Cited by 1,933Vitamin D Research StudiesParathyroid Disorders and TreatmentsVitamin K Research Studies

The DOI matches its Crossref record; 131 of the 133 references it cites were found in a registry or an index.

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

Open access

Bikle, Daniel D.·2014·Chemistry & Biology

DOI 10.1016/j.chembiol.2013.12.016PMC PMC3968073

Open this paper in CoChat — free account Open PDF

Abstract

Vitamin D3 is made in the skin from 7-dehydrocholesterol under the influence of UV light. Vitamin D2 (ergocalciferol) is derived from the plant sterol ergosterol. Vitamin D is metabolized first to 25 hydroxyvitamin D (25OHD), then to the hormonal form 1,25-dihydroxyvitamin D (1,25(OH)2D). CYP2R1 is the most important 25-hydroxylase; CYP27B1 is the key 1-hydroxylase. Both 25OHD and 1,25(OH)2D are catabolized by CYP24A1. 1,25(OH)2D is the ligand for the vitamin D receptor (VDR), a transcription factor, binding to sites in the DNA called vitamin D response elements (VDREs). There are thousands of these binding sites regulating hundreds of genes in a cell-specific fashion. VDR-regulated transcription is dependent on comodulators, the profile of which is also cell specific. Analogs of 1,25(OH)2D are being developed to target specific diseases with minimal side effects. This review will examine these different aspects of vitamin D metabolism, mechanism of action, and clinical application.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.chembiol.2013.12.016

