Toxicity effects of the organic UV-filter 4-Methylbenzylidene camphor in zebrafish embryos
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Ultraviolet (UV) filters are widely used in personal care products and due to their lipophilicity these chemicals tend to bioaccumulate in the aquatic biota. 4-Methylbenzylidene camphor (4-MBC) is one of the most used UV-filters, and it is commonly detected in freshwater fish tissues. This substance is suspected to be an endocrine disruptor due to its interaction with Hypothalamus-Pituitary-Gonadal (HPG) and HP-Thyroid (HPT)-axis. The main objective of this study was to evaluate the effects of 4-MBC on apical endpoints, biochemical markers and on genes involved in endocrine pathways in Danio rerio. Zebrafish embryos were exposed to 4-MBC (0.083-0.77 mg/l) from 0 to 96 h post-fertilization (hpf). Hatching, heart rate and malformations were the apical endpoints assessed. Alterations on neurotransmission and oxidative stress were evaluated through acetylcholinesterase (AChE), catalase (CAT) and glutathione S-transferase (GST) enzymatic activities. Endocrine effects were analysed by the expression of genes involved in HPG and HPT-axis of embryos exposed 96 h to the EC 10 of 4-MBC (0.19 mg/l). Exposure to 4-MBC induced morphological abnormalities during embryonic development, including notochord curvature, delayed absorption of yolk sac and pericardial oedema. Concentration of 0.77 mg/l 4-MBC decreased embryo heart rate at 48h. At neurotransmission level, an induction of AChE at concentrations above 0.15 mg/l was observed. Malformations and decreased heart rate along with alterati…
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4-MBC at 0.19-0.77 mg/L causes neurotoxicity, malformations, decreased heart rate and gene expression, and altered sexual differentiation in zebrafish embryos.
“Neurotoxicity and malformations, decrease in heart rate and gene expression, as well as alteration in sexual differentiation were some of the consequences seen in zebrafish embryos Danio renio regarding to 3-(4-methylbenzylidene) camphor (7) at concentrations between 0.19 and 0.77 mg/L [96].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [96]
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
Stages of embryonic development of the zebrafish
Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., & Schilling, T. F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030302 · Cited by 12,037 · see citing works
[51] Assays for differentiation of glutathione S-Transferases
Habig, W. H., & Jakoby, W. B. (1981) · Methods in Enzymology · doi:10.1016/s0076-6879(81)77053-8 · Cited by 2,419 · see citing works
Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment
Ebele, A. J., Abou-Elwafa Abdallah, M., & Harrad, S. (2017) · Emerging Contaminants · doi:10.1016/j.emcon.2016.12.004 · Cited by 2,023 · see citing works
CRC handbook of methods for oxygen radical research
Bogomolets, B. B. (1985) · Experimental Gerontology · doi:10.1016/0531-5565(85)90021-x · Cited by 1,554 · see citing works
Molecular Physiology of Cardiac Repolarization
Nerbonne, J. M., & Kass, R. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00002.2005 · Cited by 1,054 · see citing works
Brausch, J., & Rand, G. M. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2010.11.018 · Cited by 986 · see citing works
In Vitro and in Vivo Estrogenicity of UV Screens
Schlumpf, M., Cotton, B., Conscience-Egli, M., Haller, V., Steinmann, B., & LICHTENSTEIGER, W. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109239 · Cited by 847 · see citing works
Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss lakes
Balmer, M. E., Buser, H.-R., Müller, M. D., & Poiger, T. (2005) · Environmental Science & Technology · doi:10.1021/es040055r · Cited by 779 · see citing works
A practical approach to RT-qPCR—Publishing data that conform to the MIQE guidelines
Taylor, S., Wakem, M., Dijkman, G., Alsarraj, M., & Nguyen, M. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.005 · Cited by 776 · see citing works
Livingstone, D. R. (1998) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(98)10008-9 · Cited by 524 · see citing works
Krause, M., Klit, A., Blomberg Jensen, M., Søeborg, T., Frederiksen, H., Schlumpf, M., Lichtensteiger, W., Skakkebaek, N. E., & Drzewiecki, K. T. (2012) · International Journal of Andrology · doi:10.1111/j.1365-2605.2012.01280.x · Cited by 461 · see citing works
Barata, C., Varó, I., Navarro, J. C., Arun, S., & Porte, C. (2005) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cca.2005.01.013 · Cited by 418 · see citing works
Endocrine activity and developmental toxicity of cosmetic UV filters—an update
Schlumpf, M., Schmid, P., Durrer, S., Conscience, M., Maerkel, K., Henseler, M., Gruetter, M., Herzog, I., Reolon, S., Ceccatelli, R., et al. (2004) · Toxicology · doi:10.1016/j.tox.2004.06.043 · Cited by 410 · see citing works
Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity
González‐Burgos, E., & Gómez-Serranillos, M. P. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712803833335 · Cited by 408 · see citing works
Groh, K. J., Pakdel, F., Segner, H. E., Kah, O., & Eggen, R. I. L. (2007) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2007.03.005 · Cited by 335 · see citing works
Schreurs, R. H. M. M. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfi035 · Cited by 330 · see citing works
Guilhermino, L. M., Lopes, M. C., Carvalho, A. P., & Soared, A. M. V. M. (1996) · Chemosphere · doi:10.1016/0045-6535(95)00360-6 · Cited by 295 · see citing works
Buser, H., Balmer, M. E., Schmid, P., & Kohler, M. (2006) · Environmental Science and Technology · doi:10.1021/es052088s · Cited by 240 · see citing works
Kazeto, Y., Place, A. R., & Trant, J. M. (2004) · Aquatic Toxicology · doi:10.1016/j.aquatox.2004.04.008 · Cited by 227 · see citing works
Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole
Yu, L., Chen, M., Liu, Y., Gui, W., & Zhu, G. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.04.001 · Cited by 218 · see citing works
Inhibition of Acetylcholinesterase Activity by Monoterpenoids with a p-Menthane Skeleton
Miyazawa, M., Watanabe, H., & Kameoka, H. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf960398b · Cited by 210 · see citing works
Inui, M., Adachi, T., Takenaka, S., Inui, H., Nakazawa, M., Ueda, M., Watanabe, H., Mori, C., Iguchi, T., & Miyatake, K. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00340-8 · Cited by 201 · see citing works
Estrogenic activity of UV filter mixtures.
Kunz, P., & Fent, K. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.07.014 · Cited by 195 · see citing works
Fent, K., Kunz, P., Zenker, A. K., & Rapp, M. (2010) · Marine Environmental Research · doi:10.1016/j.marenvres.2009.10.010 · Cited by 171 · see citing works
Schmutzler, C., Gotthardt, I., Hofmann, P. J., Radović, B., Kovács, G. L., Stemmler, L., Nobis, I., Bacinski, A., Mentrup, B., Ambrugger, P., et al. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9369 · Cited by 153 · see citing works
(2018) · Elsevier eBooks · doi:10.1016/c2014-0-00920-3 · Cited by 137 · see citing works
Developmental toxicity of UV filters and environmental exposure: a review.
Schlumpf, M., Durrer, S., Faass, O., Ehnes, C., Fuetsch, M., Gaille, C., Henseler, M., Hofkamp, L. E., Maerkel, K., Reolon, S., et al. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00856.x · Cited by 127 · see citing works
Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.
Rodil, R., Schrader, S., & Moeder, M. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.04.042 · Cited by 119 · see citing works
Gao, L., Yuan, T., Zhou, C., Cheng, P., Bai, Q., Ao, J.-J., Wang, W.-H., & Zhang, H. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.09.041 · Cited by 114 · see citing works
Toxicity and cardiac effects of carbaryl in early developing zebrafish (Danio rerio) embryos
Lin, C., Hui, M., & Cheng, S. H. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.04.013 · Cited by 113 · see citing works
Cadmium Affects Muscle Type Development and Axon Growth in Zebrafish Embryonic Somitogenesis
Chow, E. S. H. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg046 · Cited by 113 · see citing works
Mueller, S. O., Kling, M., Firzani, P. A., Mecky, A., Duranti, E., Shields-Botella, J., Delansorne, R., Broschard, T. H., & Kramer, P.-J. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00016-x · Cited by 112 · see citing works
Mindnich, R., Haller, F., Halbach, F., Moeller, G., de Angelis, M. H., & Adamski, J. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01853 · Cited by 107 · see citing works
Benedé, J. L., Chisvert, A., Salvador, A., Sánchez-Quiles, D., & Tovar‐Sánchez, A. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.12.033 · Cited by 102 · see citing works
Self-citationLiu, H., Sun, P., Liu, H.-X., Yang, S.-G., Wang, L.-S., & Wang, Z.-Y. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.05.017 · Cited by 86 · see citing works
Maerkel, K., Durrer, S., Henseler, M., Schlumpf, M., & Lichtensteiger, W. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.10.026 · Cited by 72 · see citing works
Molecular basis of sex and reproductive status in breeding zebrafish
Santos, E. M., Workman, V. L., Paull, G. C., Filby, A. L., Look, K. J. W. V., Kille, P., & Tyler, C. R. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00284.2006 · Cited by 71 · see citing works
Li, V. W. T., Tsui, M., Chen, X.-P., Hui, M., Jin, L., Lam, R. H., Yu, R., Murphy, M., Cheng, J.-P., Lam, P., et al. (2016) · Environmental science and pollution research international · doi:10.1007/s11356-016-6180-9 · Cited by 68 · see citing works
Toxicity of organic UV-filters to the aquatic midge Chironomus riparius.
