The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The Interferon-Inducible Protein Viperin Inhibits Influenza Virus Release by Perturbing Lipid Rafts
Open accessAbstract
Interferons initiate the host antiviral response by inducing a number of genes, most with no defined antiviral function. Here we show that the interferon-induced protein viperin inhibits influenza A virus release from the plasma membrane of infected cells. Viperin expression altered plasma membrane fluidity by affecting the formation of lipid rafts, which are detergent-resistant membrane microdomains known to be the sites of influenza virus budding. Intracellular interaction of viperin with farnesyl diphosphate synthase (FPPS), an enzyme essential for isoprenoid biosynthesis, decreased the activity of the enzyme. Overexpression of FPPS reversed viperin-mediated inhibition of virus production and restored normal membrane fluidity, and reduction of FPPS levels by siRNA inhibited virus release and replication, indicating that the FPPS interaction underlies viperin's effects. These findings suggest that targeting the release stage of the life cycle may affect the replication of many enveloped viruses. Furthermore, FPPS may be an attractive target for antiviral therapy.
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Cites
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Self-citation
Cited by
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Interferon-stimulated genes and their antiviral effector functions
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Iwasaki, A., & Pillai, P. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3665 · Cited by 1,068
Radical S-Adenosylmethionine Enzymes
Broderick, J. B., Duffus, B. R., Duschene, K. S., & Shepard, E. M. (2014) · Chemical Reviews · doi:10.1021/cr4004709 · Cited by 830
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Metadata
- Authors
- Wang, X., Hinson, E. R., & Cresswell, P.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 2
- Issue
- 2
- Pages
- 96-105
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2092498488
- Cited by
- 477
- References
- 28
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, X., Hinson, E. R., & Cresswell, P. (2007). The Interferon-Inducible Protein Viperin Inhibits Influenza Virus Release by Perturbing Lipid Rafts. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2007.06.009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
