The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress
Open accessAbstract
Summary Development of multifunctional stimuli-responsive nanomedicine is appealing for effective cancer treatment. Herein, we utilize the biocompatible CaCO3 nanoparticles as the template to guide the formation of pH-dissociable hollow coordination nanostructures, in which meso-tetra-(4-carboxyphenyl)porphine (TCPP), a sonosensitizer, acts as the organic bridging molecule and ferric ion serves as the metallic center. L-buthionine sulfoximine (BSO), an inhibitor for glutathione (GSH) biosynthesis, can be simultaneously loaded during the preparation of TCPP-Fe@CaCO3, obtaining BSO-TCPP-Fe@CaCO3 with pH-responsive dissociation to endow fast release of Ca2+ and BSO under an acidic tumor microenvironment. Such BSO-TCPP-Fe@CaCO3 confers synergistic oxidative stress amplification via intracellular Ca2+-overloading-induced mitochondria damage, BSO-mediated GSH depletion, and TCPP-mediated sonodynamic therapy (SDT), leading to remarkable cell death. Consequently, tumors on the mice treated with BSO-TCPP-Fe@CaCO3 administration and subsequent ultrasound exposure are effectively suppressed. Our work thus highlights a facile strategy to prepare pH-dissociable nanomedicine for effective SDT treatment of tumors via triple amplification of tumor oxidative stress.
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Wang, C., Cao, F., Ruan, Y., Jia, X., Zhen, W., & Jiang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903981 · Cited by 411
Cited by
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Self-citationZheng, P., Ding, B., Jiang, Z., Xu, W., Li, G., Ding, J., & Chen, X. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04778 · Cited by 359
Yang, N., Gong, F., Liu, B., Hao, Y., Chao, Y., Lei, H., Yang, X., Gong, Y., Wang, X., Liu, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29938-6 · Cited by 196
Self-citationDong, C., Dai, X., Wang, X., Lu, Q., Chen, L., Song, X., Ding, L., Huang, H., Feng, W., Chen, Y., et al. (2022) · Advanced Materials · doi:10.1002/adma.202205680 · Cited by 130
Metadata
- Authors
- Dong, Z., Feng, L., Hao, Y., Li, Q., Chen, M., Yang, Z., Zhao, H., & Liu, Z.
- Venue
- Chem
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 6
- Issue
- 6
- Pages
- 1391-1407
- ISSN
- 2451-9294 (ISSN-L)
- OpenAlex
- W3011462768
- Cited by
- 331
- References
- 1
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dong, Z., Feng, L., Hao, Y., Li, Q., Chen, M., Yang, Z., Zhao, H., & Liu, Z. (2020). Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress. Chem. https://doi.org/10.1016/j.chempr.2020.02.020
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