The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology
Open accessAbstract
Summary Marine life forms are an important source of structurally-diverse and biologically-active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents. These success stories have had to overcome difficulties inherent to natural products-derived drugs, such as adequate sourcing of the agent and issues related to structural complexity. Nevertheless, several marine-derived agents are now approved, most as `first-in-class' drugs, with 5 of 7 appearing in the past few years. Additionally, there is a rich pipeline of clinical and pre-clinical marine compounds to suggest their continued application in human medicine. Understanding of how these agents are biosynthetically assembled has accelerated in recent years, especially through interdisciplinary approaches, and innovative manipulations and re-engineering of some of these gene clusters are yielding novel agents of enhanced pharmaceutical properties compared with the natural product.
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Cites
How were new medicines discovered?
Swinney, D. C., & Anthony, J. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3480 · Cited by 1,812
Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567
Halichondrins-antitumor polyether macrolides from a marine sponge
Hirata, Y., & Uemura, D. (1986) · Pure and Applied Chemistry · doi:10.1351/pac198658050701 · Cited by 519
Luesch, H., Moore, R. E., Paul, V. J., Mooberry, S. L., & Corbett, T. H. (2001) · Journal of Natural Products · doi:10.1021/np010049y · Cited by 378
Siegl, A., Kamke, J., Hochmuth, T., Piel, J., Richter, M., Liang, C., Dandekar, T., & Hentschel, U. (2011) · The ISME Journal · doi:10.1038/ismej.2010.95 · Cited by 276
Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
High-value products from microalgae—their development and commercialisation
Borowitzka, M. A. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9983-9 · Cited by 1,585
Exploring the ocean for new drug developments: Marine pharmacology
Malve, H. (2016) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.171700 · Cited by 420
Kurita, K. L., Glassey, E., & Linington, R. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507743112 · Cited by 156
Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials
Choudhary, A., Naughton, L., Montánchez, I., Dobson, A., & Rai, D. (2017) · Marine Drugs · doi:10.3390/md15090272 · Cited by 138
Metadata
- Authors
- Gerwick, W. H., & Moore, B. S.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 19
- Issue
- 1
- Pages
- 85-98
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W1967408138
- Cited by
- 601
- References
- 5
- FWCI
- 32.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gerwick, W. H., & Moore, B. S. (2012). Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2011.12.014
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