Recent advances in clinical practice challenges and opportunities in the management of obesity
Open accessAbstract
Despite advances in understanding the roles of adiposity, food intake, GI and adipocyte-related hormones, inflammatory mediators, the gut–brain axis and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low-cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the GI tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasise non-surgical approaches through lifestyle modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyses current central, peripheral or hormonal targets to treat obesity and addresses challenges and opportunities to develop novel approaches for obesity.
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Lifestyle intervention alone typically produces about 5% to 7% weight loss, which is gradually regained and leaves many poor responders.
“Lifestyle intervention alone is generally associated with moderate weight loss of around 5–7% that is gradually regained and yields a great proportion of poor responders [24].”
From Efficacy of GLP-1 RA Approved for Weight Management in Patients With or Without Diabetes: A Narrative Review (2022) · cites this paper as [24]
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Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,452 · see citing works
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
The Look AHEAD Research Group (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212914 · Cited by 2,908 · see citing works
(1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.4.899 · Cited by 2,705 · see citing works
Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
Cummings, D., Weigle, D., Frayo, R. S., Breen, P. A., Ma, M. K., Dellinger, E., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,499 · see citing works
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351 · see citing works
Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
Schauer, P. R., Kashyap, S. R., Wolski, K., Brethauer, S. A., Kirwan, J. P., Pothier, C. E., Thomas, S., Abood, B., Nissen, S. E., & Bhatt, D. L. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200225 · Cited by 2,164 · see citing works
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works
Sjöström, L. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12012 · Cited by 1,835 · see citing works
Metabolic/Bariatric Surgery Worldwide 2011
Buchwald, H., & Oien, D. M. (2013) · Obesity Surgery · doi:10.1007/s11695-012-0864-0 · Cited by 1,698 · see citing works
Inhibition of Food Intake in Obese Subjects by Peptide YY <sub>3–36</sub>
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604 · see citing works
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
The Look AHEAD Research Group (2007) · Diabetes Care · doi:10.2337/dc07-0048 · Cited by 1,522 · see citing works
Long-term persistence of hormonal adaptations to weight loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., & Proietto, J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105816 · Cited by 1,449 · see citing works
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
Flint, A., Raben, A., Astrup, A., & Holst, J. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci990 · Cited by 1,402 · see citing works
Long-term weight-loss maintenance: a meta-analysis of US studies
Anderson, J. W., Konz, E. C., Frederich, R. C., & Wood, C. L. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.5.579 · Cited by 1,351 · see citing works
Gastrointestinal regulation of food intake
Cummings, D. E., & Overduin, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30227 · Cited by 1,216 · see citing works
Nichols, D. E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.002 · Cited by 1,211 · see citing works
Astrup, A., Rössner, S., Van Gaal, L., Rissanen, A., Niskanen, L., Al Hakim, M., Madsen, J., Rasmussen, M. F., & Lean, M. E. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61375-1 · Cited by 1,163 · see citing works
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157 · see citing works
Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity
Liou, A. P., Paziuk, M., Luevano, J.-M., Machineni, S., Turnbaugh, P. J., & Kaplan, L. M. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005687 · Cited by 1,007 · see citing works
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 1× · see citing works
“73 74 These peptides exert their effects through interaction with the afferent vagal and spinal nerve fi bres innervating the gut, or by entering the blood stream to function as hormones, in fl uencing the area postrema or hypothalamic areas through the locally permeable BBB. GLP-1 is the major known…”
BackgroundRubino, F., Forgione, A., Cummings, D. E., Vix, M., Gnuli, D., Mingrone, G., Castagneto, M., & Marescaux, J. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000224726.61448.1b · Cited by 928 · see citing works
Multicenter, placebo-controlled trial of lorcaserin for weight management.
