The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Gender differences in the effects of childhood maltreatment on adult depression and anxiety: A systematic review and meta-analysis
Abstract
Child maltreatment has well-documented long-term, adverse effects on mental health, but it is not clear whether there are gender differences in these effects. We conducted a systematic review to investigate whether there are gender differences in the effects of maltreatment on adult depression and anxiety. Medline, PsycINFO, Web of Science, and Lilacs were searched for relevant studies published up to May 2016. Eligible studies included population-based studies (with a cohort, case-control or cross-sectional design) which assessed maltreatment during childhood or adolescence (≤18 years) and its association with major depression or generalized anxiety disorder (DSM/ICD diagnostic criteria) in adulthood (>18 years) separately for females and males. Meta-analysis was performed to estimate the association between each exposure and outcome using fixed and random effects models. Pooled odds ratios (OR) were estimated separately for women and men and compared. Five studies of physical and sexual abuse were included in the meta-analyses. These provided twenty-two effects sizes estimates (11 for men, 11 for women) for associations between physical/sexual abuse and depression/anxiety. Exposure to each kind of abuse increased the odds of depression/anxiety. Associations were larger for women than for men, however, these gender differences were not statistically significant. Physical and sexual abuse in childhood/adolescence are risk factors for depression/anxiety in adulthood and the effect could be larger for women; however, currently there is insufficient evidence to definitively identify gender differences in the effects of maltreatment.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Childhood maltreatment is known to substantially increase the risk of developing neuropsychiatric conditions in adulthood, including anxiety and mood disorders (1–3).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [3]
In the citing paper
“Women with a history of CSA have stronger anxiety and depression symptoms than men [ 29 ].”
From Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis (2023) · cites this paper as [29]
Citations
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Downs, S. H., & Black, N. (1998) · Journal of Epidemiology and Community Health · doi:10.1136/jech.52.6.377 · Cited by 8,252
Transforming our world: the 2030 Agenda for Sustainable Development
(2022) · doi:10.5040/9781509934058.0025 · Cited by 6,750
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006
Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876
Norman, R. E., Byambaa, M., De, R., Butchart, A., Scott, J., & Vos, T. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001349 · Cited by 3,387
Reprint—Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & and the PRISMA Group (2009) · Physical Therapy · doi:10.1093/ptj/89.9.873 · Cited by 2,486
Gender differences in depression: Critical review
Piccinelli, M., & Wilkinson, G. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.177.6.486 · Cited by 2,376
The prevalence of child maltreatment across the globe: review of a series of meta-analyses
Stoltenborgh, M., Bakermans‐Kranenburg, M. J., Alink, L. R. A., & van IJzendoorn, M. H. (2015) · Child Abuse Review · doi:10.1002/car.2353 · Cited by 1,542
Nanni, V., Uher, R., & Danese, A. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020335 · Cited by 1,480
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–278 of 278
Fei, S., Wang, Y., Gao, Y., & Chen, W. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121655 · Cited by 2
Gender Differences and Comorbidities in Major Depression
Jaber, M. H., Kahwaji, H., Eid, D., Atat, M. E., & Fakhoury, M. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-6872-7_13 · Cited by 1
Zhan, X., Li, K., Zheng, Y., Yang, G., & Luo, X. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1023749 · Cited by 2
Yona, L., & Spilsbury, J. C. (2023) · International Journal on Child Maltreatment Research Policy and Practice · doi:10.1007/s42448-023-00183-8 · Cited by 1
Bérubé, A., Pétrin, R., & Blais, C. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1374872 · Cited by 2
Bornscheuer, L., Landstedt, E., Gauffin, K., & Almquist, Y. B. (2025) · BMC Public Health · doi:10.1186/s12889-025-21531-y · Cited by 1
Kira, I. A., Irfan, S., Shuwiekh, H. A. M., & Bujold-Bugeaud, M. (2025) · Current Psychology · doi:10.1007/s12144-025-07828-6 · Cited by 1
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0001 · Cited by 1
Central Neural Circuits Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0005 · Cited by 1
Alloparental Behavior and Paternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0007 · Cited by 1
