The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough
Open accessAbstract
Summary Integrated HIV-1 genomes are found within actively transcribed host genes in latently infected CD4+ T cells. Readthrough transcription of the host gene might therefore suppress HIV-1 gene expression and promote the latent infection that allows viral persistence in patients on therapy. To address the effect of host gene readthrough, we used homologous recombination to insert HIV-1 genomes in either orientation into an identical position within an intron of an active host gene (HPRT). Constructs were engineered to permit or block readthrough transcription of HPRT. Readthrough transcription inhibited HIV-1 gene expression for convergently orientated provirus but enhanced HIV-1 gene expression when HIV-1 was in the same orientation as the host gene. Orientation had a >10 fold effect on HIV-1 gene expression. Due to the nature of HIV-1 integration sites in vivo, this orientation-dependent regulation can influence the vast majority of infected cells and adds another complexity to the maintenance of latency.
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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
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Self-citationQuantification of latent tissue reservoirs and total body viral load in HIV-1 infection
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Self-citationHIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
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Self-citationMalim, M. H., Hauber, J., Le, S.-Y., Maizel, J. V., & Cullen, B. R. (1989) · Nature · doi:10.1038/338254a0 · Cited by 1,280
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Cited by
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Ho, Y.-C., Shan, L., Hosmane, N. N., Wang, J., Laskey, S. B., Rosenbloom, D. I. S., Lai, J., Blankson, J. N., Siliciano, J. D., & Siliciano, R. F. (2013) · Cell · doi:10.1016/j.cell.2013.09.020 · Cited by 1,405
Self-citationComparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies
Eriksson, S., Graf, E. H., Dahl, V., Strain, M. C., Yukl, S. A., Lysenko, E. S., Bosch, R. J., Lai, J., Chioma, S., Emad, F., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003174 · Cited by 567
Self-citationTowards an HIV cure: a global scientific strategy
The International AIDS Society Scientific Working Group on HIV Cure (2012) · Nature Reviews Immunology · doi:10.1038/nri3262 · Cited by 554
Siliciano, R. F., & Greene, W. C. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007096 · Cited by 513
Self-citationInternational AIDS Society global scientific strategy: towards an HIV cure 2016
International AIDS Society Towards a Cure Working Group, Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4108 · Cited by 425
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Metadata
- Authors
- Han, Y., Lin, Y. B., An, W., Xu, J., Yang, H.-C., O'Connell, K., Dordai, D., Boeke, J. D., Siliciano, J. D., & Siliciano, R. F.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 4
- Issue
- 2
- Pages
- 134-146
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2052680578
- Cited by
- 215
- References
- 7
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough. https://app.cochat.ai/papers/10.1016/j.chom.2008.06.008
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- Han, Y., Lin, Y. B., An, W., Xu, J., Yang, H.-C., O'Connell, K., Dordai, D., Boeke, J. D., Siliciano, J. D., & Siliciano, R. F. (2008). Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2008.06.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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