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: 1α,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene
Kim, M. S., Fujiki, R., Kitagawa, H., & Kato, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.014 · Cited by 83
Retracted
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898
The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis
Pittas, A. G., Lau, J., Hu, F. B., & Dawson-Hughes, B. F. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0298 · Cited by 2,048
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D 3
Gombart, A. F., Borregaard, N., & Koeffler, H. P. (2005) · The FASEB Journal · doi:10.1096/fj.04-3284com · Cited by 1,145
Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts
van Etten, E., & Mathieu, C. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.06.002 · Cited by 882
A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolutionPreprint
Ramagopalan, S. V., Heger, A., Berlanga‐Taylor, A. J., Maugeri, N., Lincoln, M. R., Burrell, A., Handunnetthi, L., Handel, A. E., Disanto, G., Orton, S. M., et al. (2010) · Genome Research · doi:10.1101/gr.107920.110 · Cited by 881
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand
Rochel, N., Wurtz, J. M., Mitschler, A., Klaholz, B., & Moras, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80413-x · Cited by 842
Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis
Tripkovic, L., Lambert, H., Hart, K. H., Smith, C. P. S., Bucca, G., Penson, S., Chope, G. A., Hyppönen, E., Berry, J., Vieth, R., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.031070 · Cited by 786
Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences
Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T. J., Anderson, R. R., Blank, I. H., Parrish, J. A., & Elias, P. M. (1980) · Science · doi:10.1126/science.6251551 · Cited by 778
Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency
Bischoff-Ferrari, H. A., Willett, W. C., Wong, J. B., Stuck, A. E., Staehelin, H. B., Orav, E. J., Thoma, A., Kiel, D. P., & Henschkowski, J. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.600 · Cited by 773
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
Cheng, J. B., Levine, M. A., Bell, N. H., Mangelsdorf, D. J., & Russell, D. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402490101 · Cited by 770
Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin
Norman, A. W., Frankel, B. J., Heldt, A., & Grodsky, G. M. (1980) · Science · doi:10.1126/science.6250216 · Cited by 724
Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitamin D3: Genomic and non-genomic mechanisms
Haussler, M. R., Jurutka, P. W., Mizwicki, M. T., & Norman, A. W. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.05.010 · Cited by 713
Mutations inCYP24A1and Idiopathic Infantile Hypercalcemia
Schlingmann, K. P., Kaufmann, M., Weber, S., Irwin, A., Goos, C., John, U., Misselwitz, J., Klaus, G., Kuwertz-Bröking, E., Fehrenbach, H., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103864 · Cited by 686
Control of autoimmune diseases by the vitamin D endocrine system
Adorini, L., & Penna, G. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0855 · Cited by 573
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D
Jones, G., Prosser, D. E., & Kaufmann, M. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.11.003 · Cited by 548
25-Hydroxyvitamin D 3 1α-Hydroxylase and Vitamin D Synthesis
Takeyama, K., Kitanaka, S., Sato, T., Kobori, M., Yanagisawa, J., & Kato, S. (1997) · Science · doi:10.1126/science.277.5333.1827 · Cited by 537
The case against ergocalciferol (vitamin D2) as a vitamin supplement1,2
Houghton, L. A., & Vieth, R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.694 · Cited by 528
Fibroblast growth factor-23 regulates parathyroid hormone and 1α-hydroxylase expression in cultured bovine parathyroid cells
Krajisnik, T., Björklund, P., Marsell, R., Ljunggren, Ö., Åkerström, G., Jonsson, K. B., Westin, G., & Larsson, T. E. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0267 · Cited by 473
Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T Cell Profile
Daniel, C., Sartory, N. A., Zahn, N., Radeke, H. H., & Stein, J. M. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.127209 · Cited by 471
Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial
Mitri, J., Dawson-Hughes, B. F., Hu, F. B., & Pittas, A. G. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.011684 · Cited by 438
Dietary and Serum Phosphorus Regulate Fibroblast Growth Factor 23 Expression and 1,25-Dihydroxyvitamin D Metabolism in Mice
Perwad, F., Azam, N., Zhang, M. Y. H., Yamashita, T., Tenenhouse, H. S., & Portale, A. A. (2005) · Endocrinology · doi:10.1210/en.2005-0777 · Cited by 424
Cloning of Human 25-Hydroxyvitamin D-1 -Hydroxylase and Mutations Causing Vitamin D-Dependent Rickets Type 1
Fu, G. K., Lin, D., Zhang, M. Y. H., Bikle, D. D., Shackleton, C. H. L., Miller, W. L., & Portale, A. A. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.13.0035 · Cited by 421