Campos, D., Gravato, C., Quintaneiro, C., Golovko, O., Žlábek, V., Soares, A., & Pestana, J. (2017) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2017.05.005 · Cited by 66 · see citing works
Self-citationMushtaq, N., Schmatz, R., Pereira, L. B., Ahmad, M., Stefanello, N., Vieira, J. M., Abdalla, F. H., Rodrigues, M., Baldissarelli, J., Pelinson, L. P., et al. (2013) · Cell Biochemistry and Function · doi:10.1002/cbf.3014 · Cited by 65 · see citing works
Urbatzka, R., Rocha, E., Reis, B., Cruzeiro, C., Monteiro, R. A. F., & Rocha, M. J. (2012) · Environmental Pollution · doi:10.1016/j.envpol.2012.01.018 · Cited by 65 · see citing works
Personal Care Products in the Aquatic Environment
Díaz-Cruz, M., & Barceló, D. (2015) · The handbook of environmental chemistry · doi:10.1007/978-3-319-18809-6 · Cited by 64 · see citing works
Torres, T., Cunha, I., Martins, R., & Santos, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101762 · Cited by 62 · see citing works
Araújo, M., Rocha, R. J., Soares, A., Benedé, J. L., Chisvert, A., & Monteiro, M. (2018) · Science of the Total Environment · doi:10.1016/j.scitotenv.2018.02.112 · Cited by 60 · see citing works
Self-citationWu, C., Huang, X., Lin, J., & Liu, J. (2014) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-014-0087-6 · Cited by 56 · see citing works
Assessment of multiple hormone activities of a UV-filter (octocrylene) in zebrafish (Danio rerio).
Zhang, Q., Ma, X.-Y. Y., Wang, X.-C. C., & Ngo, H. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.06.037 · Cited by 52 · see citing works
Schiller, V., Wichmann, A., Kriehuber, R., Eilebrecht, E., Giesy, J. P., Hecker, M., & Fenske, M. (2012) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2012.09.005 · Cited by 49 · see citing works
Biochemical targets of xenobiotics: Biomarkers in amphibian ecotoxicology
Venturino, A., & de D’Angelo, A. M. P. (2005) · Applied Herpetology · doi:10.1163/1570754054507433 · Cited by 47 · see citing works
Effects of 4-MBC and triclosan in embryos of the frog Pelophylax perezi.
Martins, D., Monteiro, M., Soares, A., & Quintaneiro, C. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.03.038 · Cited by 45 · see citing works
Self-citationEcotoxicity of two organic UV-filters to the freshwater caddisfly Sericostoma vittatum.
