincent, R. P., Bloom, S. R., Buurman, W. A., le Roux, C. W., Schaper, N. C., Bouvy, N. D., & Greve, J. W. M. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0921-3 · Cited by 148 · see citing works
Self-citationEscalona, A., Pimentel, F., Sharp, A. C., Becerra, P., M, M. S., Turiel, D., Muñoz, R., Claudia Bambs, S., Guzmán, S., Ibañez, L. A., et al. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31825498c4 · Cited by 112 · see citing works
Perceived barriers to bariatric surgery among morbidly obese patients
Afonso, B. B., Rosenthal, R. J., Li, K. M., Zapatier, J., & Szomstein, S. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.07.006 · Cited by 82 · see citing works
Pelsers, M. M. A. L., Morovat, A., Alexander, G., Hermens, W. T., Trull, A. K., & Glatz, J. F. C. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.11.2055 · Cited by 81 · see citing works
The Impact of Bariatric Surgery on Nonalcoholic Steatohepatitis
Rabl, C., & Campos, G. M. (2012) · Seminars in liver disease (Print) · doi:10.1055/s-0032-1306428 · Cited by 72 · see citing works
Effects of Weight Loss Surgeries on Liver Disease
Blackburn, G. L., & Mun, E. C. (2004) · Seminars in Liver Disease · doi:10.1055/s-2004-860866 · Cited by 38 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674 · see citing works
Evolution of NAFLD and Its Management
Mundi, M. S., Velapati, S. R., Patel, J. R., Kellogg, T. A., Dayyeh, B. K. A., & Hurt, R. T. (2019) · Nutrition in Clinical Practice · doi:10.1002/ncp.10449 · Cited by 289 · see citing works
Bower, G., Toma, T., Harling, L., Jiao, L. R., Efthimiou, E., Darzi, A. W., Athanasiou, T., & Ashrafian, H. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1691-x · Cited by 255 · see citing works
Endoscopic bariatric therapies
Dayyeh, B. K. A., Edmundowicz, S. A., Jonnalagadda, S. S., Kumar, N., Larsen, M. C., Sullivan, S. A., Thompson, C. C., & Banerjee, S. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2015.02.023 · Cited by 159 · see citing works
Recent advances in clinical practice challenges and opportunities in the management of obesity
Acosta, A., Abu Dayyeh, B. K., Port, J. D., & Camilleri, M. (2014) · Gut · doi:10.1136/gutjnl-2013-306235 · Cited by 91 · see citing works
Adverse Events of the Duodenal-Jejunal Bypass Liner: a Systematic Review
Betzel, B., Drenth, J. P. H., & Siersema, P. D. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3441-3 · Cited by 53 · see citing works
Betzel, B., Homan, J., Aarts, E. O., Janssen, I. M. C., de Boer, H., Wahab, P. J., Groenen, M. J. M., & Berends, F. J. (2016) · Surgical Endoscopy · doi:10.1007/s00464-016-5299-6 · Cited by 48 · see citing works
Popov, V., & Lim, J. K. (2015) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2015.00019 · Cited by 46 · see citing works
Effect of intragastric balloons on liver enzymes: A systematic review and meta-analysis
Popov, V. B., Thompson, C. C., Kumar, N., Ciarleglio, M. M., Deng, Y., & Laine, L. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4178-2 · Cited by 43 · see citing works
Endocrine effects of duodenal–jejunal exclusion in obese patients with type 2 diabetes mellitus
Kaválková, P., Mráz, M., Trachta, P., Kloučková, J., Cinkajzlová, A., Lacinová, Z., Haluzíková, D., Beneš, M., Vlasáková, Z., Burda, V., et al. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0206 · Cited by 41 · see citing works
Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis
Corey, K. E., & Rinella, M. E. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4083-8 · Cited by 40 · see citing works
Endoscopic bariatric and metabolic therapies for non-alcoholic fatty liver disease