Self-citation
Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures: An Updated Meta-analysis for the U.S. Preventive Services Task Force
Chung, M., Lee, J., Terasawa, T., Lau, J., & Trikalinos, T. A. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-12-201112200-00005 · Cited by 421
De-orphanization of Cytochrome P450 2R1
Cheng, J. B., Motola, D., Mangelsdorf, D. J., & Russell, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307028200 · Cited by 411
Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.
Demay, M. B., Kiernan, M. S., DeLuca, H. F., & Kronenberg, H. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8097 · Cited by 403
Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1α-hydroxylase knockout mice
Zhou, C., Lu, F., Cao, K., Xu, D., Goltzman, D., & Miao, D. (2008) · Kidney International · doi:10.1038/ki.2008.101 · Cited by 402
The Effect of Vitamin D on Falls: A Systematic Review and Meta-Analysis
Murad, M. H., Elamin, K. B., Elnour, N. O. A., Elamin, M. B., Alkatib, A. A., Fatourechi, M. M., Almandoz, J. P., Mullan, R. J., Lane, M. A., Liu, H., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1193 · Cited by 401
The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3
Pike, J. W., & Meyer, M. B. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.02.007 · Cited by 395
Inactivation of the 25-Hydroxyvitamin D 1α-Hydroxylase and Vitamin D Receptor Demonstrates Independent and Interdependent Effects of Calcium and Vitamin D on Skeletal and Mineral Homeostasis
Panda, D. K., Miao, D., Bolivar, I., Li, J., Huo, R., Hendy, G. N., & Goltzman, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310271200 · Cited by 393
Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac Hypertrophy
Chen, S., Law, C. S., Grigsby, C. L., Olsen, K., Hong, T., Zhang, Y., Yeghiazarians, Y., & Gardner, D. G. (2011) · Circulation · doi:10.1161/circulationaha.111.032680 · Cited by 352
Sunlight Regulates the Cutaneous Production of Vitamin D 3 by Causing Its Photodegradation*
Webb, A. R., DeCosta, B. R., & Holick, M. F. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-5-882 · Cited by 347
Association of Vitamin D With Insulin Resistance and β-Cell Dysfunction in Subjects at Risk for Type 2 Diabetes
Kayaniyil, S., Vieth, R., Retnakaran, R. R., Knight, J. A., Qi, Y., Gerstein, H. C., Perkins, B. A., Harris, S. B., Zinman, B., & Hanley, A. J. (2010) · Diabetes Care · doi:10.2337/dc09-2321 · Cited by 346
The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro
Huhtakangas, J. A., Olivera, C. J., Bishop, J. E., Zanello, L. P., & Norman, A. W. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0116 · Cited by 337
Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D
St‐Arnaud, R., Arabian, A., Travers, R., Barletta, F., Raval-Pandya, M., Chapin, K., Depovere, J., Mathieu, C., Christakos, S., Demay, M. B., et al. (2000) · Endocrinology · doi:10.1210/endo.141.7.7579 · Cited by 334
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo
Zhu, J. G., Ochalek, J. T., Kaufmann, M., Jones, G., & DeLuca, H. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315006110 · Cited by 331
Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis.
Adams, J. S., & Gacad, M. A. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.161.4.755 · Cited by 326
The 25-Hydroxyvitamin D 1-Alpha-Hydroxylase Gene Maps to the Pseudovitamin D-Deficiency Rickets (PDDR) Disease Locus
St‐Arnaud, R., Messerlian, S., Moir, J. M., Omdahl, J. L., & Glorieux, F. H. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.10.1552 · Cited by 324
Vitamin D and the skin: Physiology and pathophysiology
Bikle, D. D. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9194-0 · Cited by 274
Self-citation
Vitamin D and Bone
Bikle, D. D. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0098-z · Cited by 273
Self-citation
1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.
Bikle, D. D., Nemanic, M. K., GEE, E., & Elias, P. W. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112609 · Cited by 269
Self-citation
Immune Regulation of 25-Hydroxyvitamin-D3-1α-Hydroxylase in Human Monocytes
Stoffels, K., Overbergh, L., Giulietti, A., Verlinden, L., Bouillon, R., & Mathieu, C. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050908 · Cited by 256
1α,25‐Dihydroxyvitamin D 3 modulates human adipocyte metabolism via nongenomic action
Shi, H., Norman, A. W., Okamura, W. H., Sen, A., & Zemel, M. B. (2001) · The FASEB Journal · doi:10.1096/fj.01-0584fje · Cited by 253
25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death
Brøndum-Jacobsen, P., Benn, M., Jensen, G. B., & Nordestgaard, B. G. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.248039 · Cited by 244
Expression of VDR and CYP24A1 mRNA in human tumors
Anderson, M. G., Nakane, M., Ruan, X., Kroeger, P. E., & Wu-Wong, J. R. (2005) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-005-0059-7 · Cited by 240
Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands
Tocchini-Valentini, G. D., Rochel, N., Wurtz, J., Mitschler, A., & Moras, D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091018698 · Cited by 229
Differential effects of vitamin D receptor activators on vascular calcification in uremic rats
Mizobuchi, M., Finch, J. L., Martin, D. R., & Slatopolsky, E. (2007) · Kidney International · doi:10.1038/sj.ki.5002406 · Cited by 224
Ribozyme knockdown functionally links a 1,25(OH) 2 D 3 membrane binding protein (1,25D 3 -MARRS) and phosphate uptake in intestinal cells
Nemere, I., Farach‐Carson, M. C., Rohe, B., Sterling, T. M., Norman, A. W., Boyan, B. D., & Safford, S. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402207101 · Cited by 223
Analytical measurement and clinical relevance of vitamin D3 C3-epimer
Bailey, D., Veljkovic, K., Yazdanpanah, M., & Adeli, K. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.10.037 · Cited by 212
Intestinal Vitamin D Receptor Is Required for Normal Calcium and Bone Metabolism in Mice
Xue, Y., & Fleet, J. C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.12.051 · Cited by 202
A new analog of calcitriol, 19-nor-1,25-(OH)2D2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia
Slatopolsky, E., Finch, J. L., Ritter, C., Denda, M., Morrissey, J. J., Brown, A., & DeLuca, H. F. (1995) · American Journal of Kidney Diseases · doi:10.1016/0272-6386(95)90455-7 · Cited by 201
VDR/RXR and TCF4/β-Catenin Cistromes in Colonic Cells of Colorectal Tumor Origin: Impact on c-FOS and c-MYC Gene Expression
Meyer, M. B., Goetsch, P. D., & Pike, J. W. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1109 · Cited by 201
Cloning and expression of rat 25-hydroxyvitamin D 3 -1α-hydroxylase cDNA
Shinki, T., Shimada, H., Wakino, S., Anazawa, H., Hayashi, M., Saruta, T., DeLuca, H. F., & Suda, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12920 · Cited by 200
Distinct Conformational Changes Induced by 20-epi Analogues of 1α,25-Dihydroxyvitamin D3 Are Associated with Enhanced Activation of the Vitamin D Receptor
Peleg, S., Sastry, M., Collins, E. D., Bishop, J. E., & Norman, A. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10551 · Cited by 199
Expression of the Vitamin D Receptor Is Increased in the Hypertrophic Heart
Chen, S., Glenn, D. J., Wei Min, N. I., Grigsby, C. L., Olsen, K., Nishimoto, M., Law, C. S., & Gardner, D. G. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.119602 · Cited by 199
Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog
Takeyama, K., Masuhiro, Y., Fuse, H., Endoh, H., Murayama, A., Kitanaka, S., Suzawa, M., Yanagisawa, J., & Kato, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1049 · Cited by 198
Two Vitamin D Response Elements Function in the Rat 1,25-Dihydroxyvitamin D 24-Hydroxylase Promoter
Zierold, C., Darwish, H. M., & DeLuca, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1675 · Cited by 192
Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes
Bacchetta, J., Sea, J. L., Chun, R. F., Lisse, T. S., Wesseling‐Perry, K., Gales, B., Adams, J. S., Salusky, I. B., & Hewison, M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1740 · Cited by 190
Dual metabolic pathway of 25‐hydroxyvitamin D3 catalyzed by human CYP24
Sakaki, T., Sawada, N., Komai, K., Shiozawa, S., Yamada, S., Yamamoto, K., Ohyama, Y., & Inouye, K. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01680.x · Cited by 186
Differential Effects of Vitamin D Analogs on Vascular Calcification
Figueras, A. C., Panizo, S., Parisi, E., Fernández, E., & Valdivielso, J. M. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070305 · Cited by 184
Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?
Zhu, J. G., & DeLuca, H. F. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.01.013 · Cited by 177
A potent analog of 1α,25-dihydroxyvitamin D 3 selectively induces bone formation
Shevde, N. K., Plum, L. A., Clagett‐Dame, M., Yamamoto, H., Pike, J. W., & DeLuca, H. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202471299 · Cited by 176
The Vitamin D Sterol–Vitamin D Receptor Ensemble Model Offers Unique Insights into Both Genomic and Rapid-Response Signaling
Mizwicki, M. T., & Norman, A. W. (2009) · Science Signaling · doi:10.1126/scisignal.275re4 · Cited by 170
Prevalence and associations of vitamin D deficiency in foreign-born persons with tuberculosis in London
Ustianowski, A., Shaffer, R., Collin, S. M., Wilkinson, R. J., & Davidson, R. (2004) · Journal of Infection · doi:10.1016/j.jinf.2004.07.006 · Cited by 166
CYP3A4 is a Human Microsomal Vitamin D 25-Hydroxylase
Gupta, R. P., Hollis, B. W., Patel, S. B., Patrick, K. S., & Bell, N. H. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301257 · Cited by 159
Vitamin D analogs: Therapeutic applications and mechanisms for selectivity
Brown, A. J., & Slatopolsky, E. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.04.001 · Cited by 157
