The DOI matches its Crossref record; 131 of the 133 references it cites were found in a registry or an index.
Vitamin D Metabolism, Mechanism of Action, and Clinical Applications
Open accessAbstract
Vitamin D3 is made in the skin from 7-dehydrocholesterol under the influence of UV light. Vitamin D2 (ergocalciferol) is derived from the plant sterol ergosterol. Vitamin D is metabolized first to 25 hydroxyvitamin D (25OHD), then to the hormonal form 1,25-dihydroxyvitamin D (1,25(OH)2D). CYP2R1 is the most important 25-hydroxylase; CYP27B1 is the key 1-hydroxylase. Both 25OHD and 1,25(OH)2D are catabolized by CYP24A1. 1,25(OH)2D is the ligand for the vitamin D receptor (VDR), a transcription factor, binding to sites in the DNA called vitamin D response elements (VDREs). There are thousands of these binding sites regulating hundreds of genes in a cell-specific fashion. VDR-regulated transcription is dependent on comodulators, the profile of which is also cell specific. Analogs of 1,25(OH)2D are being developed to target specific diseases with minimal side effects. This review will examine these different aspects of vitamin D metabolism, mechanism of action, and clinical application.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Vitamin D3 is modified through the mitochondria in the liver and kidney to assume its active form, 1,25 vitamin D (Bikle, 2014).”
From Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020) · cites this paper as Bikle, 2014
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“supplementation effects depend strongly on baseline status, assay standardization, dose, formulation, adherence, and population context [1,2,3,4,5,6].”
From Vitamin D Supplementation, Total Testosterone, and Androgen Bioavailability Markers in Adult Men: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2026) · cites this paper as [2]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Many other tissues express CYP27B1 too which can modulate the local level of this hormone utilizing plasma 25(OH)D as substrate [10, 14, 51].”
From The serum vitamin D metabolome: what we know and what is still to discover (2019) · cites this paper as [14]
In the citing paper
“3-Epi-1α,25(OH)2D3 generally has reduced biological activity compared to 1α,25(OH)2D3 [14, 73–75] and is discussed further in Sections 2.1.3 and 3.6.”
From The serum vitamin D metabolome: what we know and what is still to discover (2019) · cites this paper as [14]
In the citing paper
“Serum 1α,25(OH)2D3 and 1α,25(OH)2D2 are produced in the kidney by the action of CYP27B1 on 25(OH)D obtained from the circulation [14].”
From The serum vitamin D metabolome: what we know and what is still to discover (2019) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: 1α,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene
Kim, M. S., Fujiki, R., Kitagawa, H., & Kato, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.014 · Cited by 83
RetractedToll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898
The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis
Pittas, A. G., Lau, J., Hu, F. B., & Dawson-Hughes, B. F. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0298 · Cited by 2,048
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865
Gombart, A. F., Borregaard, N., & Koeffler, H. P. (2005) · The FASEB Journal · doi:10.1096/fj.04-3284com · Cited by 1,145
Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts
van Etten, E., & Mathieu, C. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.06.002 · Cited by 882
Ramagopalan, S. V., Heger, A., Berlanga‐Taylor, A. J., Maugeri, N., Lincoln, M. R., Burrell, A., Handunnetthi, L., Handel, A. E., Disanto, G., Orton, S. M., et al. (2010) · Genome Research · doi:10.1101/gr.107920.110 · Cited by 881
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand
Rochel, N., Wurtz, J. M., Mitschler, A., Klaholz, B., & Moras, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80413-x · Cited by 842
Tripkovic, L., Lambert, H., Hart, K. H., Smith, C. P. S., Bucca, G., Penson, S., Chope, G. A., Hyppönen, E., Berry, J., Vieth, R., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.031070 · Cited by 786
Research works printed but not linked: 1
- Norman, 1997, Mol. Endocrinol., 11, 1518
Cited by
Sorted by citations
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., & Carmeliet, G. (2015) · Physiological Reviews · doi:10.1152/physrev.00014.2015 · Cited by 2,105
Exploring vitamin D metabolism and function in cancer
Jeon, S., & Shin, E. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0038-9 · Cited by 581
Roth, D. E., Abrams, S. A., Aloia, J. F., Bergeron, G., Bourassa, M. W., Brown, K. H., Calvo, M. S., Cashman, K. D., Combs, G. F., De‐Regil, L. M., et al. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13968 · Cited by 541
How UV Light Touches the Brain and Endocrine System Through Skin, and Why
Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452
Vitamin D Toxicity–A Clinical Perspective
Marcinowska-Suchowierska, E., Kupisz-Urbańska, M., Łukaszkiewicz, J., Płudowski, P., & Jones, G. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00550 · Cited by 447
da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., Rathi, K. S., Smith, S. M., Stear, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.002 · Cited by 402
“Vitamin D3 is modified through the mitochondria in the liver and kidney to assume its active form, 1,25 vitamin D (Bikle, 2014).”