Shakoor, S., Mankee‐Williams, A., Otis, M., & Bhui, K. S. (2021) · doi:10.31234/osf.io/gz3q9 · Cited by 1
Unique neural signatures of childhood sexual abuse revisitedPreprint
Brosch, K., Hammes, V., Usemann, P. L., Stein, F., Zika, S., Schrott, F., Thomas‐Odenthal, F., Teutenberg, L., Meinert, S. L., Thiel, K., et al. (2025) · medRxiv · doi:10.1101/2025.02.10.25322009 · Cited by 1
Evolutionary Perspectives on the Parental Brain
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0011
Anxiety Reduction and Maternal Aggression in Postpartum Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0006
Development of the Parental Brain in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0009
Development of the Parental Brain in Humans
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0010
Brain Mechanisms Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0004
Gómez‐Vallejo, S., González, B. P., Vizcaíno, E. J. V., & Noval-Aldaco, E. (2019) · Springer eBooks · doi:10.1007/978-3-030-15179-9_19
EARLY EXPERIENCES OF ONLINE SEXUAL VICTIMIZATION AND PSYCHOPATHOLOGICAL SYMPTOMS IN ADULTHOOD
TEIXEIRA, C. L. R. D. M. (2022) · doi:10.17771/pucrio.acad.59139
von Koch, L. (2022) · Elsevier eBooks · doi:10.1016/b978-3-437-23031-8.00007-8
Life Course Socioeconomic Trajectories and Health
Hardy, R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780192864642.003.0017
Factors That Influence the Relationship Between Childhood Abuse and Adulthood Depression
Jiang, Y. (2023) · Lecture Notes in Education Psychology and Public Media · doi:10.54254/2753-7048/9/20230205
Kuzminskaite, E. (2023) · doi:10.5463/thesis.371
Problemas de sueño en estudiantes de posgrado en salud en Medellín, Colombia
Peláez, V. D. M. M., Agudelo, J. B., Echeverri, A. M. M., Barrera, S. V., Wiedemann, L., Carmona, M. A. Z., & Gómez, O. I. Q. (2023) · Informes Psicológicos · doi:10.18566/infpsic.v23n2a11
Addictions et groupes spécifiques : les adolescents, les personnes âgées et les femmes
Graziani, P., & Romo, L. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77964-0.00005-2
Larson, E. R., Moussa‐Tooks, A. B., & Wisner, K. (2024) · doi:10.31219/osf.io/uv84k
A Review of Research on Child Abuse
庞, 林. (2024) · Advances in Psychology · doi:10.12677/ap.2024.143144
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0006
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0003
Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0004
Scardera, S., Geoffroy, M., Langevin, R., Perret, L., Collin-Vézina, D., Voronin, I., Gouin, J., Meng, X.-F., Boivin, M., & Ouellet-Morin, I. (2024) · Development and Psychopathology · doi:10.1017/s0954579424001688 · Cited by 1
The importance of self-concept and how it relates to street children
Julien, G. (2025) · International Journal of Sociology and Anthropology · doi:10.5897/ijsa2025.1013
Gee, G., Black, C., Mulder, S., Brown, S., Gibbs, J., Biggs, L. J., Kennedy, H., & Milroy, H. (2025) · First Nations Health and Wellbeing - The Lowitja Journal · doi:10.1016/j.fnhli.2025.100076
Influence of childhood maltreatment on malignant self-regard
Barbera, E. R., Ceroni, D. B., Peters, W., & Yalch, M. M. (2025) · Journal of Family Trauma Child Custody & Child Development · doi:10.1080/26904586.2025.2575340
Effects of a Parenting Program on Parenting Outcomes in Mothers with Adverse Childhood Experiences
Lotto, C. R., Altafim, E. R. P., & Linhares, M. B. M. (2025) · Adversity and Resilience Science · doi:10.1007/s42844-025-00185-0
Han, Q., Pang, M. Y. C., & She, R. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120820
Li, J., Jin, Y., Xu, S., Luo, X., Wilson, A. D., Li, H., Wang, X., Sun, X., & Wang, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24152499
Hansen, C. D., Kirkeby, M. J., Kjelmann, K. G., Jh, A., & Møberg, R. J. (2021) · Figshare · doi:10.6084/m9.figshare.16960574
Gama, C. M. F., Portugal, L. C. L., Gonçalves, R., de Souza Junior, S., Vilete, L. M. P., Mendlowicz, M. V., Figueira, I. L. D. V., Volchan, E., David, I. A., Oliveira, L., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14234506
Salmon, S., Dávila, I. G., Taillieu, T., Stewart-Tufescu, A., Duncan, L., Fortier, J., Struck, S., Georgiades, K., MacMillan, H. L., Kimber, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19728164
Additional file 1 of Sexual and physical abuse and depressive symptoms in the UK Biobank
Chaplin, A. B., Jones, P. B., & Khandaker, G. M. (2021) · Figshare · doi:10.6084/m9.figshare.14608561
Bordignon, E., Miranda, V. I. A., de Mola Zanatti, C. L., Menezes, A. M. B., da Silva, H. D. G., Wehrmeister, F. C., & Murray, J. (2024) · Figshare · doi:10.6084/m9.figshare.26642641
He, X., Wang, M., Du, Y., Ye, Z., Yang, Y., & Guo, C. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121169
Infurna, M. R., Spicuzza, V., Bevacqua, E., Piombo, M. A., Riolo, M., Aiello, P. M., Grutta, S. L., & Epifanio, M. S. (2026) · Current Psychology · doi:10.1007/s12144-025-08932-3