Smith, S. R., Weissman, N. J., Anderson, C. M., Sanchez, M., Chuang, E., Stubbe, S., Bays, H., & Shanahan, W. R. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909809 · Cited by 911 · see citing works
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
Toft-Nielsen, M.-B., Damholt, M. B., Madsbad, S., Hilsted, L. M., Hughes, T. E., Michelsen, B. K., & Holst, J. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7750 · Cited by 869 · see citing works
Metabolic/bariatric surgery worldwide 2008
Buchwald, H., & Oien, D. M. (2009) · Obesity Surgery · doi:10.1007/s11695-009-0014-5 · Cited by 826 · see citing works
Bariatric Surgery Worldwide 2003
Buchwald, H., & Williams, S. E. (2004) · Obesity Surgery · doi:10.1381/0960892042387057 · Cited by 731 · see citing works
Allison, D. B., Gadde, K. M., Garvey, W. T., Peterson, C. A., Schwiers, M. L., Najarian, T., Tam, P. Y., Troupin, B., & Day, W. W. (2012) · Obesity · doi:10.1038/oby.2011.330 · Cited by 711 · see citing works
Neuroendocrine control of food intake
Valassi, E., Scacchi, M., & Cavagnini, F. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.06.004 · Cited by 649 · see citing works
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
Cone, R. D., Cowley, M. A., Butler, A. A., Fan, W., Dl, M., & Low, M. J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801913 · Cited by 591 · see citing works
Peterli, R., Wölnerhanssen, B. K., Peters, T. T. A., Devaux, N., Kern, B. E., Christoffel-Courtin, C., Drewe, J., von Flüe, M., & Beglinger, C. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181ae32e3 · Cited by 559 · see citing works
Laferrère, B., Heshka, S., Wang, K., Khan, Y., McGinty, J., Teixeira, J., Hart, A. B., & Olivan, B. (2007) · Diabetes Care · doi:10.2337/dc06-1549 · Cited by 532 · see citing works
Metabolic surgery profoundly influences gut microbial–host metabolic cross-talk
Li, J. V., Ashrafian, H., Bueter, M., Kinross, J. K., Sands, C. J., le Roux, C. W., Bloom, S. R., Darzi, A. W., Athanasiou, T., Marchesi, J. R., et al. (2011) · Gut · doi:10.1136/gut.2010.234708 · Cited by 444 · see citing works
Hormonal and Metabolic Mechanisms of Diabetes Remission after Gastrointestinal Surgery
Thaler, J. P., & Cummings, D. E. (2009) · Endocrinology · doi:10.1210/en.2009-0367 · Cited by 443 · see citing works
Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine
Fitzgerald, L. W., Burn, T. C., Brown, B. S., Patterson, J. P., Corjay, M. H., Valentine, P. A., Sun, J., Link, J. R., Abbaszade, I. G., Hollis, J. M., et al. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26444-0 · Cited by 440 · see citing works
Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus
Lee, W. (2011) · Archives of Surgery · doi:10.1001/archsurg.2010.326 · Cited by 436 · see citing works
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
Launay, J., Hervé, P., Peoc’h, K., Tournois, C., Callebert, J., Nebigil, C. G., Étienne-Selloum, N., Drouet, L. O., Humbert, M. J. C., Simonneau, G., et al. (2002) · Nature Medicine · doi:10.1038/nm764 · Cited by 433 · see citing works
Muscelli, E., Mari, A., Casolaro, A., Camastra, S., Seghieri, G., Gastaldelli, A., Holst, J. J., & Ferrannini, E. (2008) · Diabetes · doi:10.2337/db07-1315 · Cited by 409 · see citing works
Thomsen, W. J., Grottick, A. J., Menzaghi, F., Saldana, H. R., Espitia, S. A., Yuskin, D., Whelan, K. T., Martin, M. W., Morgan, M. E., Chen, W., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.133348 · Cited by 403 · see citing works
Ørskov, C., Holst, J. J., & Nielsen, O. V. (1988) · Endocrinology · doi:10.1210/endo-123-4-2009 · Cited by 400 · see citing works
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP
Theodorakis, M. J., Carlson, O. D., Michopoulos, S., Doyle, M. E., Juhaszova, M., Petraki, K., & Egan, J. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00326.2004 · Cited by 391 · see citing works
Page, K. A., Chan, O., Arora, J., Belfort-DeAguiar, R., Dzuira, J., Roehmholdt, B., Cline, G. W., Naik, S., Sinha, R., Constable, R. T., et al. (2013) · JAMA · doi:10.1001/jama.2012.116975 · Cited by 379 · see citing works
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
Ste. Marie, L., Miura, G. I., Marsh, D. J., Yagaloff, K., & Palmiter, R. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220409497 · Cited by 366 · see citing works
Korner, J., Bessler, M., Inabnet, W., Taveras, C., & Holst, J. J. (2007) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2007.08.004 · Cited by 344 · see citing works
Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes
Lenard, N. R., & Berthoud, H. (2008) · Obesity · doi:10.1038/oby.2008.511 · Cited by 338 · see citing works
The vagus nerve, food intake and obesity
Berthoud, H.-R. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2007.08.024 · Cited by 316 · see citing works
Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production
Wang, P. Y. T., Caspi, L., Lam, C., Chari, M., Li, X., Light, P. E., Juárez, R. G., Ang, M. L. T., Schwartz, G. J., & Lam, T. K. T. (2008) · Nature · doi:10.1038/nature06852 · Cited by 293 · see citing works
Relation of obesity to consummatory and anticipatory food reward
Stice, E. M., Spoor, S. T. P., Ng, J., & Zald, D. H. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.020 · Cited by 289 · see citing works
Neuropeptides, food intake and body weight regulation: a hypothalamic focus
Hillebrand, J. J., de Wied, D., & Adan, R. A. H. (2002) · Peptides · doi:10.1016/s0196-9781(02)00269-3 · Cited by 286 · see citing works
Wilson, H., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D. A., Drucker, D. J., Pérez–Tilve, D., & Seeley, R. J. (2013) · Diabetes · doi:10.2337/db12-1498 · Cited by 286 · see citing works
Dayyeh, B. K. A., Rajan, E., & Gostout, C. J. (2013) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2013.04.197 · Cited by 282 · see citing works
Schouten, R., Rijs, C. S., Bouvy, N. D., Hameeteman, W. M., Koek, G. H., Janssen, I. M. C., & Greve, J.-W. M. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181bdfbff · Cited by 279 · see citing works
Gastric volume rather than nutrient content inhibits food intake
Phillips, R. J., & Powley, T. L. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.3.r766 · Cited by 269 · see citing works
Hileman, S. M., Pierroz, D. D., Masuzaki, H., Bjørbæk, C., El-Haschimi, K., Banks, W. A., & Flier, J. S. (2002) · Endocrinology · doi:10.1210/endo.143.3.8669 · Cited by 267 · see citing works
Yousseif, A., Emmanuel, J. J., Karra, E., Millet, Q., Elkalaawy, M., Jenkinson, A. D., Hashemi, M., Adamo, M., Finer, N., Fiennes, A., et al. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1066-0 · Cited by 260 · see citing works
The importance of the gut microbiota after bariatric surgery
Aron‐Wisnewsky, J., Dore, J. M., & Clément, K. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.161 · Cited by 259 · see citing works
Sleeve gastrectomy and type 2 diabetes mellitus: a systematic review
Gill, R. S., Birch, D. W., Shi, X., Sharma, A. M., & Karmali, S. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.07.011 · Cited by 256 · see citing works
Selective Reduction in Neural Responses to High Calorie Foods Following Gastric Bypass Surgery
Ochner, C. N., Kwok, Y., Conceição, E., Pantazatos, S. P., Puma, L. M., Carnell, S., Teixeira, J. A., Joy Hirsch, C., & Geliebter, A. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e318203a289 · Cited by 249 · see citing works
The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction
Dileone, R., Taylor, J. R., & Picciotto, M. R. (2012) · Nature Neuroscience · doi:10.1038/nn.3202 · Cited by 244 · see citing works
MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin
Delhanty, P. J. D., Neggers, S. J. C. M. M., & van der Lely, A. J. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0456 · Cited by 237 · see citing works
The direct and indirect controls of meal size
Smith, G. P. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00038-g · Cited by 234 · see citing works
Stefater, M. A., Pérez–Tilve, D., Chambers, A. P., Wilson, H., Sandoval, D. A., Berger, J., Toure, M. H., Tschöp, M. H., Woods, S. C., & Seeley, R. J. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.02.059 · Cited by 222 · see citing works
Sohn, J., Xu, Y., Jones, J. E., Wickman, K., Williams, K. W., & Elmquist, J. K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.012 · Cited by 196 · see citing works
Distributed Neural Control of Energy Balance: Contributions from Hindbrain and Hypothalamus
Grill, H. J. (2006) · Obesity · doi:10.1038/oby.2006.312 · Cited by 192 · see citing works
Nightingale, J. M., Kamm, M. A., van der Sijp, J. R., Ghatei, M. A., Bloom, S. R., & Lennard‐Jones, J. E. (1996) · Gut · doi:10.1136/gut.39.2.267 · Cited by 188 · see citing works
Roux‐en‐Y Gastric Bypass Enhances Energy Expenditure and Extends Lifespan in Diet‐induced Obese Rats
