The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer
Open accessAbstract
Summary Cancer cells couple heightened lipogenesis with lipolysis to produce fatty acid networks that support malignancy. Monoacylglycerol lipase (MAGL) plays a principal role in this process by converting monoglycerides, including the endocannabinoid 2-arachidonoylglycerol (2-AG), to free fatty acids. Here, we show that MAGL is elevated in androgen-independent versus androgen-dependent human prostate cancer cell lines, and that pharmacological or RNA-interference disruption of this enzyme impairs prostate cancer aggressiveness. These effects were partially reversed by treatment with fatty acids or a cannabinoid receptor-1 (CB1) antagonist, and fully reversed by co-treatment with both agents. We further show that MAGL is part of a gene signature correlated with epithelial-to-mesenchymal transition and the stem-like properties of cancer cells, supporting a role for this enzyme in pro-tumorigenic metabolism that, for prostate cancer, involves the dual control of endocannabinoid and fatty acid pathways.
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Emerging roles of lipid metabolism in cancer metastasis
Luo, X., Cheng, C., Tan, Z., Li, N., Tang, M., Yang, L., & Cao, Y. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0646-3 · Cited by 677
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Zechner, R., Madeo, F., & Kratky, D. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.76 · Cited by 550
Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids
Zaidi, N., Lupien, L., Kuemmerle, N. B., Kinlaw, W. B., Swinnen, J. V., & Smans, K. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.08.005 · Cited by 477
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Metadata
- Authors
- Nomura, D. K., Lombardi, D. P., Chang, J. W., Niessen, S., Ward, A. M., Long, J. Z., Hoover, H. H., & Cravatt, B. F.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 18
- Issue
- 7
- Pages
- 846-856
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W1994816149
- Cited by
- 270
- References
- 52
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nomura, D. K., Lombardi, D. P., Chang, J. W., Niessen, S., Ward, A. M., Long, J. Z., Hoover, H. H., & Cravatt, B. F. (2011). Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2011.05.009
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