Yi, D., Bayer, T., Badenhorst, C. P. S., Wu, S., Doerr, M., Höhne, M., & Bornscheuer, U. T. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01575j · Cited by 387
Garvin, M. R., Alvarez, C., Miller, J. I., Prates, E. T., Walker, A. M., Amos, B. K., Mast, A. E., Justice, A. C., Aronow, B. J., & Jacobson, D. (2020) · eLife · doi:10.7554/elife.59177 · Cited by 372
Vitamin D, infections and immunity
Ismailova, A., & White, J. H. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09679-5 · Cited by 381
Physiological functions of Vitamin D in adipose tissue
Abbas, M. A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.08.004 · Cited by 375
Vitamin D and cardiovascular health
de la Guía-Galipienso, F., Martínez‐Ferrán, M., Vallecillo, N., Lavie, C. J., Sanchis‐Gomar, F., & Pareja-Galeano, H. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.025 · Cited by 364
Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism
Walsh, C. T., Tu, B. P., & Tang, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00510 · Cited by 315
Khundmiri, S. J., Murray, R. D., & Lederer, E. D. (2016) · Comprehensive physiology · doi:10.1002/cphy.c140071 · Cited by 376
Jain, A., Chaurasia, R., Sengar, N. S., Singh, M., Mahor, S., & Narain, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-77093-z · Cited by 295
Latic, N., & Erben, R. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186483 · Cited by 316
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Infante, M., Ricordi, C., Sanchez, J. E., Clare-Salzler, M. J., Padilla, N., Fuenmayor, V., Chavez, C., Alvarez, A., Baidal, D. A., Alejandro, R., et al. (2019) · Nutrients · doi:10.3390/nu11092185 · Cited by 283
Vitamin D Deficiency and Oral Health: A Comprehensive Review
Botelho, J., Machado, V., Proença, L., Delgado, A. S., & Mendes, J. J. (2020) · Nutrients · doi:10.3390/nu12051471 · Cited by 289
The serum vitamin D metabolome: what we know and what is still to discover
Tuckey, R. C., Cheng, C. Y. S., & Slominski, A. T. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.09.003 · Cited by 245
Could Vitamins Help in the Fight Against COVID-19?
Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020) · Nutrients · doi:10.3390/nu12092550 · Cited by 234
Janoušek, J., Pilařová, V., Macáková, K., Nomura, A., Veiga-Matos, J., da Silva, D. D., Remião, F., Saso, L., Malá‐Ládová, K., Malý, J., et al. (2022) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2022.2070595 · Cited by 273
Functions of vitamin D in bone
Goltzman, D. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1648-y · Cited by 232
Assessment of vitamin D status – a changing landscape
Herrmann, M., Farrell, C.-J. L., Pusceddu, I., Fabregat-Cabello, N., & Cavalier, E. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0264 · Cited by 245
Contreras-Bolívar, V., García-Fontana, B., García‐Fontana, C., & Muñoz‐Torres, M. (2021) · Nutrients · doi:10.3390/nu13103491 · Cited by 260
Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis
Goltzman, D., Mannstadt, M., & Marcocci, C. (2018) · Frontiers of hormone research · doi:10.1159/000486060 · Cited by 214
Yin, P., Xie, S., Zhuang, Z., He, X., Tang, X., Tian, L., Liu, Y., & Niu, J. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735864 · Cited by 215
Argano, C., Mirarchi, L., Amodeo, S., Orlando, V., Torres, A., & Corrao, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015485 · Cited by 261
Mousavi, S. E., Amini, H., Heydarpour, P., Amini Chermahini, F., & Godderis, L. (2019) · Environment International · doi:10.1016/j.envint.2018.11.052 · Cited by 202
Carpenter, T. O., Shaw, N. J., Portale, A. A., Ward, L. M., Abrams, S. A., & Pettifor, J. M. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.101 · Cited by 215
The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis
Liu, W., Zhang, L., Xu, H., Li, Y., Hu, C.-M., Yang, J., & Sun, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092736 · Cited by 209
The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders
Szymczak-Pajor, I., Drzewoski, J., & Śliwińska, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186644 · Cited by 214
Turner, R. M., & Pirmohamed, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010022 · Cited by 206
Vitamin D and the Pathophysiology of Inflammatory Skin Diseases
Umar, M., Sastry, K. S., Ali, F. A., Khulaifi, M. A., Wang, E., & Chouchane, A. I. (2018) · Skin Pharmacology and Physiology · doi:10.1159/000485132 · Cited by 198
Role of phosphate sensing in bone and mineral metabolism
Chande, S., & Bergwitz, C. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0076-3 · Cited by 197
Cancer prevention and treatment using combination therapy with natural compounds
Sauter, E. R. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2020.1738218 · Cited by 197
Vitamin D deficiency in children and adolescents with obesity: a meta-analysis
Fiamenghi, V. I., & de Mello, E. D. (2020) · Jornal de Pediatria · doi:10.1016/j.jped.2020.08.006 · Cited by 205
The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights
Pike, J. W., Meyer, M. B., Lee, S.-M., Onal, M., & Benkusky, N. A. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88887 · Cited by 193
Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond
Cyprian, F. S., Lefkou, E. E., Varoudi, K., & Girardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02739 · Cited by 191
Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept
Altieri, B., Muscogiuri, G., Barrea, L., Mathieu, C., Vallone, C., Mascitelli, L., Bizzaro, G., Altieri, V. M., Tirabassi, G., Balercia, G., et al. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9405-9 · Cited by 191
Karras, S. Ν., Wagner, C. L., & Castracane, V. D. (2017) · Metabolism · doi:10.1016/j.metabol.2017.10.001 · Cited by 179
Controversies in Vitamin D: A Statement From the Third International Conference
Giustina, A., Bouillon, R., Binkley, N., Sempos, C. T., Adler, R. A., Bollerslev, J., Dawson‐Hughes, B., Ebeling, P. R., Feldman, D., Heijboer, A. C., et al. (2020) · JBMR Plus · doi:10.1002/jbm4.10417 · Cited by 179
Rinninella, E., Mele, M. C., Merendino, N., Cintoni, M., Anselmi, G., Caporossi, A., Gasbarrini, A., & Minnella, A. M. (2018) · Nutrients · doi:10.3390/nu10111677 · Cited by 185
Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
Serna, J., & Bergwitz, C. (2020) · Nutrients · doi:10.3390/nu12103001 · Cited by 204
Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy
Vinci, P., Panizon, E., Tosoni, L. M., Cerrato, C., Pellicori, F., Mearelli, F., Biasinutto, C., Fiotti, N., Girolamo, F. G. D., & Biolo, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111687 · Cited by 188
Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends
Yagüe, M. D. L. P., Yurrita, L. C., Cabañas, M. C., & Cenzual, M. C. (2020) · Nutrients · doi:10.3390/nu12020579 · Cited by 172
Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?