Stylopoulos, N., Hoppin, A. G., & Kaplan, L. M. (2009) · Obesity · doi:10.1038/oby.2009.207 · Cited by 187 · see citing works
Peripheral administration of PYY3–36 produces conditioned taste aversion in mice
Halatchev, I. G., & Cone, R. D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.003 · Cited by 186 · see citing works
Williams, D. L., Kaplan, J. M., & Grill, H. J. (2000) · Endocrinology · doi:10.1210/endo.141.4.7410 · Cited by 182 · see citing works
Gersin, K. S., Rothstein, R. I., Rosenthal, R. J., Stefanidis, D., Deal, S. E., Kuwada, T. S., Laycock, W. S., Adrales, G. L., Vassiliou, M., Szomstein, S., et al. (2010) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2009.11.051 · Cited by 177 · see citing works
Effects of Peptide YY and Neuropeptide Y on Gastric Emptying in Man
Allen, J. M., Fitzpatrick, M. L., Yeats, J. C., Darcy, K., Adrian, T. E., & Bloom, S. R. (2009) · Digestion · doi:10.1159/000199117 · Cited by 168 · see citing works
Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults
Gantz, I., Erondu, N., Mallick, M., Musser, B., Krishna, R., Tanaka, W. K., Snyder, K., Stevens, C., Stroh, M. A., Zhu, H., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1806 · Cited by 163 · see citing works
Camilleri, M., Toouli, J., Herrera, M. F., Kulseng, B. E., Kow, L., Pantoja, J. P., Mårvik, R., Johnsen, G., Billington, C. J., Moody, F. G., et al. (2008) · Surgery · doi:10.1016/j.surg.2008.03.015 · Cited by 159 · see citing works
Self-citationEffects of Bariatric Surgery on Glucose Homeostasis and Type 2 Diabetes
Bradley, D. P., Magkos, F., & Klein, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.114 · Cited by 153 · see citing works
Endoscopic Duodenal–Jejunal Bypass Liner Rapidly Improves Type 2 Diabetes
de Jonge, C., Rensen, S. S., Verdam, F. J., Vincent, R. P., Bloom, S. R., Buurman, W. A., le Roux, C. W., Schaper, N. C., Bouvy, N. D., & Greve, J. W. M. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0921-3 · Cited by 148 · see citing works
Scolapio, J. S. (2010) · Yearbook of Gastroenterology · doi:10.1016/s0739-5930(10)79499-x · Cited by 146 · see citing works
Fundus Functionality and Ghrelin Concentrations after Bariatric Surgery
Frühbeck, G., Caballero, A. D., & Gil, M. J. (2004) · New England Journal of Medicine · doi:10.1056/nejm200401153500323 · Cited by 140 · see citing works
Shah, M., Law, J. H., Micheletto, F., Sathananthan, M., Man, C. D., Cobelli, C., Rizza, R. A., Camilleri, M., Zinsmeister, A. R., & Vella, A. V. (2013) · Diabetes · doi:10.2337/db13-0954 · Cited by 134 · see citing works
Self-citationCummings, B. P., Strader, A. D., Stanhope, K. L., Graham, J. L., Lee, J., Raybould, H. E., Baskin, D. G., & Havel, P. J. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.005 · Cited by 104 · see citing works
The blood-brain barrier: connecting the gut and the brain
Banks, W. A. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2007.08.027 · Cited by 104 · see citing works
Geloneze, B., Geloneze, S. R., Fiori, C., Stabe, C. F. C., Tambascia, M. A., Chaim, É. A., Astiarraga, B., & Pareja, J. C. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9844-4 · Cited by 102 · see citing works
Glucagon-like peptides 1 and 2 in health and disease: A review
Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2013) · Peptides · doi:10.1016/j.peptides.2013.01.014 · Cited by 100 · see citing works
Fry, M., Hoyda, T. D., & Ferguson, A. V. (2007) · PubMed · Cited by 93 · see citing works
Electrical activity‐triggered glucagon‐like peptide‐1 secretion from primary murine L‐cells
Rogers, G. J., Tolhurst, G., Ramzan, A., Habib, A. M., Parker, H. E., Gribble, F. M., & Reimann, F. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.198069 · Cited by 86 · see citing works
Gut–Brain Axis: Regulation of Glucose Metabolism
Heijboer, A. C., Pijl, H., van den Hoek, A. M., Havekes, L. M., Romijn, J. A., & Corssmit, E. P. M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01492.x · Cited by 86 · see citing works
Strader, A. D., Clausen, T. R., Goodin, S., & Wendt, D. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9754-x · Cited by 86 · see citing works
Hypothalamic melanocortin neurons integrate signals of energy state
Cowley, M. A. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.087 · Cited by 85 · see citing works
Nestoridi, E., Kvas, S., Kucharczyk, J. R., & Stylopoulos, N. (2012) · Endocrinology · doi:10.1210/en.2011-2041 · Cited by 85 · see citing works