Dayyeh, B. K. A., Bazerbachi, F., Graupera, I., & Cárdenas, A. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.07.026 · Cited by 33 · see citing works
Current Treatment of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Hung, C. K., & Bodenheimer, H. C. (2017) · Clinics in Liver Disease · doi:10.1016/j.cld.2017.08.012 · Cited by 30 · see citing works
Bariatric surgery and nonalcoholic fatty liver disease
Bower, G., Athanasiou, T., Isla, A., Harling, L., Li, J. V., Holmes, E. C., Efthimiou, E., Darzi, A. W., & Ashrafian, H. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000375 · Cited by 26 · see citing works
Han, H., Hu, C.-X., Wang, L., Zhang, G., Liu, S., Li, F., Sun, D., & Hu, S. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1308-9 · Cited by 25 · see citing works
Ren, M., Zhou, X., Zhang, Y., Mo, F., Yang, J., Yu, M., & Ji, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.931519 · Cited by 21 · see citing works
Goh, Y. M., Toumi, Z., & Date, R. S. (2016) · Surgical Endoscopy · doi:10.1007/s00464-016-4952-4 · Cited by 19 · see citing works
Bariatric and Metabolic Endoscopy: A New Paradigm
Telese, A., Sehgal, V., Magee, C. G., Naik, S., Alqahtani, S. A., Lovat, L. B., & Haidry, R. J. (2021) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000364 · Cited by 19 · see citing works
Ren, M., Zhou, X., Yu, M., Cao, Y., Xu, C., Yu, C., & Ji, F. (2023) · Digestive Endoscopy · doi:10.1111/den.14409 · Cited by 17 · see citing works
Howell, J. A., Balderson, G. A., Hellard, M. E., Gow, P. J., Strasser, S. I., Stuart, K. A., Wigg, A. J., Jeffrey, G. P., Gane, E. J., & Angus, P. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13082 · Cited by 17 · see citing works
Tasabehji, D., Saleh, S., & Mokadem, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124012 · Cited by 14 · see citing works
Ren, M., Zhou, X., Lv, L., & Ji, F. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00448 · Cited by 12 · see citing works
Lim, W. H., Lin, S. Y., Ng, C. H., Tan, D. J. H., Xiao, J., Yong, J. N., Tay, P. W. L., Syn, N. L. X., Chin, Y. H., Chan, K. E., et al. (2022) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn-21-520 · Cited by 9 · see citing works
Emini, M., Bhargava, R., Aldhwayan, M. M., Chhina, N., Flores, M. R., Aldubaikhi, G., Lababidi, M. A., Al-Najim, W., Miras, A. D., Ruban, A., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae214 · Cited by 4 · see citing works
Riedel, N., Laubner, K., Lautenbach, A., Schön, G., Schlensak, M., Stengel, R., Eberl, T., Dederichs, F., Aberle, J., & Seufert, J. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3144-9 · Cited by 9 · see citing works
Yu, H.-H., Hsieh, M.-C., Wu, S.-Y., Sy, E. D., & Shan, Y.-S. (2019) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s190631 · Cited by 9 · see citing works
Hollenbach, M., Prettin, C., Gundling, F., Schepp, W., Seufert, J., Stein, J. M., Rösch, T., Aberle, J., Feisthammel, J., Petroff, D., et al. (2018) · BMC Gastroenterology · doi:10.1186/s12876-018-0838-3 · Cited by 8 · see citing works
You, H., Wen, X., Zhu, C., Chen, M., Dong, L., Zhu, Y., Liu, Y., Bu, L., Zhang, M., Zhou, D., et al. (2020) · Obesity Surgery · doi:10.1007/s11695-019-04307-3 · Cited by 8 · see citing works
Primary endoscopic therapies for obesity and metabolic diseases
Kumbhari, V., Oberbach, A., & Nimgaonkar, A. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000203 · Cited by 7 · see citing works
Cytokeratin 18 in nonalcoholic fatty liver disease: value and application
Wu, Y. S., Zhou, J., Zhang, J., & Li, H. (2024) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2024.2413941 · Cited by 8 · see citing works