Bilezikian, J. P., Formenti, A. M., Adler, R. A., Binkley, N., Bouillon, R., Lazaretti‐Castro, M., Marcocci, C., Napoli, N., Rizzoli, R., & Giustina, A. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09693-7 · Cited by 179
A Guide to Improving the Care of Patients with Fragility Fractures, Edition 2
Mears, S. C., & Kates, S. L. (2015) · Geriatric Orthopaedic Surgery & Rehabilitation · doi:10.1177/2151458515572697 · Cited by 175
Clark, A. P., & Mach, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00627 · Cited by 171
Decoding the Role of CYP450 Enzymes in Metabolism and Disease: A Comprehensive Review
Abdelmonem, B. H., Abdelaal, N. M., Anwer, E. K. E., Rashwan, A. A., Hussein, M. A., Ahmed, Y. F., Khashana, R., Hanna, M. M., & Abdelnaser, A. (2024) · Biomedicines · doi:10.3390/biomedicines12071467 · Cited by 185
Exploring links between vitamin D deficiency and COVID-19
Mohan, M., Cherian, J. J., & Sharma, A. K. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008874 · Cited by 164
Vitamin D receptor(s): In the nucleus but also at membranes?
Zmijewski, M. A., & Carlberg, C. (2020) · Experimental Dermatology · doi:10.1111/exd.14147 · Cited by 164
Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level
Bikle, D. D. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvz038 · Cited by 172
Self-citationPhysiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi)
Jacquillet, G., & Unwin, R. J. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2231-z · Cited by 158
Plausible ergogenic effects of vitamin D on athletic performance and recovery
Dahlquist, D. T., Dieter, B. P., & Koehle, M. S. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0093-8 · Cited by 151
Chung, C., Silwal, P., Kim, I.-S., Modlin, R. L., & Jo, E. (2020) · Immune Network · doi:10.4110/in.2020.20.e12 · Cited by 152
Vitamin D regulates microbiome-dependent cancer immunity
Giampazolias, E., Pereira da Costa, M., Lam, K. C., Lim, K. H. J., Cardoso, A., Piot, C., Chakravarty, P., Blasche, S., Patel, S., Biram, A., et al. (2024) · Science · doi:10.1126/science.adh7954 · Cited by 151
Protective links between vitamin D, inflammatory bowel disease and colon cancer
Meeker, S. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i3.933 · Cited by 154
Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis
Surdu, A. M., Stănoiu-Pînzariu, O., Ciobanu, D. M., Negru, A. G., Cainap, S. S., Lazea, C., Iacob, D., Săraci, G., Tirinescu, D. C., Borda, I. M., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9020172 · Cited by 147
Chaiprasongsuk, A., Janjetovic, Z., Kim, T.-K., Jarrett, S. G., D'Orazio, J. A., Holick, M. F., Tang, E. K. Y., Tuckey, R. C., Panich, U., Li, W., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101206 · Cited by 146
Vitamin D and SARS-CoV-2 virus/COVID-19 disease
Lanham-New, S. A., Webb, A. R., Cashman, K. D., Buttriss, J., Fallowfield, J. L., Masud, T., Hewison, M., Mathers, J. C., Kiely, M. E., Welch, A. A., et al. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000089 · Cited by 145
Genomics in Personalized Nutrition: Can You “Eat for Your Genes”?
Mullins, V. A., Bresette, W., Johnstone, L. M., Hallmark, B., & Chilton, F. H. (2020) · Nutrients · doi:10.3390/nu12103118 · Cited by 163
The Many Roles of Cholesterol in Sepsis: A Review
Hofmaenner, D. A., Kleyman, A., Press, A. T., Bauer, M. W., & Singer, M. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202105-1197tr · Cited by 152
Santonocito, S., Giudice, A., Polizzi, A., Troiano, G., Merlo, E. M., Sclafani, R., Grosso, G., & Isola, G. (2022) · Nutrients · doi:10.3390/nu14122426 · Cited by 144
Slominski, A. T., Kim, T.-K., Hobrath, J. V., Oak, A. S. W., Tang, E. K. Y., Tieu, E. W., Li, W., Tuckey, R. C., & Jetten, A. M. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.09.024 · Cited by 143
Negri, M., Gentile, A., de Angelis, C., Montò, T., Patalano, R., Colao, A., Pivonello, R., & Pivonello, C. (2020) · Nutrients · doi:10.3390/nu12061798 · Cited by 142
The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences
Bandera-Merchán, B., Morcillo, S., Martín‐Núñez, G. M., Tinahones, F. J., & Macías‐González, M. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.11.020 · Cited by 144
Putzu, A., Belletti, A., Cassina, T., Clivio, S., Monti, G., Zangrillo, A., & Landoni, G. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.10.029 · Cited by 139
Immunomodulatory Role of Vitamin D: A Review
Skrobot, A., Demkow, U. A., & Wachowska, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_246 · Cited by 141
Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation
Bakke, D., & Sun, J. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy092 · Cited by 135
Immune Modulatory Effects of Vitamin D on Viral Infections
Siddiqui, M., Manansala, J. S., Abdulrahman, H. A., Nasrallah, G. K., Smatti, M. K., Younes, N., Thani, A. A. A., & Yassine, H. M. (2020) · Nutrients · doi:10.3390/nu12092879 · Cited by 136
Gáll, Z., & Székely, O. (2021) · Nutrients · doi:10.3390/nu13113672 · Cited by 159
Olmos‐Ortiz, A., Avila, E., Durand-Carbajal, M., & Dı́az, L. (2015) · Nutrients · doi:10.3390/nu7010443 · Cited by 138
Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival
Yao, S., Kwan, M. L., Ergas, I. J., Roh, J. M., Cheng, T. D., Hong, C., McCann, S. E., Tang, L., Davis, W., Liu, S., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.4188 · Cited by 138
Kamai, E. M., McElrath, T. F., & Ferguson, K. K. (2019) · Environmental Health · doi:10.1186/s12940-019-0480-8 · Cited by 138
Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry
Pizzini, A., Aichner, M., Sahanic, S., Boehm, A., Egger, A., Hoermann, G., Kurz, K., Widmann, G., Bellmann‐Weiler, R., Weiß, G., et al. (2020) · Nutrients · doi:10.3390/nu12092775 · Cited by 130
Szymczak-Pajor, I., Miazek, K., Selmi, A., Balcerczyk, A., & Śliwińska, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020956 · Cited by 147
Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies
Gois, P. H. F., Wolley, M. J., Ranganathan, D., & Seguro, A. C. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081773 · Cited by 131
Vitamin D, a modulator of musculoskeletal health in chronic kidney disease
Molina, P., Carrero, J. J., Bover, J., Chauveau, P., Mazzaferro, S., & Ureña, P. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12218 · Cited by 134
The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies
Bellerba, F., Muzio, V., Gnagnarella, P., Facciotti, F., Chiocca, S., Bossi, P., Cortinovis, D. L., Chiaradonna, F., Serrano, D., Raimondi, S., et al. (2021) · Nutrients · doi:10.3390/nu13103378 · Cited by 137
van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M. R., & Verheyen, N. (2017) · International Journal of Endocrinology · doi:10.1155/2017/7454376 · Cited by 133
Han, Y., Chen, A., Umansky, K. B., Oonk, K. A., Choi, W.-Y., Dickson, A. L., Ou, J., Cigliola, V., Yifa, O., Cao, J., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.001 · Cited by 119
Inflammatory biomarkers of frailty
Vatic, M., von Haehling, S., & Ebner, N. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110858 · Cited by 123
Altieri, B., Grant, W. B., Della Casa, S., Orio, F., Pontecorvi, A., Colao, A., Sarno, G., & Muscogiuri, G. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1136922 · Cited by 113
Miners, J. O., Yang, X., Knights, K., & Zhang, L. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.757 · Cited by 119
Katsarou, A., & Pantopoulos, K. (2018) · Pharmaceuticals · doi:10.3390/ph11040127 · Cited by 115
Szaleniec, M., Wojtkiewicz, A. M., Bernhardt, R., Borowski, T., & Donova, M. V. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9239-3 · Cited by 113
UV-irradiated mushrooms as a source of vitamin D 2 : A review
Taofiq, O., Fernandes, Â. S. F., Barros, L., Barreiro, M. F., & Ferreira, I. C. F. R. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.10.008 · Cited by 109
Vieyra-Garcia, P. A., & Wolf, P. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107784 · Cited by 114
Vitamin D and the risk for cancer: A molecular analysis
Carlberg, C., & Velleuer, E. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114735 · Cited by 114
Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases
Pál, É., Ungvari, Z. I., Benyó, Z., & Várbı́ró, S. (2023) · Nutrients · doi:10.3390/nu15020334 · Cited by 117
Vitamin D signaling in intestinal innate immunity and homeostasis
Dimitrov, V., & White, J. H. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.010 · Cited by 108
Vitamin D and Neurodegenerative Diseases
Wang, W., Li, Y., & Meng, X. (2022) · Heliyon · doi:10.1016/j.heliyon.2023.e12877 · Cited by 119
Systemic drugs that influence titanium implant osseointegration
Apostu, D., LUCACIU, O. P., Lucaciu, G. D. O., Crisan, B. V., Crişan, L., Băciuț, M. F., Onisor, F. G., Băciuț, G., Câmpian, R. S., & Bran, S. (2016) · Drug Metabolism Reviews · doi:10.1080/03602532.2016.1277737 · Cited by 105
The role of vitamin D and vitamin D binding protein in chronic liver diseases
Pop, T. L., Sîrbe, C., Benţa, G., Mititelu, A., & Grama, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810705 · Cited by 105
“Generally, in the first stage, exogenous calcium is used and only in its absence is endogenous calcium used [6].”