A Downstream Intergenic Cluster of Regulatory Enhancers Contributes to the Induction of CYP24A1 Expression by 1α,25-Dihydroxyvitamin D3
Meyer, M. B., Goetsch, P. D., & Pike, J. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.119958 · Cited by 153
Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity
Slominski, A. T., Janjetovic, Z., Fuller, B. E., Zmijewski, M. A., Tuckey, R. C., Nguyen, M. N., Sweatman, T., Li, W., Zjawiony, J., Miller, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009907 · Cited by 149
C-3 Epimerization of Vitamin D3 Metabolites and Further Metabolism of C-3 Epimers
Kamao, M., Tatematsu, S., Hatakeyama, S., Sakaki, T., Sawada, N., Inouye, K., Ozono, K., Kubodera, N., Reddy, G. S., & Okano, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311473200 · Cited by 149
Multifunctional Enhancers Regulate Mouse and Human Vitamin D Receptor Gene Transcription
Zella, L. A., Meyer, M. B., Nerenz, R. D., Lee, S. M., Martowicz, M. L., & Pike, J. W. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0140 · Cited by 145
Comparison of equilibrium and disequilibrium assay conditions for ergocalciferol, cholecalciferol and their major metabolites
Hollis, B. W. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90063-3 · Cited by 138
Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Duranton, F., Rodríguez-Ortiz, M. E., Duny, Y., Rodríguez, M., Daurès, J., & Argilés, À. (2013) · American Journal of Nephrology · doi:10.1159/000346846 · Cited by 132
Vitamin D and Prevention of Cancer — Ready for Prime Time?
Manson, J. E., Mayne, S. T., & Clinton, S. K. (2011) · New England Journal of Medicine · doi:10.1056/nejmp1102022 · Cited by 132
Alternative Splicing of Vitamin D-24-Hydroxylase
Ren, S., Nguyen, L., Wu, S., Encinas, C., Adams, J. S., & Hewison, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414522200 · Cited by 126
Comparison of 6-s-cis- and 6-s-trans-Locked Analogs of 1α,25-Dihydroxyvitamin D3 Indicates That the 6-s-cis Conformation Is Preferred for Rapid Nongenomic Biological Responses and That Neither 6-s-cis- nor 6-s-trans-Locked Analogs Are Preferred for Genomic Biological Responses
Norman, A. W., Okamura, W. H., Hammond, M. W., Bishop, J. E., Dormanen, M. C., Bouillon, R., BAELEN, H. V., Ridall, A. L., Daane, E., Khoury, R., et al. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.10.9993 · Cited by 123
Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone
Meyer, M. B., Goetsch, P. D., & Pike, J. W. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.011 · Cited by 122
Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds.
Moghadasian, M. H. (2004) · PubMed · Cited by 118
Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators
Ma, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25901 · Cited by 118
ANALOGS OF 1,25-DIHYDROXYVITAMIN D 3 AS DOSE-REDUCING AGENTS FOR CLASSICAL IMMUNOSUPPRESSANTS12
van Etten, E., Brǎnişteanu, D. D. D., Verstuyf, A., Waer, M., Bouillon, R., & Mathieu, C. (2000) · Transplantation · doi:10.1097/00007890-200005150-00032 · Cited by 114
Cardiac Functions in Children with Vitamin D Deficiency Rickets
Uysal, S., Kalaycı, A. G., & Baysal, K. (1999) · Pediatric Cardiology · doi:10.1007/s002469900464 · Cited by 111
Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice
Teichert, A., Elalieh, H. Z., Elias, P. M., Welsh, J., & Bikle, D. D. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.196 · Cited by 104
Self-citation
1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion.
Brown, A. J., Ritter, C. S., Slatopolsky, E., Muralidharan, K. R., OKAMURA, W. H., & Reddy, G. S. (1999) · PubMed · Cited by 103
Vitamin D Receptor Signaling Inhibits Atherosclerosis in Mice
Szeto, F. L., Reardon, C. A., Yoon, D., Wang, Y., Wong, K. E., Chen, Y., Kong, J., Liu, S. Q., Thadhani, R., Getz, G. S., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1329 · Cited by 100
The mechanism for the disparate actions of calcitriol and 22- oxacalcitriol in the intestine
Brown, A. J., Finch, J. L., Grieff, M., Ritter, C. S., Kubodera, N., Nishii, Y., & Slatopolsky, E. (1993) · Endocrinology · doi:10.1210/endo.133.3.8396012 · Cited by 99
Old wine in new bottles: vitamin D in the treatment and prevention of tuberculosis
Martineau, A. R. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111003326 · Cited by 98
Sunlight Vitamin D and Skin Cancer
Mason, R. S., & Reichrath, J. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520611307010083 · Cited by 98
Porcine Microsomal Vitamin D3 25-Hydroxylase (CYP2D25)
Hosseinpour, F., & Wikvall, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004185200 · Cited by 94
The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules.
Bikle, D. D., & Rasmussen, H. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107932 · Cited by 94
Self-citation
Parathyroid hormone regulates 25-hydroxyvitamin D 3 -24-hydroxylase mRNA by altering its stability
Zierold, C., Mings, J. A., & DeLuca, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241516798 · Cited by 90
