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Cited by 128Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionGenetically Modified Organisms Research

The DOI matches its Crossref record; 226 of the 237 references it cites were found in a registry or an index.

Fourth generation biofuel from genetically modified algal biomass: Challenges and future directions.

Shokravi, Hoofar, Shokravi, Zahra, Heidarrezaei, Mahshid, Ong, Hwai Chyuan, Rahimian Koloor, Seyed Saeid, Petrů, Michal, Lau, Woei Jye, Ismail, Ahmad Fauzi·2021·Chemosphere
DOI 10.1016/j.chemosphere.2021.131535
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Abstract

Genetic engineering applications in the field of biofuel are rapidly expanding due to their potential to boost biomass productivity while lowering its cost and enhancing its quality. Recently, fourth-generation biofuel (FGB), which is biofuel obtained from genetically modified (GM) algae biomass, has gained considerable attention from academic and industrial communities. However, replacing fossil resources with FGB is still beset with many challenges. Most notably, technical aspects of genetic modification operations need to be more fully articulated and elaborated. However, relatively little attention has been paid to GM algal biomass. There is a limited number of reviews on the progress and challenges faced in the algal genetics of FGB. Therefore, the present review aims to fill this gap in the literature by recapitulating the findings of recent studies and achievements on safe and efficient genetic manipulation in the production of FGB. Then, the essential issues and parameters related to genome editing in algal strains are highlighted. Finally, the main challenges to FGB pertaining to the diffusion risk and regulatory frameworks are addressed. This review concluded that the technical and biosafety aspects of FGB, as well as the complexity and diversity of the related regulations, legitimacy concerns, and health and environmental risks, are among the most important challenges that require a strong commitment at the national/international levels to reach a global consensus.

Overview

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Crossref · 10.1016/j.chemosphere.2021.131535

Cites

226 of 226 references verified0 citation errors · 0 not checkable

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Citations

Cites

Items 201–226 of 226

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11 of the 237 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Brookes, 2021, Economic and environmental impact of genetically modified crops in Asia Pacific, Genet. Modif. Crop. Asia Pacific, 9
  2. Lee, 2016, High-performance empirical analysis of metabolic pathways in microalgae using cell-free system
  3. Sanner, 2016, The struggle for CRISPR: a billion dollar question in intellectual property, U. Ill. JL Tech. Pol’y, 431

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Metadata

Authors
Shokravi, H., Shokravi, Z., Heidarrezaei, M., Ong, H. C., Rahimian Koloor, S. S., Petrů, M., Lau, W. J., & Ismail, A. F.
Affiliations
  • University of Technology Malaysia (MY)
  • Islamic Azad University, Science and Research Branch (IR)
  • University of Technology Sydney (AU)
  • Technical University of Liberec (CZ)
Corresponding author
Ong, Hwai Chyuan
ORCID
Venue
Chemosphere
Publisher
Elsevier BV
Published
2021-12
Volume
285
Pages
131535
ISSN
0045-6535 (ISSN-L)
DOI
10.1016/j.chemosphere.2021.131535
OpenAlex
W3181545766
Cited by
127
References
237
Citations by year
2026: 13 · 2025: 30 · 2024: 28 · 2023: 31 · 2022: 19 · 2021: 6
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Chemosphere (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universiti Teknologi Malaysia
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
Keywords
fourth-generation biofuels, genetically modified algae, algal biomass, genome editing, biosafety, risk assessment, biofuel regulation, environmental risk
MeSH terms
Genetic Engineering, Plants, Biomass, Biofuels, Microalgae

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