Campos, D., Gravato, C., Fedorova, G., Burkina, V., Soares, A., & Pestana, J. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.05.021 · Cited by 44 · see citing works
Self-citationCaspillo, N. R., Volkova, K., Hallgren, S., Olsson, P., & Porsch-Hällström, I. (2014) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2014.04.003 · Cited by 44 · see citing works
Kazeto, Y., Goto-Kazeto, R., Place, A. R., & Trant, J. M. (2003) · Fish Physiology and Biochemistry · doi:10.1023/b:fish.0000030466.23085.94 · Cited by 43 · see citing works
Schiller, V., Zhang, X., Hecker, M., Schäfers, C., Fischer, R., & Fenske, M. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.06.005 · Cited by 37 · see citing works
Lorenzetti, S., Altieri, I., Arabi, S., Balduzzi, D., Bechi, N., Cordelli, E., Galli, C., Ietta, F., Modina, S., Narciso, L., et al. (2011) · PubMed · doi:10.4415/ann_11_04_16 · Cited by 36 · see citing works
Inhibition of cholinesterases by phenolic acids detected in beer: A dose-response model approach
Szwajgier, D. (2013) · AFRICAN JOURNAL OF BIOTECHNOLOGY · Cited by 11 · see citing works
Environmental Monitoring of Cosmetic Ingredients
Chisvert, A., Giokas, D. L., Benedé, J. L., & Salvador, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-444-63508-2.00016-3 · Cited by 11 · see citing works
Self-citationAnalytical Methodologies for the Determination of Personal Care Products in Water Samples
Chisvert, A., & Salvador, A. (2014) · The handbook of environmental chemistry · doi:10.1007/698_2014_265 · Cited by 5 · see citing works
Self-citationTorres, T. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/smcw-ff44 · Cited by 5 · see citing works
4-methylbenzylidene-camphor (4MBC) causes pituitary effects comparable to hypothyroidism
Hamann, I., Schmutzler, C., Kirschmeyer, P., Jarry, H., & Köhrle, J. (2006) · 8th European Congress of Endocrinology incorporating the British Endocrine Societies · Cited by 4 · see citing works
Gotthardt, I., Schmutzler, C., Kirschmeyer, P., Wuttke, W., Jarry, H., & Köhrle, J. (2008) · 10th European Congress of Endocrinology · Cited by 2 · see citing works
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Risks of organic UV filters: A review of environmental and human health concern studies
Huang, Y., Law, J. C.-F., Lam, T.-K., & Leung, K. S.-Y. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142486 · Cited by 232 · see citing works
Carve, M., Nugegoda, D., Allinson, G., & Shimeta, J. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115894 · Cited by 138 · see citing works
UV Filters: Challenges and Prospects
Jesus, A., Sousa, E., Cruz, M., Cidade, H., Lobo, J., & Almeida, I. (2022) · Pharmaceuticals · doi:10.3390/ph15030263 · Cited by 132 · see citing works
Ultraviolet Filters for Cosmetic Applications
Nițulescu, G., Lupuliasa, D., Adam-Dima, I., & Nițulescu, G. (2023) · Cosmetics · doi:10.3390/cosmetics10040101 · Cited by 90 · see citing works
Huang, X.-X., Li, Y.-Y., Wang, T.-T., Liu, H., Shi, J.-Q., & Zhang, X.-S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17020651 · Cited by 64 · see citing works
Hemalatha, D., Rangasamy, B., Nataraj, B., Maharajan, K., Narayanasamy, A., & Ramesh, M. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139851 · Cited by 64 · see citing works
Nataraj, B., Maharajan, K., Hemalatha, D., Rangasamy, B., Arul, N., & Ramesh, M. (2019) · Science of the Total Environment · doi:10.1016/j.scitotenv.2019.134546 · Cited by 57 · see citing works
Evaluation of toxicity of Personal Care Products (PCPs) in freshwaters: zebrafish as a model.