Browning, K. N., Fortna, S. R., & Hajnal, A. S. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.249268 · Cited by 84 · see citing works
Zechner, J. F., Mirshahi, U. L., Satapati, S., Berglund, E. D., Rossi, J., Scott, M. M., Still, C. D., Gerhard, G. S., Burgess, S. C., Mirshahi, T., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.11.022 · Cited by 84 · see citing works
Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypass
Romanova, I. V., Ramos, E. J. B., Xu, Y., Quinn, R., Chen, C., George, Z. M., Inui, A., Das, U. N., & Meguid, M. M. (2004) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2004.07.013 · Cited by 76 · see citing works
Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man
Witte, A.-B., Grybäck, P., Holst, J. J., Hilsted, L., Hellström, P. M., Jacobsson, H., & Schmidt, P. T. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.07.013 · Cited by 72 · see citing works
Is there evidence for a set point that regulates human body weight?
Müller, M. J., Bosy‐Westphal, A., & Heymsfield, S. B. (2010) · F1000 Medicine Reports · doi:10.3410/m2-59 · Cited by 72 · see citing works
Klein, S., Fabbrini, E., Patterson, B. W., Polonsky, K. S., Schiavon, C. A., Correa, J. L., Salles, J. E. N., WAJCHENBERG, B. L., & COHEN, R. V. (2012) · Obesity · doi:10.1038/oby.2011.377 · Cited by 69 · see citing works
Azzara, A. V., Sokolnicki, J. P., & Schwartz, G. J. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00883-1 · Cited by 62 · see citing works
Page, K. A., Arora, J., Qiu, M., Relwani, R., Constable, R. T., & Sherwin, R. S. (2008) · Diabetes · doi:10.2337/db08-1224 · Cited by 62 · see citing works
A Pilot Study of the Duodenal-Jejunal Bypass Liner in Low Body Mass Index Type 2 Diabetes
COHEN, R. V., Neto, M. G., Correa, J. L., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2814 · Cited by 57 · see citing works
Effects of the biliopancreatic diversion on energy balance in the rat
Nadreau, É., Baraboi, E. D., Samson, P., Blouin, A., Hould, F.-S., Marceau, P., Biron, S., & Richard, D. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803166 · Cited by 56 · see citing works
Ileal interposition improves glucose tolerance and insulin sensitivity in the obese Zucker rat
Culnan, D. M., Albaugh, V. L., Sun, M., Lynch, C. J., Lang, C. H., & Cooney, R. N. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00525.2009 · Cited by 55 · see citing works
Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia
Habegger, K. M., Al–Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C., Gao, Y., Lehti, M., Ottaway, N., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-304583 · Cited by 54 · see citing works
Regulation of food intake by gastrointestinal hormones
Baynes, K., Dhillo, W. S., & Bloom, S. R. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000245537.43142.63 · Cited by 52 · see citing works
Appetite Suppressants and Valvular Heart Disease
Devereux, R. B. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809103391109 · Cited by 52 · see citing works
Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes
COHEN, R. V., le Roux, C. W., Papamargaritis, D., Salles, J. E. N., Petry, T. B. Z., Correa, J. L., Pournaras, D. J., Neto, M. G., Martins, B. D. C., Sakai, P., et al. (2013) · Diabetic Medicine · doi:10.1111/dme.12268 · Cited by 49 · see citing works
Gut Hormones: A Weight Off Your Mind
Gardiner, J., Jayasena, C. N., & Bloom, S. R. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01729.x · Cited by 49 · see citing works
Silk, D. B. A., Webb, J. P. W., Lane, A., et al. (1974) · Gut · doi:10.1136/gut.15.6.444 · Cited by 45 · see citing works
de Jonge, C., Rensen, S. S., Koek, G. H., Joosten, M. F., Buurman, W. A., Bouvy, N. D., & Greve, J. W. M. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.029 · Cited by 43 · see citing works
Shah, P. S., Todkar, J. S., & Shah, S. S. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.06.007 · Cited by 43 · see citing works
Li, P., Fu, P., Chen, J., Wang, L., & Wang, D. (2012) · Hepatogastroenterology · doi:10.5754/hge12510 · Cited by 31 · see citing works
Lighting up the hypothalamus: coordinated control of feeding behavior
Williams, K. W., & Elmquist, J. K. (2011) · Nature Neuroscience · doi:10.1038/nn0311-277 · Cited by 28 · see citing works
Paulsen, S. J., Larsen, L. K., Jelsing, J., Janßen, U., Gerstmayer, B., & Vrang, N. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.09.024 · Cited by 21 · see citing works
Obesity surgery: happy with less or eternally hungry?
