The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B
Open accessAbstract
Entry into host macrophages and evasion of intracellular destruction mechanisms, including phagosome-lysosome fusion, are critical elements of Mycobacterium tuberculosis (Mtb) pathogenesis. To achieve this, the Mtb genome encodes several proteins that modify host signaling pathways. PtpA, a low-molecular weight tyrosine phosphatase, is a secreted Mtb protein of unknown function. The lack of tyrosine kinases in the Mtb genome suggests that PtpA may modulate host tyrosine phosphorylated protein(s). We report that a genetic deletion of ptpA attenuates Mtb growth in human macrophages, and expression of PtpA-neutralizing antibodies simulated this effect. We identify VPS33B, a regulator of membrane fusion, as a PtpA substrate. VPS33B and PtpA colocalize in Mtb-infected human macrophages. PtpA secretion combined with active-phosphorylated VPS33B inhibited phagosome-lysosome fusion, a process arrested in Mtb infections. These results demonstrate that PtpA is essential for Mtb intracellular persistence and identify a key host regulatory pathway that is inactivated by Mtb.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
THE STRUCTURE AND MECHANISM OF PROTEIN PHOSPHATASES: Insights into Catalysis and Regulation
Barford, D., Das, A. K., & Egloff, M.-P. (1998) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.27.1.133 · Cited by 706
Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages
Walburger, A., Koul, A., Ferrari, G., Nguyen, L., Prescianotto-Baschong, C., Huygen, K., Klebl, B., Thompson, C., Bacher, G., & Pieters, J. (2004) · Science · doi:10.1126/science.1099384 · Cited by 595
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
Vergne, I., Chua, J., Lee, H.-H., Lucas, M., Belisle, J., & Deretic, V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409716102 · Cited by 541
Banta, L. M., Robinson, J. S., Klionsky, D. J., & Emr, S. D. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1369 · Cited by 410
Gissen, P., Johnson, C. A., Morgan, N. V., Stapelbroek, J. M., Forshew, T., Cooper, W. N., McKiernan, P. J., Klomp, L. W. J., Morris, A. A. M., Wraith, J. E., et al. (2004) · Nature Genetics · doi:10.1038/ng1325 · Cited by 340
Rieder, S. E., & Emr, S. D. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.11.2307 · Cited by 304
The TB epidemic from 1992 to 2002
Raviglione, M. C. (2003) · Tuberculosis · doi:10.1016/s1472-9792(02)00071-9 · Cited by 267
Cowley, S., Ko, M., Pick, N., Chow, R., Downing, K. J., Gordhan, B. G., Betts, J. C., Mizrahi, V., Smith, D. A., Stokes, R. W., et al. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04085.x · Cited by 254
Self-citationThe Inactivation Mechanism of Low Molecular Weight Phosphotyrosine-protein Phosphatase by H2O2
Caselli, A., Marzocchini, R., Camici, G., Manao, G., Moneti, G., Pieraccini, G., & Ramponi, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32554 · Cited by 213
Cited by
Virulence factors of the Mycobacterium tuberculosis complex
Forrellad, M. A., Klepp, L. I., Gioffré, A., Sabio y García, J., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F. (2013) · Virulence · doi:10.4161/viru.22329 · Cited by 622
Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance
Pieters, J. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.006 · Cited by 503
Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 312
Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis
Hmama, Z., Peña‐Díaz, S., Joseph, S., & Av‐Gay, Y. (2015) · Immunological Reviews · doi:10.1111/imr.12268 · Cited by 290
Self-citationMycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
Mehra, A., Zahra, A., Thompson, V., Sirisaengtaksin, N., Wells, A., Porto, M., Köster, S., Penberthy, K., Kubota, Y., Dricot, A., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003734 · Cited by 192
Metadata
- Authors
- Bach, H., Papavinasasundaram, K. G., Wong, D., Hmama, Z., & Av-Gay, Y.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 3
- Issue
- 5
- Pages
- 316-322
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2065627587
- Cited by
- 332
- References
- 22
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B. https://app.cochat.ai/papers/10.1016/j.chom.2008.03.008
- The paper
- Bach, H., Papavinasasundaram, K. G., Wong, D., Hmama, Z., & Av-Gay, Y. (2008). Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2008.03.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