DePorter, J. D., Eshelman, L. R., & Messman, T. L. (2026) · Journal of Child Sexual Abuse · doi:10.1080/10538712.2026.2633627
Pochigaeva, K., Druzhkova, T. A., Onufriev, M. V., Guekht, A. B., & Gulyaeva, N. V. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026010126
Liu, C., Liu, X., & Wang, S. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1725710
Experiences of childhood emotional maltreatment and emotional intelligence in young men
Suslow, T., Rufer, M., Kersting, A., & Hoepfel, D. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1755465
Onyechi, T., & Nwosu, E. O. (2026) · Children and Youth Services Review · doi:10.1016/j.childyouth.2026.108868
Fullerton, A. J., Issanov, A., & Meza, R. (2026) · Canadian Journal of Public Health · doi:10.17269/s41997-026-01173-2
Bennett, S., Robb, K. A., Zortea, T. C., & O’Connor, R. C. (2026) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2026.108024 · Cited by 1
Multi-omic molecular signatures from peripheral blood samples of patients with mood disorders
Mokhtari, A. (2022) · theses.fr (ABES) · doi:10.70675/6e6b049ez0ae2z40f2za015z47c5c58102d3
Sirparanta, A. (2024) · theses.fr (ABES) · doi:10.70675/01e34829zd16az44abz83d6z94398e631330
Pathways of Victimization: Examining Pathways From Early Childhood Victimization by Sex
Gilbreath, S., & Novak, A. S. (2026) · Violence and Victims · doi:10.1891/vv-2025-0078
Chen, J.-K., Wu, C., & Wang, Z.-Y. (2026) · Journal of Aggression, Maltreatment & Trauma · doi:10.1080/10926771.2026.2660185
Jang, H.-Y., & Kim, J. (2026) · Social Science & Medicine (1967) · doi:10.1016/j.socscimed.2026.119426
A Systematic Review of the Relationship Between Maltreatment and Mentalization in Middle Childhood
Kerr-Davis, A., Westlake, M. F., Midgley, N., & Hillman, S. (2026) · Journal of Child & Adolescent Trauma · doi:10.1007/s40653-026-00924-0
Kısacık, E., & Altınışık, B. (2026) · Klinik Psikoloji Dergisi · doi:10.57127/kpd.26024438.1945185
Faus, D. P., de Moraes, C. L., Reichenheim, M. E., Castro, M. C., Miliauskas, C. R., Marques, E. S., & Taquette, S. R. (2026) · Cadernos de Saúde Pública · doi:10.1590/0102-311xen185425
Maternal Childhood Maltreatment, Social Support, and Self‐Insight Effects on Psychological Stress
Nakajima, M. (2026) · Japanese Psychological Research · doi:10.1111/jpr.70037
Lapomarda, G., Frajo-Apor, B., Autengruber, G., Hofer, A., & Morawetz, C. (2026) · Journal of Child & Adolescent Trauma · doi:10.1007/s40653-026-00946-8
Gender Matters: The Effect of Parental Violence on Youth Mental Health Mediated via Parenting Styles
Huang, C., Shen, A. C., Hsieh, Y., Hwa, H., Wei, H.-S., & Feng, J. (2026) · Family Relations · doi:10.1111/fare.70257
Völker, M. P., Kresken, A. L., Foo, J. C., Frank, J., Reinhard, I., Klinger-König, J., Zillich, L., de Sá, D. S. F., Mikolajczyk, R., Leitzmann, M., et al. (2026) · Psychotherapy and Psychosomatics · doi:10.1159/pps/aemag008
Afreen, S., & Khan, F. (2026) · Children and Youth Services Review · doi:10.1016/j.childyouth.2026.109275
Influence of Childhood Maltreatment on Narcissism
Bedrossian, E. N., Barbera, E. R., & Yalch, M. M. (2026) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2026.2734397
Yu, Y., Wang, Y., Gu, L., Kang, P., Yang, Y., Hu, L., & Yu, T. (2026) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2026.108334
Critical windows: timing of child maltreatment exposure and adult mental health
Otten, D., Schalinski, I., Fegert, J. M., Jud, A., Brähler, E., & Clemens, V. (2026) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-026-01188-0
Hou, Y., Sullivan, T. P., Zang, E. X., Saxena, S., Gupta, M., Singh, N. C., & Mukherjee, B. (2026) · medRxiv · doi:10.64898/2026.10.09.26365161
Metadata
- Authors
- Gallo, E. A. G., Munhoz, T. N., Loret de Mola, C., & Murray, J.
- Affiliations
- Universidade Federal de Pelotas (BR)
- Corresponding author
- Murray, Joseph
- Venue
- Child Abuse & Neglect
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 79
- Pages
- 107-114
- ISSN
- 0145-2134 (ISSN-L)
- OpenAlex
- W2790792517
- Cited by
- 279
- References
- 56
- Citations by year
- 2026: 28 · 2025: 38 · 2024: 34 · 2023: 45 · 2022: 42 · 2021: 36 · 2020: 34 · 2019: 16 · 2018: 6
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Child Abuse & Neglect (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Keywords
- child abuse, gender differences, adult depression, generalized anxiety disorder, physical abuse, sexual abuse, childhood adversity, adolescent maltreatment, mental health outcomes
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Child, Child Abuse, Depressive Disorder, Major, Major Depressive Disorder, Epidemiologic Methods, Female, Humans, Male, Mental Health, Sex Factors, Adult Survivors of Child Abuse
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review