Zicarelli, G., Multisanti, C., Falco, F., & Faggio, C. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.103923 · Cited by 47 · see citing works
Cahova, J., Blahová, J., Plhalová, L., Svobodová, Z., & Faggio, C. (2021) · Water · doi:10.3390/w13162203 · Cited by 49 · see citing works
Ultraviolet Filters: Dissecting Current Facts and Myths
Breakell, T., Kowalski, I., Foerster, Y., Kramer, R., Erdmann, M., Berking, C., & Heppt, M. V. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102986 · Cited by 45 · see citing works
Occurrence, effects, and ecological risks of chemicals in sanitizers and disinfectants: A review
Musee, N., Ngwenya, P., Motaung, L. K., Moshuhla, K., & Nomngongo, P. (2023) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2023.01.003 · Cited by 35 · see citing works
Xian, H., Li, Z.-M., Bai, R., Ye, R.-Y., Feng, Y., Zhong, Y.-Z., Liang, B.-X., Huang, Y.-J., Guo, J., Wang, B.-J., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134298 · Cited by 36 · see citing works
Multisanti, C. R., Zicarelli, G., Caferro, A., Filice, M., Faggio, C., Vazzana, I., Blahová, J., Lakdawala, P., Cerra, M. C., Imbrogno, S., et al. (2024) · Antioxidants · doi:10.3390/antiox13060734 · Cited by 40 · see citing works
Liang, M., Yan, S., Chen, R., Hong, X.-S., & Zha, J.-M. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126224 · Cited by 33 · see citing works
Ka, Y., & Ji, K. (2022) · Ecotoxicology · doi:10.1007/s10646-022-02555-1 · Cited by 37 · see citing works
Tapia‐Salazar, M., Diaz-Sosa, V. R., & Cárdenas‐Chávez, D. L. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.01.007 · Cited by 35 · see citing works
Cahova, J., Blahova, J., Marsalek, P., Doubkova, V., Franc, A., Garajová, M., Tichy, F., Mares, J., & Svobodova, Z. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145570 · Cited by 34 · see citing works
Lyu, Y., Zhong, F., Tang, Z., He, Y., & Han, X. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.118612 · Cited by 30 · see citing works
Developmental toxicity assessment of 4-MBC in Danio rerio embryo-larval stages.
Prakash, V., Jain, V., Chauhan, S. S., Parthasarathi, R., Roy, S., & Anbumani, S. (2021) · Science of the Total Environment · doi:10.1016/j.scitotenv.2021.149920 · Cited by 28 · see citing works
Multiresidue Analysis of Organic UV Filters and UV Stabilizers in Fish of Common Consumption
Gimeno-Monforte, S., Montesdeoca-Esponda, S., Sosa-Ferrera, Z., Santana-Rodríguez, J. J., Castro, Ó., Pocurull, E., & Borrull, F. (2020) · Foods · doi:10.3390/foods9121827 · Cited by 26 · see citing works
Cuccaro, A., Marchi, L. D., Oliva, M., Battaglia, F., Meucci, V., Fumagalli, G., Freitas, R., & Pretti, C. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113739 · Cited by 30 · see citing works
Gayathri, M., Sutha, J., Mohanthi, S., Ramesh, M., & Poopal, R.-K. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109688 · Cited by 26 · see citing works
Yang, J., Zhou, W., Shi, D., Pan, F., Sun, W., Yang, P., & Li, X. (2023) · Antioxidants · doi:10.3390/antiox12010192 · Cited by 22 · see citing works
Zhao, G., Gao, M., Guo, S., Zeng, S., Ye, C., Wang, M., Anwar, Z., Hu, B., & Hong, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164073 · Cited by 22 · see citing works
Cuccaro, A., Freitas, R., Marchi, L. D., Monni, G., Meucci, V., Oliva, M., Fumagalli, G., & Pretti, C. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122490 · Cited by 18 · see citing works
Lorigo, M., Quintaneiro, C., Lemos, M. C., Martinez‐de‐Oliveira, J., Breitenfeld, L., & Cairrão, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061376 · Cited by 21 · see citing works
Self-citation4-Methylbenzylidene camphor induced neurobehavioral toxicity in zebrafish (Danio rerio) embryos
Prakash, V., Chauhan, S. S., Ansari, M. I., Jagdale, P. R., Ayanur, A., Parthasarathi, R., & Anbumani, S. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117746 · Cited by 18 · see citing works
Lucas, J., Logeux, V., Rodrigues-Stien, A., Stien, D., & Lebaron, P. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12582-w · Cited by 17 · see citing works
Du, Z., Xia, Z., Zhang, M., Wei, Y., Malhotra, N., Saputra, F., Audira, G., Roldan, M. J. M., Hsiao, C., Hao, E., et al. (2021) · Cardiovascular Toxicology · doi:10.1007/s12012-021-09682-x · Cited by 16 · see citing works
Lax, C., Wicksell, E., Grip, A., Niemi, J. V. L., Liu, W., Rafeletou, A., Kudłak, B., & Schiöth, H. B. (2023) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13901 · Cited by 16 · see citing works
Ka, Y., Lee, I., & Ji, K. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117170 · Cited by 16 · see citing works
Stolecka, A., Mielczarek, P., Koziarska, M., & Gruszecka-Kosowska, A. (2025) · Water Research · doi:10.1016/j.watres.2025.123423 · Cited by 13 · see citing works
Yang, Q.-Y., Tian, L., Wang, W., Chen, X., & Tao, J. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116053 · Cited by 15 · see citing works
A Systematic Review on Occurrence and Ecotoxicity of Organic UV Filters in Aquatic Organisms
Prakash, V., & Anbumani, S. (2021) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/398_2021_68 · Cited by 14 · see citing works
Effect of benzophenone-3 on the blood cells of zebrafish ( Danio rerio )
de Oliveira-Lima, J., da Cunha, R. L. D., & de Brito‐Gitirana, L. (2022) · Journal of Environmental Science and Health Part B · doi:10.1080/03601234.2021.2022946 · Cited by 14 · see citing works
Beiras, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-08-102971-8.00005-6 · Cited by 14 · see citing works
Colás-Ruiz, N. R., Pintado-Herrera, M. G., Santonocito, M., Salerno, B., Tonini, F., Lara-Martín, P., & Hampel, M. (2023) · Science of the Total Environment · doi:10.1016/j.scitotenv.2023.169178 · Cited by 11 · see citing works
Rafeletou, A., Niemi, J. V. L., Lagunas‐Rangel, F. A., Liu, W., Kudłak, B., & Schiöth, H. B. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170999 · Cited by 11 · see citing works
Mokh, S., Nassar, R., Berry, A., Khatib, M. E., Doumiati, S., Taha, M., Ezzeddine, R., & Iskandarani, M. A. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16970-0 · Cited by 11 · see citing works
Effects of exposure to the UV-filter 4-MBC during Solea senegalensis metamorphosis
Araújo, M., Soares, A., & Monteiro, M. (2021) · Environmental science and pollution research international · doi:10.1007/s11356-021-14235-4 · Cited by 9 · see citing works
Self-citationBeljin, J., Kragulj-Isakovski, M., Simetić, T., Đukanović, N., Molnar-Jazić, J., Maletić, S., & Vujić, M. (2024) · Applied Sciences · doi:10.3390/app14209424 · Cited by 9 · see citing works
Maddaleno, A. S., Guardia-Escote, L., Vinardell, M. P., Teixidó, E., & Mitjans, M. (2025) · Cosmetics · doi:10.3390/cosmetics12040175 · Cited by 8 · see citing works
Greco, A., Franchi, E., Denegri, M., Ambrosino, S., Magri, F., Coperchini, F., & Rotondi, M. (2025) · Environmental Health · doi:10.1186/s12940-025-01229-9 · Cited by 6 · see citing works
Heilgeist, S., Sekine, R., Clases, D., Sahin, O., & Stewart, R. (2023) · ACS ES&T Water · doi:10.1021/acsestwater.2c00656 · Cited by 5 · see citing works
Lu, X., Sun, L., Chen, J., Wang, J., Guan, M., & Xu, S. (2025) · Integrative Zoology · doi:10.1111/1749-4877.13036 · Cited by 6 · see citing works
Monjezi, Z., Vosough, M., & Salemi, A. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14440-1 · Cited by 6 · see citing works
Cuccaro, A., Marchi, L. D., Pirone, A., Monni, G., Meucci, V., Lazzarini, G., Fumagalli, G., Oliva, M., Miragliotta, V., Freitas, R., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124930 · Cited by 5 · see citing works
Wu, X., Zhou, C.-Y., Wang, J., Cao, M.-X., Wang, L., & Liang, Y. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2025.107334 · Cited by 4 · see citing works
Prakash, V., Ansari, M. I., Chauhan, S. S., Parthasarathi, R., & Anbumani, S. (2024) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2024.110051 · Cited by 5 · see citing works
Ju, H., Zhang, Y., Qin, Y., Liu, J., Tang, Y., Sokolova, I. M., & Diao, X. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140603 · Cited by 4 · see citing works
Cuccaro, A., Moreira, A., Marchi, L. D., Meucci, V., Soares, A. M. V. M., Pretti, C., & Freitas, R. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136405 · Cited by 4 · see citing works