BackgroundInfluentialPhysiological regulation of calcium and phosphorus utilization in laying hens
Sinclair-Black, M., Garcia-Mejia, R. A., & Ellestad, L. E. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1112499 · Cited by 104
New developments in our understanding of vitamin D metabolism, action and treatment
Christakos, S., Li, S., Cruz, J. D. L., & Bikle, D. D. (2019) · Metabolism · doi:10.1016/j.metabol.2019.06.010 · Cited by 103
Self-citationVitamin D and diabetes: Where do we stand?
Mathieu, C. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.01.036 · Cited by 106
Vitamin D and Ocular Diseases: A Systematic Review
Chan, H.-N., Zhang, X. J., Ling, X.-T., Bui, C. H. T., Wang, Y., Ip, P., Chu, W. K., Chen, L. J., Tham, C. C. Y., Yam, J. C. S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084226 · Cited by 107
Osteoporosis therapies and their mechanisms of action (Review)
Kim, B., Cho, Y., & Lim, W. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10815 · Cited by 106
“Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis”
Rawat, D., Roy, A., Maitra, S., Shankar, V., Khanna, P., & Baidya, D. K. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.102189 · Cited by 100
On the role of classical and novel forms of vitamin D in melanoma progression and management
Slominski, A. T., Brożyna, A. A., Skobowiat, C., Zmijewski, M. A., Kim, T., Janjetović, Z., Oak, A. S. W., Jóźwicki, W., Jetten, A. M., Mason, R. S., et al. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.06.013 · Cited by 100
Metadata
- Authors
- Bikle, D. D.
- Affiliations
- San Francisco VA Medical Center (US)
- Corresponding author
- Bikle, Daniel D.
- ORCID
- Bikle, Daniel D.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 21
- Issue
- 3
- Pages
- 319-329
- ISSN
- 1074-5521 (ISSN-L)
- PMC
- PMC3968073
- OpenAlex
- W1976776496
- Cited by
- 1,933
- References
- 133
- Citations by year
- 2026: 148 · 2025: 189 · 2024: 196 · 2023: 272 · 2022: 219 · 2021: 211 · 2020: 228 · 2019: 142 · 2018: 135 · 2017: 84 · 2016: 60 · 2015: 37 · 2014: 10
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Defense
- National Institutes of Health (AR050023)
- National Cancer Institute (CA110338)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR038386, R01AR050023, P01AR039448)
- National Center for Research Resources (P41RR001614)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- vitamin D metabolism, vitamin D3, vitamin D2, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, CYP2R1, CYP27B1, CYP24A1, vitamin D receptor, vitamin D response element, transcriptional regulation, vitamin D analogs, 7-dehydrocholesterol, ergosterol
- MeSH terms
- Cytochrome P-450 Enzyme System, DNA, Humans, Immune System, Metabolic Diseases, Neoplasms, Vitamin D, Receptors, Calcitriol, Response Elements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