Ren, M., Yi, X., Pan, H., Zhou, X., Yu, M., & Ji, F. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000615 · Cited by 6 · see citing works
You, H., Ma, H., Wang, X., Wen, X., Zhu, C., Mao, W., Bu, L., Zhang, M., Yin, J., Du, L., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.993137 · Cited by 6 · see citing works
Soares, G. M., Cantelli, K. R., Balbo, S., Ribeiro, R. A., Alegre-Maller, A. C. P., Barbosa-Sampaio, H., Boschero, A., Araújo, A. C. F., & Bonfleur, M. L. (2017) · Life Science · doi:10.1016/j.lfs.2017.08.035 · Cited by 6 · see citing works
Role of bariatric surgery in treatment of non-alcoholic fatty liver disease
Kermansaravi, M., Ebrahimian, M., Delbari, D., Khamoushi, S., & Kabir, A. (2017) · Journal of Contemporary Medical Sciences · doi:10.22317/jcms.12201701 · Cited by 3 · see citing works
MCMASTER, J. J., Rich, G. G., Shanahan, E. R., Do, A., Fletcher, L. M., Kutyla, M. J., Tallis, C. J., Jones, M. P., Talley, N. J., Macdonald, G. A., et al. (2020) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001353 · Cited by 3 · see citing works
Novel Endoscopic Bariatric Therapies for the Management of Nonalcoholic Steatohepatitis
Gala, K. S., Razzak, F. A., Rapaka, B., & Dayyeh, B. K. A. (2022) · Seminars in Liver Disease · doi:10.1055/a-1946-6285 · Cited by 2 · see citing works
Ghusn, W., Sridharan, M., Fromer, R., Ozdemir, M., Haff, M. G., & Vargas, E. J. (2025) · Biomedicines · doi:10.3390/biomedicines13102437 · Cited by 2 · see citing works
Small Bowel Target Devices and Techniques
Edmundowicz, S. A. (2017) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2017.01.001 · Cited by 2 · see citing works
Weber, C. E., Marcotte, E. R., & Chand, B. (2016) · Techniques in Gastrointestinal Endoscopy · doi:10.1016/j.tgie.2016.11.005
Various treatment modalities of nafld: a systematic review
Pratap, V. B., Amarthaluri, S., & Patil, R. (2023) · International Journal of Alternative and Complementary Medicine · doi:10.46797/ijacm.v4i2.497
Peche, A. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21672-5.00020-2
Endo-hepatology: Bridging the gap between lumen and liver
Abdelhamed, W., & El-Kassas, M. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i46.113145
Juárez-Hernández, E., Bautista-Mondragón, C. A., López-Pérez-Alférez, A., Castro‐Narro, G., & López-Méndez, I. (2026) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2026.102153
- Authors
- de Jonge, C., Rensen, S. S., Koek, G. H., Joosten, M. F., Buurman, W. A., Bouvy, N. D., & Greve, J. W. M.
- Affiliations
- Maastricht University Medical Centre (NL)
- Atrium Medisch Centrum Parkstad (NL)
- Corresponding author
- Greve, Jan Willem M.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 11
- Issue
- 11
- Pages
- 1517-1520
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W1997991426
- Cited by
- 43
- References
- 22
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 2
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (acceptedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Keywords
- duodenal-jejunal bypass liner, non-alcoholic fatty liver disease, obesity, type 2 diabetes, liver enzymes, caspase-cleaved cytokeratin 18, liver fatty acid binding protein, liver fibrosis, hepatic steatosis, plasma biomarkers, device removal, weight loss, endoscopic bariatric therapy
- MeSH terms
- Adolescent, Adult, Aged, Anastomosis, Surgical, Fatty Liver, Female, Humans, Liver Function Tests, Male, Middle Aged, Plasma, Treatment Outcome, Bariatric Surgery, Young Adult, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