2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts
Yamamoto, H., Shevde, N. K., Warrier, A., Plum, L. A., DeLuca, H. F., & Pike, J. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304737200 · Cited by 90
The Role of the Vitamin D Receptor and ERp57 in Photoprotection by 1α,25-Dihydroxyvitamin D3
Sequeira, V. B., Rybchyn, M. S., Tongkao‐on, W., Gordon‐Thomson, C., Malloy, P. J., Nemere, I., Norman, A. W., Reeve, V. E., Halliday, G. M., Feldman, D., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1161 · Cited by 88
The first genome-wide view of vitamin D receptor locations and their mechanistic implications.
Carlberg, C., Seuter, S., & Heikkinen, S. (2012) · PubMed · Cited by 87
The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3
Pike, J. W., & Meyer, M. B. (2012) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2012.03.004 · Cited by 86
Regulation of 1,25-Dihydroxyvitamin D Production in Human Keratinocytes by Interferon-γ*
Bikle, D. D., Pillai, S. G., GEE, E., & Hincenbergs, M. (1989) · Endocrinology · doi:10.1210/endo-124-2-655 · Cited by 83
Self-citation
Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol)
Adorini, L., Penna, G., Amuchastegui, S., Cossetti, C., Aquilano, F., Mariani, R., Fibbi, B., Morelli, A., Uskoković, M. R., Colli, E., et al. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.065 · Cited by 82
Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia
Crescioli, C., Ferruzzi, P., Caporali, A., Scaltriti, M., Bettuzzi, S., Mancina, R., Gelmini, S., Serio, M., Villari, D., Vannelli, G. B., et al. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500591 · Cited by 82
Sunlight Vitamin D and Skin Cancer
Mason, R. S., & Reichrath, J. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152013804487272 · Cited by 81
In Vitro Stimulation of 25-Hydroxycholecalciferol lα- Hydroxylation by Parathyroid Hormone in Chick Kidney Slices: Evidence for a Role for Adenosine 3′,5′- Monophosphate *
Rost, C. R., Bikle, D. D., & Kaplan, R. A. (1981) · Endocrinology · doi:10.1210/endo-108-3-1002 · Cited by 80
Self-citation
Vitamin D and the heart
Gardner, D. G., Chen, S., & Glenn, D. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2013 · Cited by 79
Tumor necrosis factor‐alpha induces vitamin D‐1‐hydroxylase activity in normal human alveolar macrophages
Pryke, A. M., Duggan, C., White, C., Posen, S., & Mason, R. S. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041420327 · Cited by 77
Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications
Bikle, D. D. (2009) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-009-9033-y · Cited by 76
Self-citation
Selective inhibition of vitamin D hydroxylases in human keratinocytes11Abbreviations: VD: vitamin D3; 25(OH)D3: 25-hydroxyvitamin D3; 3H-25(OH)D3: [26,27n-3H] 25-hydroxyvitamin D3; 1α,25(OH)2D3: 1α,25-dihydroxyvitamin D3; 1α,25(OH)2-3epi-D3: 1α,25-dihydroxyvitamin-3-epi-D3; 1α,24(R),25(OH)3D3: 1α,24(R),25-trihydroxyvitamin D3, 1α,25(OH)2-24oxo-D3: 1α,25-dihydroxy-24oxo-vitamin D3; 1α,23(S),25(OH)3-24oxo-D3: 1α,23(S),25-trihydroxy-24oxo-vitamin D3; calcitroic acid: 1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3; CYP: cytochrome P450; 1α-hydroxylase: 25-hydroxyvitamin D3-1α-hydroxylase; 24-hydroxylase (CYP24), 1α,25-hydroxyvitamin D3-24-hydroxylase; PHK, primary human keratinocytes; KGM: keratinocyte growth medium; HPLC, high performance liquid chromatography; IC50: half-maximum inhibitor concentration; SD: standard deviation.
Schuster, I., Egger, H., Bikle, D. D., Herzig, G., Reddy, G. S., Stuetz, A., Stuetz, P. L., & Vorisek, G. (2001) · Steroids · doi:10.1016/s0039-128x(00)00159-8 · Cited by 74
Self-citation
The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion.
Bikle, D. D., Murphy, E. W., & Rasmussen, H. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107933 · Cited by 74
Self-citation
Induction of the Vitamin D 24-Hydroxylase (CYP24) by 1,25-Dihydroxyvitamin D 3 Is Regulated by Parathyroid Hormone in UMR106 Osteoblastic Cells 1
Armbrecht, H. J., Hodam, T. L., Boltz, M. A., Partridge, N. C., Brown, A. J., & Kumar, V. B. (1998) · Endocrinology · doi:10.1210/endo.139.8.6134 · Cited by 73
The Mechanism of 1,25-Dihydroxyvitamin D3Autoregulation in Keratinocytes
Xie, Z., Munson, S. J., Huang, N., Portale, A. A., Miller, W. L., & Bikle, D. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201404200 · Cited by 72
Self-citation
24-Hydroxylation of 1,25-dihydroxyergocalciferol. An unambiguous deactivation process.
Horst, R. L., Reinhardt, T. A., Ramberg, C. F., Koszewski, N. J., & Napoli, J. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67647-1 · Cited by 69
In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1 alpha,25- and 1 beta,25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity.
Qaw, F. S., Calverley, M. J., Schroeder, N. J., Trafford, D. J. H., Makin, H. L. J., & Jones, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54147-8 · Cited by 66