Self-citationLorigo, M., Breitenfeld, L., Monteiro, M. S., Soares, A. M. V. M., Quintaneiro, C., & Cairrão, E. (2025) · Pharmaceuticals · doi:10.3390/ph18121897 · Cited by 3 · see citing works
Self-citationMalinovska, V., Kuklina, I., Grabicová, K., Buřič, M., & Kozák, P. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115012 · Cited by 3 · see citing works
Exposure effects of the UV-filter 4-MBC to "Solea senegalensis" metamorphosisPreprint
Araújo, M., Soares, A., & Monteiro, M. (2021) · Research Square · doi:10.21203/rs.3.rs-166939/v1
Self-citationSunscreen Challenges: Stability, Systemic Absorption, and Environmental Concerns
Rajan, R. (2024) · Springer eBooks · doi:10.1007/978-981-97-3195-4_11 · Cited by 2 · see citing works
Subahar, R., Nur, L. S. E., Huang, A., Wijaya, R. S., Yulhasri, Y., Susanto, L., & Winita, R. (2022) · International Journal of Mosquito Research · doi:10.22271/23487941.2022.v9.i6b.648 · Cited by 2 · see citing works
Gautam, K., Singh, S., Jain, V., Vamadevan, B., Roy, S. K., & Anbumani, S. (2025) · Journal of Environmental Science · doi:10.1016/j.jes.2025.09.043 · Cited by 1 · see citing works
Gayathri, M., Sutha, J., Mohanthi, S., & Ramesh, M. (2025) · Chemistry and ecology · doi:10.1080/02757540.2025.2569330 · Cited by 1 · see citing works
Rolo, P., Pestana, J., & Campos, D. (2025) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2025.104899 · Cited by 1 · see citing works
SPF – super problematična formula? Aktivni sastojci krema za sunčanje u vodenom okolišu
Blažević, I., Kos, K., Kovačević, M., Marković, T., Sović, L., & Miloloža, M. (2023) · Kemija u industriji · doi:10.15255/kui.2022.053
Xie, Q., Lu, D., Ma, R., Zeng, X., & Guo, J. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128319753240730052138
Am-Shalom, M., Kanfy-Weinberger, R., Kramarsky‐Winter, E., Kushmaro, A., Alegría, C., Vaca, G., Pazmiño, D. A., Muñoz‐Pérez, J. P., Yépez, M., & Ochoa‐Herrera, V. (2026) · Regional Studies in Marine Science · doi:10.1016/j.rsma.2026.105101
Park, J. W., Baek, H. J., & Hwang, I. J. (2026) · Fisheries and aquatic sciences · doi:10.47853/fas.2026.e28
Zhang, Y., Ren, J., She, L., Sun, C., Guan, Z., Xia, S., Li, J., Liu, J., & Peng, Y. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128571
Chen, Q., Ma, X., Qi, Y., Fang, B., Wen, S., Shao, B., Zhao, X., & Liu, X. (2026) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2026.08.016
Lu, X., Guan, M., Suqi, T., Hu, J., Sun, L., Wang, J., Chen, J., Zhang, H., & Xu, S. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129076
- Authors
- Quintaneiro, C., Teixeira, B., Benedé, J. L., Chisvert, A., Soares, A. M. V. M., & Monteiro, M. S.
- Affiliations
- University of Aveiro (PT)
- Universitat de València (ES)
- Corresponding author
- Quintaneiro, Carla
- Venue
- Chemosphere
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 218
- Pages
- 273-281
- ISSN
- 0045-6535 (ISSN-L)
- OpenAlex
- W2900725560
- Cited by
- 66
- References
- 63
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 7 · 2021: 12 · 2020: 6 · 2019: 2
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Chemosphere (publishedVersion)
- PubMed (publishedVersion)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc-nd)
- Funders
- CESAM
- UID/AMB (50017/2013)
- FCT/MEC
- FEDER (POCI-01-0145-FEDER-007638)
- Programa Operacional Capital Humano/União Europeia (SFRH/BPD/89951/2012)
- MSM (SFRH/BPD/100448/2014)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- 4-methylbenzylidene camphor, UV filters, endocrine disruption, zebrafish embryos, zebrafish, hypothalamic-pituitary-gonadal axis, hypothalamic-pituitary-thyroid axis, aromatase gene expression, acetylcholinesterase, catalase, glutathione S-transferase, oxidative stress, neurotransmission, embryonic malformations, heart rate
- MeSH terms
- Acetylcholinesterase, Animals, Camphor, Embryo, Nonmammalian, Endocrine System, Enzyme Induction, Filtration, Glutathione Transferase, Synaptic Transmission, Zebrafish, Oxidative Stress, Endocrine Disruptors
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