Shin, A. C., & Berthoud, H. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.009 · Cited by 19 · see citing works
Obesity and bariatrics for the endoscopist: new techniques
Dayyeh, B. K. A., & Thompson, C. C. (2011) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x11398737 · Cited by 18 · see citing works
Metabolic and Neuroendocrine Consequences of a Duodenal-Jejunal Bypass in Rats on a Choice Diet
Warne, J. P., Padilla, B. E., Horneman, H. F., Ginsberg, A. B., Pecoraro, N. C., Akana, S. F., & Dallman, M. F. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181961d5d · Cited by 11 · see citing works
État de l’art sur le Marquage de Spin Artériel ou ASL
Monet, P., Franc, J., Brasseur, A., et al. (2009) · Journal de Radiologie · doi:10.1016/s0221-0363(09)73242-1 · Cited by 11 · see citing works
Abe, T., Ohashi, T., & Tamai, M. (1998) · Ophthalmic Research · doi:10.1159/000055482 · Cited by 9 · see citing works
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Semaglutide 2.4 mg for the treatment of obesity: key elements of the STEP trials 1 to 5
Kushner, R. F., Calanna, S., Davies, M., Dicker, D., Garvey, W. T., Goldman, B., Lingvay, I., Thomsen, M., Wadden, T. A., Wharton, S., et al. (2020) · Obesity · doi:10.1002/oby.22794 · Cited by 288 · see citing works
“Thus, there is a necessity for developing more effective novel treatment approaches that address these central nervous system processes (2,9,10).”
BackgroundInfluentialJensterle, M., Rizzo, M., Haluzík, M., & Janež, A. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02153-x · Cited by 215 · see citing works
<scp>GLP</scp> ‐1 receptor agonists: Nonglycemic clinical effects in weight loss and beyond
Ryan, D., & Acosta, A. (2015) · Obesity · doi:10.1002/oby.21107 · Cited by 112 · see citing works
Self-citationAguilar-Olivos, N. E., Almeda-Valdes, P., Aguilar-Salinas, C. A., Uribe, M., & Méndez-Sánchez, N. (2016) · Metabolism · doi:10.1016/j.metabol.2015.09.004 · Cited by 100 · see citing works
Exenatide in obesity with accelerated gastric emptying: a randomized, pharmacodynamics study
Acosta, A., Camilleri, M., Burton, D., O'Neill, J., Eckert, D., Carlson, P., & Zinsmeister, A. R. (2015) · Physiological Reports · doi:10.14814/phy2.12610 · Cited by 78 · see citing works
Self-citationCamilleri, M., & Lupianez-Merly, C. (2024) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002519 · Cited by 41 · see citing works
Self-citation
- Authors
- Acosta, A., Abu Dayyeh, B. K., Port, J. D., & Camilleri, M.
- Affiliations
- Mayo Clinic (US)
- Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic College of Medicine, Rochester, Minnesota, USA
- Corresponding author
- Camilleri, Michael
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2014-01-08
- Volume
- 63
- Issue
- 4
- Pages
- 687-695
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC4170188
- OpenAlex
- W2031397949
- Cited by
- 91
- References
- 117
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 9 · 2019: 7 · 2018: 2 · 2017: 11 · 2016: 7 · 2015: 15 · 2014: 8
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (RO1-DK67071, DK67071)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067071, T32DK007198, R01-DK67071)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- obesity, obesity treatment, bariatric surgery, lifestyle modification, anti-obesity drugs, gut-brain axis, adipokines, gastrointestinal hormones, inflammation, obesity pathophysiology, weight loss sustainability, obesity-related comorbidities
- MeSH terms
- Central Nervous System, Humans, Obesity, Bariatric Surgery, Incretins, Weight Reduction Programs, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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