The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products
Open accessAbstract
Summary Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.
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Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20085f · Cited by 2,076
Self-citationantiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
Weber, T., Blin, K., Duddela, S., Krug, D., Kim, H. U., Bruccoleri, R., Lee, S. Y., Fischbach, M. A., Müller, R., Wohlleben, W., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv437 · Cited by 1,868
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
Cimermancic, P., Medema, M. H., Claesen, J., Kurita, K., Wieland Brown, L. C., Mavrommatis, K., Pati, A., Godfrey, P. A., Koehrsen, M., Clardy, J., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.034 · Cited by 981
Havarstein, L. S., Diep, D. B., & Nes, I. F. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02295.x · Cited by 612
Synthesis at the molecular frontier
Wender, P. A., & Miller, B. L. (2009) · Nature · doi:10.1038/460197a · Cited by 579
A roadmap for natural product discovery based on large-scale genomics and metabolomics
Doroghazi, J. R., Albright, J. C., Goering, A. W., Ju, K.-S., Haines, R. R., Tchalukov, K. A., Labeda, D. P., Kelleher, N. L., & Metcalf, W. W. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1659 · Cited by 476
Nonribosomal peptide synthetases: structures and dynamics
Strieker, M., Tanović, A., & Marahiel, M. A. (2010) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.01.009 · Cited by 441
Gavrish, E., Sit, C. S., Cao, S., Kandror, O., Spoering, A., Peoples, A., Ling, L., Fetterman, A., Hughes, D., Bissell, A., et al. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.01.014 · Cited by 423
Follow the leader: the use of leader peptides to guide natural product biosynthesis
Oman, T. J., & van der Donk, W. A. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.286 · Cited by 408
Self-citationLasso Peptides: An Intriguing Class of Bacterial Natural Products
Hegemann, J. D., Zimmermann, M., Xie, X., & Marahiel, M. A. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00156 · Cited by 393
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Metadata
- Authors
- Ortega, M. A., & van der Donk, W. A.
- Venue
- Cell Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 23
- Issue
- 1
- Pages
- 31-44
- ISSN
- 2451-9448 (ISSN-L)
- 2451-9456
- OpenAlex
- W2252545027
- Cited by
- 287
- References
- 94
- FWCI
- 29.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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