Regulation of the Porcine 1,25-Dihydroxyvitamin D3-24-Hydroxylase (CYP24) by 1,25-Dihydroxyvitamin D3 and Parathyroid Hormone in AOK-B50 Cells
Zierold, C., Reinholz, G. G., Mings, J. A., Prahl, J. M., & DeLuca, H. F. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1964 · Cited by 66
Single A326G mutation converts human CYP24A1 from 25-OH-D 3 -24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH) 2 D 3 -26,23-lactone
Prosser, D. E., Kaufmann, M., O’Leary, B. M., Byford, V., & Jones, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702093104 · Cited by 65
Tumor Necrosis Factor-α Regulation of 1,25-Dihydroxy vitamin D Production by Human Keratinocytes*
Bikle, D. D., Pillai, S. G., GEE, E., & Hincenbergs, M. (1991) · Endocrinology · doi:10.1210/endo-129-1-33 · Cited by 63
Self-citation
Monocyte 1α-hydroxylase regulation: induction by inflammatory cytokines and suppression by dexamethasone and uremia toxin
Gyetko, M. R., Hsu, C. H., Wilkinson, C. C., Patel, S., & Young, E. W. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.1.17 · Cited by 63
Metabolism of 1α,25-dihydroxyvitamin D3 and its C-3 epimer 1α,25-dihydroxy-3-epi-vitamin D3 in neonatal human keratinocytes
Reddy, G. S., Muralidharan, K. R., Okamura, W. H., Tserng, K., & McLane, J. A. (2001) · Steroids · doi:10.1016/s0039-128x(00)00228-2 · Cited by 60
Vitamin D and Skin Cancer
Bikle, D. D. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3472s · Cited by 56
Self-citation
ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects
Matsumoto, T., & Kubodera, N. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.088 · Cited by 56
Vitamin D Analogs
Jones, G. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.02.003 · Cited by 55
Vitamin D analogues targeting CYP24 in chronic kidney disease
Posner, G. H., Helvig, C. F., Cuerrier, D., Collop, D., Kharebov, A. Z., Ryder, K., Epps, T., & Petkovich, M. P. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.065 · Cited by 50
Calcemic Activity of 19-Nor-1,25(OH)2D2 Decreases with Duration of Treatment
Brown, A. J., Finch, J. L., Takahashi, F., & Slatopolsky, E. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11112088 · Cited by 48
Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase
Rahmaniyan, M., Patrick, K. S., & Bell, N. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00201.2004 · Cited by 45
Nuclear receptor 4A2 and C/EBPβ regulate the parathyroid hormone-mediated transcriptional regulation of the 25-hydroxyvitamin D3-1α-hydroxylase
Zierold, C., Nehring, J. A., & DeLuca, H. F. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.11.028 · Cited by 44
Cloning, Structure, and Expression of a cDNA Encoding Vitamin D325-Hydroxylase
Postlind, H., Axén, E., Bergman, T., & Wikvall, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7551 · Cited by 43
In vitro action of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol on matrix organization and mineral distribution in rabbit growth plate
Plachot, J. J., du Bois, M. B., Halpern, S., Cournot, G., Garabédian, M., & BALSAN, S. (1982) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(82)90027-3 · Cited by 42
Diversity and Substrate Specificity in the Structures of Steroidogenic Cytochrome P450 Enzymes
Sugimoto, H., & Shiro, Y. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.818 · Cited by 42
Regulation of the 25-Hydroxyvitamin D-1α-Hydroxylase Gene and Its Splice Variant
Flanagan, J. N., Wang, L., Tangpricha, V., Reichrath, J., Chen, T. C., & Holick, M. F. (2003) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-55580-0_12 · Cited by 38
Interaction of Two Novel 14-Epivitamin D3 Analogs with Vitamin D3 Receptor-Retinoid X Receptor Heterodimers on Vitamin D3 Responsive Elements
Verlinden, L., Verstuyf, A., Quack, M., Camp, M. V., van Etten, E., Clercq, P. D., Vandewalle, M., Carlberg, C., & Bouillon, R. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.4.625 · Cited by 34
The development of vitamin D3 analogues for the treatment of osteoporosis
Nishii, Y., Sato, K., & Kobayashi, T. (1993) · Osteoporosis International · doi:10.1007/bf01621903 · Cited by 31
Peroxisome targeting of porcine 17?-hydroxysteroid dehydrogenase type IV/D-specific multifunctional protein 2 is mediated by its C-terminal tripeptide AKI
M�ller, G. A., L�ders, J., Markus, M., Husen, B., Veldhoven, P. P. V., & Adamski, J. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990401)73:1 · Cited by 24
Vitamin D analogs and coactivators.
Eelen, G., Verlinden, L., Clercq, P. D., Vandewalle, M., Bouillon, R., & Verstuyf, A. (2006) · PubMed · Cited by 19
Increased biological potency of hexafluorinated analogs of 1,25-dihydroxyvitamin D3 on bovine parathyroid cells
Imanishi, Y., Inaba, M., Seki, H., Koyama, H., Nishizawà, Y., Morii, H., & Otani, S. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00112-0 · Cited by 18
Vitamin D Analogs
Jones, G. (2012) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2012.03.016 · Cited by 15

