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Cited by 4,830Venous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis MechanismsAtrial Fibrillation Management and Outcomes

The DOI matches its Crossref record; 610 of the 610 references it cites were found in a registry or an index.

Antithrombotic Therapy for VTE Disease

Kearon, Clive, Akl, Elie A., Ornelas, Joseph, Blaivas, Allen, Jimenez, David, Bounameaux, Henri, Huisman, Menno, King, Christopher S., Morris, Timothy A., Sood, Namita, Stevens, Scott M., Vintch, Janine R.E., Wells, Philip, Woller, Scott C., Moores, Lisa·2016·Chest
DOI 10.1016/j.chest.2015.11.026
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Abstract

Background We update recommendations on 12 topics that were in the 9th edition of these guidelines, and address 3 new topics.Methods We generate strong (Grade 1) and weak (Grade 2) recommendations based on high- (Grade A), moderate- (Grade B), and low- (Grade C) quality evidence.Results For VTE and no cancer, as long-term anticoagulant therapy, we suggest dabigatran (Grade 2B), rivaroxaban (Grade 2B), apixaban (Grade 2B), or edoxaban (Grade 2B) over vitamin K antagonist (VKA) therapy, and suggest VKA therapy over low-molecular-weight heparin (LMWH; Grade 2C). For VTE and cancer, we suggest LMWH over VKA (Grade 2B), dabigatran (Grade 2C), rivaroxaban (Grade 2C), apixaban (Grade 2C), or edoxaban (Grade 2C). We have not changed recommendations for who should stop anticoagulation at 3 months or receive extended therapy. For VTE treated with anticoagulants, we recommend against an inferior vena cava filter (Grade 1B). For DVT, we suggest not using compression stockings routinely to prevent PTS (Grade 2B). For subsegmental pulmonary embolism and no proximal DVT, we suggest clinical surveillance over anticoagulation with a low risk of recurrent VTE (Grade 2C), and anticoagulation over clinical surveillance with a high risk (Grade 2C). We suggest thrombolytic therapy for pulmonary embolism with hypotension (Grade 2B), and systemic therapy over catheter-directed thrombolysis (Grade 2C). For recurrent VTE on a non-LMWH anticoagulant, we suggest LMWH (Grade 2C); for recurrent VTE on LMWH, we suggest increasing the LMWH dose (Grade 2C).Conclusions Of 54 recommendations included in the 30 statements, 20 were strong and none was based on high-quality evidence, highlighting the need for further research.

Overview

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Crossref · 10.1016/j.chest.2015.11.026

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610 of 610 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 3

  1. Kahn, 2014, Graduated compression stockings to treat acute leg pain associated with proximal DVT. A randomised controlled trial, Thromb Haemost, 112, 1137
  2. 2012, Pulmonary thromboendarterectomy for treatment of pulmonary hypertension (structured abstract), Health Technol Assess Database
  3. Mismetti, 2015, Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial, JAMA, 313, 1627, 10.1001/jama.2015.3780 · DOI · Paper page

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Metadata

Authors
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., Stevens, S. M., Vintch, J. R. E., Wells, P., Woller, S. C., & Moores, L.
Affiliations
  • McMaster University (CA)
  • American College of Chest Physicians (US)
  • VA New Jersey Health Care System (US)
  • University of Geneva (CH)
  • Leiden University Medical Center (NL)
  • Virginia Commonwealth University (US)
  • University of California San Diego (US)
  • The Ohio State University (US)
  • University of Utah (US)
  • Harbor–UCLA Medical Center (US)
  • University of Ottawa (CA)
  • Uniformed Services University of the Health Sciences (US)
Corresponding author
Akl, Elie A.
ORCID
Venue
Chest
Publisher
Elsevier BV
Published
2016-02
Volume
149
Issue
2
Pages
315-352
ISSN
0012-3692 (ISSN-L)
DOI
10.1016/j.chest.2015.11.026
OpenAlex
W2225937646
Cited by
4,830
References
610
Citations by year
2026: 173 · 2025: 244 · 2024: 270 · 2023: 321 · 2022: 420 · 2021: 630 · 2020: 697 · 2019: 607 · 2018: 621 · 2017: 530 · 2016: 244
FWCI
627.82
Type
journal article
Language
en
Update notices
erratum (2016-10-01)
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • CHEST Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
American College of Chest Physicians
Topics
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Keywords
venous thromboembolism, antithrombotic therapy, anticoagulation, dabigatran, rivaroxaban, apixaban, edoxaban, vitamin K antagonists, low molecular weight heparin, cancer-associated thrombosis, inferior vena cava filter, post-thrombotic syndrome, compression stockings, subsegmental pulmonary embolism, thrombolysis, recurrent venous thromboembolism, catheter-directed thrombolysis
MeSH terms
Drug Administration Schedule, Fibrinolytic Agents, Humans, Societies, Medical, Evidence-Based Medicine, International Normalized Ratio, Venous Thrombosis

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