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Cited by 169Phytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative StressNutritional Studies and Diet

The DOI matches its Crossref record; 264 of the 266 references it cites were found in a registry or an index.

A review of dietary phytochemicals and their relation to oxidative stress and human diseases

Guan, Ruirui, Van Le, Quyet, Yang, Han, Zhang, Dangquan, Gu, Haiping, Yang, Yafeng, Sonne, Christian, Lam, Su Shiung, Zhong, Jiateng, Jianguang, Zhu, Liu, Runqiang, Peng, Wanxi·2021·Chemosphere
DOI 10.1016/j.chemosphere.2020.129499
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Abstract

Phytochemicals refer to active substances in plant-based diets. Phytochemicals found in for example fruits, vegetables, grains and seed oils are considered relatively safe for consumption due to mammal-plant co-evolution and adaptation. A number of human diseases are related to oxidative stress caused by for example chemical environmental contaminants in air, water and food; while also lifestyle including smoking and lack of exercise and dietary preferences are important factors for disease development in humans. Here we explore the dietary sources of antioxidant phytochemicals that have beneficial effects on oxidative stress, cardiovascular and neurological diseases as well as cancer. Plant-based diets usually contain phenolic acids, flavonoids and carotenoids, which have strong antioxidant properties, and therefore remove the excess of active oxygen in the body, and protect cells from damage, reducing the risk of cardiovascular and Alzheimer's disease. In most cases, obesity is related to diet and inactivity and plant-based diets change lipid composition and metabolism, which reduce obesity related hazards. Cruciferous and Allium vegetables are rich in organic sulphides that can act on the metabolism of carcinogens and therefore used as anti-cancer and suppressing agents while dietary fibres and plant sterols may improve intestinal health and prevent intestinal diseases. Thus, we recommend a diet rich in fruits, vegetables, and grains as its content of phytochemicals may have the potential to prevent or improve a broad sweep of various diseases.

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Research works printed but not linked: 8

  1. Balík, 2020, Beer and beer-based beverage contain lignans, J. Food Sci. Technol., 1–5
  2. Essa, 2012, Neuroprotective effect of natural products against Alzheimer’s disease, Neurochem. Res., 37, 1829, 10.1007/s11064-012-0799-9 · DOI · Paper page
  3. Haminiuk, 2012, Phenolic compounds in fruits–an overview, Int. J. Food Sci. Technol., 47, 2023, 10.1111/j.1365-2621.2012.03067.x · DOI · Paper page
  4. Kumar, 2013, Chemistry and biological activities of flavonoids: an overview, Sci. World J., 1
  5. Liu, 2004, Potential synergy of phytochemicals in cancer prevention: mechanism of action, Adv. Nutr., 134, 3479
  6. Liu, 2013, Health-promoting components of fruits and vegetables in the diet, Adv. Nutr., 4, 384S, 10.3945/an.112.003517 · DOI · Paper page
  7. Vermerris, 2008, Isolation and identification of phenolic compounds, Phenolic Compound Biochemistry, 151, 196
  8. Williams, 2011, Natural products as a source of Alzheimer’s drug leads, Nat. Prod. Rep., 28, 48, 10.1039/C0NP00027B · DOI · Paper page

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Metadata

Authors
Guan, R., Van Le, Q., Yang, H., Zhang, D., Gu, H., Yang, Y., Sonne, C., Lam, S. S., Zhong, J., Jianguang, Z., Liu, R., & Peng, W.
Affiliations
  • Henan Agricultural University (CN)
  • Aarhus University (DK)
  • Universiti Malaysia Terengganu (MY)
  • Henan Medical University (CN)
  • Henan University of Chinese Medicine (CN)
  • Henan Institute of Science and Technology (CN)
Corresponding author
  • Sonne, Christian
  • Peng, Wanxi
ORCID
Venue
Chemosphere
Publisher
Elsevier BV
Published
2021-05
Volume
271
Pages
129499
ISSN
0045-6535 (ISSN-L)
DOI
10.1016/j.chemosphere.2020.129499
OpenAlex
W3121099329
Cited by
169
References
266
Citations by year
2026: 22 · 2025: 37 · 2024: 41 · 2023: 35 · 2022: 23 · 2021: 11
FWCI
14.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Chemosphere (publishedVersion)
  • PubMed (publishedVersion)
Funders
Henan University (21IRTSTHN020)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
dietary phytochemicals, oxidative stress, antioxidants, plant-based diet, phenolic acids, flavonoids, carotenoids, cardiovascular disease, Alzheimer's disease, cancer prevention, obesity, cruciferous vegetables, Allium vegetables, organosulfur compounds, dietary fiber, phytosterols, gut health, environmental pollutants, lifestyle factors
MeSH terms
Animals, Antioxidants, Diet, Fruit, Humans, Vegetables, Oxidative Stress, Phytochemicals

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