Flagged first, then by citations

2 of the 133 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Norman, 1997, Mol. Endocrinol., 11, 1518

Sorted by citations

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., & Carmeliet, G. (2015) · Physiological Reviews · doi:10.1152/physrev.00014.2015 · Cited by 2,105
Exploring vitamin D metabolism and function in cancer
Jeon, S., & Shin, E. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0038-9 · Cited by 576
Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries
Roth, D. E., Abrams, S. A., Aloia, J. F., Bergeron, G., Bourassa, M. W., Brown, K. H., Calvo, M. S., Cashman, K. D., Combs, G. F., De‐Regil, L. M., et al. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13968 · Cited by 541
How UV Light Touches the Brain and Endocrine System Through Skin, and Why
Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452
Vitamin D Toxicity–A Clinical Perspective
Marcinowska-Suchowierska, E., Kupisz-Urbańska, M., Łukaszkiewicz, J., Płudowski, P., & Jones, G. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00550 · Cited by 447

See all 1,933

Authors: Bikle, D. D.
Affiliations: San Francisco VA Medical Center (US)
Corresponding author: Bikle, Daniel D.
ORCID: Bikle, Daniel D.
Venue: Chemistry & Biology
Publisher: Elsevier BV
Published: 2014-03
Volume: 21
Issue: 3
Pages: 319-329
ISSN: 1074-5521 (ISSN-L)
DOI: 10.1016/j.chembiol.2013.12.016
PMC: PMC3968073
OpenAlex: W1976776496
Cited by: 1,933
References: 133
Citations by year: 2026: 148 · 2025: 189 · 2024: 196 · 2023: 272 · 2022: 219 · 2021: 211 · 2020: 228 · 2019: 142 · 2018: 135 · 2017: 84 · 2016: 60 · 2015: 37 · 2014: 10
FWCI: 9.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Chemistry & Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: U.S. Department of Defense
National Institutes of Health (AR050023)
National Cancer Institute (CA110338)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR038386, R01AR050023, P01AR039448)
National Center for Research Resources (P41RR001614)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Keywords: vitamin D metabolism, vitamin D3, vitamin D2, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, CYP2R1, CYP27B1, CYP24A1, vitamin D receptor, vitamin D response element, transcriptional regulation, vitamin D analogs, 7-dehydrocholesterol, ergosterol
MeSH terms: Cytochrome P-450 Enzyme System, DNA, Humans, Immune System, Metabolic Diseases, Neoplasms, Vitamin D, Receptors, Calcitriol, Response Elements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks